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VVCWVPYEQLRLAPAAKAVAVMMDTTNQANPAEADTRDEVVVKCPATGEIVGTVAVTTVDGVAAAAARLR AAQPEWQRLGVSGRAYWLGRWRDWMLDHRDDLLTPLQLETGKSWGDAGIEIATVQVINYWIDNAAEFLAD QPVRPYGAANAAKKLTIVYEPYPLVGVITPWNGPLSVPLLDVPAALLAGCAVLSKPSEFTPLAWQHAVEG WKQIGAPDVLDVVFGFGETGAALVDVVDYVMFTGSVGTGRRIAVAAAERLIPCGLELGGKDAMIVCADAD IDRAVDGAVWGGFAYTGQVCISVERIYVEAPVFDTFVSKLVARTSQLRQGMDAGHDYSCEIGSMTTAQQL EIVSRHVDDAVRKGAKVLIGGKTRDPGGDGLFYEPTVLVDVDHDMDCMREETFGPTLPVMKVRDVAEAIE KANDCRFGLSGSVWTRDKAKAIDIARRLNTGTVNINNVITGIFQIGVPMAGWKESGLGTRSGGAEGIRKY CHPKSIVAERVAMKKELLWYPYSRKKGSFAEKVVRMLSARDWRRRLGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3111 | gabD1_1 | - | 100% (538) | succinate-semialdehyde dehydrogenase |
| M. marinum M | MMAR_1607 | putA_2 | e-116 | 45.10% (510) | succinate-semialdehyde dehydrogenase |
| M. marinum M | MMAR_2571 | gabD2 | 7e-85 | 40.80% (473) | succinate-semialdehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1760 | gabD2 | 2e-81 | 39.68% (499) | succinic semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0132 | - | 1e-108 | 45.30% (479) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv1731 | gabD2 | 2e-81 | 39.68% (499) | succinic semialdehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 9e-51 | 31.80% (456) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4136c | - | 1e-122 | 48.25% (487) | putative aldehyde dehydrogenase |
| M. avium 104 | MAV_2647 | - | 2e-65 | 35.92% (476) | betaine-aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0889 | - | 1e-111 | 43.99% (491) | succinic semialdehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3138 | - | 1e-115 | 45.26% (506) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2361 | gabD1_1 | 0.0 | 98.14% (538) | succinate-semialdehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0771 | - | 1e-114 | 46.14% (479) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1760|M.bovis_AF2122/97 -------------MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKP
Rv1731|M.tuberculosis_H37Rv -------------MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKP
MMAR_3111|M.marinum_M MVCWVPYEQLRLAPAAKAVAVMMDTTNQANPAEADTRDEVVVKCPATGEI
MUL_2361|M.ulcerans_Agy99 MVCWVPYEQLRLAPAAKAVAVMMDTTNQANPAEADTRDEVVVKCPATGEI
Mflv_0132|M.gilvum_PYR-GCK ----------------------MTATSDAHTANPFTGTGTITN-PATGAV
