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THASARPAALLPDHLEMYRRMWVLRLLDMALEEMRADGLMESPVSTALGQEAVSIGATAALTEGDLVLAS RRAHALHVGVDLPLGPMIAELIGQDSTCDHADQLNSPERSGAADQCPLLAVGHAYSQWLDNSDRVTLCIT GPDDVNSGAFVQAANMAVLWHLPVVIVVESVPGVGVAGRLRGAPGHGGDACQRIPSVTVDGHDVQAVRRC VATAVQRARAGAGPTVVRAITYRSSDFPSFDGDYDAAATEPFLDPLVFTGGRLKAGGADAAQLCDVERTA RKLVADAVALAKSGTCPGHDGRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4784 | - | - | 100% (304) | dehydrogenase |
| M. marinum M | MMAR_3489 | - | 2e-19 | 28.76% (299) | pyruvate dehydrogenase E1 component (alpha subunit) |
| M. marinum M | MMAR_3323 | - | 1e-15 | 28.16% (245) | pyruvate dehydrogenase E1 component (alpha subunit) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0866 | - | 5e-72 | 48.58% (317) | dehydrogenase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0843 | - | 2e-71 | 47.95% (317) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4918c | - | 2e-13 | 26.71% (292) | pyruvate dehydrogenase E1 component alpha subunit |
| M. avium 104 | MAV_0873 | - | 8e-47 | 42.07% (290) | dehydrogenase E1 component superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4712 | - | 5e-12 | 28.93% (242) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. thermoresistible (build 8) | TH_4167 | - | 5e-19 | 28.81% (295) | PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase |
| M. ulcerans Agy99 | MUL_3775 | pdhA | 3e-12 | 28.89% (225) | pyruvate dehydrogenase E1 component (alpha subunit) PdhA |
| M. vanbaalenii PYR-1 | Mvan_1408 | - | 3e-21 | 28.97% (290) | pyruvate dehydrogenase (acetyl-transferring) |
CLUSTAL 2.0.9 multiple sequence alignment
TH_4167|M.thermoresistible__bu ------------------MATQLDVEAPTSANDR----------------
Mvan_1408|M.vanbaalenii_PYR-1 -----------------------------MDSGQ----------------
MSMEG_4712|M.smegmatis_MC2_155 MAMQYSSAPGYDTGFDPEPVQLVAADGSPSPDRPPSRYSRDLPPET----
MUL_3775|M.ulcerans_Agy99 ------------MTVGLEPVQLVNADGEPTDEH---RYSRDLPEET----
MAB_4918c|M.abscessus_ATCC_199 ----------------METIQLLDSDGNRIENPEYMPLVSDILDEDGLTQ
Mb0866|M.bovis_AF2122/97 ------------------MTRTSEGLAAFVVDQLE---------------
Rv0843|M.tuberculosis_H37Rv ------------------MTRTSEGLAAFVVDQLE---------------
MMAR_4784|M.marinum_M ------------------MTHASARPAALLPDHL----------------
MAV_0873|M.avium_104 ------------------MTAPEH-------DDRL---------------
.
TH_4167|M.thermoresistible__bu AIALYRLMSKVHHADARVRKGLSSGEIAMSYWPVTGQEAMSAGAALALSD
Mvan_1408|M.vanbaalenii_PYR-1 ARDLLTDMIRVRRMEEKCAELYSESKIRGFLHLYVGEEAVAAGSLRALGP
MSMEG_4712|M.smegmatis_MC2_155 LSWLYESMVVTRNLDVEFVNLQRQGELALFAS-CRGQEAAQIGAAACLRK
MUL_3775|M.ulcerans_Agy99 LCWLYEMMVVTRELDAEFINLKRQGELALFAS-CRGQEAAQVGATACLRK
MAB_4918c|M.abscessus_ATCC_199 LRALYRDMVVVRRIDNESTALQRQGELALWAP-LLGQEAAQVGSARALRH
Mb0866|M.bovis_AF2122/97 --ELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGE
Rv0843|M.tuberculosis_H37Rv --ELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGE
MMAR_4784|M.marinum_M --EMYRRMWVLRLLDMALEEMRADGLMESPVSTALGQEAVSIGATAALTE
MAV_0873|M.avium_104 --EPYRRMWVLRLLDMALDESAVGAAIDDDAPVDFGQEAVAVGAVAALRP
* : : . : *:** *: .*
TH_4167|M.thermoresistible__bu GDQLVSTYR--GLGDVVAKGIDLAGYFGEILGRRTGLSRGKAGAMGISDP
Mvan_1408|M.vanbaalenii_PYR-1 DDAVVATYR--EHAHALLRGVPMTSIMAEMFGKVQGCSRGRGGSMHLFDA
MSMEG_4712|M.smegmatis_MC2_155 TDWLFPQYR--EIGAFLLRGITPAQMGAVWRGKWHGG---------LSFT
MUL_3775|M.ulcerans_Agy99 TDWLFPQYR--ELGAYLVRGIPPGHVGAAWRGTWHGG---------LEFT
MAB_4918c|M.abscessus_ATCC_199 DDFAFTSFR--EHGVAYCRGIEPTAMLQFWRGSTQSG---------WNPR
Mb0866|M.bovis_AF2122/97 GDVIITTHR--PHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADP
Rv0843|M.tuberculosis_H37Rv GDVIITTHR--PHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADP
MMAR_4784|M.marinum_M GDLVLASRR--AHALHVGVDLPLGPMIAELIGQDS----TCDHADQLNSP
MAV_0873|M.avium_104 GDLVNATTPRFRHAQQIGLGLPLGPAIAELLGTTRGGAGGSRKSGAADWK
* . . . *
TH_4167|M.thermoresistible__bu DHGIAWTTGIVGAGPLFANGIALAASIRGTGQVVLVSFGDGATSIGYVHE
Mvan_1408|M.vanbaalenii_PYR-1 DRRFYGGNAIVSGGLPLAAGLALADAHQGRNRVTACYFGEGAVAEGAFHE
MSMEG_4712|M.smegmatis_MC2_155 GKCVAPIAIPIGTHGLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHE
MUL_3775|M.ulcerans_Agy99 KKCCVPISVPIGTQALHAVGAAQAAQRLGEDSVTVAFLGDGATSEGDVHE
MAB_4918c|M.abscessus_ATCC_199 DHNVTAPAIIVGAQALHATGYAMGVKFDGSDTAVIAYFGDGATSQGDVSE
Mb0866|M.bovis_AF2122/97 RAGLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNE
Rv0843|M.tuberculosis_H37Rv RAGLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNE
MMAR_4784|M.marinum_M ER-----SGAADQCPLLAVGHAYSQWLDNSDRVTLCITGPDDVNSGAFVQ
MAV_0873|M.avium_104 QALAN--ESALGQSTLFALGDANAQRMAGDGRVTLCAIAGSDTHSVEFAT
* * * . . . .. .
TH_4167|M.thermoresistible__bu AMNMAALWNLPVVFFCQNNAWAECTAMERYTRTARLSDRAQGYGMPGVTV
Mvan_1408|M.vanbaalenii_PYR-1 SLNMAVLWRLPVLFCCENNLYAMGTALRRELSQTDLTVKAAAYNVPTLAV
MSMEG_4712|M.smegmatis_MC2_155 AFNLATVFRAPCVFFIQNNQWAISVPVSRQQAGPTIAHRAIGYGMPGIRV
MUL_3775|M.ulcerans_Agy99 ALNFAAVFDAGCVFYVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRV
MAB_4918c|M.abscessus_ATCC_199 AFAFASSFGAPVVFFCQNNQWAISEPVRVQSHLP-LAARGIGFGVPGIQV
Mb0866|M.bovis_AF2122/97 AADLAAVWQLPVVILVENIRGALSVHLGRYTHEPRVYRRAVAYGMPGVSV
Rv0843|M.tuberculosis_H37Rv AADLAAVWQLPVVILVENIRGALSVHLDRYTHEPRVYRRAVAYGMPGVSV
MMAR_4784|M.marinum_M AANMAVLWHLPVVIVVESVPGVG--VAGRLRGAPGHGGDACQR-IPSVTV
MAV_0873|M.avium_104 AAKIAASWRLPVVFVVQNVRGGPDARRCAYRSET----------MPMALV
: :* : :: :. . :* *
TH_4167|M.thermoresistible__bu DGTDPRAVHDAVAEAVTRARSGGGPTFVEALAYRLQGHYFG-DTMAYADP
Mvan_1408|M.vanbaalenii_PYR-1 DGMDVAACQFAAQEAVEHIRRGGGPFFVEFRTYRFRAHSMF-DPELYRDK
MSMEG_4712|M.smegmatis_MC2_155 DGNDVLACYAVMSEAAERARRGEGPTLIEAVTYRMGPHTTSDDPTRYRPA
MUL_3775|M.ulcerans_Agy99 DGNDVLACYAVTAVAAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQ
MAB_4918c|M.abscessus_ATCC_199 DGNDVLAVTAATRMALRRAREGSGPTLIEAVTYRMGPHTTSDDPTKYRNA
Mb0866|M.bovis_AF2122/97 DGNDVEAVRDCVANAVVRARAGGGPTLVQAITYRTTDFSGSDRGGYR---
Rv0843|M.tuberculosis_H37Rv DGNDVEAVRDCVANAVVRARAGGGPTLVQAITYRTTDFSGSDRGGYR---
MMAR_4784|M.marinum_M DGHDVQAVRRCVATAVQRARAGAGPTVVRAITYRSSDFPSFD-GDY----
MAV_0873|M.avium_104 DGRDVVAVGDSVGQAVRHASAGDGPSLVEAITYRTN--------------
** * * * : * ** .:. :**
TH_4167|M.thermoresistible__bu DELAAKRADPPFDRYRRRLIDEGIATAATLDQIDAELAAQVDAAFAAARD
Mvan_1408|M.vanbaalenii_PYR-1 AEVEQWRQRDPIAMFTDRCTGEGLLAPEDVAAIEESVGVELSDAVAYAEA
MSMEG_4712|M.smegmatis_MC2_155 EEVEAWAARDPIARYRTYLQNIGVWTERLEERVAARSSRLCAELRDAIVG
MUL_3775|M.ulcerans_Agy99 EEVDHWLALDPISRYRSYLQGQGLWSQRLEVRVAARSGRLRAELREAVFG
MAB_4918c|M.abscessus_ATCC_199 AELDEWRAKDPLARVEKYLESRGALSESEKHRIAALADEVAAQLRAGCLG
Mb0866|M.bovis_AF2122/97 DLAGSEQFLDPLIFARRRLIAAGTTRGR-LDEQERAACQQVADAVAFAKD
Rv0843|M.tuberculosis_H37Rv DLAGSEQFLDPLIFARRRLIAAGTTRGR-LDEQERAACQQVADAVAFAKA
MMAR_4784|M.marinum_M DAAATEPFLDPLVFTGGRLKAGGADAAQ-LCDVERTARKLVADAVALAKS
MAV_0873|M.avium_104 ----HPVAIDPLVLARRRLMADGVDPDR-LVEVERGARHLVAEAMACAKA
*: *
TH_4167|M.thermoresistible__bu AEPLGPEELTGDVFTGNGTELADGTVPRVALPEGETEELGLVQAIHRTLD
Mvan_1408|M.vanbaalenii_PYR-1 GTWEDVEDLERDVLTPAGGQR-----------------------------
MSMEG_4712|M.smegmatis_MC2_155 APDVDPAEMFDTVYADITPELARQRDQLLSELAKEA--------------
MUL_3775|M.ulcerans_Agy99 ASDFDVDDVFTTVFAEITPGLQTQRQQLRAELDRID--------------
MAB_4918c|M.abscessus_ATCC_199 TVEPTAADMFNHVYAEPHPLVSAERRDYLEYLATFEDEGTYAS-------
Mb0866|M.bovis_AF2122/97 RARPNGGGPISRPTSGWHQQPKTRF-------------------------
Rv0843|M.tuberculosis_H37Rv RARPNGGGPISRPTSGWHQQPKTRF-------------------------
MMAR_4784|M.marinum_M GTCPGHDG---RS-------------------------------------
MAV_0873|M.avium_104 LVRARRSDAVSAPDR-WSAAS-----------------------------
TH_4167|M.thermoresistible__bu RAMAADDSIILLGEDIGDRSGGGMFKITAGLSAKYGEERVRDTPIAESSI
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu IGAALGASLAGLRPVAELMFMDFLGVAMDQIANHVAKVRYMSGGRRGAPL
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu VIRTMVGTAAGAQHSQALEAWAMHTPGLKVVWPSTAADAAGLLNACLRED
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu DPCLFIESMKLYYGGGKGPVPVADYVIPLGQADVKRVGSDVTICTYGVLV
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu HAALEAAKTLAGEGVSVEVVDLRTLVPLDLQTVLDSVRKTKRLVVAHESV
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu GFCGPGAEIAAAVGTELFAELAAPIQRVAGTYTPVPRAATLEAACRPDAT
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu KLSDAVRRIM
Mvan_1408|M.vanbaalenii_PYR-1 ----------
MSMEG_4712|M.smegmatis_MC2_155 ----------
MUL_3775|M.ulcerans_Agy99 ----------
MAB_4918c|M.abscessus_ATCC_199 ----------
Mb0866|M.bovis_AF2122/97 ----------
Rv0843|M.tuberculosis_H37Rv ----------
MMAR_4784|M.marinum_M ----------
MAV_0873|M.avium_104 ----------