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MRRTRRSSASRSAARLVRPAIPSVVSVALLVTVPAVANADSRTDSIAALIADVARANQRLDDLSAAVELE QEGVNKAMVAVETARDEAAAAEHELEASQQAVKDANAAIAAAQHRFDTFAAATYMNGPSDSYLTATSPDE IIAAATAAKTLAASAQTVMANLERARTRQVNKESASRLAEQKADKAAEDAKTSQDAAVTALTDTQRKFDQ QREEVNRLAAERDEAEAKLQAARLVAWSSAGAEGPPPGAMWDPGARPGNGRRWDGWDPTLPQIPSANIPG DPIAVVNQVLGISATSAQVTANMGQNFLQQLGILKPTDTGITNAATGATRIPRVYGRQASEYVIRRGMAQ IGVPYSWGGGNAAGPSKGIDSGAGITGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPTSQMRRGDVI FYGPGGSQHVTLYLGNGQMLEAPDIGLKVRVAPVRTSGMTPFVVRYIEY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1486 | - | - | 100% (469) | cell wall-associated hydrolase |
| M. ulcerans Agy99 | MUL_1487 | inv2 | 8e-72 | 63.41% (205) | invasion protein Inv2 |
| M. ulcerans Agy99 | MUL_1557 | - | 2e-36 | 51.91% (131) | inv protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1513 | - | 0.0 | 81.99% (472) | invasion protein |
| M. gilvum PYR-GCK | Mflv_3663 | - | 1e-147 | 56.33% (490) | NLP/P60 protein |
| M. tuberculosis H37Rv | Rv1477 | - | 0.0 | 81.99% (472) | invasion protein |
| M. leprae Br4923 | MLBr_01812 | - | 0.0 | 76.41% (479) | putative exported p60 protein homologue |
| M. abscessus ATCC 19977 | MAB_2728c | - | 1e-117 | 47.84% (485) | invasion protein Inv1 |
| M. marinum M | MMAR_2284 | iipA | 0.0 | 98.93% (469) | invasion and intracellular persistence protein, IipA |
| M. avium 104 | MAV_3301 | - | 0.0 | 75.44% (456) | invasion protein |
| M. smegmatis MC2 155 | MSMEG_3145 | - | 1e-155 | 58.89% (506) | secreted cell wall-associated hydrolase |
| M. thermoresistible (build 8) | TH_0436 | - | 1e-147 | 58.67% (467) | Possible inv protein |
| M. vanbaalenii PYR-1 | Mvan_2747 | - | 1e-147 | 56.47% (487) | NLP/P60 protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1486|M.ulcerans_Agy99 MRRTRRSSASRSAARLVRPAIPS-VVSVALLVTVPAVANADS-RTDSIAA
MMAR_2284|M.marinum_M MRRTRRSSASRSAARLVRPAIPS-VVSVALLVSVPAVVNADS-RTDSIAA
Mb1513|M.bovis_AF2122/97 MRRNRRGSPARPAARFVRPAIPS-ALSVALLVCTPGLATADP-QTDTIAA
Rv1477|M.tuberculosis_H37Rv MRRNRRGSPARPAARFVRPAIPS-ALSVALLVCTPGLATADP-QTDTIAA
MLBr_01812|M.leprae_Br4923 MKRPRRGSVSRPTARFVRPAIPS-LVSAALLVSLPVLATADP-DGDNLGT
MAV_3301|M.avium_104 --------------------MPS-VLSVALLICTPGLAQADP-AADNLAA
MSMEG_3145|M.smegmatis_MC2_155 MRRTVRALATRVHGRVCAVPLVV-GMLLATALYGGGPAAADPAAPDNLAT
TH_0436|M.thermoresistible__bu -------------------------MALATTINCGSVAVADPGDPNEVAT
Mflv_3663|M.gilvum_PYR-GCK MRRTPGGAS---ASRLCAASLAF-GMVLTVPNLAPHLALAQPAQADGIAR
Mvan_2747|M.vanbaalenii_PYR-1 MRRPVGSAS---ASRLCAASLAI-GMVMTVPNLAPNLALAQPAQADGMAR
MAB_2728c|M.abscessus_ATCC_199 MKRTVNDRFAVRGKRTVATALMVPPLLVAGLMMFPTTVAVTSAEPNDMAS
: : . . . : :.