Mvan_0771|M.vanbaalenii_PYR-1 -------------------MGFMTATSDVQPPHTFTGTGTIRN-PATGAV
MSMEG_0889|M.smegmatis_MC2_155 ----------------------MTATPEVDLPNPYTGTGTIHN-PATGAV
TH_3138|M.thermoresistible__bu ----------------------MTATSGVDA----TETATIRN-PATGGV
MAB_4136c|M.abscessus_ATCC_199 ----------------------MTTTSENLVSTPSDTSHDVRN-PANGQV
MAV_2647|M.avium_104 ---------MTLLPESVPMVELAASYAAGKWVSGAHAGTLDVTSPATGEL
MLBr_02573|M.leprae_Br4923 -------------------------------------MSIATINPATGET
.*
Mb1760|M.bovis_AF2122/97 LTTIPVGTAADVEAAFAEARAAQTDWAKRPVIERAAVIRRYRDLVIENRE
Rv1731|M.tuberculosis_H37Rv LTTIPVGTAADVEAAFAEARAAQTDWAKRPVIERAAVIRRYRDLVIENRE
MMAR_3111|M.marinum_M VGTVAVTTVDGVAAAAARLRAAQPEWQRLGVSGRAYWLGRWRDWMLDHRD
MUL_2361|M.ulcerans_Agy99 VGTVPVTTVDGVAAAAARLRAAQPEWQRLGVSGRACWLGRWRDWMLDHRD
Mflv_0132|M.gilvum_PYR-GCK AGTVHWTDPADVAQVAAGLRTAQREWEARGPKGRAKVLARYALWLGEHRA
Mvan_0771|M.vanbaalenii_PYR-1 AGEVRWTDPADVARLAAGLRTAQREWETRGPKGRAKVLARYAVWLGEHRD
MSMEG_0889|M.smegmatis_MC2_155 AGEVRWTDPADVPRIAAGLREAQKEWEARGPKGRAKVLARYAVWLGDHRD
TH_3138|M.thermoresistible__bu AGEVRWTDPADVPRITAGLREAQRHWEARGPKGRAKVLARYAVWLGEHRD
MAB_4136c|M.abscessus_ATCC_199 VGRVNWTDPSDIPGIVAQLAKAQPSWERLGPEGRGQVLARFAQWLIDNTG
MAV_2647|M.avium_104 LGTVGIAGPDDVGAAVAAARGALQSWGRVAPADRGAALGRLADALSARKG
MLBr_02573|M.leprae_Br4923 VKTFTPTTQDEVEDAIARAYARFDNYRHTTFTQRAKWANATADLLEAEAN
. : * : *. : .
Mb1760|M.bovis_AF2122/97 FLMDLLQAEAGKARWAAQEEIVDLIANANYYARVCVDLLKP--RKAQPLL
Rv1731|M.tuberculosis_H37Rv FLMDLLQAEAGKARWAAQEEIVDLIANANYYARVCVDLLKP--RKAQPLL
MMAR_3111|M.marinum_M DLLTPLQLETGKSWGDAGIEIATVQVIN-YWIDNAAEFLADQPVRPYGAA
MUL_2361|M.ulcerans_Agy99 DLLTPLQLETGKSWGDAGIEIATVQVIN-YWIDNAAEFLADQPVRPYGAA
Mflv_0132|M.gilvum_PYR-GCK EIERLLIAETGKSAVDAAQEVPLILMITSYYVRTMEKALAPESRPAALPF
Mvan_0771|M.vanbaalenii_PYR-1 EIERLLIAETGKSAADAAQEVPLIIMITSYYVRTMAKALAPETRPASLPF
MSMEG_0889|M.smegmatis_MC2_155 EIEKLLIAETGKSAVDAAQEVPLILMILSYYIKTVEKAMAPEKRPAPLPF
TH_3138|M.thermoresistible__bu EIERLLIAETGKSAVDAAQEVPLILMITSYYIKTMEKALAPETRPASMPL
MAB_4136c|M.abscessus_ATCC_199 RIEAQLIAETGKSKIDGGIEIPSILAIIAYYAPKAAEFLAPESRPASSIA
MAV_2647|M.avium_104 ELADLTTAEIGSP---RSWSTFGQVITAVGVLRAYASITPHYPFSTTRPS
MLBr_02573|M.leprae_Br4923 QSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLAD--EPAEAAA
* *.. . .
Mb1760|M.bovis_AF2122/97 PGIGKTTVCYQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSQ
Rv1731|M.tuberculosis_H37Rv PGIGKTTVCYQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSQ
MMAR_3111|M.marinum_M NAAKKLTIVYEPYPLVGVITPWNGPLSVPLLDVPAALLAGCAVLSKPSEF
MUL_2361|M.ulcerans_Agy99 NAAKKLTIVYEPYPLVGVITPWNGPLSVPLLDVPAALLAGCAVLSKPSEF
Mflv_0132|M.gilvum_PYR-GCK LSIKKITVHYRPRPVVGIIAPWNYPVANALMDAIGALAAGCAVLLKPSER
Mvan_0771|M.vanbaalenii_PYR-1 LSIKKITVHYRPRPVVGIIAPWNYPVANALMDAVGALAAGCAVLLKPSER
MSMEG_0889|M.smegmatis_MC2_155 LSIKKIEVHYRPRAVVGIIAPWNYPVANAMMDAIGALAAGCSVLLKPSER
TH_3138|M.thermoresistible__bu LKIKKITVHHRPRPVVGVIAPWNYPVANALMDAIGALAAGCAVLLKPSER
MAB_4136c|M.abscessus_ATCC_199 MNTKKITVHQRPRKVVGVISPWNYPVALGYWDVIPALLAGCSVLLKPSER
MAV_2647|M.avium_104 VTGGTVEVRQLPVGVVGAIVPWNTPLFIAALKLGPALAAGCTVVLKPAPD
MLBr_02573|M.leprae_Br4923 VGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASN
. * :* : *** *: ** ** : *
Mb1760|M.bovis_AF2122/97 TPYCALACAELLYRAGLPRALYAIVPGPGSVVGTAITDN--CDYLMFTGS
Rv1731|M.tuberculosis_H37Rv TPYCALACAELLYRAGLPRALYAIVPGPGSVVGTAITDN--CDYLMFTGS
MMAR_3111|M.marinum_M TPLAWQHAVEGWKQIGAP-DVLDVVFGFG-ETGAALVDV--VDYVMFTGS
MUL_2361|M.ulcerans_Agy99 TPLAWQHAVEGWKQIGAP-DVLDVVFGFG-ETGAALVDV--VDYVMFTGS
Mflv_0132|M.gilvum_PYR-GCK TPLTAELLLRGWLEAGGP-DVLALAQGAR-AVSEAVIDN--SDFIQFTGS
Mvan_0771|M.vanbaalenii_PYR-1 TPLTAELLLRGWLDSGGP-DVLALAQGAR-EVSEAVIDN--SDYIQFTGS
MSMEG_0889|M.smegmatis_MC2_155 TPLTAEVLLRGWLDSGAP-EVFALAQGAR-AVSEAVIDN--SDYIQFTGS
TH_3138|M.thermoresistible__bu TPLTAELLLRGWLESGAP-EVFALAQGAR-EVSEAVVDN--ADFIQFTGS
MAB_4136c|M.abscessus_ATCC_199 TPLSDELIANGWAEIGGP-PVFEVVHGAR-EVGEALVDN--VDFVQFTGS
MAV_2647|M.avium_104 APLEFGVLMEAIEEAGLPDGVVNVVNGGA-ETGELLTEHPGVDKVSFTGS
MLBr_02573|M.leprae_Br4923 VPQCALYLADVIARGGFPEDCFQTLLISANGVEAILRDPR-VAAATLTGS
.* * * . : : :***
Mb1760|M.bovis_AF2122/97 SATGSRLAEHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSN
Rv1731|M.tuberculosis_H37Rv SATGSRLAEHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSN
MMAR_3111|M.marinum_M VGTGRRIAVAAAERLIPCGLELGGKDAMIVCADADIDRAVDGAVWGGFAY
MUL_2361|M.ulcerans_Agy99 VGTGRRIAVAAAERLIPCGLELGGKDAMIVCADADIDRAVDGAVWGGFAY
Mflv_0132|M.gilvum_PYR-GCK SATGAKVMERAARRLTPVSLELGGKDPMIVLEDADVDLAAHAAVWGAMFN
Mvan_0771|M.vanbaalenii_PYR-1 TATGVKVMERAARRLTPVSLELGGKDPMIVLEDADIDLAAHAAVWGAMFN
MSMEG_0889|M.smegmatis_MC2_155 SATGAKVMERAARRLTPVSLELGGKDPMIVLEDADIELAANAAVWGAMFN
TH_3138|M.thermoresistible__bu TATGIKVMERAARRLTPVSLELGGKDPMIVLEDADIELAANAAVWGAMFN
MAB_4136c|M.abscessus_ATCC_199 TATGKKIMERAARRLTPVSLELGGKDPMLVLPDADVKRAAHAAVWGSMFN
MAV_2647|M.avium_104 TAVGARIAASCGSRIRRCSTELGGKSAAIVLPDAPLETTVPGLVAGVMGN
MLBr_02573|M.leprae_Br4923 EPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQN
.* : .. .: ****... :* .* :. .. . . .
