For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PAMDAAGLAAFAPVSRLINDAIAAERLPGAVVVVGHGGKIVFHQAYGSRKLAGEQGLDGVSAPAEAMTED TIFDIASLTKCLATATAIMQLYEQGKVGFDDPVQNHLPGFNPASDPQRAQVTVRMLLTQTSGEPVDVGLQ DVWGLDGADRVEGIHRALSTPLQSPPGREFRYSDINYILLGALLEKIAGEAEDGYVAQHVFAPIGMQDSD FLPAAKACGPHSVRGAAIGWAPAPAGRPRAPCPAGTWDTALLSHIAPTALDEESGADPSRNPNFNRLLRG TVHDPTARRMGGVAGHAGVFSTAHDVSSFAQALLDRLAGRPSTFPLTQATCELMTTPQQPGHDMAQLDAA NAAAREALAHRPNRTDPMLAPRYPAISGQTLFGFGWDIDTPYSAPRGVVFPIGSFGGTGFTGTSLWIDPG SDSYVVLLSNAIHLRGSTPISDLRGQVATAAALALGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3399 | - | - | 100% (458) | hypothetical protein MMAR_3399 |
| M. marinum M | MMAR_2827 | - | 2e-16 | 28.72% (195) | lipoprotein |
| M. marinum M | MMAR_4623 | - | 3e-12 | 25.51% (247) | penicillin binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1957 | - | 2e-21 | 35.90% (195) | lipoprotein |
| M. gilvum PYR-GCK | Mflv_0495 | - | 1e-145 | 58.42% (457) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1922 | - | 2e-21 | 35.90% (195) | lipoprotein |
| M. leprae Br4923 | MLBr_00119 | lipE | 3e-05 | 20.98% (410) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4800 | - | 1e-160 | 62.86% (447) | putative beta-lactamase |
| M. avium 104 | MAV_3991 | - | 0.0 | 73.15% (447) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_6805 | - | 1e-146 | 58.17% (447) | beta-lactamase |
| M. thermoresistible (build 8) | TH_4016 | - | 1e-147 | 60.00% (440) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_1772 | - | 7e-09 | 26.61% (218) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_5895 | - | 1e-158 | 63.05% (452) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1957|M.bovis_AF2122/97 ---------------------------------MDSTVTASIRRMLGLLA
Rv1922|M.tuberculosis_H37Rv ---------------------------------MDSTVTASIRRMLGLLA
MMAR_3399|M.marinum_M ------------------------------------------------MP
MAV_3991|M.avium_104 ------------------------------------------------ML
Mflv_0495|M.gilvum_PYR-GCK ---------------------------------MTRS-STRLRRLGAAGA
MSMEG_6805|M.smegmatis_MC2_155 MSAGSAPLVTPRRKNALHAATASRTARYRRPVRLSRSRVPRLCAIGAVFA
TH_4016|M.thermoresistible__bu --------------------------------------------------
Mvan_5895|M.vanbaalenii_PYR-1 ---------------------------------MPGSRVARLCAAGSLLL
MAB_4800|M.abscessus_ATCC_1997 -------------------------------MKVPGSHATRVCAVATVLL