MUL_1486|M.ulcerans_Agy99 LIADVARANQRLDDLSAAVELEQEGVNKAMVAVETARDEAAAAEHELEAS
MMAR_2284|M.marinum_M LIADVARANQRLDDLSAAVELEQEGVNKAMVAVETARDEAAAAEHELEAS
Mb1513|M.bovis_AF2122/97 LIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVS
Rv1477|M.tuberculosis_H37Rv LIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVS
MLBr_01812|M.leprae_Br4923 LIADVAKVNQRLEDLGAAIETEEQSVNKAMVSVEMARDNAVAAEHDCEVS
MAV_3301|M.avium_104 LIANVAKANQRLQNLSAEIQTEQESVNKALVDVETARDNAAAAQHDLEAS
MSMEG_3145|M.smegmatis_MC2_155 LVAKVASADQKLQELGAAIQTQQETVNKAIVDVQAARDAAAAAQRELEAG
TH_0436|M.thermoresistible__bu LVAAVANVNQKLQELGAAVQQKKESVNKALVDLQEARDAAEAAQAELKAA
Mflv_3663|M.gilvum_PYR-GCK LVTDVANVNQQLQDLGAQIQMQQESVNKAILDVQTARDDAAAAQLDVDAS
Mvan_2747|M.vanbaalenii_PYR-1 LVTDVADINQQLQDLGAQIQMQQESVNKAILDVQTARDDAAAAQLEVDAS
MAB_2728c|M.abscessus_ATCC_199 LITQLADTNQQIEQLTADVQTQQESINKGLVDLQAARDNAASAAAQVAEG
*:: :* :*::::* :: ::: :**.:: :: *** * :* : .
MUL_1486|M.ulcerans_Agy99 QQAVKDANAAIAAAQHRFDTFAAATYMNGPSDSYLTATSPDEIIAAATAA
MMAR_2284|M.marinum_M QQAVKDANAAIAAAQHRFDTFAAATYMNGPSDSYLTATSPDEIIAAATAA
Mb1513|M.bovis_AF2122/97 QRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAA
Rv1477|M.tuberculosis_H37Rv QRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAA
MLBr_01812|M.leprae_Br4923 QQSVKDANTAINAAQHRFDSFAAATYMNGPSGSYLTATSPDDIIATATAA
MAV_3301|M.avium_104 QQAVKDANAAIAGAQRRFDTFAAAAYMNGPSNSYLTARNPDDIIATEAAA
MSMEG_3145|M.smegmatis_MC2_155 QRGVADANAAIEAAQKRFDSFAAATYMNGPSRSYLTATDPADIVNTTATG
TH_0436|M.thermoresistible__bu QESVETANTAIEDAQKRFDTFAAATYVNGPSVSYLTASDPADVLDTAVAG
Mflv_3663|M.gilvum_PYR-GCK AQRVKDANAAIAAAQARFDKFAAAMYVRGPSSSYLTASDPTDILHTAAAG
Mvan_2747|M.vanbaalenii_PYR-1 AQRVKDANAAIAAAQDRFDTFAASMYVSGPSSSYLTATDPTDILNTAATG
MAB_2728c|M.abscessus_ATCC_199 QRAVDAANGAIEEAQGKFDRMAAATYMAGPSTSYLTATNPDDVVRLASVT
. * ** ** ** :** :**: *: *** ***:* .* ::: .
