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SFVIAVPEVVGSAASEVAGIGSALGEATAAAAAPTVQVLAAAQDEVSQAIAAVFSTHAQAYQAASAQAQS LGQRFAQALAAGAGSYSSAEAAAAAVLANPAQVVSGDLLAAINAPVLSLTGRPLIGNGANGAPGTGANGA AGGWLLGDGGAGGSGAPGMAGGNGGAAGLWGTGGAGGAGGRTFNGDGGNGGAGGAGGWLMGTGGAGGAGG AGGFSGTGDGGSGGAGGAGGLLGGGGVGGAGGFSNGGTGGVGGTGGAGGVLSGVVGAGGGHGGTGGYGAF DGGAGGVGGHAGLLGGPGGAGGDGGDTFGGGSGGAGGAGGDGGWAFGSGGTGGTGGYGGAGGAGGSGGDA GLLFSNGGAGGTGGFGETGGEGGAGGGAGWLGDGGAGGTGGAANIGSGGDGGGGGTGGTLLGNGGAGGAG GHGPTDGGAGGTGGNAVVVGNGGNGGIGGTGPTTGTTGAGGIGGLLLGLDGYNAPTSTSPIHVAQQQALV AINSPVQDLTGRPLIGNGTPAPAGSGADGTPGGWLLGDGGAGGSAVAGSDGAGGSGGAAGLWGTGGTGGA GARSTTGNGGAGGAGGAGGWLSGDGGTGGTGGAATFNGATGGNGGDAGNGGLFGAGGNGGAGGAGLGNPG FGGAGGNGGAGGLLSGLVGAGGGHGGAGGLGVSPSTPAALAGGGIGGAGGDAGLLGGAGGAGGTGGSGAF DVTSTGGTGGAGGNAGFLFGSGGIGGPGGFAVAASGNGGQGGHAGLLWSSGGAGGAGAFSVSGPAGAGGH GGDAGWLGNGGAGGTGGISRNGNGGDGGAGGSGGELLGVGGAGGQGGQANAGGGTGTGGEGGDGGDAGLI GDGGNGGNAGTDTDGTPTGDPGTGGTGGTLLGANGNAGMG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1195 | - | - | 100% (881) | PE-PGRS family protein, PE_PGRS9_4 |
| M. marinum M | MMAR_3326 | - | 0.0 | 74.80% (889) | PE-PGRS family protein |
| M. marinum M | MMAR_4399 | - | 0.0 | 64.23% (931) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0767 | PE_PGRS9 | 0.0 | 62.22% (884) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-152 | 46.97% (758) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv0746 | PE_PGRS9 | 0.0 | 63.60% (827) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01556 | infB | 6e-09 | 27.99% (318) | translation initiation factor IF-2 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 4e-40 | 33.40% (509) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_4827 | - | 2e-24 | 44.51% (173) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-143 | 39.65% (918) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 9e-41 | 42.52% (294) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_3062 | - | 0.0 | 60.60% (896) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-147 | 45.88% (741) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0767|M.bovis_AF2122/97 --------------------------------------------------
Rv0746|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1195|M.marinum_M --------------------------------------------------
MUL_3062|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 --------------------------------------------------
Mb0767|M.bovis_AF2122/97 ------------------MSFVLAMPEVLGSAATDLAALGSVLGAADAAA
Rv0746|M.tuberculosis_H37Rv ------------------MSFVLAMPEVLGSAATDLAALGSVLGAADAAA
MMAR_1195|M.marinum_M ------------------MSFVIAVPEVVGSAASEVAGIGSALGEATAAA
MUL_3062|M.ulcerans_Agy99 ------------------MAFVLAVPDMVAEAAADLAGVGSVIDAANTAA
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------------MSIIDFILNLFRDPVEAASYVADPEAAL
MAV_4827|M.avium_104 ------------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEED
MLBr_01556|M.leprae_Br4923 -------MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASSTVEAPV
Mb0767|M.bovis_AF2122/97 AAT--------------------------------TTGIVAAVQDEVSAA
Rv0746|M.tuberculosis_H37Rv AAT--------------------------------TTGIVAAAQDEVSAA
MMAR_1195|M.marinum_M AAP--------------------------------TVQVLAAAQDEVSQA