MUL_1772|M.ulcerans_Agy99 ----------------------------------MGVARPRWRGPRAAWF
MLBr_00119|M.leprae_Br4923 ------------------------------------MTSDGKIRVPTDLD
Mb1957|M.bovis_AF2122/97 ATLLLGGCTGQHTTRTAAS---------------------TTYTPHIKAS
Rv1922|M.tuberculosis_H37Rv ATLLLGGCTGQHTTRTAAS---------------------TTYTPHIKAS
MMAR_3399|M.marinum_M AMDAAG-------------------------------------LAAFAPV
MAV_3991|M.avium_104 TLVAASSTGRVVHTSPSEAPPASMTPHASLVPEST------SPAEDFTTI
Mflv_0495|M.gilvum_PYR-GCK VVLALGACGDRPEPPGTSAVRPPATPTRVLPSPPPPVPE-VTPTGDFSAV
MSMEG_6805|M.smegmatis_MC2_155 VVAATSCSRPAPAPREPAPATGIAAASPAPTAPPTQVTQPVTPTGDFSAV
TH_4016|M.thermoresistible__bu -------------------------------------------------V
Mvan_5895|M.vanbaalenii_PYR-1 TLATAPSCGQPGHPTDPPPPS-TGTPTATATATAT------DPVADFAAV
MAB_4800|M.abscessus_ATCC_1997 ALAGIPSCGRPAQP--------ITAPS-------------IVPTGPFAPI
MUL_1772|M.ulcerans_Agy99 AGARKPSDGRRLTRRPPAAN---------------------LNPVNLDAN
MLBr_00119|M.leprae_Br4923 AVTAIGDEDHS-----------------------------DIDSAAVERI
Mb1957|M.bovis_AF2122/97 SQDVLDGAINADEPGCSAAVGVEGKVIWSGVRGIADLASG----------
Rv1922|M.tuberculosis_H37Rv SQDVLDGAINADEPGCSAAVGVEGKVIWSGVRGIADLASG----------
MMAR_3399|M.marinum_M SRLINDAIAAERLPGAVVVVGHGGKIVFHQAYGSRKLAGEQGLDGVSAPA
MAV_3991|M.avium_104 SKLVNDAIAARGLPGAVVMVGHGGKVVFHQAYGSRKLAGEPGLDGAPAPA
Mflv_0495|M.gilvum_PYR-GCK ARLVEDAIAARRLPGAVVQVGHAGKVVFRRAFGVRKLESEPGLDGAPAPA
MSMEG_6805|M.smegmatis_MC2_155 TRLVDDAVAARRLPGAVVQIGHAGKIVFRAAFGARKLDGEPGLDGSPSPA
TH_4016|M.thermoresistible__bu IGQVDDAVAVRRLPGAVVQIGHAGEVVFRQAFGSRKLAGEPGPTGEPTPA
Mvan_5895|M.vanbaalenii_PYR-1 SQLMHDAIAAHRLPGAVVQIGHAGKIVFRQAFGSRKLAGEPGLDGSPAPA
MAB_4800|M.abscessus_ATCC_1997 TTLVNDAVAAPRLPGAVVEIGHAGKIVFRQAFGWRKLPDEPGLNGSPAPA
MUL_1772|M.ulcerans_Agy99 QADIREVCDAGLLSGAVTVVWQHGEVLQVNEIGYRDVEAG----------
MLBr_00119|M.leprae_Br4923 WQATRHWYQAGMHPAIQLCIRQHGRVVLNRAIGHG--WGNAPTDPHDAEK
. .. : *.:: *
Mb1957|M.bovis_AF2122/97 AKITTDTVFDIASVSKQFT-ATAILLLVEAGKLTLDDPISQYVPELP---
Rv1922|M.tuberculosis_H37Rv AKITTDTVFDIASVSKQFT-ATAILLLVEAGKLTLDDPISQYVPELP---
MMAR_3399|M.marinum_M EAMTEDTIFDIASLTKCLATATAIMQLYEQGKVGFDDPVQNHLPGFNPA-
MAV_3991|M.avium_104 EPMTEDTIFDLASLTKCLATAVAVMQLYEQGKVAFDDPVQKYLPAFNTT-
Mflv_0495|M.gilvum_PYR-GCK EPMTEDTVFDIASLTKSLATATAVMQLHEQGRVRIDEPVQTYLPGFNPA-
MSMEG_6805|M.smegmatis_MC2_155 EPMTEDTLFDLASLTKSIATTTAVLQLYEQGKIRLDEPVQTYLPDFNPT-