MUL_1486|M.ulcerans_Agy99 KTLAASAQTVMANLERARTRQVNKESASRLAEQKADKAAEDAKTSQDAAV
MMAR_2284|M.marinum_M KTLAASAQTVMANLERARTRQVNKESASRLAKQKADKAAEEAKTSQDAAV
Mb1513|M.bovis_AF2122/97 KTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKASQDAAV
Rv1477|M.tuberculosis_H37Rv KTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKASQDAAV
MLBr_01812|M.leprae_Br4923 RTLTASSQAVMANLQRARTEQVNKESAARLAKQKADKAADDAKASMDAAV
MAV_3301|M.avium_104 KTLTASSQTVMAKLQQARTEQVNRESAARLAKQNADKAAADAKASQDAAV
MSMEG_3145|M.smegmatis_MC2_155 QALIASSQQVMAKLQRARTEQVNRESAARLAKEKADQAARDAESSQDNAV
TH_0436|M.thermoresistible__bu QVLATSAQQVMKNLQQARTEQVNKESLARLAKQRADEKLAAAQASQEAAV
Mflv_3663|M.gilvum_PYR-GCK QSLSISSQKVMADLQRARTEQVNKESAARLAKQKADDAVKAAETSQQDAV
Mvan_2747|M.vanbaalenii_PYR-1 QALAISSQKVMADLQRARTEQVNRESAARLAKKQADDAVKAAETSQQDAV
MAB_2728c|M.abscessus_ATCC_199 KSVEASSQTVMDNLRRARTEQVNKQSQARAIQEKADQAAADAQQQQDDLV
: : *:* ** .*.:***.:** :* :* ::.**. *: . : *
MUL_1486|M.ulcerans_Agy99 TALTDTQRKFDQQREEVNRLAAERDEAEAKLQAARLVAWSSA-----GAE
MMAR_2284|M.marinum_M TALTDTQRKFDQQREEVNRLAAERDEAEAKLQAARLVAWSSA-----GAE
Mb1513|M.bovis_AF2122/97 AALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAWSSE-----GGQ
Rv1477|M.tuberculosis_H37Rv AALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAWSSE-----GGQ
MLBr_01812|M.leprae_Br4923 AALTASKRKFDEQRDEVNRLAAERDEAQARLEVAQIAAATWVPGM--GGH
MAV_3301|M.avium_104 AALTNSRQKFDEQREQMIRLATERDQAQAKLEAAKRQLSTPG-------S
MSMEG_3145|M.smegmatis_MC2_155 AALKQAQQTFNAQQGELERLAAERAAAQAELDSVRKVSATGNAAP-AAAP
TH_0436|M.thermoresistible__bu NALTEAQETFGAQQAELQKLTAEREAAQAKLNEVRTMSAATAGAT-SGAN
Mflv_3663|M.gilvum_PYR-GCK SALTKAQETFKAQQTELDRLTAERAQAQARLQQARSLAAPSSPAPSSPAP
Mvan_2747|M.vanbaalenii_PYR-1 SALTNAQQTFKAQQVELDRLTAERARAQAKLQEARTPAAPTGGAP-AAAP
MAB_2728c|M.abscessus_ATCC_199 SAMKDVQKKLEAQRGVAADLTAKKKSAEAQLAAARGPAYAASTAT---AR
*:. :..: *: *:::: *:*.* .: .
MUL_1486|M.ulcerans_Agy99 GPPPG-------------AMWDPG----ARPGNGRRWDG-----------
MMAR_2284|M.marinum_M GPPPG-------------AMWDPG----ARPGNGRRWDG-----------
Mb1513|M.bovis_AF2122/97 GAPPF-------------RMWDPG----SGPAGGRAWDGL----------
Rv1477|M.tuberculosis_H37Rv GAPPF-------------RMWDPG----SGPAGGRAWDGL----------
MLBr_01812|M.leprae_Br4923 GTPPFG------------DRWEPGSPASAGPAGGRKWDG-----------
MAV_3301|M.avium_104 G-----------------DRWETGSAGAPAPSAGRQWDGA----------
MSMEG_3145|M.smegmatis_MC2_155 AAAPAPAAAPAPVPNSAPAPVPGAQPNPQAAAGNWDRAPSGPASSGQNWA
TH_0436|M.thermoresistible__bu GSAPA------------AAPTPGAASGTQDPARNWDRAPGGPVVPYGDPS
Mflv_3663|M.gilvum_PYR-GCK AAAPT------------GAATGAGAPAPGGSGSSWDVDP----ATGNRET
Mvan_2747|M.vanbaalenii_PYR-1 TGATT------------PAPGSSAAPAPGGASPNWDVDP----ATGNRET
MAB_2728c|M.abscessus_ATCC_199 VINPS------------AAIAGNGNEWTEGPAPVSSGGQ-----------
. ..