MUL_3062|M.ulcerans_Agy99 AGS--------------------------------TTGIVAAAEDEVSAA
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ANAG--------------------------------LSAVSAAQVGAVMP
MAV_4827|M.avium_104 AID--------------------------------VTGADDAATASAPDR
MLBr_01556|M.leprae_Br4923 ARRLR-----------------------------ESFGGIKPAADKGAEQ
Mb0767|M.bovis_AF2122/97 IAALFSAHG-------------RAYQVASAQAAAVHAQFVEALSAGAGAY
Rv0746|M.tuberculosis_H37Rv IAALFSAHG-------------RAYQVASAQAAAVHAQFVEALSAGAGAY
MMAR_1195|M.marinum_M IAAVFSTHA-------------QAYQAASAQAQSLGQRFAQALAAGAGSY
MUL_3062|M.ulcerans_Agy99 IAALFSGHG-------------QAYQQISTRVAEFHAQFERVFAAGVQAY
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VVAESVASN-----------------YGYQSQWVNTGNPIHDLSGNLQNY
MAV_4827|M.avium_104 VISAILG------------------------TREGAADAGLQLSSIGVTW
MLBr_01556|M.leprae_Br4923 VATKAQAKR-----------------LGESLDQTLDRALDKAVAGNGATT
Mb0767|M.bovis_AF2122/97 AS-----------------------AEAAGAAVLANPAQSVQQDLLAAVN
Rv0746|M.tuberculosis_H37Rv AS-----------------------AEAAGAAVLANPAQSVQQDLLAAVN
MMAR_1195|M.marinum_M SS-----------------------AEAAAAAVLANPAQVVSGDLLAAIN
MUL_3062|M.ulcerans_Agy99 SG-----------------------AEAANASFLQDPLQTA----LNATN
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 YA-----------------------AQPDGPSILSPSLLSPRDNDFLSHN
MAV_4827|M.avium_104 TD-------------------------QLEAAALRDALAARRIDNVMLVS
MLBr_01556|M.leprae_Br4923 -------------------------AAPVQVDHSAAVVPIVAGEGPSTAH
Mb0767|M.bovis_AF2122/97 AQSVALTGRPLIGNGANGAPG-----TGANGAPGGWLLGNGGAGGSAAAG
Rv0746|M.tuberculosis_H37Rv AQSVALTGRPLIGNGANGAPG-----TGANGAPGGWLLGNGGAGGSAAAG
MMAR_1195|M.marinum_M APVLSLTGRPLIGNGANGAPG-----TGANGAAGGWLLGDGGAGGSGAP-
MUL_3062|M.ulcerans_Agy99 KPVQDLTGRPLVGNGANGVPG-----TGANGAAGGWLLGNGGAGGSGAA-
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG-
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG-
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA-
TH_3810|M.thermoresistible__bu ----------------------------VDG-------------------
MAB_4284c|M.abscessus_ATCC_199 DTDFASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIG
MAV_4827|M.avium_104 AFLAAAALAQNVG-GAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQ
MLBr_01556|M.leprae_Br4923 REELAPPAGQPSEQPGVPLPGQQGTPAAPHPGHPGMPTGPHPGPAPKPGG
Mb0767|M.bovis_AF2122/97 SGLPGGAGGAAG---LFGTGGAGGAGGSS---TVGDGG--AGGAGGSGGW
Rv0746|M.tuberculosis_H37Rv SGLPGGAGGAAG---LFGTGGAGGAGGSS---TVGDGE--AGGAGGSGGW
MMAR_1195|M.marinum_M -GMAGGNGGAAG---LWGTGGAGGAGGRT---FNGDGG--NGGAGGAGGW
MUL_3062|M.ulcerans_Agy99 -GQAGGDGGAAG---LIGAGGAGGAGGNSPLRNTANGG--NGGTGGAGGL
Mflv_5091|M.gilvum_PYR-GCK -GGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGA
Mvan_1264|M.vanbaalenii_PYR-1 -SGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGA
MSMEG_0868|M.smegmatis_MC2_155 -GLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGG
TH_3810|M.thermoresistible__bu ---DGGSGGRTG---LFSKLSRGGDGGDG-------------GLGGNGGH
MAB_4284c|M.abscessus_ATCC_199 DGAVAVGGSNSG-------PIASGQGSTAVNGDVRDSNIINADHGSNVGV
MAV_4827|M.avium_104 QIRAESYGDAAG---QLSAMVAGLEKLESLPGGLLLVG-SGVDVAPLKQV
MLBr_01556|M.leprae_Br4923 RPPRVGNNPFSSAQSVARPIPRPPAPRPSASPSSMSPR-PGGAVGGGGPR
. . .