Mb1760|M.bovis_AF2122/97 AGQLCISIERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFS--VDMGSLI
Rv1731|M.tuberculosis_H37Rv AGQLCISIERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFS--VDMGSLI
MMAR_3111|M.marinum_M TGQVCISVERIYVEAPVFDTFVSKLVARTSQLRQGMDAGHDYSCEIGSMT
MUL_2361|M.ulcerans_Agy99 TGQVCISVERIYVEALVFDTFVSKLVARTAQLRQGMDAGRDYSCEIGSMT
Mflv_0132|M.gilvum_PYR-GCK AGQTCVSVERVYVLDQVYDQFVDAVVRDVAKLQVGAGEGN----AFGALI
Mvan_0771|M.vanbaalenii_PYR-1 AGQTCVSVERVYVLEQVYDQFVAAVVRDVESLKMGAGEGN----AFGALI
MSMEG_0889|M.smegmatis_MC2_155 AGQTCVSVERVYVLESVYDQFVAATVRAVENLKMGAGEGY----DFGSLI
TH_3138|M.thermoresistible__bu AGQTCVSVERVYVLAPVYEQFVAAVVRAVEKLEVGAGEGR----HFGALI
MAB_4136c|M.abscessus_ATCC_199 AGQTCVSVERVYVHDSIYEQFVDLVVEEVRGLEIGAGLDH----SVGAMI
MAV_2647|M.avium_104 NGQLCAALTRIVLPRSRYDEFVAALTAAVAELIVGDPADRVT--DIGPLI
MLBr_02573|M.leprae_Br4923 NGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDT--DVGPLA
** * : *. : *. : * . .*.:
Mb1760|M.bovis_AF2122/97 SEAQLKTVSGHVDDATAKGAKVIAGGKARP-DIGPLFYEPTVLTNVAPEM
Rv1731|M.tuberculosis_H37Rv SEAQLKTVSGHVDDATAKGAKVIAGGKARP-DIGPLFYEPTVLTNVAPEM
MMAR_3111|M.marinum_M TAQQLEIVSRHVDDAVRKGAKVLIGGKTRDPGGDGLFYEPTVLVDVDHDM
MUL_2361|M.ulcerans_Agy99 AAQQLEIVSRHVDDAVCKGAKVLIGGKTRDPGGDGLFYKPTVLVDVDHDM
Mflv_0132|M.gilvum_PYR-GCK DDDQVAVTERHVADALAKGARALTGGTRGA--GSGSFYEPTVLVDVDHAM
Mvan_0771|M.vanbaalenii_PYR-1 DDSQVEITARHVEDALAKGARALTGGKRGS--GPGSFYEPTVLVDVDHSM
MSMEG_0889|M.smegmatis_MC2_155 DAGQVDITERHVNEALEKGAKALTGGKRPE--DGGSFYPPTVLVDVDHSM
TH_3138|M.thermoresistible__bu DESQLAVTERHVADAVARGAKVLTGGRRKD--GPGCFYEPTVLVDVDHSM
MAB_4136c|M.abscessus_ATCC_199 DENQLEVVDRHVRQAVSSGARALTGGARIP--GHGSFYAPTVLVDVDHSM
MAV_2647|M.avium_104 NEAARDRVEGFLRRARQDGATVLVGGERPN---RPGWFLSPAVVAATNDM
MLBr_02573|M.leprae_Br4923 TESGRAQVEQQVDAAAAAGAVIRCGGKRPD--RPGWFYPPTVITDITKDM
. : * ** ** :: ...:. *
Mb1760|M.bovis_AF2122/97 ECAANETFGPVVSIYPVADV-----DEAVEKANDTDYGLNASVWAGSTAE
Rv1731|M.tuberculosis_H37Rv ECAANETFGPVVSIYPVADV-----DEAVEKANDTDYGLNASVWAGSTAE
MMAR_3111|M.marinum_M DCMREETFGPTLPVMKVRDV-----AEAIEKANDCRFGLSGSVWTRDKAK
MUL_2361|M.ulcerans_Agy99 DCMREETFGPTLPVMKVRDV-----AEAIEKANDCRFGLSGSVWTRDKAK
Mflv_0132|M.gilvum_PYR-GCK LCMTEETFGPTLPIMRVSTV-----DEAVRLANDSPYGLSAAVFSKDLER
Mvan_0771|M.vanbaalenii_PYR-1 ACMTEETFGPTLPIMKVSSV-----EEAVRLANDSPYGLSAAVFSRDVDR
MSMEG_0889|M.smegmatis_MC2_155 SCMNEETFGPTLPIMKVSSV-----EEAVRLANDSPYGLSASVFSKDTER
TH_3138|M.thermoresistible__bu MCMTEETFGPTLPIMKVSSV-----AEAVRLANDTPYGLSGSVFSQDVER
MAB_4136c|M.abscessus_ATCC_199 DCMREETFGPTLPIMRYSEE-----SEAIALANDSEYGLSASVWSKDRRR
MAV_2647|M.avium_104 EIAREEVFGPVAVVIAYDDTGADDVAEAVAIANDSRYGLVGAVWSADAER
MLBr_02573|M.leprae_Br4923 ALYTDEVFGPVASVYCATNI-----DDAIEIANATPFGLGSNAWTQNESE
:*.***. : :*: ** :** . .:: . .
