For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ETLGAPELSFASLPMAADRGVGWKVLRDAGRVVSVDGIFYLTHREDVLAALRDPELFSSKKAFDVLGSPL PLVPISFDPPEHTRFRKILQPFFSPHTLKEMLPSLQQQAIEIIERVAAQGECEVVADVAIPYPSQVFLTL FGLPLEDRDKLVAWKTSVIAISEAPSLEDADLTPALELVAYLTEAINARRADPGPDILSQLLNGEEPLDD AEIMGLSFLFVLAGLDTVTAAMSSALLELARNPELRATLHDDPDQIDVFVEEIVRLEPPAPMLPRVTTTE VTIGDVTLPADTMVRLCVAAINRDDSDEISTNDVVMDGKVHRHWGFGGGPHRCLGSHLARLELKLIVGEW LRRIPEFSVKVGEEPQIVFPASTFSLERVPLKLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2548 | - | - | 100% (385) | putative cytochrome P450 143 |
| M. avium 104 | MAV_2931 | - | e-128 | 57.18% (383) | P450 heme-thiolate protein |
| M. avium 104 | MAV_1953 | - | e-100 | 50.53% (374) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1813c | cyp143 | 1e-139 | 61.01% (377) | cytochrome P450 143 |
| M. gilvum PYR-GCK | Mflv_1764 | - | 1e-136 | 59.84% (381) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1785c | cyp143 | 1e-139 | 61.01% (377) | cytochrome P450 143 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-36 | 31.63% (313) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 6e-43 | 32.65% (343) | cytochrome P450 |
| M. marinum M | MMAR_2631 | cyp143A3 | 1e-146 | 65.52% (377) | cytochrome P450 143A3 Cyp143A3 |
| M. smegmatis MC2 155 | MSMEG_5038 | - | 2e-44 | 33.53% (334) | putative cytochrome P450 123 |
| M. thermoresistible (build 8) | TH_2897 | - | 6e-48 | 35.36% (345) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_3106 | cyp143A3 | 1e-145 | 65.25% (377) | cytochrome P450 143A3 Cyp143A3 |
| M. vanbaalenii PYR-1 | Mvan_4983 | - | 1e-131 | 59.79% (378) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1764|M.gilvum_PYR-GCK MTATAAPLG----LPQVLYGDLPM----------------------SRDR
Mvan_4983|M.vanbaalenii_PYR-1 MSA----------LPHVLYGDLPM----------------------AADR
MMAR_2631|M.marinum_M MSAPRDERD----IPHFVYAELPM----------------------ATDR
MUL_3106|M.ulcerans_Agy99 MSAPRDERD----IPHFVYAELPM----------------------ATDR
MAV_2548|M.avium_104 MET----LG----APELSFASLPM----------------------AADR
Mb1813c|M.bovis_AF2122/97 MTTPGEDHAGSFYLPRLEYSTLPM----------------------AVDR
Rv1785c|M.tuberculosis_H37Rv MTTPGEDHAGSFYLPRLEYSTLPM----------------------AVDR
MAB_1406c|M.abscessus_ATCC_199 MSVDVSHT----VAPRYVPGTADN----------------------WTNP
MSMEG_5038|M.smegmatis_MC2_155 MGADLSHP----AVA-FELANADT----------------------WADP
TH_2897|M.thermoresistible__bu MTASDVTVS----PADYDPADQEG----------------------LQDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
* . :
Mflv_1764|M.gilvum_PYR-GCK GHGWATLRDLGPVLYGDG-------WFYLTRREDVLAALRNPEVFSSRIA
Mvan_4983|M.vanbaalenii_PYR-1 GAGWATLREFGPVAYGDG-------WYYLTRRDDVLAALRNPEVFSSRIA
MMAR_2631|M.marinum_M GRGWATLRDAGPVVIGDG-------FYYLTRRDDVLDALRHPEVFSSKRA
MUL_3106|M.ulcerans_Agy99 GRGWATLRDAGPVVIGDG-------FYYLTRRDDVLDALRHPEVFSSKRA
MAV_2548|M.avium_104 GVGWKVLRDAGRVVSVDG-------IFYLTHREDVLAALRDPELFSSKKA
Mb1813c|M.bovis_AF2122/97 GVGWKTLRDAGPVVFMNG-------WYYLTRREDVLAALRNPKVFSSRKA
Rv1785c|M.tuberculosis_H37Rv GVGWKTLRDAGPVVFMNG-------WYYLTRREDVLAALRNPKVFSSRKA
MAB_1406c|M.abscessus_ATCC_199 WPMYAALRDHDPVHHVVPEYTPDQDYYVLTRHADVYEAARDWETFSSARG
MSMEG_5038|M.smegmatis_MC2_155 WDMYTALRDHDPVHHVVPPERPHHDYFVLSRHADIWAAARDHETYSSAQG
TH_2897|M.thermoresistible__bu QPMYRALRAARVAYSEKQE----GGFYALARYEDVHGAARDWQTFSSADG
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMP------LTVFSSFSDCDEALRHPLSASDRLK
: .* :: * * *. *.