Mb0767|M.bovis_AF2122/97 LLGTGGVGGVGGLG----AGAGGAGGVGGAG-------------------
Rv0746|M.tuberculosis_H37Rv LLGTGGVGGVGGLG----AGAGGAGGVGGAG-------------------
MMAR_1195|M.marinum_M LMGTGGAGGAGGAGGFSGTGDGGSGGAGGAG-------------------
MUL_3062|M.ulcerans_Agy99 LFGPGGVGGAGGAS----FLTGGTGGDGGAG-------------------
Mflv_5091|M.gilvum_PYR-GCK TGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG-------------
Mvan_1264|M.vanbaalenii_PYR-1 TGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG-------------
MSMEG_0868|M.smegmatis_MC2_155 TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPN
TH_3810|M.thermoresistible__bu GGGTGIIS------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 DQSQTRVGG-----------------------------------------
MAV_4827|M.avium_104 LQTTTFLDVSVAEE------------------------------------
MLBr_01556|M.leprae_Br4923 PPRTGVPRPGGGRPGAPVGGRSDAGGGNYRG-------------------
Mb0767|M.bovis_AF2122/97 ---GLLGAGGHGGAGGLG-----AVTGGVGGAGGAGGLL-----------
Rv0746|M.tuberculosis_H37Rv ---GLLGAGGHGGAGGLG-----AVTGGVGGTGGAGGLL-----------
MMAR_1195|M.marinum_M ---GLLGGGGVGGAGGFSN----GGTGGVGGTGGAGGVLSGVVGAGGGHG
MUL_3062|M.ulcerans_Agy99 ---GLFGAGGLGGVGGSG------NVGGNGGAGGAGGLLAGLVGAGGGDG
Mflv_5091|M.gilvum_PYR-GCK -AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG--------------
Mvan_1264|M.vanbaalenii_PYR-1 -AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG--------------
MSMEG_0868|M.smegmatis_MC2_155 VTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVD
TH_3810|M.thermoresistible__bu ----LLSLAGNGGNGGNG-------YRTTDNN------------------
MAB_4284c|M.abscessus_ATCC_199 ---DYTNVSGHGSADIDKSVTVVDDHSQRNTTN-----------------
MAV_4827|M.avium_104 ----PETALARGAALAAAN-----APLFASST------------------
MLBr_01556|M.leprae_Br4923 ---GGVGALPGGGSGGFRGRPGGGGHGGGGRPGQRGG-------------
.. .
Mb0767|M.bovis_AF2122/97 ------------------AGLLAGPGGAG-----------------GTGG
Rv0746|M.tuberculosis_H37Rv ------------------AGLLAGPGGAG-----------------GTGG
MMAR_1195|M.marinum_M GTGGYGAFDGGAGGVGGHAGLLGGPGGAG-----------------GDGG
MUL_3062|M.ulcerans_Agy99 GSGGLG-AAGGDGGNGGRAGLFGGAGGAG-----------------GMG-
Mflv_5091|M.gilvum_PYR-GCK --AVGAAGAAG------TVGTAGATGGTG---------------TGANGG
Mvan_1264|M.vanbaalenii_PYR-1 --AIGTAGVAG------AAGTAGATGGTG---------------VGGNGG
MSMEG_0868|M.smegmatis_MC2_155 GHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGG
TH_3810|M.thermoresistible__bu -------------------ALDGGHGGNG-------------------GN
MAB_4284c|M.abscessus_ATCC_199 -----------------INDSFNTDRSTN-----------------IGSG
MAV_4827|M.avium_104 -----------------AALAYAQDPGTG-----------------AVDQ
MLBr_01556|M.leprae_Br4923 -----------------AAGAFGRPGGAPR-----------RGRKSKRQK
.
Mb0767|M.bovis_AF2122/97 RGFLN-DGGVGGAG-------------------GNAGLLFGAGGTGGSGG
Rv0746|M.tuberculosis_H37Rv RGFLN-NGGVGGAG-------------------GNAGLLFGAGGTGGSGG
MMAR_1195|M.marinum_M DTFGGGSGGAGGAG-------------------GDGGWAFGSGGTGGTG-
MUL_3062|M.ulcerans_Agy99 -ATGGHSGGDGGAG-------------------GDAGLLFGTGGAGGAGG
Mflv_5091|M.gilvum_PYR-GCK AGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGG
Mvan_1264|M.vanbaalenii_PYR-1 AGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGG
MSMEG_0868|M.smegmatis_MC2_155 HSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGE
TH_3810|M.thermoresistible__bu VGFFS---------------------------------LFNLGGAGGWGG
MAB_4284c|M.abscessus_ATCC_199 NTTNTEIGSHNQAN---------------------IGTSTSAGGSAAVGG
MAV_4827|M.avium_104 YSLPDYLYVPVDPE-----------------PGDDELAYSAVGEEDAESP
MLBr_01556|M.leprae_Br4923 RQEYDSMQAPVVGG-------------VRLPHGNGETIRLARGASLSDFA
* .
Mb0767|M.bovis_AF2122/97 AGLGGDGGAGGAG--GNAGVLFGNAGSGGTG-------------------
Rv0746|M.tuberculosis_H37Rv AGLGGDGGAGGAG--GNTGVLFGNAGSGGTG-------------------
MMAR_1195|M.marinum_M -GYGGAGGAGGSG--GDAGLLFSNGGAGGTG-------------------
MUL_3062|M.ulcerans_Agy99 HAFDGDGGAGGAG--GNAGLMFSSGGSGGVG-------------------
Mflv_5091|M.gilvum_PYR-GCK Q--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG---------
Mvan_1264|M.vanbaalenii_PYR-1 Q--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG---------
MSMEG_0868|M.smegmatis_MC2_155 IYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASG
TH_3810|M.thermoresistible__bu S---------------------GVDGVDVVG-------------------
MAB_4284c|M.abscessus_ATCC_199 N----AGLAGNAGLAGNAGLAGNAGLAGNAG-------------------
MAV_4827|M.avium_104 TVVIEKLFLPEDSEPRRRPVLLVGSGLAVVG-------------------
MLBr_01556|M.leprae_Br4923 EKIDANPAALVQALFNLGEMVTATQSVGDETLELLG--------------
Mb0767|M.bovis_AF2122/97 ------GFGDTDGGAGGAGGDAGWLGS----------------------G
Rv0746|M.tuberculosis_H37Rv ------GFGDTDGGAGGAGGDAGWLGS----------------------G
MMAR_1195|M.marinum_M ------GFGET-GGEGGAGGGAGWLGD----------------------G
MUL_3062|M.ulcerans_Agy99 ------GAGSIDGGAGGAGGDAGWLGG----------------------G
Mflv_5091|M.gilvum_PYR-GCK ----LQGGKGGDGGAGGKGGDADSMGS------------------AGATG
Mvan_1264|M.vanbaalenii_PYR-1 ----LQGGQGGDGGTGGTGGDATSMGE------------------AGATG
MSMEG_0868|M.smegmatis_MC2_155 TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANG
TH_3810|M.thermoresistible__bu --------GNPDGGTPGAHGES----------------------------
MAB_4284c|M.abscessus_ATCC_199 -----LAGNAGLAGNAGLAGNAGLAGN---------------------AG
MAV_4827|M.avium_104 -------ISAVLALEIALAIGIRTTGT---------------------VA
MLBr_01556|M.leprae_Br4923 -----SEMNYNVQVVSPEDEDRELLEP----------------FDLTYGE
Mb0767|M.bovis_AF2122/97 GVGGAGGFGETG-------------------DGGVGGAGGKA--------
Rv0746|M.tuberculosis_H37Rv GVGGAGGFGETG-------------------DGGVGGAGGKA--------
MMAR_1195|M.marinum_M GAGGTGGAANIG-------------------SGGDGGGGGTG--------
MUL_3062|M.ulcerans_Agy99 GAGGAGGFGTIS-------------------DGGAGGRGGGG--------
Mflv_5091|M.gilvum_PYR-GCK GKGGNGGNGGRGGLFG---------------KGGNAGNGAD---------
Mvan_1264|M.vanbaalenii_PYR-1 GKGGNGGNGGRGSLFG---------------RGGNAGNGGN---------
MSMEG_0868|M.smegmatis_MC2_155 AVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN
TH_3810|M.thermoresistible__bu --HTPGVYTDRQ---------------------GEDGEDGTG--------
MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAG-------------------LAGNAGLAGNAG-------
MAV_4827|M.avium_104 LQPTPNQHLIVP------------------TEQAPAPPPVQAS-------
MLBr_01556|M.leprae_Br4923 DQGDEDELQVRPPVVT---------------VMGHVDHGKTRLLDTIR--
. .
Mb0767|M.bovis_AF2122/97 ----------GLLIGNGGAGGAG---------------------------
Rv0746|M.tuberculosis_H37Rv ----------GLLIGNGGAGGAGGQGAVTGGTGGAGGDG-----------
MMAR_1195|M.marinum_M ----------GTLLGNGGAGGAGGHGPTDGGAGGTGGNA-----------
MUL_3062|M.ulcerans_Agy99 ----------GQLLGNGGAGGAGGQGGNDGGAGGLGGNG-----------
Mflv_5091|M.gilvum_PYR-GCK -------------GGTGGAGGAGGTGG-TGGAGGTGG-------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------GGTGGNGGNGGTGG-TGGNGGTGG-------------
MSMEG_0868|M.smegmatis_MC2_155 GPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHST
TH_3810|M.thermoresistible__bu -------------TGIGG--------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------LAGNAGLAGNAGLAGNAGLAGNAG--------------
MAV_4827|M.avium_104 -------------APQPKISVPEPVAAPKPLSPPVAAPLP----------
MLBr_01556|M.leprae_Br4923 ----------KANVREAEAGGITQHIGAYQVGVDLDGSER--------LI
Mb0767|M.bovis_AF2122/97 VLIGNGGNAGIGGTGPTAGDTGAGGISGLLLGADGFNAPASASPLHTLKQ
Rv0746|M.tuberculosis_H37Rv VLIGNGGNAGIGGTGPTAGDTGAGGISGLLLGADGFNTPASASPLHTLKQ
MMAR_1195|M.marinum_M VVVGNGGNGGIGGTGPTTGTTGAGGIGGLLLGLDGYNAPTSTSPIHVAQQ
MUL_3062|M.ulcerans_Agy99 VLIGNGGNGGVGGVGETPGGDGGGGISGLLLGADGFNAPAGSSPVHALQQ
Mflv_5091|M.gilvum_PYR-GCK ----TGGTGGIGGAGSTGGTGGTGGTGGTG-GTGGTG-GTGGTGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1 ----TGGTGGIGGAGSTGGTGGTGGTGGTG-GTGGTG-GTGGTGGTGGTG
MSMEG_0868|M.smegmatis_MC2_155 GQTDTGGNGGRGGDGGTFVNAGANGNGGAG-GAGGVSEGEGGTGGHGGDG
TH_3810|M.thermoresistible__bu ----RGGNGG------------------------------SSSGTHPMAE
MAB_4284c|M.abscessus_ATCC_199 ----LAGNAGLAGNAGLAGNAGLAGNAGLAGNAAVAG--NAAVAGNAAVA
MAV_4827|M.avium_104 -AAPPPAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDPVSPP
MLBr_01556|M.leprae_Br4923 TFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAAD
.
Mb0767|M.bovis_AF2122/97 QALAAINAPTQTLTGRPLIGNGTPGAVGSGATGAPGG-----WLLGDGGA
Rv0746|M.tuberculosis_H37Rv QALAAINAPTQTLTGRPLIGNGTPGAVGSGATGAPGG-----WLLGDGGA
MMAR_1195|M.marinum_M QALVAINSPVQDLTGRPLIGNGTPAPAGSGADGTPGG-----WLLGDGGA
MUL_3062|M.ulcerans_Agy99 QALAAINAPVQELTGRPLIGNGLPGSAGSGAAGAPGG-----WLLGDGGA
Mflv_5091|M.gilvum_PYR-GCK GKGGTGGTGGAGGTG----GDGGTG--GTGGTGGTG---------GTGGT
Mvan_1264|M.vanbaalenii_PYR-1 GKGGTGGTGGDGGTG----GTGGTG--GTGGTGGTG---------GTGGT
MSMEG_0868|M.smegmatis_MC2_155 GRGGDGALGGNGGTGGVGLGNGGKG--GNGGNGGNGGTYVDPSHTGAGGN
TH_3810|M.thermoresistible__bu D--------------------------GEHVKALDGR---------PGLD
MAB_4284c|M.abscessus_ATCC_199 GNAAVGGVLNTGVSG----AIGGSSHVGGAINESLGG---------SGSV
MAV_4827|M.avium_104 QLLAPPRLSVPQPVQPPVRVPQPPSPPQVGGTVPQSP-------PQHQTP
MLBr_01556|M.leprae_Br4923 VPIVVAVNKIDKEGADPAKIRGQLTEYGLVAEDFGGD---------TMFI
.
Mb0767|M.bovis_AF2122/97 GGSGAAG-------------SGAPGGAGG----AAGLWGTGGAG------
Rv0746|M.tuberculosis_H37Rv GGSGAAG-------------SGAPGGAGG----AAGLWGTGGAGGAGG-S
MMAR_1195|M.marinum_M GGSAVAG-------------SDGAGGSGG----AAGLWGTGGTGGAGARS
MUL_3062|M.ulcerans_Agy99 GGSAAAT-------------PGAAGGAGG----AAGLVGAGGAGGAG---
Mflv_5091|M.gilvum_PYR-GCK GGTGGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG-----
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG-----
MSMEG_0868|M.smegmatis_MC2_155 GGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEAL--
TH_3810|M.thermoresistible__bu GGNGSHG---------------GNGGHGG----RGGFLGIGGSGG-----
MAB_4284c|M.abscessus_ATCC_199 GGSTAVG-------------GGAHTGVGG---GVSTGVGVGSHVG-----
MAV_4827|M.avium_104 PGEGTPP------------KPDGPGNYGG------GHVPTPGAGG-----
MLBr_01556|M.leprae_Br4923 DISAKVG-------------TNIEALLEAVLLTADAALDLRANSG-----
. .
Mb0767|M.bovis_AF2122/97 -----------GAGGWLLGDGGAGGIGGASTVLG----------------
Rv0746|M.tuberculosis_H37Rv SAGGGGAGGAGGAGGWLLGDGGAGGIGGASTVLG----------------
MMAR_1195|M.marinum_M TTGNGGAGGAGGAGGWLSGDGGTGGTGGAATFNG----------------
MUL_3062|M.ulcerans_Agy99 ----------ANTGISNPGFGGAGGAGGAGAGAGG---------------
Mflv_5091|M.gilvum_PYR-GCK ----------------TGGTGGQGG-LGGGGGTG----------------
Mvan_1264|M.vanbaalenii_PYR-1 ----------------TGGTGGQGG-LGGVGGTG----------------
MSMEG_0868|M.smegmatis_MC2_155 --IRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQ
TH_3810|M.thermoresistible__bu -------------------WGGHGGNGGDTDADG----------------
MAB_4284c|M.abscessus_ATCC_199 --------------------GGISESLGGSGSVG----------------
MAV_4827|M.avium_104 -------------------SGGSGGGHVPTPGAG----------------
MLBr_01556|M.leprae_Br4923 -------------------MEAQGVAIEAHLDRG----------------
. . *
Mb0767|M.bovis_AF2122/97 -------GTGGGGG---VGGLWGAGGAGGAGGTG----LVG-GDGGAGGA
Rv0746|M.tuberculosis_H37Rv -------GTGGGGG---VGGLWGAGGAGGAGGTG----LVG-GDGGAGGA
MMAR_1195|M.marinum_M -------ATGGNGGDAGNGGLFGAGGNGGAGGAG----LGNPGFGGAGGN
MUL_3062|M.ulcerans_Agy99 -------GVGEAGG---AGGLLGAGGTGGGGGVAPS--LVDGGTGGAGGA
Mflv_5091|M.gilvum_PYR-GCK -------GQGGTGG---TGGQGGTGGTGGTGGTG--------GTGGAGGD
Mvan_1264|M.vanbaalenii_PYR-1 -------GTGGTGG---TGGQGGTGGTGGTGGTG--------GTGGAGGD
MSMEG_0868|M.smegmatis_MC2_155 ASGTATDGHGGSGI---NGGHGGNGGQGTIEANGPSAVASGIGAGGNGGD
TH_3810|M.thermoresistible__bu -------GNGGDGG---NGGSAGRGGTGGLRGVF----------GINGGN
MAB_4284c|M.abscessus_ATCC_199 -------GSTAVGG----GAHTGVGG-GVSTGVGVG---SHVGGGISESL
MAV_4827|M.avium_104 -------GSGGSGG-----GHVPTPGTGGPGGTG----------GSGGGH
MLBr_01556|M.leprae_Br4923 --------RGPVATVLVQRGTLRIGDSVVAGDAYGR----VRRMVDEHGV
. . . .
Mb0767|M.bovis_AF2122/97 GGTGGLLAGLIGAGGGHGGTGGLNTN-------GDGGVGGAGGNAG-MLA
Rv0746|M.tuberculosis_H37Rv GGTGGLLAGLIGAGGGHGGTGGLSTN-------GDGGVGGAGGNAG-MLA
MMAR_1195|M.marinum_M GGAGGLLSGLVGAGGGHGGAGGLGVSPSTPAALAGGGIGGAGGDAG-LLG
MUL_3062|M.ulcerans_Agy99 GGAGGLFGGIFGAGGGDGGAGGFTGG-----IDGAGGVGGAGGNTG-LLG
Mflv_5091|M.gilvum_PYR-GCK GGLGGLGG--FGGSGGTGGQGGLGGP--------GGSTGGAGGAGG--QA
Mvan_1264|M.vanbaalenii_PYR-1 GGLGGLGG--FGGVGGTGGQGGQGGP--------GGSTGGAGGAGG--QA
MSMEG_0868|M.smegmatis_MC2_155 GIDGGLGG--NGGDGVVNTTANAANP--------GSATGTATGGDGGKAT
TH_3810|M.thermoresistible__bu GRAG------LGGRGXXXX---------------GGGVGAAVRSGNGVFS
MAB_4284c|M.abscessus_ATCC_199 GGSGSVGGSTAVGGGAHTGVGGGVNT----------GVGVGSHVGGGISE
MAV_4827|M.avium_104 VPTPGAGTPGGSGGGHLPFPGAGSTP---------GGSGGGHLPTPGAGT
MLBr_01556|M.leprae_Br4923 DIEAALPSSPVQVIGFTSVPGAGDNFLVVD---EDRIARQIADRRSARKR
*
Mb0767|M.bovis_AF2122/97 GPGGAGGAGGDG----ENLDTGGDGGAGGSAGLLFGSGGAGGAGGFG---
Rv0746|M.tuberculosis_H37Rv GPGGAGGAGGDG----ENLDTGGDGGAGGSAGLLFGSGGAGGAGGFG---
MMAR_1195|M.marinum_M GAGGAGGTGGSGAF--DVTSTGGTGGAGGNAGFLFGSGGIGGPGGFA---
MUL_3062|M.ulcerans_Agy99 GPGGSGGSGGDGIAKLGFNVDGGAGGAGVNGGFLFGSGGTGGFGGVG---
Mflv_5091|M.gilvum_PYR-GCK GTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG---
Mvan_1264|M.vanbaalenii_PYR-1 GVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG---
MSMEG_0868|M.smegmatis_MC2_155 GTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNA
TH_3810|M.thermoresistible__bu GGGG---------------TPSAGFGVPTTIQFPAGSCTSRAVSREG---
MAB_4284c|M.abscessus_ATCC_199 SLGGSGSVGG-------STAVGGGAHTSAINDALGGSGSVGGSTAVG---
MAV_4827|M.avium_104 PGGGLGGFGG---------GHAPAPGGGLGGGGGHAPAPGGGLGGFG---
MLBr_01556|M.leprae_Br4923 NALAARSRKRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALMG---
. . .