MUL_1486|M.ulcerans_Agy99 -WDPTLPQIPSANIPGDPIAVVNQVLGISATSAQVTANMGQNFLQQLGIL
MMAR_2284|M.marinum_M -WDPTLPQIPSANIPGDPIAVVNQVLGISATSAQVTANMGRNFLQQLGIL
Mb1513|M.bovis_AF2122/97 -WDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRKFLEQLGIL
Rv1477|M.tuberculosis_H37Rv -WDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRKFLEQLGIL
MLBr_01812|M.leprae_Br4923 -WDPTLPQVPSANVPGDPIAVINQVLGYAATSTQVTASMGRNFLQQLGIL
MAV_3301|M.avium_104 -WDPTLPMIPSANVPGDPIAVINQVLGISATSTQVTAGLGRNFLQQLGIL
MSMEG_3145|M.smegmatis_MC2_155 VWDPTLPAIPSAFVSGDPIAIINAVLGIASTSAQVTADMGRSFLQKLGIL
TH_0436|M.thermoresistible__bu QWDLTLPAIPSAFVSGDPIAIINASLQIAATSAQVTADLGRRFLQRLGLV
Mflv_3663|M.gilvum_PYR-GCK AWDMTLPQIPSAFVSGDPIQIINAVLKIITTSVEITQNLGRKFLQSIGLL
Mvan_2747|M.vanbaalenii_PYR-1 AWDMTLPQIPSAFVSGDPVQIINAVLKIITTSIEITQNMGRKFLQSIGLL
MAB_2728c|M.abscessus_ATCC_199 -WDTTLPMIASANVPTDPTQTINMVLGIGNTAANVGQSA---VCGVIGIF
** *** :.** :. ** :* * *: :: . . :*:.
MUL_1486|M.ulcerans_Agy99 KPTDTGITNAATGATR--IPRVYGRQASEYVIRRGMAQIGVPYSWGGGNA
MMAR_2284|M.marinum_M KPTDTGITNAATGATR--IPRVYGRQASEYVIRRGMAQIGVPYSWGGGNA
Mb1513|M.bovis_AF2122/97 QPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVPYSWGGGNA
Rv1477|M.tuberculosis_H37Rv QPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVPYSWGGGNA
MLBr_01812|M.leprae_Br4923 KPNDTGITNAPIGSTQGRIPRVYGRQASEYVIRRGISQIGVPYSWGGGNA
MAV_3301|M.avium_104 KPDDTGITNAAPGGVGARIPRVYGRQATEYVIRRGMSQIGVPYSWGGGNA
MSMEG_3145|M.smegmatis_MC2_155 -PTPTGFTN-------GAIPRVYGREAVEYVIRRGMSQIGVPYSWGGGNA
TH_0436|M.thermoresistible__bu -PTPTGYTNE------GGIPRVYGRQATEYVIQRAMSQIGVPYSWGGGNA
Mflv_3663|M.gilvum_PYR-GCK -PTPTGITN-------GAIPALHGRNATEYVIKRGMSQMGVPYSWGGGNA
Mvan_2747|M.vanbaalenii_PYR-1 -PTPTGITN-------GAIPTLYGRQATEYVIKRGMSQMGVPYSWGGGNA
MAB_2728c|M.abscessus_ATCC_199 CPKAAPAAAAS-GEGGEYLPKVYGRENVERVIARAGSAMGTPYSWGGGSY
* : : :* ::**: * ** *. : :*.*******.