TH_4016|M.thermoresistible__bu EPMTEDTMFDLASLTKSLATTVAVLQLAEQGRLRVDDPVQSHLPEFNPQ-
Mvan_5895|M.vanbaalenii_PYR-1 EPMTEDTIFDLASLSKSLATAPAFLQLYERGLVRIDEPVQTYLPEFNPA-
MAB_4800|M.abscessus_ATCC_1997 EPMTDDTIFDIASLTKPLATSVAVLQLYEGGRVHIDEPVQAYLPDFNPT-
MUL_1772|M.ulcerans_Agy99 LPMQRDTLFRIASMTKPVTVAAAMSMVDE-GKIALRDPITRWAPELRDIR
MLBr_00119|M.leprae_Br4923 IPVTTDTPFCAYSAAKAIT-ATVVHMLVERGHFSLDDRVCEYLPTYTSYG
: ** * * :* .: : .. : * * . . : : *
Mb1957|M.bovis_AF2122/97 -------------DWAQTVTVEQLMHQTSGIPDYVALLAARG--YQVSDR
Rv1922|M.tuberculosis_H37Rv -------------DWAQTVTVEQLMHQTSGIPDYVALLAARG--YQVSDR
MMAR_3399|M.marinum_M -----------SDPQRAQVTVRMLLTQTSGEPVDVGLQDVWG--LDGADR
MAV_3991|M.avium_104 -----------NDPQRAKVTIRMLLTNTSGEGIDVSLRDPWG--LAGPDK
Mflv_0495|M.gilvum_PYR-GCK -----------GDPRRAAVTVRMLLTHTSGIAGDLSLDGPWG--LAGPDK
MSMEG_6805|M.smegmatis_MC2_155 -----------GDPRRARVTLRMLLTHTSGIAGDLSLDGPWG--LTAADK
TH_4016|M.thermoresistible__bu -----------HDPRRARVTLRMLLTHTSGIAGDLSLDGPWG--LDRPDK
Mvan_5895|M.vanbaalenii_PYR-1 -----------GDPRRAQVTLRMLLTHTSGLAGDLSLDGPWG--LDKPDK
MAB_4800|M.abscessus_ATCC_1997 -----------NDPRRDQVTLRMLLTHTSGIGGDLSHQGPWG--LKQADK
MUL_1772|M.ulcerans_Agy99 VLDDPHGPLDRTHPTRRPILIEDLLTHTSGLAYSFSVSGDISRAYMRLPF
MLBr_00119|M.leprae_Br4923 ---------------KHRTTIRHVLTHSAGVPFPTGPRPDVT---RADDH
:. :: :::* .
Mb1957|M.bovis_AF2122/97 TIEAEARQALAAAPELQFKPGTRFDYSNSNYLLLG-EIVHRASGQPLPEF
Rv1922|M.tuberculosis_H37Rv TIEAEARQALAAAPELQFKPGTRFDYSNSNYLLLG-EIVHRASGQPLPEF
MMAR_3399|M.marinum_M VEGIHR----ALSTPLQSPPGREFRYSDINYILLG-ALLEKIAGEAEDGY
MAV_3991|M.avium_104 AEGIHR----ALTTPLQSAPAGEFRYSDINYLLLG-ALLEKITGEDEDDY
Mflv_0495|M.gilvum_PYR-GCK ADGVRR----ALGAWVVSDPGEGFHYSDINFIILG-ALVEKITGEPEDSY
MSMEG_6805|M.smegmatis_MC2_155 AEGVKR----ALAAWVVFEPGAMFHYSDIGFIILG-TLVEKITGQSLDGY
TH_4016|M.thermoresistible__bu AEGVRR----ALGAWVVHEPGRLFHYSDIGFILLG-AIVEKLTGEPLDVY
Mvan_5895|M.vanbaalenii_PYR-1 ADGIRR----ALAAWVVFDPGEIFHYSDINFILVG-AIIEKLTGEQLDSY
MAB_4800|M.abscessus_ATCC_1997 ADGIHR----ALTTPLAFDPGTTFHYSDINFIILG-ALVEKVTGQTLDIY
MUL_1772|M.ulcerans_Agy99 GHGSDAWLAELAALPLVHQPGERVTYS-HAIDLLG-VIMSRIDDKPFYQV
MLBr_00119|M.leprae_Br4923 AYAQQK----LSELRPFYRPGLVHIYHALTWGPLMREIIWTATGKEIRDI
*. * : :: .:
Mb1957|M.bovis_AF2122/97 LSAEIFQPLGLA--------------------------------------
Rv1922|M.tuberculosis_H37Rv LSAEIFQPLGLA--------------------------------------
MMAR_3399|M.marinum_M VAQHVFAPIGMQDSDFLPAAKACGPHSVRGAAIGWAPAPAGRPRAPCPAG
MAV_3991|M.avium_104 VQHHVFGPLGMHDTRYLPPAKACGPHIIRGAAIAWAPN--GEPMTECPEW
Mflv_0495|M.gilvum_PYR-GCK VDRNVFAPLKMSETRYLPVTKVCGPHRVRGTAI--AADPHGQAVDNCPDG
MSMEG_6805|M.smegmatis_MC2_155 VREHVFAPLGMSDTYYLPAANACGPHEIRGNAL--VSDPDGPRTTDCPAD
TH_4016|M.thermoresistible__bu VTENVFAPLGMADTRYLPVSKACGPIRMVGNAV--VED-ESAEPTPCGED
Mvan_5895|M.vanbaalenii_PYR-1 VRDRVFAPLGMTDTRYLPAAKTCGPHEIRGTTV--ALGHYPPWIGQCPAG
MAB_4800|M.abscessus_ATCC_1997 VQDNIFAPLGMNETRYLPAAKACGPHHIVGTAI--TLEEGPRAAPDCATG
MUL_1772|M.ulcerans_Agy99 LDERILGPAGMTDTG-----------------------------------
MLBr_00119|M.leprae_Br4923 LAAEILDPLGFRWTNFGVAEEDVPLVALSHATG-----------------
: .:: * :
Mb1957|M.bovis_AF2122/97 -MVVDPVGKVPNKAVSYEKG-------TGGNRSEYRVGNPAWEQIG----
Rv1922|M.tuberculosis_H37Rv -MVVDPVGKVPNKAVSYEKG-------TGGNRSEYRVGNPAWEQIG----
MMAR_3399|M.marinum_M TWDTALLSHIAPTALDEESGADPSRNPNFNRLLRGTVHDPTARRMGGVAG
MAV_3991|M.avium_104 TWRTTLLPRIAPTARDEESRDDPSKNPDYYALLRGTVHDPTARRMGGVAG
Mflv_0495|M.gilvum_PYR-GCK TWNIDLLERIAPTALDEDT---PGLNPDYGYPLRGTVHDPTARRMGGVAG
MSMEG_6805|M.smegmatis_MC2_155 SWSTGLLTRVAPTALDEDT---PGINPHFGLPLRGTVHDPTARRMGGVAG
TH_4016|M.thermoresistible__bu RWSTSLRARIAPTSCDGDT---PDLNPHRGRLLRGTVHDPTARRMGGVSG
Mvan_5895|M.vanbaalenii_PYR-1 TWSTALLPRIAPTARDGDT---PGLNPDYGHLLRGTVHDPTARRMGGVTG
MAB_4800|M.abscessus_ATCC_1997 AWSTALLTRIAPTAHDEDT---PGINPHYGRLIRGTVHDPTARRMGGVAG
MUL_1772|M.ulcerans_Agy99 FFVSTQAQRRAATMYRLDE---------LDQLRHDVMGPPHVRPPSFCNA
MLBr_00119|M.leprae_Br4923 ----RPLPPIIAAIFRKAIG---------GTVHEVIPYTNTPPFLTTIVP
.
Mb1957|M.bovis_AF2122/97 DGGIQTTPSQLARWADNYRTGSVGGLKLLEAQLAG----AVETEPG----
Rv1922|M.tuberculosis_H37Rv DGGIQTTPSQLARWADNYRTGSVGGLKLLEAQLAG----AVETEPG----
MMAR_3399|M.marinum_M HAGVFSTAHDVSSFAQALLDRLAGRPSTFPLTQATCELMTTPQQPGHDMA
MAV_3991|M.avium_104 NAGVFSTAHDVGVYAQALLDRLAGRPSDFPLQQGTVELMTTPQQPGHDPR
Mflv_0495|M.gilvum_PYR-GCK SAGVFTTVHDMGRFAQALLDRVAGRPSPFPLSQAGARMMTTPQQPA----
MSMEG_6805|M.smegmatis_MC2_155 SAGVFTTVHDLGLFAQALLDRRANRPSTFPLQQATVELMTTPQQPG----
TH_4016|M.thermoresistible__bu SAGVFSTAADVGSYAQALLDRLAGRPSRFPLRRSTLQMMTSPQQPGHAPG
Mvan_5895|M.vanbaalenii_PYR-1 SAGVFSTVGDVGRFAQALLDGLAGRPSAFPLTRSTLEMMTTPQQPGHTPG
MAB_4800|M.abscessus_ATCC_1997 SAGVFSTAGDVGRYCQALLDRLAGRPSTFPLKRATLELMTSPAQPGHNDG
MUL_1772|M.ulcerans_Agy99 GGGLWSTADDYLRFVRLLLGDGTIDGVRVLSPESVRLMRTDRLSDEHKRH
MLBr_00119|M.leprae_Br4923 SSNTVSTANELSRFAEIWLRGGELDGIRVLRSETLLGAVAECRRLR----
.. :* : : . :
Mb1957|M.bovis_AF2122/97 --------------------------------GGDRYGAG-----IVSRA
Rv1922|M.tuberculosis_H37Rv --------------------------------GGDRYGAG-----IVSRA
MMAR_3399|M.marinum_M QLDAANAAAREALAHRPNRTDPMLAPRYPAISGQTLFGFGWDIDTPYSAP
MAV_3991|M.avium_104 QLEAANRAARSG------------TPNYPAIKGQNLFGFGWDIDTGYSRP
Mflv_0495|M.gilvum_PYR-GCK -------------------------------PGRDLRGFGWDIDTAHSGP
MSMEG_6805|M.smegmatis_MC2_155 -------------------------------AGPDLRGLGWDIDTPHSRP
TH_4016|M.thermoresistible__bu QLDVANKAAREAVLSASDDPL--LAPDYPAVPGRDLRGFGWDIDTNQSRP
Mvan_5895|M.vanbaalenii_PYR-1 QLEAANDAIRTATENDPDS----TARNYPAVPGQDLRGFGWDIDTAHSRP
MAB_4800|M.abscessus_ATCC_1997 QLKAANDAARLAIEKTSNSTDPLLAPGYPAIAGQNLRGLGWDIDTELSKP
MUL_1772|M.ulcerans_Agy99 N--------------------------FLGAPFWVGRGFGLNLSVVTDPV
MLBr_00119|M.leprae_Br4923 -------------------------PDFVVGLMPARWGTGFILGTNKFGP
* *
Mb1957|M.bovis_AF2122/97 DGTLDH----AGAWAG----FVTAFHISSDRRTSVAISCNTDKPDPVAMA
Rv1922|M.tuberculosis_H37Rv DGTLDH----AGAWAG----FVTAFHISSDRRTSVAISCNTDKPDPVAMA
MMAR_3399|M.marinum_M RGVVFP----IGSFGGTGFTGTSLWIDPGSDSYVVLLSNAIHLRGSTPIS
MAV_3991|M.avium_104 RGRVFP----IGSFGNTGFTGTTLWMDPGSDTYVILLSNSIHLRGSPPIS
Mflv_0495|M.gilvum_PYR-GCK RGSVFP----VGSFGHTGFTGVSVWLDPESDTYVVILGNVIHQRGGPPIT
MSMEG_6805|M.smegmatis_MC2_155 RGTVFP----VGSFGHTGFTGVSMWMDPGSDTYVIVLANVIHQRGGPPIA
TH_4016|M.thermoresistible__bu RGSVFP----VGSFGHTGFTGVTLWIDPGSDTYVVVLANVIHQPGGPPVA
Mvan_5895|M.vanbaalenii_PYR-1 RGTLFP----VGSFGHAGFTGVTLWMDPGSDTYVVVLANVIHQPGGPPIV
MAB_4800|M.abscessus_ATCC_1997 RGMLFP----IGSFGHSGFTGVTLWLDPGSDTYVVVLANVIHQRGGPPIV
MUL_1772|M.ulcerans_Agy99 QSTPLFGPGGLGTFSWPGAYGTWWQADPGADLILLYLIQHCPDLSVNAAA
MLBr_00119|M.leprae_Br4923 FGRNAP-----AAFGHLGLVNIAIWADPQRSMAAGLIS--SGKPGQDPNA
. .::. . : . .
Mb1957|M.bovis_AF2122/97 DALGRLWM--------------------
Rv1922|M.tuberculosis_H37Rv DALGRLWM--------------------
MMAR_3399|M.marinum_M DLRGQVATAAALALGL------------
MAV_3991|M.avium_104 NLRGDVATAAARALHLYGAAPP------
Mflv_0495|M.gilvum_PYR-GCK PLSGAVATEAARALHLYGS---------
MSMEG_6805|M.smegmatis_MC2_155 TLSGDVATEAARALHLYGT---------
TH_4016|M.thermoresistible__bu PLSGRVATLAARALHLYGT---------
Mvan_5895|M.vanbaalenii_PYR-1 NLSGEVATATAQALGLYR----------
MAB_4800|M.abscessus_ATCC_1997 RLSGHIATVAARMLDLYRN---------
MUL_1772|M.ulcerans_Agy99 AVAGNPGLAKLRTAQPRFVRRTYRALGL
MLBr_00119|M.leprae_Br4923 GRYGALMNTITAEIPVH-----------
*