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MRLVRLLGMVLTILAAGLLLGPPAGAQPPFRLSNYVTDNAGVLTSSGRTAVTAAVDRLYADRRIRLWVVY VENFSGQSALNWAQRTTRTSELGNYDALLAVATTGREYAFLVPSAMPGVSEGQVDNVRRYQIEPALHDGD YSGAAVAAANGLNRSPSSSSRVVLLVTVGIIVIVVAVLLVVMRHRNRRRRADELAAARRVDPTNVMALAA VPLQALDDLSRSMVVDVDNAVRTSTNELALAIEEFGERRTAPFTQAVNNAKAALSQAFTVRQQLDDNTPE TPAQRRELLTRVIVSAAHADRELASQTEAFEKLRDLVINAPARLDLLTQQYVELTTRIGPTQQRLAELHT EFDAAAMTSIAGNVTTATERLAFADRNISAARDLADQAVSGRQAGLVDAVRAAESALGQARALLDAVDSA ATDIRHAVASLPAVVADIQTGIKRANQHLQQAQQPQTGRTGDLIAARDAAARALDRARGAADPLTAFDQL TKVDADLDRLLATLAEEQATADRLNRSLEQALFTAESRVRAVSEYIDTRRGSIGPEARTRLAEAKRQLEA AHDRKSSNPTEAIAYANAASTLAAHAQSLANADVQSAQRAYTRRGGNNAGAILGGIIIGDLLSGGTRGGL GGWIPTSFGGSSNAPGSSPDGGFLGGGGRF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2345 | - | - | 100% (660) | POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2374 | - | 0.0 | 100.00% (660) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_2720 | - | 0.0 | 56.42% (670) | hypothetical protein Mflv_2720 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1706c | - | 1e-165 | 49.12% (680) | hypothetical protein MAB_1706c |
| M. marinum M | MMAR_3652 | - | 0.0 | 72.81% (662) | hypothetical protein MMAR_3652 |
| M. avium 104 | MAV_2041 | - | 0.0 | 69.17% (665) | hypothetical protein MAV_2041 |
| M. smegmatis MC2 155 | MSMEG_4484 | - | 0.0 | 57.97% (690) | putative transmembrane protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3816 | - | 0.0 | 56.74% (668) | hypothetical protein Mvan_3816 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2720|M.gilvum_PYR-GCK ---MRVARLLP-LLLALLTVGL---LGAPAASAEPPLRLPTYLTDRAGAL
Mvan_3816|M.vanbaalenii_PYR-1 MAVMRVARLLP-MLLAVLTLGL---LCAPGVAAEPPLRLPTYLTDNAGAL
MSMEG_4484|M.smegmatis_MC2_155 ---MRIGRLFS-LLLAILTTGL---LVAPAAAAEPPLRLATQITDQAGAL
Rv2345|M.tuberculosis_H37Rv ---MRLVRLLG-MVLTILAAGL---LLGPPAGAQPPFRLSNYVTDNAGVL
Mb2374|M.bovis_AF2122/97 ---MRLVRLLG-MVLTILAAGL---LLGPPAGAQPPFRLSNYVTDNAGVL
MMAR_3652|M.marinum_M ---MRIPRLLG-VILMIFTTGL---LLAPPSGAQPPFRLASYVTDNADAL
MAV_2041|M.avium_104 ---MRTARLLA-VLAALLTVGLSAGLLAPPAGAQPPLRLSDYLTDTAGVL
MAB_1706c|M.abscessus_ATCC_199 ---MRLLRALAGLLGVLIAVCAPTLLLAPVASADPPFRIPGYVTDRAGAL
** * : :: ::: * .* .*:**:*:. :** *..*
Mflv_2720|M.gilvum_PYR-GCK DAAGESEVQTAIDQLYDDKRIRLWVVYVEDFSGQSAQTWAQTTFTRSDLG
Mvan_3816|M.vanbaalenii_PYR-1 DTAGTAEVQAAIDRLYNEERIRLWVVFVDDFSGQDAQTWTQTTFARSDLG
MSMEG_4484|M.smegmatis_MC2_155 SASQAASVQRALDRLYDDRRIKLWVVFVEDFSGQNYIGWAQNTMRLSDFG
Rv2345|M.tuberculosis_H37Rv TSSGRTAVTAAVDRLYADRRIRLWVVYVENFSGQSALNWAQRTTRTSELG
Mb2374|M.bovis_AF2122/97 TSSGRTAVTAAVDRLYADRRIRLWVVYVENFSGQSALNWAQRTTRTSELG
MMAR_3652|M.marinum_M TSSGRAKVTTAVNQLYTERHVRLWVVYVDDFSGQSATNWAQRTMQTSELG
MAV_2041|M.avium_104 SDSGRKAITTAVDKLYTDRHIRLWVVYVDTFSGQTATRWAQDTLRTSDLG
MAB_1706c|M.abscessus_ATCC_199 KNP--AKVRAAVDQLYDQQHVRLWVVYVKDFEGTDPTAWADKTIKASNLG
. : *:::** :.:::****:*. *.* *:: * *::*
Mflv_2720|M.gilvum_PYR-GCK DQDVILAVATVDRAYALITPRGG--AVRADIDEVRTQQVEPRLRAGDWAG
Mvan_3816|M.vanbaalenii_PYR-1 NQDVILAVATVDRAYALIAPKGG--AVRVDIDKVRTQQVEPLLRTGDWAG
MSMEG_4484|M.smegmatis_MC2_155 DDDALLAVATVDRAFAFQVPDTL--VDTARADDIRRNSIGPSLRREDWAG
Rv2345|M.tuberculosis_H37Rv NYDALLAVATTGREYAFLVPSAMPGVSEGQVDNVRRYQIEPALHDGDYSG
Mb2374|M.bovis_AF2122/97 NYDALLAVATTGREYAFLVPSAMPGVSEGQVDNVRRYQIEPALHDGDYSG
MMAR_3652|M.marinum_M DYDAILAVATVARSYAFLVPSTVDGITSSQVESLRRNKIEPKLRDGDWAG
MAV_2041|M.avium_104 DYDALLAVATTDRAYAFLVPPTIRGVNQSRVDALRHNKIEPALHDGDWSG
MAB_1706c|M.abscessus_ATCC_199 DRDALLAVATEERSYAFQVASGIKNVSDSEIENLRTNTIEPALRTSDWDG
: *.:***** * :*: .. : :* : * *: *: *
Mflv_2720|M.gilvum_PYR-GCK AAVAAAQGL----AGSGGGSVSWFGVIVALALIALALTILVLWQRRRRRK
Mvan_3816|M.vanbaalenii_PYR-1 AAVAAAEGL----AGSGGGSVSWTGVLVVLAVIALALAALVLWQRRRRRK
MSMEG_4484|M.smegmatis_MC2_155 AAIAAADQLNTEPASATGGGVSWPALLIVLGIIAVLIGILWIWSRRRRAK
Rv2345|M.tuberculosis_H37Rv AAVAAANGLN-----RSPSSSSRVVLLVTVGIIVIVVAVLLVVMRHRNRR
Mb2374|M.bovis_AF2122/97 AAVAAANGLN-----RSPSSSSRVVLLVTVGIIVIVVAVLLVVMRHRNRR
MMAR_3652|M.marinum_M AAVAAADGLN-----KSPRPSGGIPLLVVLSVLAVAVAIFWIVMRYRASR
MAV_2041|M.avium_104 AAVAAATGLD-----TAPGSSGRVILLATLAALLVAVMGLLLVMRYRGRR
MAB_1706c|M.abscessus_ATCC_199 AAIKTATGLES--AASSSASIPWKPVLGALAFGAVLVGAFMLFSWFRTRS
**: :* * :: .:. : : : : *
Mflv_2720|M.gilvum_PYR-GCK RREAEFAAAQRVDPSDPEALAAVPLDALDDLSRKIVVDVDNEVRTSESEL
Mvan_3816|M.vanbaalenii_PYR-1 RREAEFAAAQRVDPSDANALAAVPLDALDELSRKIVVDVDNELRTSESEL
MSMEG_4484|M.smegmatis_MC2_155 RRKAEFEAAKRVDPTDPDALASVPLEALDALSREIVVDVDNAVRTSQAEL
Rv2345|M.tuberculosis_H37Rv RRADELAAARRVDPTNVMALAAVPLQALDDLSRSMVVDVDNAVRTSTNEL
Mb2374|M.bovis_AF2122/97 RRADELAAARRVDPTNVMALAAVPLQALDDLSRSMVVDVDNAVRTSTNEL
MMAR_3652|M.marinum_M RRTNALAAARRVDPTDARALAAVPLDVLDELSRSMVVDVDNAVRTSSNEL
MAV_2041|M.avium_104 RRAAALAAARRLDPTDLDALAALPLPTLDDLSRALVVDVDNALRTSANEL
MAB_1706c|M.abscessus_ATCC_199 RRRAEIEAAKGIDPSDAEALAKQPVTALDGLSKSIVVNVDNAVRTSEAEL
** : **: :**:: *** *: .** **: :**:*** :*** **
Mflv_2720|M.gilvum_PYR-GCK ALAVEEFGAQDTAAFTRAVEGAKTTLAQALNVRHILDDAVPETPMQRRDL
Mvan_3816|M.vanbaalenii_PYR-1 ALAVEEFGEQDTAPFSRAVANARTTLAQALNVRQILDDAVPETPMQRRDL
MSMEG_4484|M.smegmatis_MC2_155 ELAVEEFGAKRTEPFTTAVANARKALAQAFNVRQILDDDVPETPLQQRDL
Rv2345|M.tuberculosis_H37Rv ALAIEEFGERRTAPFTQAVNNAKAALSQAFTVRQQLDDNTPETPAQRREL
Mb2374|M.bovis_AF2122/97 ALAIEEFGERRTAPFTQAVNNAKAALSQAFTVRQQLDDNTPETPAQRREL
MMAR_3652|M.marinum_M AVAIDEFGEQRTAPFSQAVSNAKAALSQAFSVRQQLDDSTPETPAQRRDL
MAV_2041|M.avium_104 DLAVAEFGDQRTQPFTQAVTNAKAALSQAFTVRQQLDDGMPETPAQRREL
MAB_1706c|M.abscessus_ATCC_199 ALAVEEFGTESTAPFQQAVDSAKKALAQAFSVRKQLDDAIPETPLEQRRL
:*: *** . * .* ** .*: :*:**:.**: *** **** ::* *
Mflv_2720|M.gilvum_PYR-GCK LTRVIVAAAKADQELEAQREAFAALRDLVINAPSRLDTLTQQMIDLTTRI
Mvan_3816|M.vanbaalenii_PYR-1 LTRVIVAAAKADRELEAQREAFAQLRDLLINAPSRLDTLTQQMVDLTARL
MSMEG_4484|M.smegmatis_MC2_155 LTRVIVSAARADRELEAQSAAFEQLRDLVINAPARLDLMTQQMVDLSARI
Rv2345|M.tuberculosis_H37Rv LTRVIVSAAHADRELASQTEAFEKLRDLVINAPARLDLLTQQYVELTTRI
Mb2374|M.bovis_AF2122/97 LTRVIVSAAHADRELASQTEAFEKLRDLVINAPARLDLLTQQYVELTTRI
MMAR_3652|M.marinum_M LTRVIVSAANADRELESQTEAFEKLRDLVINAPARLDLLTQRYIELTTRI
MAV_2041|M.avium_104 LTQVIVSAARADRELESQTEAFEGLRDLVINAPSRLDGLTQQYVELTARI
MAB_1706c|M.abscessus_ATCC_199 LIDVITTAARADRTLEDQSSAFDALRNLVINAPAKLDTLTQQVVAVTARL
* **.:**.**: * * ** **:*:****::** :**: : :::*:
Mflv_2720|M.gilvum_PYR-GCK TPAEQTLQQLKSQFAASALVSVSDNIDEARSRLAYADQSITTARTLVSRP
Mvan_3816|M.vanbaalenii_PYR-1 TPAEQTLEQLKSQFAETALVSVSDNIDEARQRLAFADQSITTARGLVSRP
MSMEG_4484|M.smegmatis_MC2_155 ETSQQTLAALHTQFDARALESVAGNVDTARERLAFADRNITTARGLVSRP
Rv2345|M.tuberculosis_H37Rv GPTQQRLAELHTEFDAAAMTSIAGNVTTATERLAFADRNISAARDLADQA
Mb2374|M.bovis_AF2122/97 GPTQQRLAELHTEFDAAAMTSIAGNVTTATERLAFADRNISAARDLADQA
MMAR_3652|M.marinum_M APTEQRLVELHDEFGATALSSISANVASAHELLAFADSNISSARELSAKA
MAV_2041|M.avium_104 GPAEQQLAALHNEFSAAALTSVSGNVTAAKERLAFADRNIGTARELAGQA
MAB_1706c|M.abscessus_ATCC_199 PESERILGQLRTEFDAAALASIGDNVAEATERVRFADSRITHGRELAARA
::: * *: :* *: *:. *: * . : :** * .* * :.
Mflv_2720|M.gilvum_PYR-GCK AH-RQGGLVDAIHSAEAALGQARTLLDAVDSASTDINRAVTGLPAVIADI
Mvan_3816|M.vanbaalenii_PYR-1 AD-RQGGLVDAIHAAEAALGQARTLLDAVDSASTDINRAVTGLPAVIADI
MSMEG_4484|M.smegmatis_MC2_155 AA-DQTGLVDAVRAAESALSQARTLLDAVDSASTDINRALAGLPAAVADI
Rv2345|M.tuberculosis_H37Rv VSGRQAGLVDAVRAAESALGQARALLDAVDSAATDIRHAVASLPAVVADI
Mb2374|M.bovis_AF2122/97 VSGRQAGLVDAVRAAESALGQARALLDAVDSAATDIRHAVASLPAVVADI
MMAR_3652|M.marinum_M VSGQQTGLVDAVRAAESALGQARSLLDAVDSAAGDIRHAVATMPSVLADI
MAV_2041|M.avium_104 VSGQQGRLVDAVRAAESALGQARSLLDAVDHAAGDIRHAIDQLPSAMADI
MAB_1706c|M.abscessus_ATCC_199 LEGQQMSLVDAIRGAESALTQANALLDAIDNAANNIRHAIDSLAASIADT
* ****::.**:** **.:****:* *: :*.:*: :.: :**
Mflv_2720|M.gilvum_PYR-GCK QNGINSAGAQLAQG---SVAVATELSDARDAAVQAVAEAQSSGETDPLGA
Mvan_3816|M.vanbaalenii_PYR-1 QNGINQAGAQLAQG---NVAVATELSTARDAAVQAVSQAQSTGNSDPLGA
MSMEG_4484|M.smegmatis_MC2_155 EAGIEQANDLLAQP---DTPQADKLATARDAAVQAAGEAKSNGTADPLGT
Rv2345|M.tuberculosis_H37Rv QTGIKRANQHLQQAQQPQTGRTGDLIAARDAAARALDRAR--GAADPLTA
Mb2374|M.bovis_AF2122/97 QTGIKRANQHLQQAQQPQTGRTGDLIAARDAAARALDRAR--GAADPLTA
MMAR_3652|M.marinum_M QAGIQHANEQLQKSPANKSAYAAELIAARDAAARAVDNARVTGAADPLSA
MAV_2041|M.avium_104 ENDIKRAAELLAATRDTKSGHAAELAAARDAATRAVEGARAGAPDDPLGA
MAB_1706c|M.abscessus_ATCC_199 KSDIAQAEEFQKQG---RLPSSEELTKAHDAAVAAVADAERIGATDPLTA
: .* * : .* *:***. * *. . *** :
Mflv_2720|M.gilvum_PYR-GCK FTRLTQADADLDRLLAEVAEERETAARLSRTFDQALFNAQSRVRAVSDYI
Mvan_3816|M.vanbaalenii_PYR-1 FTRLTQADADLDRLLAEVAEERETAERLSRTFDQALFNAQSRVRAVSDYI
MSMEG_4484|M.smegmatis_MC2_155 FTRLTQADADLDQLLATVHEQREAAERLARTLEQAIFTAESRITAVSDYI
Rv2345|M.tuberculosis_H37Rv FDQLTKVDADLDRLLATLAEEQATADRLNRSLEQALFTAESRVRAVSEYI
Mb2374|M.bovis_AF2122/97 FDQLTKVDADLDRLLATLAEEQATADRLNRSLEQALFTAESRVRAVSEYI
MMAR_3652|M.marinum_M FAQLTTADADLDRLLAAIAQEQANAEHLRRSLEQALFTAESRIRAVSDYI
MAV_2041|M.avium_104 FGQLTKADAGLNAVLAAVAQERAAAERLARSLEQALFTAQSRVRAVSDYI
MAB_1706c|M.abscessus_ATCC_199 FTHLAAADAQLDKLLAAAQEERAAAERRARVLDQALVAARQRLDAVNQYI
* :*: .** *: :** ::: * : * ::**:. *..*: **.:**
Mflv_2720|M.gilvum_PYR-GCK DTRRGAIGPEARTRLAEAVRQLQAARDKQDTNLNEAIAHANGAAMLAAQA
Mvan_3816|M.vanbaalenii_PYR-1 DTRRGAIGPEARTRLAEAVRQLQAARDKRETNLNEAIAHANGAAMLAAQA
MSMEG_4484|M.smegmatis_MC2_155 ETRRGSIGPEARTRLAEATRQLEAARAKRSTNPNEAVAHANGASTLAAQA
Rv2345|M.tuberculosis_H37Rv DTRRGSIGPEARTRLAEAKRQLEAAHDRKSSNPTEAIAYANAASTLAAHA
Mb2374|M.bovis_AF2122/97 DTRRGSIGPEARTRLAEAKRQLEAAHDRKSSNPTEAIAYANAASTLAAHA
MMAR_3652|M.marinum_M DTRRGSIGPEARTRLAEAGRRLDAAQSYRSTNPTEAIAQANAASTLAANA
MAV_2041|M.avium_104 DTRRGSIGPEARTRLAEAQRHLHAAADRRATDPADAIAHANAASTLAAEA
MAB_1706c|M.abscessus_ATCC_199 GLHRGAVGARTRWNLDEAQRRLAAAEQSRASNPSDAILFANGAAELATQA
:**::*..:* .* ** *:* ** : :: :*: **.*: **:.*
Mflv_2720|M.gilvum_PYR-GCK QSLANSDVTAAQRHFNGPYGGGGGGGQMGAVIGGILIGNVLSGVLRGGLG
Mvan_3816|M.vanbaalenii_PYR-1 QSLANSDVTAAQRHFSGPYGGGGGG-QMGAVIGGILIGNVLSGALRGGFG
MSMEG_4484|M.smegmatis_MC2_155 QSLANDDVRAAQRSYTSHHGGGGAD--MGAVLGGIIIGNVLRGGFGGGGG
Rv2345|M.tuberculosis_H37Rv QSLANADVQSAQRAYT---RRGGNN--AGAILGGIIIGDLLSGGTRGGLG
Mb2374|M.bovis_AF2122/97 QSLANADVQSAQRAYT---RRGGNN--AGAILGGIIIGDLLSGGTRGGLG
MMAR_3652|M.marinum_M QSLANSDVQAAQRAYT---RQGGNN--TGAVLGGIIIGDLLSGGMRGGFG
MAV_2041|M.avium_104 QSLANGDVQAARRAYP---RGGGGD--MGAMLGGIIIGDLLSSGMRGGFG
MAB_1706c|M.abscessus_ATCC_199 QYSAQQEVQSAQRYYGNGYGGYSVAGDVAGNVAGAVIGGILRGMLSGGAG
* *: :* :*:* : . .. :.* :**.:* . ** *
Mflv_2720|M.gilvum_PYR-GCK GGGFGGGFG--GGGFGGG---------------GGGGFSGGGGRF
Mvan_3816|M.vanbaalenii_PYR-1 GGGFGGGFG--GGGFGGG---------------GGG-FSGGGGRF
MSMEG_4484|M.smegmatis_MC2_155 YGGYGGGFGGFGGGFGGGRSSGRPTSYGGSSHSSGRNYGGGGGRF
Rv2345|M.tuberculosis_H37Rv -GWIPTSFGGSSNAPGSS---------------PDGGFLGGGGRF
Mb2374|M.bovis_AF2122/97 -GWIPTSFGGSSNAPGSS---------------PDGGFLGGGGRF
MMAR_3652|M.marinum_M -GWSPTSFGGSSGSSGDS---------------SGGGFLGGGGRF
MAV_2041|M.avium_104 -GWSPASFGGSTSSSG-------------------GGVLGGGGRF
MAB_1706c|M.abscessus_ATCC_199 HHSSWSGSGSSSYGGSSR--------------SSGSSFRGGGGRF
. * . . ******