MUL_1486|M.ulcerans_Agy99 AGPSKGIDSGAGITGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPTS
MMAR_2284|M.marinum_M AGPSKGIDSGAGITGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPTS
Mb1513|M.bovis_AF2122/97 AGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPSS
Rv1477|M.tuberculosis_H37Rv AGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPSS
MLBr_01812|M.leprae_Br4923 AGPSRGIDSGAGITGFDCSGLVLYSFAGVGIRLPHYSGSQYNLGRKIPSA
MAV_3301|M.avium_104 AGPSKGIDSGANIVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPSS
MSMEG_3145|M.smegmatis_MC2_155 AGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAGRKIPSS
TH_0436|M.thermoresistible__bu AGPSRGIDSGANTVGFDCSGLVLYAFAGVGIKLPHYSGAQYNLGRKIPSA
Mflv_3663|M.gilvum_PYR-GCK AGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAGRKVPSS
Mvan_2747|M.vanbaalenii_PYR-1 SGPSRGIDQGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAGRKVPSS
MAB_2728c|M.abscessus_ATCC_199 NGPTRGIDSGAGTVGYDCSGLMMYGFAAVGIRLRHYTGYQYNSGRKVPSA
**::***.**. .*:*****::* **.***:* **:* *** ***:*::
MUL_1486|M.ulcerans_Agy99 QMRRGDVIFYGPGGSQHVTLYLGNGQMLEAPDIGLKVRVAPVRTSGMTPF
MMAR_2284|M.marinum_M QMRRGDVIFYGPGGSQHVTLYLGNGQMLEAPDIGLKVRVAPVRTSGMTPF
Mb1513|M.bovis_AF2122/97 QMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVRTAGMTPY
Rv1477|M.tuberculosis_H37Rv QMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVRTAGMTPY
MLBr_01812|M.leprae_Br4923 QMRRGDVIFYGPGGSQHVTIYLGHGQMLEAPDIGLRVRVAPVRTSGMTPY
MAV_3301|M.avium_104 QMRRGDVIFYGPGGSQHVTIYLGDGQMLEAPDIGLKVRVAPVRTSGMTPY
MSMEG_3145|M.smegmatis_MC2_155 QMRRGDMIFYGPNASQHVAMYLGNGQMLEAPYTGSHVKVSPVRTSGMTPY
TH_0436|M.thermoresistible__bu QMRRGDVIFYGPGGSQHVTIYLGNGQMIEAPYTGSHVKISPVRTSGMTPY
Mflv_3663|M.gilvum_PYR-GCK QMRRGDMIFYGPNASQHVAMYLGDGQMLEAPYTGSVVKISPVRTSGMTPY
Mvan_2747|M.vanbaalenii_PYR-1 QMRRGDMIFYGPNASQHVAMYLGDGQMLEAPYTGSVVKISPVRTSGMTPF
MAB_2728c|M.abscessus_ATCC_199 QMKRGDMIFYGPNASQHVALYLGNGQMLEAPNTGDVVKVSPVRTSGMTPY
**:***:*****..****::***.***:*** * *:::****:****:
MUL_1486|M.ulcerans_Agy99 VVRYIEY
MMAR_2284|M.marinum_M VVRYIEY
Mb1513|M.bovis_AF2122/97 VVRYIEY
Rv1477|M.tuberculosis_H37Rv VVRYIEY
MLBr_01812|M.leprae_Br4923 VVRYIEY
MAV_3301|M.avium_104 VVRYIEW
MSMEG_3145|M.smegmatis_MC2_155 VTRLIEY
TH_0436|M.thermoresistible__bu VVRYIEW
Mflv_3663|M.gilvum_PYR-GCK VTRMIEW
Mvan_2747|M.vanbaalenii_PYR-1 VTRMIEW
MAB_2728c|M.abscessus_ATCC_199 VTRMIEW
*.* **: