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MSFVTAVPELVESAAQDLAGIRSALVEAAQAVAAPTTALAAAGEDEVSAAIAALFGTFGQEYQAVSAQAA SFHESFVRVLSGAAASYVEAEVANGAALLAGESAAAAVSGGFSGGLTAGLSAELALQAANSLATAFGSGV SGLALQTGGALVSGLGTGLVQTGEVIVSAGQALQNLGSFMAGAGAGLSAQASAALTQAMNLGGSLSAQLG ASLSGNFNLALPELIAGFNNGLTGLIQTGQTITTSLIGSAGSGLGALFQTGGTVLTNFGSALPEFAAQLS GAISATVGSSLPGLVGAFDSGFTGLVQAGQSLATNLAGSVGGGLDALIQTGETLAGGLTASLSAPVLAAQ LSAALQASFGTSLPELVAAFTGGLNGLVQAGQTLAANVAGNFGGGLSGLLEAGQVLMANLAGGFSLPALA AQISAAVQASFGASFPEVVAAFTGGLSGLVQAGQTLAANLVGGFSLPALAAQISAAVQASFGASFPEAVA AFTGGLNGLVQAGQTLAANLAGSLGGGFNALVEVGQALAANLVGGFSLPTLAAELSAALQASFGASFPEA VAAFTGGLNGLVQAGQSLAANLAGSLGGGFNALIEVGQALAANLVGGFSLPALAAQISAALQASFGASFP EAVAAFTGGLNGLVQAGQSLAANLAGSLGGGFNALIEVGQALAANLVGGFSLPTLAAQISAALQASFGAS FPEAVAAFTGGLNGLVQAGQTLAANLAGSFGGGLTGLLEAGQVLMANLAGGFSLPTLAAQISAALQASFG ASFPEAVAAFTGGLNGLVQAGQTLAANLAGSLGGGFNALVEVGQALAANLVGGFSLPTLAAQISAALQAS FGASFPEAVAAFTGGLNGLVQAGQTLAANLAGSLGGGFNALIEVGQALAANLVGGFSLPALAAQISAALQ ASFGASFPEVVAAFTGGLNGLVQAGQTLAANLAGSFGGGFNALVEVGQALAANLVGGFSLPALAAQISAA LQASFGASFPEVVAAFTGGLNGLVQAGQSLAANLAGSFGGGFNALIEVGQALAANLVGGFSLPALAAQIS AALQASFGASFPEVVAAFTGGLNGLVQAGQTLAANLAGSFGGGLSGLLEAGQVLMANLVGGFSLPALAAQ ISAALQASFGASFPEVVAAFTGGLNGLVQAGQSLAANLAGSFGGGLSGLLQAGQVLMANLVGGFSLPTLA AELSAALQASFGASLPEAVAAFTGGLNGLVRAGQTLAANLAGSFGGGLSGLLQAGQVLMANLVGGFSLPT LAAELSAALQASFGASLPEAVAAFTGGLNGLVQAGQTLAANLAGSFGGGLSGLLEAGQVLMANLVGGFSL PTLAAELSAALQASFGASFPEAVAAFTGGLNGLVQAGQTLAANLAGSFGGGLTGLLEAGQVLMANLVGGF SLPTLAAELSAALQASFGASFPEVVAAFTGGLNGLVQAGQSLAANLAGSLGGGFNALVEVGQALAANLVG GFSLPTLAAELSAALQASFGASFPEVVAAFTGGLNGLVQAGQSLAANLAGSFGGGFNALIEVGQALAANL VGGFSLPALAAQISAALQASFGASFPEVVAAFTGGLNGLVQAGQTLAANLAGSFGGGLSGLLEAGQVLMA NLVGGFSLPALAAQISAALQASFGASFPEVVAAFTGGLNGLVQAGQSLAANLAGSFGGGLSGLLQAGQAL MANLVGGFSLPTLAAELSAALQASFGASFPEAVAAFTGGLNGLVQAGQSLAANLAGSLGGGFNALIEVGQ ALAANLVGGFSLPALAAQISAALQASFGASFPEAVAAFTGGLNGLVQAGQSLAANLAGSFGGGLTGLLEA GQVLMANLAGGFSLPTLAAQISAALQASFGASFPEAVAAFTGGLNGLVQAGQSLAANLAGSLGGGFNALI EVGQALAANLVGGFSLPALAAQISAALQASFGASFPEAVAAFTGGLNGLVQAGQTLAANLAGSLGGGFNA LIEVGQALAANLAGGFSLPTLAAELSAALQASFGASFPEVVAAFTGGLNGLVQAGQTLAANLAGSLGGGF NALVEVGQALAANLVGGFSLPALAAQISAALQASFGASFPEAVAAFTGGLNGLVQAGQSLAANLAGSLGG GFNALIEVGQALAANLVGGFSLPTLAAQISAALQASLGTSFPELMAGFTGGFTGLLQTGQSLAGNLVGSF GGGLDALIQTGQNVAANLVGAFNAPALLAGLNSGLNGLVQTGASLAGNLAGAFGAGLPELATQLSAALSA SLSGDLSAELSAALTASLANTASGLLSGLAQTGATLAGGIGGGLLGLIGTGETLASSLAGGVSGLLGTGE SLLMIWQNATAEVTGALSDAVVASIGVGLPGLSQAAVTLSTGIANASVGLTQTGGVIVSALDNAALGITG DISAALANLQLAIQAALNASFGVQVAA
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2461 | - | - | 100% (2407) | PE-PGRS family protein |
M. marinum M | MMAR_5294 | - | 7e-76 | 26.69% (2507) | PE-PGRS family protein |
M. marinum M | MMAR_4287 | - | 3e-65 | 33.21% (828) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3538 | PE_PGRS54 | 2e-45 | 27.47% (1485) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 5e-12 | 25.58% (684) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3508 | PE_PGRS54 | 3e-57 | 26.82% (2010) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 6e-10 | 33.33% (96) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 1e-13 | 23.93% (723) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_0534 | - | 4e-16 | 44.90% (98) | PE family protein |
M. smegmatis MC2 155 | MSMEG_2991 | - | 3e-09 | 24.47% (425) | permease of the major facilitator superfamily protein |
M. thermoresistible (build 8) | TH_4429 | - | 2e-11 | 21.33% (2166) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 3e-41 | 27.95% (1009) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 5e-11 | 26.54% (682) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_2461|M.marinum_M -------------------------------------MS-FVTAVPELVE MAV_0534|M.avium_104 -------------------------------------MS-FLMVRPEILD MLBr_01183|M.leprae_Br4923 -------------------------------------MPLFLNAEPQALT Mb3538|M.bovis_AF2122/97 --------------------------------------MSFVLIAPEFVT Rv3508|M.tuberculosis_H37Rv --------------------------------------MSFVLIAPEFVT Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 --------------------------------------MSFVSVGPGLLE TH_4429|M.thermoresistible__bu VTTPVGSIRIDLSIDGSNLGDEITAAVQKHVKAALGELNEVLAEVQAQME MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------MSIIDFIL MSMEG_2991|M.smegmatis_MC2_155 -----------------------------------------MRIRTAAPG MMAR_2461|M.marinum_M SAAQDLAGIRSALVEAAQAVAAPT--------TALAAAGEDEVSAAIAAL MAV_0534|M.avium_104 AAARELHGINAAVLQSNSAAVTPT--------TALAPAAADVVSLVTAAR MLBr_01183|M.leprae_Br4923 AAANTLEGLSAATVASNAAAAQLT--------TEIAPPAADDVSILLAHF Mb3538|M.bovis_AF2122/97 AAAGDLTNLGSSISAANASAASAT--------TQVLAAGADEVSARIAAL Rv3508|M.tuberculosis_H37Rv AAAGDLTNLGSSISAANASAASAT--------TQVLAAGADEVSARIAAL Mflv_5091|M.gilvum_PYR-GCK -----------------------------------------------MVT Mvan_1264|M.vanbaalenii_PYR-1 --------MMFLAPPGGPGPISAA--------IQLTSTGSEATEPWYVVS MUL_4367|M.ulcerans_Agy99 AAARDLAGLGAGLREANLAAAGAT--------VGVLPAAGDEVSAAIAEL TH_4429|M.thermoresistible__bu STSRASASAATGVGQAGKAAREATGGMSDMQQASQAAAQATKTAGDAARA MAB_4284c|M.abscessus_ATCC_199 NLFRDPVEAASYVADPEAALANAG-------LSAVSAAQVGAVMPVVAES MSMEG_2991|M.smegmatis_MC2_155 TTTPTLALIILLALLNAVTPFSVD--------MYMSAFPAMAVEFGTSAS MMAR_2461|M.marinum_M FGTFGQEYQAVSAQAASFHESFVRVLSGAAASYVEAEVANGAALLAGESA MAV_0534|M.avium_104 FSRHGLAFQEVSAQAAQLRDQFATTLGISAGSYAAAEIAN---------- MLBr_01183|M.leprae_Br4923 FSGHGRQYQAHASQGATNHQDLIQSLLTSSSAYAGTETAN---------- Mb3538|M.bovis_AF2122/97 FGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAA------AAEQI Rv3508|M.tuberculosis_H37Rv FGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAA------AAEQI Mflv_5091|M.gilvum_PYR-GCK FG--------------------------GGATPTPTSLG------AAAVD Mvan_1264|M.vanbaalenii_PYR-1 FG--------------------------GSGAPTPNNLA------ASLVD MUL_4367|M.ulcerans_Agy99 FGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALNMWPLQELEQQ TH_4429|M.thermoresistible__bu AGSGMDDMGRASDGAADRTSKAGRAASQASGEFGRFSRAAERASAVSKQL MAB_4284c|M.abscessus_ATCC_199 VASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILS---------- MSMEG_2991|M.smegmatis_MC2_155 VVQLTLTTFLIGLATGQLFIGQLSDRLGRRGPLLVGIVAC---------L . MMAR_2461|M.marinum_M AAAVSGGFSGGLTAGLSAELALQAANSLATAFGSGVSGLALQTGGALVSG MAV_0534|M.avium_104 TAAVG--------------------------------------------- MLBr_01183|M.leprae_Br4923 HDSL---------------------------------------------- Mb3538|M.bovis_AF2122/97 VLGVINAPTQALLGRPLIGDGANATT-PGGAGGAGGLLFGNGGAG-AAGA Rv3508|M.tuberculosis_H37Rv VLGVINAPTQALLGRPLIGDGANATT-PGGAGGAGGLLFGNGGAG-AAGA Mflv_5091|M.gilvum_PYR-GCK LSGTSCG---------LICNGQ------DGTGQNGGILFGNGGSGWNSDV Mvan_1264|M.vanbaalenii_PYR-1 LSGTSCG---------LICNGQ------DGTGQNGGILFGNGGSGWNSEI MUL_4367|M.ulcerans_Agy99 ALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGILWGNGGNG-GLGA TH_4429|M.thermoresistible__bu GSGVGQAASGFVRAGDAVLGAVGKFAKWTGIGAAVSGAIGGVAGSFSVLQ MAB_4284c|M.abscessus_ATCC_199 -PSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLLDL MSMEG_2991|M.smegmatis_MC2_155 VASLLCAVSPSIEVLIMLRFVQG---------FAGAAGIVIARAIISDRS . MMAR_2461|M.marinum_M LGTGLVQTGEVIVSAGQALQNLGSFMAG-AGAGLSAQASAALTQAMNLGG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 PGQAGGPGGPAGLWGNGGPGGAGGSGGG--TGGAGGAGGWLFGVGGAGGV Rv3508|M.tuberculosis_H37Rv PGQAGGPGGPAGLWGNGGPGGAGGSGGG--TGGAGGAGGWLFGVGGAGGV Mflv_5091|M.gilvum_PYR-GCK VGMDGGNGGNGGLFGGNGGNGGNGLGGG--NGGNGGNAG-AFALFGNGGN Mvan_1264|M.vanbaalenii_PYR-1 AGVSGGNGGNAGLFGGNGGNGGNGLGSG--DGGNGGDAG-LFSLFGRGGN MUL_4367|M.ulcerans_Agy99 AGANGGAGGSAGLIGTGGVGGAGGVGAAGMTGGSGGAGGGGGWLWGAGGS TH_4429|M.thermoresistible__bu LGMNRLTSIENARSTLQGLGHDARSVEGIMDSALTAVKGTAFGLGEAATV MAB_4284c|M.abscessus_ATCC_199 SFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVRDSNIIN MSMEG_2991|M.smegmatis_MC2_155 KGSQAAKLYSVMMVIGVLAPILAPVLGGQVVAGFGWRAVFLALAGLNLVM MMAR_2461|M.marinum_M SLSAQLGASLSGNFNLALPELIAGFNNGLTGLIQTGQTITTSLIGSAGSG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GGAGGGTGGAGGPGGLIWGGGGAGGVGGAGGGTGGAGGRAELLFGAGGAG Rv3508|M.tuberculosis_H37Rv GGAGGGTGGAGGPGGLIWGGGGAGGVGGAGGGTGGAGGRAELLFGAGGAG Mflv_5091|M.gilvum_PYR-GCK GGNGG-VGVVGATG-----AVGAPGVAGATGATGVTSG----VVGGNGED Mvan_1264|M.vanbaalenii_PYR-1 GGNGG-VGIAGATG-----AVGAPGVAGATGATGVTSN----VTGGNGAD MUL_4367|M.ulcerans_Agy99 GGAAG-AGGSGGSGGWLWGNAGQTAGAGVGGAGGAGGAG---DAGDQGVS TH_4429|M.thermoresistible__bu AASAVAAGVQPGEDLTRTLKLVGDAAAIAKTDMQSMGAIFNKVATSNKVQ MAB_4284c|M.abscessus_ATCC_199 ADHGSNVGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQRNTTNIN MSMEG_2991|M.smegmatis_MC2_155 LLGALFMAGESLPPEARRPAGLKAFAGSAASVLTNRR------------- MMAR_2461|M.marinum_M ----------LGALFQTGGTVLTNFGSALPEFAAQLSGAISATVGSSLPG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 ----------GAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGGAGGAGG Rv3508|M.tuberculosis_H37Rv ----------GAG---TDGGPGATGGTGGHGGVGGDGGWLAPGGAGGAGG Mflv_5091|M.gilvum_PYR-GCK ----------AVG-------YGATGAAGAAGAAG------AAGAAGAVGS Mvan_1264|M.vanbaalenii_PYR-1 ----------AVG-------YGATGAAGAAGAAG------AAGKAGAVGS MUL_4367|M.ulcerans_Agy99 ----------GVA-------PGEAGAVGFAGGAGGAGGAGGNGVGGGVNG TH_4429|M.thermoresistible__bu GEVMAQLHDRGIPILQLLSEEIGKTAEETAKMASDGKIDFETFRNAIERG MAB_4284c|M.abscessus_ATCC_199 ----------------------DSFNTDRSTNIGSGNTTNTEIGSHNQAN MSMEG_2991|M.smegmatis_MC2_155 -----------------------FMGYTLTLSCSGAAMFSYISASPFVLQ MMAR_2461|M.marinum_M LVGAFDSGFTGLVQAGQSLATNLAGSVGGGLDALIQTGETLAGGLTASLS MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 QGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGG Rv3508|M.tuberculosis_H37Rv QGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGG Mflv_5091|M.gilvum_PYR-GCK AGAAGEAGETG-TWGNAGLPGKAGDAGGAGAVG----AAGAAGTVGTAGA Mvan_1264|M.vanbaalenii_PYR-1 AGTAGSAGAPG-VWGNAGLPGAAGAAGGAGAIG----TAGVAGAAGTAGA MUL_4367|M.ulcerans_Agy99 AGGAGGAGGVGGGGGAGASGVGAGVAGGDGGTG----GAGGAAGVGGAAG TH_4429|M.thermoresistible__bu MGGAALKAGETFEGAMANMRAALGRLGAEILKGPFESAPAVIGRVTEGID MAB_4284c|M.abscessus_ATCC_199 IGTSTSAGGSAAVGGNAGLAGNAGLAGNAGLAG----NAGLAGNAGLAGN MSMEG_2991|M.smegmatis_MC2_155 NIIGLSPRAFSFTFGGCALAVAVSGVISARLVGRFGPRKLLLGGVSAMVV MMAR_2461|M.marinum_M APVLAAQLSAALQASFGTSLPELVAAFTGGLNGLVQAGQTLAANVAGNFG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 QGGTGGAGGDGVLGGVGGTGGKGGVGGVAGLGGAGGAAGQLFSAGGAAGA Rv3508|M.tuberculosis_H37Rv QGGTGGAGGDGVLGGVGGTGGKGGVGGVAGLGGAGGAAGQLFSAGGAAGA Mflv_5091|M.gilvum_PYR-GCK TGGTG-------------TGANGGAGGVGGVGGTG-------AAGAAGGA Mvan_1264|M.vanbaalenii_PYR-1 TGGTG-------------VGGNGGAGQAGGIGGTG-------AAGAAGQA MUL_4367|M.ulcerans_Agy99 TGGTGG------------AAGVAGTGGDGGDGGAGG------AGSDASLA TH_4429|M.thermoresistible__bu VATDAVKGMVTYLRTGEVTDTFRDVFGRGDMSRRVLAGLERVRTVARQVR MAB_4284c|M.abscessus_ATCC_199 AGLAGNAG----------LAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLA MSMEG_2991|M.smegmatis_MC2_155 VAALMLLN--------VTVGGVVPAVTVALMACFMGTVGFTFANATTLAI MMAR_2461|M.marinum_M GGLSGLLEAG----QVLMANLAGGFSLPALAAQISAAVQASFGASFPEVV MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 VGVGGTGGQG----GAG--------------------------------- Rv3508|M.tuberculosis_H37Rv VGVGGTGGQG----GAGGAGAAGADAPASTGLTGGTGFAGGAGGVGGQGG Mflv_5091|M.gilvum_PYR-GCK GGLGETGTTG----GAG--------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GTAGETGVTG----GVG--------------------------------- MUL_4367|M.ulcerans_Agy99 GQAGFAGGSG----GAG--------------------------------- TH_4429|M.thermoresistible__bu DGFEELQAAWRGDDGAADWATKAVDFVRDSLARVWDIAKQLGPALAGIAA MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAG---------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 GEVRHAAGTG---------------------------------------- MMAR_2461|M.marinum_M AAFTGGLSGLVQAGQTLAANLVGGFSLPALAAQISAAVQASFGASFPEAV MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -----------------------GMGGSGADNASGIGADGGAGGTGGNAG Rv3508|M.tuberculosis_H37Rv NAIAGGINGSGGAGGTGGQGGAGGMGGSGADNASGIGADGGAGGTGGNAG Mflv_5091|M.gilvum_PYR-GCK ----------------------------------GVGGQGTAGGTG---G Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------GIGGQGTEGGTG---G MUL_4367|M.ulcerans_Agy99 ----------------------------------GVGGSAGAGGVN---G TH_4429|M.thermoresistible__bu SFAKASAAVGVSAWTIFLRTAEALVPILTTIADLITSHQGVVTALVAAYA MAB_4284c|M.abscessus_ATCC_199 -----------------------------------LAGNAGLAGNAGLAG MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M AAFTGGLNGLVQAGQTLAANLAGSLGGGFNALVEVGQALAANLVGGFSLP MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 AGGAGGAAGTGGTGGVVGAAGKAGIGG-------TGGQGGAGGAGSAGTD Rv3508|M.tuberculosis_H37Rv AGGAGGAAGTGGTGGVVGAAGKAGIGG-------TGGQGGAGGAGSAGTD Mflv_5091|M.gilvum_PYR-GCK VGGIGGAGSTGAVGGVGGKGIQGGQGL-------QGGKGGDGGAGGKGGD Mvan_1264|M.vanbaalenii_PYR-1 VGGVGGVGATGGAGGVGGKGIQGGQGL-------QGGQGGDGGTGGTGGD MUL_4367|M.ulcerans_Agy99 SGGDGGAGAAGGAGGAS--ATVAGSGG-------VGGDGGAGGAAGGGVG TH_4429|M.thermoresistible__bu LLKTGFIGAAVAAKGLAVIKTVTGWMTG-----LIGVTTAAGTVMSTTLT MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAGLAGNAGLAGNAGLAGNAG------LAGNAAVAGNAAVAGNA MSMEG_2991|M.smegmatis_MC2_155 ----SAVIGFLQYGLGAVASPLVGLAG--------EHSAVPMGVAMFTCA MMAR_2461|M.marinum_M TLAAELSAALQASFGASFPEAVAAFTGGLNGLVQAGQSLAANLAGSLGGG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 ATATGATGGTGFSGGAGGAGGAGGNTGVGGTNGSGGQGGTGGAGGAGGAG Rv3508|M.tuberculosis_H37Rv ATATGATGGTGFSGGAGGAGGAGGNTGVGGTNGSGGQGGTGGAGGAGGAG Mflv_5091|M.gilvum_PYR-GCK ADSMGSAGATGGKGGNGGNGGRGGLFGKGGNAGNGADGGTGGAGGAG--- Mvan_1264|M.vanbaalenii_PYR-1 ATSMGEAGATGGKGGNGGNGGRGSLFGRGGNAGNGGNGGTGGNGGNG--- MUL_4367|M.ulcerans_Agy99 AASLGGDGGHAGAGGAGGEGLSGG-FNTGAAGGIGGAGGAGGTGGDSG-- TH_4429|M.thermoresistible__bu TVATDADGLGSSMGGLGERTKKGMRETLRSLKALRGEIGTTMLMAGTAAT MAB_4284c|M.abscessus_ATCC_199 AVAGNAAVGGVLNTGVSGAIGGSSHVGGAINESLGGSGSVGGSTAVGG-- MSMEG_2991|M.smegmatis_MC2_155 ALAATALLVLTRGHIPSYDDELADLDADLTAVSAGESTAR---------- MMAR_2461|M.marinum_M FNALIEVGQALAANLVGG------------------------FSLPALAA MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GVGADNPTGIGGAGGTGG-------------------------------- Rv3508|M.tuberculosis_H37Rv GVGADNPTGIGGTGGTGGKGGAGGAGGQGGSSGAGGTNGSGGAGGTGGQG Mflv_5091|M.gilvum_PYR-GCK -----------GTGGTGG-------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------GTGGTGG-------------------------------- MUL_4367|M.ulcerans_Agy99 -----------GVGGVNG-------------------------------- TH_4429|M.thermoresistible__bu ATSSGIAQTIGALSSVAG-------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M QISAALQASFGASFPEAVAAFTGGLNGLVQAGQSLAANLAGSLGGGFNAL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 ------------------AGGTGGTGGAAGAGGAGGAVGTGGTGGVVGDV Rv3508|M.tuberculosis_H37Rv GAGGAGGAGADNPTGIGGAGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSV Mflv_5091|M.gilvum_PYR-GCK ------------------AGGTGGTGGTGGIGGAG---STGGTG------ Mvan_1264|M.vanbaalenii_PYR-1 ------------------NGGTGGTGGTGGIGGAG---STGGTG------ MUL_4367|M.ulcerans_Agy99 ------------------DGGAGGGGGRGGDGGSS--TSTSGVG------ TH_4429|M.thermoresistible__bu -----GALAGSIFGPAGAAIGAGIGGGIALASYLLGENARAARAAAAAQA MAB_4284c|M.abscessus_ATCC_199 ------------------GAHTGVGGGVSTG------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M IEVGQALAANLVGGFSLPTLAAQISAALQASFGASFPEAVAAFTGGLNGL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GNAGIGGTGGKGGAGGTG------------------------------FA Rv3508|M.tuberculosis_H37Rv GNAGIGGTGGTGGVGGAGGAGAAAAAGSSATG-------------GAGFA Mflv_5091|M.gilvum_PYR-GCK ---GTGGTGGTGGTGGTG-------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---GTGGTGGTGGTGGTG-------------------------------- MUL_4367|M.ulcerans_Agy99 ---GAGGAGGNGGNAGFG-----------------------------VSA TH_4429|M.thermoresistible__bu ELAQQVQRAKEAQLASLGAQKELNAALLESAGVVDEAAVAAVARTIDNLP MAB_4284c|M.abscessus_ATCC_199 --VGVGSHVGGGISESLG-------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M VQAGQTLAANLAGSFGGGLTGLLEAGQVLMANLAGGFSLPTLAAQISAAL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GGAGGAGGQGGSSG-AGGTNGSGGAGGTGGQGGAGGAGGAGADNPTGIGG Rv3508|M.tuberculosis_H37Rv GGAGGEGGAGGNSG-VGGTNGSGGAGGAGGKGGTGGAGGSGADNPTGAGF Mflv_5091|M.gilvum_PYR-GCK -GTGGTGGTGGTGG-KGGTGGTGGAGGTGGDGGTGGTGG----------- Mvan_1264|M.vanbaalenii_PYR-1 -GTGGTGGTGGTGG-KGGTGGTGGDGGTGGTGGTGGTGG----------- MUL_4367|M.ulcerans_Agy99 GGTGGSAGDGGAGGGAGGVDGVGGASGNGGAAGAGGAGGSGIG------- TH_4429|M.thermoresistible__bu EMLRGRLSDEQVQGVVESIQKLGVSSESLASQLTRGGPALDATLAALRAM MAB_4284c|M.abscessus_ATCC_199 -GSGSVGGSTAVGGGAHTGVGGGVSTGVGVGSHVG--------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M QASFGASFPEAVAAFTGGLNGLVQAGQTLAANLAGSLGGGFNALVEVGQA MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 AGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSVGNAGIG------------ Rv3508|M.tuberculosis_H37Rv AGGAGGTGGAAGAGGAGGATGTGGTGGVVGATGSAGIGG----------- Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGTGGTGGAG--DGTGGTG------------------------ Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGTGGTGGAG--DGLGGTG------------------------ MUL_4367|M.ulcerans_Agy99 AGIDGGAGGAGGTGGAAGFPGGGGTTG----------------------- TH_4429|M.thermoresistible__bu GGPDGERAADALLGVAARFDHARTRAEAAAPALSEMAQKMG--------- MAB_4284c|M.abscessus_ATCC_199 GGISESLGGSGSVGGSTAVGGGAHTG------------------------ MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M LAANLVGGFSLPTLAAQISAALQASFGASFPEAVAAFTGGLNGLVQAGQT MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -----------------------------------------------GTG Rv3508|M.tuberculosis_H37Rv -----AGGRGGDGGDGASGLGLGLSGFDGGQGGQGGAGGSAGAGGINGAG Mflv_5091|M.gilvum_PYR-GCK -----------------------------------------------GTG Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------------------------GTG MUL_4367|M.ulcerans_Agy99 ---------------------------------------------AWGTG TH_4429|M.thermoresistible__bu -------VDVLQAADDLSVALKAVPQNIPLNMDMPGAEALVGLLREAGAA MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M LAANLAGSLGGGFNALIEVGQALAANLVGGFSLPALAAQISAALQASFGA MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GTGGVGGAGGAGAAAAAGSSATGGAGFAGGAG-----------------G Rv3508|M.tuberculosis_H37Rv GAGGNGGDGGDGATGAAGLGDNGGVGGDGGAGGAAGNGGNAGVGLTAKAG Mflv_5091|M.gilvum_PYR-GCK GTGGQGGQGGQG-------------------------------------G Mvan_1264|M.vanbaalenii_PYR-1 GTGGFGGQGGQG-------------------------------------G MUL_4367|M.ulcerans_Agy99 GAGGAGGAGGAGDHGGVG------------------------------VN TH_4429|M.thermoresistible__bu VEVLGDGTVHLDVNDERVRDAITVVDSLGWAIKQVPDTKQIEITVKTDEA MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M SFPEVVAAFTGGLNGLVQAG-------QTLAANLAGSFGGGFNALVEVGQ MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 EGGAGGNSGVGGTNGSGGAG---------GAGGKGGTGGAGGSGADNPTG Rv3508|M.tuberculosis_H37Rv DGGAAGNGGNGGAGGAGGAGDNNFNGGQGGAGGQGGQGGLGGASTTSINA Mflv_5091|M.gilvum_PYR-GCK TGGTGGQGGLGGGGGTGGQG---------GTGGTGGQGGTGG-------- Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGQGGLGGVGGTGGTG---------GTGGTGGQGGTGG-------- MUL_4367|M.ulcerans_Agy99 PGDSGTAGWAGGAGGAGGAG---------GSAAFNGVNGAGG-------- TH_4429|M.thermoresistible__bu ALQRFISQMTTEMQKFTTLWITPQLTGEIPAGQPRPNPTAGGNALDPGFF MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M ALAANLVGGFSLPALAAQISAALQASFGASFPEVVAAFTGGLNGLVQAGQ MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 AGFAGGAGGTGGAAGAGGAG--------------GATGTGGTGGVVGATG Rv3508|M.tuberculosis_H37Rv NGGAGGNGGTGGKGGAGGAGTLGVGGSGGTGGDGGDAGSGGGGGFGGAAG Mflv_5091|M.gilvum_PYR-GCK ---TGGTGGTGGTGGAGGDG------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 ---TGGTGGTGGTGGAGGDG------------------------------ MUL_4367|M.ulcerans_Agy99 ---AGGNGGAGGGGGAGASG------------------------------ TH_4429|M.thermoresistible__bu IPGGRADGGVLPGYSPGRDNMLVPLSGGEGIIIPEAMRALGGSWLYQLNS MAB_4284c|M.abscessus_ATCC_199 -VGGGVNTGVGVGSHVG--------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M SLAANLAGSFGGGFNALIEVGQALAANLVGGFSLPALAAQISAALQASFG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 SAGIGGAGGRGGDGGDGASGLGLGLSGFDGGQGGQGGDGGSAGAGGINGA Rv3508|M.tuberculosis_H37Rv KAGGGGNGGRGGDGGDGASGLGLGLSGFDGGQGGQGGAGGSAGAGGINGA Mflv_5091|M.gilvum_PYR-GCK --GLGGLGGFGGSGG-------------TGGQGGLGGPGGSTG-----GA Mvan_1264|M.vanbaalenii_PYR-1 --GLGGLGGFGGVGG-------------TGGQGGQGGPGGSTG-----GA MUL_4367|M.ulcerans_Agy99 -IGAGVAGGDGGTGG-------------TGGAAGTGGAAGTGG------T TH_4429|M.thermoresistible__bu RFRPGISRRGYADGGVHRGSGALPGPVFDTRDDDEPLKLLEDIRDLLAGA MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M ASFPEVVAAFTGGLNGLVQAGQTLAANLAGSFGGGLSG------LLEAGQ MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GGAGGDGGDGGDGATGAAGLGDNGGVGGDGGAGGAAGN------GGNAGV