Mb0767|M.bovis_AF2122/97 ---FLG------GDGGAGGNAGLLLSSGGAGGFGGFGTAG--GVGGAGGN
Rv0746|M.tuberculosis_H37Rv ---FLG------GDGGAGGNAGLLLSSGGAGGFGGFGTAG--GVGGAGGN
MMAR_1195|M.marinum_M ---VAAS-----GNGGQGGHAGLLWSSGGAGGAGAFSVSGPAGAGGHGGD
MUL_3062|M.ulcerans_Agy99 ---GVGTSTGIGGAGGRGGNAGLLFSDAGVGGFGGF--------GGTGGN
Mflv_5091|M.gilvum_PYR-GCK ---AQGATG-ATGAAGKAGATGAAGAAGAAGSAG------------TTGA
Mvan_1264|M.vanbaalenii_PYR-1 ---AQGATG-ATGASGAQGSAGSAGSAGVAGSAG------------TTGA
MSMEG_0868|M.smegmatis_MC2_155 LVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIA-AIHGAITDS
TH_3810|M.thermoresistible__bu ---------IMPSSRAASARAGAACASS------------------TSRS
MAB_4284c|M.abscessus_ATCC_199 ------------GGAHTSAINESMNSSIN-----------------ASHS
MAV_4827|M.avium_104 ------------GGHSGGGLGGLGGGHK----------------------
MLBr_01556|M.leprae_Br4923 ----IQVDDEVALRVIDRGVGGITETNVNLASASDAIIIG-FNVRAEGKA
.
Mb0767|M.bovis_AF2122/97 AGWLGFGGAGGIGGIGGNANGGAGGNGGTGGQLW----GSGGAGGEGGAA
Rv0746|M.tuberculosis_H37Rv AGWLGFGGAG----------------------------------------
MMAR_1195|M.marinum_M AGWLGNGGAGGTGGISRNGNGGDGGAGGSGGELL----GVGGAGGQGGQA
MUL_3062|M.ulcerans_Agy99 AGWLGSGGSGGAGG-GSNGDGGAGGTGGSGGQIV----GDGGAGGAGGQG
Mflv_5091|M.gilvum_PYR-GCK QGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGEDGDAG
Mvan_1264|M.vanbaalenii_PYR-1 QGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGDAGDPG
MSMEG_0868|M.smegmatis_MC2_155 TAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGG
TH_3810|M.thermoresistible__bu RRSFCCSRA-----------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SSMNESFGS-----------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 TELASREGVEIRYYLVIYQAIDDIEKALRGMLKPIYEENQLGRAEIRALF
Mb0767|M.bovis_AF2122/97 LSVGDT--GGAGGVGGS-----------AGLIGTGGNGGNGGTGAN----
Rv0746|M.tuberculosis_H37Rv ------------GVGGS-----------AGLIGTGGNGGNGGTGAN----
MMAR_1195|M.marinum_M NAGGGTGTGGEGGDGGD-----------AGLIGDGGNGGNAGTDTDGTP-
MUL_3062|M.ulcerans_Agy99 DLLAAGGSGGDGGQGGD-----------AVLIGTGGNGGNGASGVL----
Mflv_5091|M.gilvum_PYR-GCK SGGSG-INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE----
Mvan_1264|M.vanbaalenii_PYR-1 SEAVD-INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE----
MSMEG_0868|M.smegmatis_MC2_155 VNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------------------SMGSHGAAGTGFEAQG----
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 RSSKVGIIAGCIISSGVVRRNAKVRLLRDNIVVTDNLTVTSLRREKDD--
Mb0767|M.bovis_AF2122/97 ----AGSPGTGGAGGLLLGQNGLNGLP-----------------------
Rv0746|M.tuberculosis_H37Rv ----AGSPGTGGAGGLLLGQNGLNGLP-----------------------
MMAR_1195|M.marinum_M ----TGDPGTGGTGGTLLGANGNAGMG-----------------------
MUL_3062|M.ulcerans_Agy99 ----AGIGGDGGSRGLLLGEDGVNGEAAPPMTHIVLLGGDFPAAAS----
Mflv_5091|M.gilvum_PYR-GCK ----GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1 ----GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155 GNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----HAQGHASETAHTTLPGAEHH--------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 ----VTEVREGFECGMTLGYSDIKEGDVIESYELVEKQRA----------