Mflv_1764|M.gilvum_PYR-GCK YDD--MISPVPLVPLG--------FDPPEHTRYRHILHPFFSPQTLAALL
Mvan_4983|M.vanbaalenii_PYR-1 YDD--MISPVPLVPLG--------FDPPEHTRYRRILHPFFSPQALGVLL
MMAR_2631|M.marinum_M FDI--LGSPLPLVPLA--------FDPPEHTRFRKVLQPFFSPHALAAML
MUL_3106|M.ulcerans_Agy99 FDI--LGSPLPLVPLA--------FDPPEHTRFRKVLQPFFSPHALAAML
MAV_2548|M.avium_104 FDV--LGSPLPLVPIS--------FDPPEHTRFRKILQPFFSPHTLKEML
Mb1813c|M.bovis_AF2122/97 LQP--PGNPLPVVPLA--------FDPPEHTRYRRILQPYFSPAALSKAL
Rv1785c|M.tuberculosis_H37Rv LQP--PGNPLPVVPLA--------FDPPEHTRYRRILQPYFSPAALSKAL
MAB_1406c|M.abscessus_ATCC_199 LTV--TYGDLEKTGMGDNPP-MVMQDPPTHTEFRKLVSRGFTPRQVTAVE
MSMEG_5038|M.smegmatis_MC2_155 LTV--NYGELELIGLADNPP-FVMQDPPTHTEFRKLVSRGFTPRQVEAVE
TH_2897|M.thermoresistible__bu ITLPAVGNPEPFIPIE--------VDPPRLQEYRRILAPLFTPAKTKEMV
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE
*** . *::: *:*
Mflv_1764|M.gilvum_PYR-GCK PSLQAQVADIVEEIARRDRCEVMAELATPYPSQVFLT--LFGLPLQ---D
Mvan_4983|M.vanbaalenii_PYR-1 PSLQAQAADIVETIAQRDACEVMAELATPYPSQVFLT--LFGLPLQ---D
MMAR_2631|M.marinum_M PSLQAQAIEIIDAIAAGSQCEVITELAIPYPSQVFLT--LFGLSLA---D
MUL_3106|M.ulcerans_Agy99 PSLQAQAIEIIDAIAAGSQCEVITKLAIPYPSQVFLT--LFGLSLA---D
MAV_2548|M.avium_104 PSLQQQAIEIIERVAAQGECEVVADVAIPYPSQVFLT--LFGLPLE---D
Mb1813c|M.bovis_AF2122/97 PSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLV--LYGLPLE---D
Rv1785c|M.tuberculosis_H37Rv PSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLV--LYGLPLE---D
MAB_1406c|M.abscessus_ATCC_199 PKVREFVVQRLERLKERGEGDIVVELFKPLPSMVVAH--YLGVPEE---D
MSMEG_5038|M.smegmatis_MC2_155 PQVREFVVERLERLRAEGGGDIVAELFKPLPSMVVAH--YLGVPEA---D
TH_2897|M.thermoresistible__bu PELRRIAREIIDDIAKRNSCEFVDEFAYMYPTVAMYRSPWMGEPLEG--E
MLBr_02088|M.leprae_Br4923 GDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICR--LLGVPYEDAPE
.: . :: . : : .. . . * . :
Mflv_1764|M.gilvum_PYR-GCK RERLIAWKDAIIAFSLTTDPSSVDLKPAVELYT-----YLSEAVAAQRDD
Mvan_4983|M.vanbaalenii_PYR-1 RERLIAWKDAIIAFSLTNDPTSVDLTPAVELYG-----YLTEAVARQREK
MMAR_2631|M.marinum_M RDRLIRWKDAIIALGLLASLDDADLTPALELTS-----YLVDAIAAHRRH
MUL_3106|M.ulcerans_Agy99 RDRLIRWKDAIIALGLLASLDDADLTPALELTS-----YLVDAIAAHRRH
MAV_2548|M.avium_104 RDKLVAWKTSVIAISEAPSLEDADLTPALELVA-----YLTEAINARRAD
Mb1813c|M.bovis_AF2122/97 RDRLIGWKDAVIAMSDRPHPTEADVAAARELLE-----YLTAMVAERRRN
