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SPIDAARVYRMMVRMRLAEEALVEAWQEGLVPGEYHSAIGEEGIVAGILTQLFEFDTLALDHRNTAPLVG RGIDLQALMLEVLGSDQGIASGMAGHMHIFDPDLRAGADGIVGAAGPLAVGHAIAHTQLHPGSVAIAFHG EAAMNQGMLMEAYNMAVAWNLPVVFVCKDNKWGITTYSKDQTGADPISRARGFGLEVASAAGHKVADVHA AAGRLIERARSGNGPGFLYVTCRRPGGHFEGDPLVGLLRAPRKQLSVWVPELRSGLTATESGSRTDKLRA MAGIGKRAARFAYDVGRTAGKDPVRRGRSLISADAATAIEAQERAEVLAAMTEARARVGKRAGFGIKTGA DR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3323 | - | - | 100% (353) | pyruvate dehydrogenase E1 component (alpha subunit) |
| M. marinum M | MMAR_3489 | - | 4e-30 | 32.48% (234) | pyruvate dehydrogenase E1 component (alpha subunit) |
| M. marinum M | MMAR_4784 | - | 1e-15 | 28.16% (245) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0866 | - | 7e-20 | 28.16% (309) | dehydrogenase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0843 | - | 3e-19 | 29.73% (222) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4918c | - | 3e-15 | 28.94% (235) | pyruvate dehydrogenase E1 component alpha subunit |
| M. avium 104 | MAV_2947 | - | 9e-32 | 34.43% (244) | dehydrogenase E1 component superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4712 | - | 7e-16 | 28.28% (244) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. thermoresistible (build 8) | TH_4167 | - | 1e-33 | 35.54% (242) | PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase |
| M. ulcerans Agy99 | MUL_3775 | pdhA | 5e-13 | 27.12% (236) | pyruvate dehydrogenase E1 component (alpha subunit) PdhA |
| M. vanbaalenii PYR-1 | Mvan_0911 | - | 1e-39 | 35.57% (253) | pyruvate dehydrogenase (acetyl-transferring) |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2947|M.avium_104 -----------------------------------MTQSAKPSP----DI
TH_4167|M.thermoresistible__bu ----------------------------------MATQLDVEAPTSANDR
MSMEG_4712|M.smegmatis_MC2_155 MAMQYSSAPGYDTGFDPEPVQLVAADGSPSPDRPPSRYSRDLPPET----
MUL_3775|M.ulcerans_Agy99 ------------MTVGLEPVQLVNADGEPTDEH---RYSRDLPEET----
MAB_4918c|M.abscessus_ATCC_199 ----------------METIQLLDSDGNRIENPEYMPLVSDILDEDGLTQ
Mb0866|M.bovis_AF2122/97 -----------------------------------MTRTSEGLAAFVVDQ
Rv0843|M.tuberculosis_H37Rv -----------------------------------MTRTSEGLAAFVVDQ
Mvan_0911|M.vanbaalenii_PYR-1 -----------------------------------MDDAVRLELYRTMRL
MMAR_3323|M.marinum_M -----------------------------------MSPID----------
MAV_2947|M.avium_104 HRRLYALMVLMKTADDRLSRGIGTGEFLCVYWPSRGQEAIAAAMGVSLRP
TH_4167|M.thermoresistible__bu AIALYRLMSKVHHADARVRKGLSSGEIAMSYWPVTGQEAMSAGAALALSD
MSMEG_4712|M.smegmatis_MC2_155 LSWLYESMVVTRNLDVEFVNLQRQGE-LALFASCRGQEAAQIGAAACLRK
MUL_3775|M.ulcerans_Agy99 LCWLYEMMVVTRELDAEFINLKRQGE-LALFASCRGQEAAQVGATACLRK
MAB_4918c|M.abscessus_ATCC_199 LRALYRDMVVVRRIDNESTALQRQGE-LALWAPLLGQEAAQVGSARALRH
Mb0866|M.bovis_AF2122/97 LEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGE
Rv0843|M.tuberculosis_H37Rv LEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGE
Mvan_0911|M.vanbaalenii_PYR-1 IRTYEEAILREYHADKKPSFDIAKGQIPGEMHLCTGQEPVPAGFGPHLRR
MMAR_3323|M.marinum_M AARVYRMMVRMRLAEEALVEAWQEGLVPGEYHSAIGEEGIVAGILTQLFE
: : * *:* . *
MAV_2947|M.avium_104 DDQLVTTYRGLHDLIGKGVGLEEIYGEMMGRTIGAGRGKGGTMHIAKPEV
TH_4167|M.thermoresistible__bu GDQLVSTYRGLGDVVAKGIDLAGYFGEILGRRTGLSRGKAGAMGISDPDH
MSMEG_4712|M.smegmatis_MC2_155 TDWLFPQYREIGAFLLRGITPAQMGAVWRGKWHGG---------LSFTGK
MUL_3775|M.ulcerans_Agy99 TDWLFPQYRELGAYLVRGIPPGHVGAAWRGTWHGG---------LEFTKK
MAB_4918c|M.abscessus_ATCC_199 DDFAFTSFREHGVAYCRGIEPTAMLQFWRGSTQSG---------WNPRDH
Mb0866|M.bovis_AF2122/97 GDVIITTHRPHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADPRA
Rv0843|M.tuberculosis_H37Rv GDVIITTHRPHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADPRA
Mvan_0911|M.vanbaalenii_PYR-1 DDAVTGPHRPHGWALAKGVDIERMTAEIFGRIDGLGKGRGGHMHLFDQDA
MMAR_3323|M.marinum_M FDTLALDHRNTAPLVGRGIDLQALMLEVLGSDQGIASGMAGHMHIFDPDL
* .* . * .
MAV_2947|M.avium_104 GVMLSTGIVGAGPPVAVGLAMAARRKGLDRVTVVSFGDGATNTGSFHEAA
TH_4167|M.thermoresistible__bu GIAWTTGIVGAGPLFANGIALAASIRGTGQVVLVSFGDGATSIGYVHEAM
MSMEG_4712|M.smegmatis_MC2_155 CVAPIAIPIGTHGLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEAF
MUL_3775|M.ulcerans_Agy99 CCVPISVPIGTQALHAVGAAQAAQRLGEDSVTVAFLGDGATSEGDVHEAL
MAB_4918c|M.abscessus_ATCC_199 NVTAPAIIVGAQALHATGYAMGVKFDGSDTAVIAYFGDGATSQGDVSEAF
Mb0866|M.bovis_AF2122/97 GLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNEAA
Rv0843|M.tuberculosis_H37Rv GLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNEAA
Mvan_0911|M.vanbaalenii_PYR-1 HFSCSG-IIAEGLPTAVGMALAFKKQGSDRVAIAVTGEGAANQGAFHESL
MMAR_3323|M.marinum_M RAGADG-IVGAAGPLAVGHAIAHTQLHPGSVAIAFHGEAAMNQGMLMEAY
: * * * . . ..: : . . *:
MAV_2947|M.avium_104 NMAALWDLPIVFVCQNNRYAEMTPTTDTMKLEHVADRAAGYGMPGVRVDG
TH_4167|M.thermoresistible__bu NMAALWNLPVVFFCQNNAWAECTAMERYTRTARLSDRAQGYGMPGVTVDG
MSMEG_4712|M.smegmatis_MC2_155 NLATVFRAPCVFFIQNNQWAISVPVSRQQAGPTIAHRAIGYGMPGIRVDG
MUL_3775|M.ulcerans_Agy99 NFAAVFDAGCVFYVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRVDG
MAB_4918c|M.abscessus_ATCC_199 AFASSFGAPVVFFCQNNQWAISEPVRVQSHLP-LAARGIGFGVPGIQVDG
Mb0866|M.bovis_AF2122/97 DLAAVWQLPVVILVENIRGALSVHLGRYTHEPRVYRRAVAYGMPGVSVDG
Rv0843|M.tuberculosis_H37Rv DLAAVWQLPVVILVENIRGALSVHLDRYTHEPRVYRRAVAYGMPGVSVDG
Mvan_0911|M.vanbaalenii_PYR-1 NLAALWKLPVVFIVEDNGWGVSVSKAQSTCIESNADRAVAYGMPGVLVKD
MMAR_3323|M.marinum_M NMAVAWNLPVVFVCKDNKWGITTYS-KDQTGADPISRARGFGLEVASAAG
:* : *: :: . :. .:*: . .
MAV_2947|M.avium_104 NDPLAVTAALEEALRRARAGSGPTFLECETFRFRGHYFG-DRMPYIPADQ
TH_4167|M.thermoresistible__bu TDPRAVHDAVAEAVTRARSGGGPTFVEALAYRLQGHYFG-DTMAYADPDE
MSMEG_4712|M.smegmatis_MC2_155 NDVLACYAVMSEAAERARRGEGPTLIEAVTYRMGPHTTSDDPTRYRPAEE
MUL_3775|M.ulcerans_Agy99 NDVLACYAVTAVAAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQEE
MAB_4918c|M.abscessus_ATCC_199 NDVLAVTAATRMALRRAREGSGPTLIEAVTYRMGPHTTSDDPTKYRNAAE
Mb0866|M.bovis_AF2122/97 NDVEAVRDCVANAVVRARAGGGPTLVQAITYRT-TDFSGSDRGGYR--DL
Rv0843|M.tuberculosis_H37Rv NDVEAVRDCVANAVVRARAGGGPTLVQAITYRT-TDFSGSDRGGYR--DL
Mvan_0911|M.vanbaalenii_PYR-1 NAVEAIYAVAGEAISRARAGGGPTLIEAETLRLWGHFEG-DPQLYR--AD
MMAR_3323|M.marinum_M HKVADVHAAAGRLIERARSGNGPGFLYVTCRRPGGHFEG-DPLVGLLRAP
*** * ** :: * . . *
MAV_2947|M.avium_104 LQAALAADPVPRFRRRLAETGVCGEAE--LARIDDDAAAAVEAALRTVLG
TH_4167|M.thermoresistible__bu LAAKRADPPFDRYRRRLIDEGIATAAT--LDQIDAELAAQVDAAFAAARD
MSMEG_4712|M.smegmatis_MC2_155 VEAWAARDPIARYRTYLQNIGVWTERL--EERVAARSSRLCAELRDAIVG
MUL_3775|M.ulcerans_Agy99 VDHWLALDPISRYRSYLQGQGLWSQRL--EVRVAARSGRLRAELREAVFG
MAB_4918c|M.abscessus_ATCC_199 LDEWRAKDPLARVEKYLESRGALSESE--KHRIAALADEVAAQLRAGCLG
Mb0866|M.bovis_AF2122/97 AGSEQFLDPLIFARRRLIAAGTTRGRL--DEQERAACQQVADAVAFAKDR
Rv0843|M.tuberculosis_H37Rv AGSEQFLDPLIFARRRLIAAGTTRGRL--DEQERAACQQVADAVAFAKAR
Mvan_0911|M.vanbaalenii_PYR-1 LDGVAALDPVPAYEAQLRADSVLSDDI--VHEVTNWAVERVESAIAFAKS
MMAR_3323|M.marinum_M RKQLSVWVPELRSGLTATESGSRTDKLRAMAGIGKRAARFAYDVGRTAGK
* .
MAV_2947|M.avium_104 ADSPAADELDRDVYAAP-----------IPFPT-----------------
TH_4167|M.thermoresistible__bu AEPLGPEELTGDVFTGNGTELADGTVPRVALPEGETEELGLVQAIHRTLD
MSMEG_4712|M.smegmatis_MC2_155 APDVDPAEMFDTVYADITPELARQRDQLLSELAKEA--------------
MUL_3775|M.ulcerans_Agy99 ASDFDVDDVFTTVFAEITPGLQTQRQQLRAELDRID--------------
MAB_4918c|M.abscessus_ATCC_199 TVEPTAADMFNHVYAEPHPLVSAERRDYLEYLATFEDEGTYAS-------
Mb0866|M.bovis_AF2122/97 ARPNGGGPISRPTSGWHQQPKTRF--------------------------
Rv0843|M.tuberculosis_H37Rv ARPNGGGPISRPTSGWHQQPKTRF--------------------------
Mvan_0911|M.vanbaalenii_PYR-1 SPEPDPATALNYQFA-----------------------------------
MMAR_3323|M.marinum_M DPVRRGRSLISADAATAIEAQERAEVLAAMTEARARVGKRAGFGIKTGAD
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu RAMAADDSIILLGEDIGDRSGGGMFKITAGLSAKYGEERVRDTPIAESSI
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3323|M.marinum_M R-------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu IGAALGASLAGLRPVAELMFMDFLGVAMDQIANHVAKVRYMSGGRRGAPL
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3323|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu VIRTMVGTAAGAQHSQALEAWAMHTPGLKVVWPSTAADAAGLLNACLRED
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3323|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu DPCLFIESMKLYYGGGKGPVPVADYVIPLGQADVKRVGSDVTICTYGVLV
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3323|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu HAALEAAKTLAGEGVSVEVVDLRTLVPLDLQTVLDSVRKTKRLVVAHESV
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3323|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu GFCGPGAEIAAAVGTELFAELAAPIQRVAGTYTPVPRAATLEAACRPDAT
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3323|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 ----------
TH_4167|M.thermoresistible__bu KLSDAVRRIM
MSMEG_4712|M.smegmatis_MC2_155 ----------
MUL_3775|M.ulcerans_Agy99 ----------
MAB_4918c|M.abscessus_ATCC_199 ----------
Mb0866|M.bovis_AF2122/97 ----------
Rv0843|M.tuberculosis_H37Rv ----------
Mvan_0911|M.vanbaalenii_PYR-1 ----------
MMAR_3323|M.marinum_M ----------