Mb1760|M.bovis_AF2122/97 GQRIAARLRSGTVNVDEGYAFAWGSLSAPMGGMGLSGVGRRHG-PEGLLK
Rv1731|M.tuberculosis_H37Rv GQRIAARLRSGTVNVDEGYAFAWGSLSAPMGGMGLSGVGRRHG-PEGLLK
MMAR_3111|M.marinum_M AIDIARRLNTGTVNINN-VITGIFQIGVPMAGWKESGLGTRSGGAEGIRK
MUL_2361|M.ulcerans_Agy99 AIDIARRLNTGTVNINN-VITGIFQIGVPMAGWKESGLGTRSGGAEGIRK
Mflv_0132|M.gilvum_PYR-GCK AEAVAVQLDCGGVNIND-VISNLMCTTAPMGGWKTSGIGARFGGPEGLRK
Mvan_0771|M.vanbaalenii_PYR-1 AKAVALQLDCGGVNVND-VISNLMCTTAPMGGWKSSGIGARFGGPEGLRK
MSMEG_0889|M.smegmatis_MC2_155 AKKIALQLDCGAVNIND-VISNLMCTTAPMGGWKTSGIGARFGGVDGVRK
TH_3138|M.thermoresistible__bu AREIALQLDCGAVNIND-VISNLMATTAPMGGWKTSGIGARFGGPEGLRK
MAB_4136c|M.abscessus_ATCC_199 AERVALQLDCGTVNIND-VIMNLSCLTAPHGGWKGSGLGSRFGGVDGLRK
MAV_2647|M.avium_104 AAAVAAQLLVGSVAVNS---TAVLDFASPFGGFKQSGIG-REGGPEGIAG
MLBr_02573|M.leprae_Br4923 QRHFIDNIVAGQVFING---MTVSYPELPFGGIKRSGYG-RELSTHGIRE
. .: * * :: * .* ** * * .*:
Mb1760|M.bovis_AF2122/97 YTESQTIATARVFNLDPPFGIPATVWQKSLLPIVRTVMKLPGRR-----
Rv1731|M.tuberculosis_H37Rv YTESQTIATARVFNLDPPFGIPATVWQKSLLPIVRTVMKLPGRR-----
MMAR_3111|M.marinum_M YCHPKSIVAERVAMKKELLWYPYSRKKGSFAEKVVRMLSARDWRRRLGR
MUL_2361|M.ulcerans_Agy99 YCHPKSIVAERVAMKKELLWYPYSRKNGSFAEKVVKMLSARDWRRRLGR
Mflv_0132|M.gilvum_PYR-GCK YCRIETVVAPRTNVGAGGNYYNNSPRALKRMNTMMTKLALIRPRR-VAK
Mvan_0771|M.vanbaalenii_PYR-1 YCRIETVVSPRTNVGAGGNYYNNSLRALKRMNKLMTKLALIRPRR-VAK
MSMEG_0889|M.smegmatis_MC2_155 FCKQETVVAPRTSVGAGGTYYNNSHKALARMNRLMTKLALARPRR-TAK
TH_3138|M.thermoresistible__bu YCRVETVVEPRTGIGAGGTYYNNSFKSLGMMNKLLTRMALVRPRR-LAK
MAB_4136c|M.abscessus_ATCC_199 YCRTEAIVDTRVTLPSEPLWYSGPSWLAPVALKSLTKLSNKALRP-FRR
MAV_2647|M.avium_104 FVEHQAIIR----------------------------------------
MLBr_02573|M.leprae_Br4923 FCNIKTVWIA---------------------------------------
: . :::