Rv1785c|M.tuberculosis_H37Rv RDRLIGWKDAVIAMSDRPHPTEADVAAARELLE-----YLTAMVAERRRN
MAB_1406c|M.abscessus_ATCC_199 RTQFDAWTDGIVAAASGGAIDIEAMQGEVAQTIGELMMYFTGLIERRRAE
MSMEG_5038|M.smegmatis_MC2_155 RAQFDGWTEAIVAANSEAGSALGAGDAVMSMTG-----YFAELIERRRRE
TH_2897|M.thermoresistible__bu KLDPEGSDDWAQNLRDSVRTFIHGFGEPSARIAGLIIEYSKKLLEHRRAN
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
* : :*
Mflv_1764|M.gilvum_PYR-GCK PREGVLSHLLHG-----DDPLTDNEAVGLSLVFVLAGLDTVTSAIGATML
Mvan_4983|M.vanbaalenii_PYR-1 PREGILSHLLHG-----DEQLTDNEAVGLSLVFVLAGLDTVTSTIGATML
MMAR_2631|M.marinum_M PGTDILSQVLLG-----DDPLDDSEALGLSYVFVLAGLDTVTSAIGAALL
MUL_3106|M.ulcerans_Agy99 PGTDILSQVLLG-----DDPLDDSEALGLSYVFVLAGLDTVTSAIGAALL
MAV_2548|M.avium_104 PGPDILSQLLNG-----EEPLDDAEIMGLSFLFVLAGLDTVTAAMSSALL
Mb1813c|M.bovis_AF2122/97 PGPDVLSQVQIG-----EDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLL
Rv1785c|M.tuberculosis_H37Rv PGPDVLSQVQIG-----EDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLL
MAB_1406c|M.abscessus_ATCC_199 PEDDTVSHLVAAGVGADGDISGTLQILGFAFTMVTGGNDTTTGMLGGAIQ
MSMEG_5038|M.smegmatis_MC2_155 PGDDTISHLVAA--GADDEAVDVLSILAFTFTMVTGGNDTTTGMLGGAVQ
TH_2897|M.thermoresistible__bu PADDIPTYLLKAEIN--GRKLTEAEMLNTLLLQFNAGPPTTGAFLSGAFW
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELDES--GDQLTEEEIIATCGLLLVAGHETTVNLIANAVL
* . : : . : . .* *. :. :.
Mflv_1764|M.gilvum_PYR-GCK ELARRPELRGALREDPEGIAVFVEEMIRLEPAAPIVGRVTTRPVTVAGVT
Mvan_4983|M.vanbaalenii_PYR-1 ELARRPELRAALLGDPDGIAGFVEEMIRLEPAAPVVGRVTTREVTVAGVT
MMAR_2631|M.marinum_M ELARRPQLRQLLRENHGQIAVFVDEIVRLEPPAPVVPRVTTREVNIAGAK
MUL_3106|M.ulcerans_Agy99 ELARRPQLRQLLRENHGQIAVFVDEIVRLEPPAPVVPRVTTREVNIAGAK
MAV_2548|M.avium_104 ELARNPELRATLHDDPDQIDVFVEEIVRLEPPAPMLPRVTTTEVTIGDVT
Mb1813c|M.bovis_AF2122/97 ELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVGGMT
Rv1785c|M.tuberculosis_H37Rv ELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVGGMT
MAB_1406c|M.abscessus_ATCC_199 LLHQNPAQRQKLIDDPSLIPGAVEEFLRLTSPVQGLARTATRDVIIGDTT
MSMEG_5038|M.smegmatis_MC2_155 LLQQHPDQRRVLTDDPDLIPDAVDEFLRLTSPVQGLARTATRDVTIGDTT
TH_2897|M.thermoresistible__bu FLAQRPDLQEVLAGDPTKIPLAMEELLRYLGPTQVSKRTTTRPVTVGGTE
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTT
: :.* * : ::* :* . *.:: : :.
Mflv_1764|M.gilvum_PYR-GCK LPAGSEVRLCLGAINRDGTDE-HSGDDLVLDGKLHKHWGFGGGPHRCLGS
Mvan_4983|M.vanbaalenii_PYR-1 LPKGAEVRLCLGAINRDGADE-HSGDDFVLDGKLHKHWGFGGGPHRCLGS
MMAR_2631|M.marinum_M IPAGSRVWLCLGAINRDGSDA-TSVNDVVMDGKVHKHWGFGGGTHRCLGS
MUL_3106|M.ulcerans_Agy99 IPAGSRVWLCLGAINRDGSDA-TSVNDVVMDGKVHKHWDFGGGTHRCLGS
MAV_2548|M.avium_104 LPADTMVRLCVAAINRDDSDE-ISTNDVVMDGKVHRHWGFGGGPHRCLGS
Mb1813c|M.bovis_AF2122/97 LPAGSPVRLCMAAVNRDGSDA-MSTDELVMDGKVHRHWGFGGGPHRCLGS
Rv1785c|M.tuberculosis_H37Rv LPAGSPVRLCMAAVNRDGSDA-MSTDELVMDGKVHRHWGFGGGPHRCLGS
MAB_1406c|M.abscessus_ATCC_199 IPAGRRALLLYGSANRDEREYGNDAAELDVLRKPRNILTFSHGNHHCLGA
MSMEG_5038|M.smegmatis_MC2_155 IPAGRKVLLLYGSGNRDEREFGPDAAQLDVRRRPRNILTFSHGAHFCLGA
TH_2897|M.thermoresistible__bu IPAKCPVGLVWAAANRDEAEF-PNAEEFVLDRFPNRHIAFGMGVHRCIGS
MLBr_02088|M.leprae_Br4923 LTEGDTMVLLLAAANRDPAVY-SRPDEFDPDRPSSRHLAFAVGSHFCLGA
:. * .: *** :. . *. * * *:*:
Mflv_1764|M.gilvum_PYR-GCK HLARMELKLVVSEWLSRIPDFDLEPGYVPEITWPSATCTLTGLPLRILR-
Mvan_4983|M.vanbaalenii_PYR-1 HLARMELRLVVTEWLSRIPDFELAPGYVPEITWPSATCTLPTLPLILTRK
MMAR_2631|M.marinum_M HLARMELSLVISEWLRRIPQFELACGYTPEIDWPSATLGLSTLTLQFTS-
MUL_3106|M.ulcerans_Agy99 HLARMELSLVISEWLCRIPQFELACGYTPEIDWPSATLGLSTLPLQFTS-
MAV_2548|M.avium_104 HLARLELKLIVGEWLRRIPEFSVKVGEEPQIVFPASTFSLERVPLKLG--
Mb1813c|M.bovis_AF2122/97 HLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS--
Rv1785c|M.tuberculosis_H37Rv HLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS--
MAB_1406c|M.abscessus_ATCC_199 AAARMQSRIALEELLTRIPDFEVDLD---GVTWADGSYVRRPLTVPIRVR
MSMEG_5038|M.smegmatis_MC2_155 AAARMQSRVALTELLTRCPDFTVDLD---AVVWAGGSYVRRPLSVPFRAG
TH_2897|M.thermoresistible__bu NVARALIQISLEEWFRQIPKFSIRPGSPTPWDVG-ISRNLQNLELVW---
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV-----
** : : : *.. : : :
Mflv_1764|M.gilvum_PYR-GCK --
Mvan_4983|M.vanbaalenii_PYR-1 TP
MMAR_2631|M.marinum_M --
MUL_3106|M.ulcerans_Agy99 --
MAV_2548|M.avium_104 --
Mb1813c|M.bovis_AF2122/97 --
Rv1785c|M.tuberculosis_H37Rv --
MAB_1406c|M.abscessus_ATCC_199 --
MSMEG_5038|M.smegmatis_MC2_155 A-
TH_2897|M.thermoresistible__bu --
MLBr_02088|M.leprae_Br4923 --