Rv3508|M.tuberculosis_H37Rv GGAGGNGGDGGDGATGAAGLGDNGGVGGDGGAGGAAGN------GGNAGV Mflv_5091|M.gilvum_PYR-GCK GGAGG-----------------QAGTAGKGGLFGGSGS------AGKAGA Mvan_1264|M.vanbaalenii_PYR-1 GGAGG-----------------QAGVAGKGGLFGGSGS------AGTAGV MUL_4367|M.ulcerans_Agy99 GGAAG-----------------AAGSAGDGGAGGAGGA------GDDGSA TH_4429|M.thermoresistible__bu GPTTAPLNVTAREVSTLADRAVGRMAGMTPGGTGPFGTPIAPRHRGYEMA MAB_4284c|M.abscessus_ATCC_199 -----------------------GGISESLGGSGSVGG------------ MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M VLMANLVGGFSLPALAAQISAALQASFGASFPEVVAAFTGGLNGLVQAGQ MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GLTAKAGDGGAAGNGGNGGAGGAGGAGDNNFNGGQGGAGGQGGQGGLGGA Rv3508|M.tuberculosis_H37Rv GLTAKAGDGGAAGNGGNGGAGGAGGAGDNNFNGGQGGAGGQGGQGGLGGA Mflv_5091|M.gilvum_PYR-GCK ----------------TGAAGASGGKGAQGATGAQGATGAQGATGATG-- Mvan_1264|M.vanbaalenii_PYR-1 ----------------TGASGASGGKGAQGATGAQGATGAQGATGATG-- MUL_4367|M.ulcerans_Agy99 G----------------VVSGDPGTAGKAGGAGGAGGVGGNGVAGGVN-- TH_4429|M.thermoresistible__bu AAAISALGGDPEKWLGAEPVSYWRERINESVQAVQQATSAMGPVVSDMGR MAB_4284c|M.abscessus_ATCC_199 ------------------STAVGGGAHTSAINDALGGSGSVG-------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M SLAANLAGSFGGGLSGLLQAGQVLMANLVGGFSLPTLAAELSAALQASFG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 STTSINANGGAGGNGGTGGKGGAGGAGTLGVGGSGGTGGDGGDAGAGGGG Rv3508|M.tuberculosis_H37Rv STTSINANGGAGGNGGTGGKGGAGGAGTLGVGGSGGTGGDGGDAGSGGGG Mflv_5091|M.gilvum_PYR-GCK ------AAGKAGATGAAGAAGAAGSAGTTGAQGSAGTNGANGANGSQGAA Mvan_1264|M.vanbaalenii_PYR-1 ------ASGAQGSAGSAGSAGVAGSAGTTGAQGSAGTNGANGANGSQGAA MUL_4367|M.ulcerans_Agy99 ------GSGGAGGAGGAGGTGGAGASGVP-ASVDGGDGGAGGAGGAAGTG TH_4429|M.thermoresistible__bu YVEALQEFARTGDLSAVQGVGLSATDSVITAITSARNKKTGRLSDTEIGA MAB_4284c|M.abscessus_ATCC_199 ------GSTAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAA MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M ASLPEAVAAFTGGLNGLVRAGQTLAANLAGSFGGGLSGLLQAGQVLMANL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GFGGAAGKAGGGGNGGVGGDGGEGATGLGLDLSGFAGGQGGQGGAGGNAG Rv3508|M.tuberculosis_H37Rv GFGGAAGKAGGGGNGGVGGDGGEGASGLGLGLSGFDGGQGGQGGAGGSAG Mflv_5091|M.gilvum_PYR-GCK GKAGATGTTGATGAAGEDGDAGSGGS------------------------ Mvan_1264|M.vanbaalenii_PYR-1 GKAGATGTTGATGAAGDAGDPGSEAV------------------------ MUL_4367|M.ulcerans_Agy99 GSGGSAGNTGAGGAGGAGGAGGSAAS------------------------ TH_4429|M.thermoresistible__bu LIEQTLGPSGYVGVLDERNASLVKSLQSFRDKVAKGSGTMTGGALVAGLP MAB_4284c|M.abscessus_ATCC_199 GTGFEAQGHAQGHASETAHTTLPGAEHH---------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M VGGFSLPTLAAELSAALQASFGASLPEAVAAFTGGLNGLVQAGQTLAANL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 AGGINGAGGTGGTGGAGGDGAPATLIGGPDGGDGGQGGIGGDGGNAGFGA Rv3508|M.tuberculosis_H37Rv AGGINGAGGAGGTGGAGGDGAPATLIGGPDGGDGGQGGIGGDGGNAGFGA Mflv_5091|M.gilvum_PYR-GCK --GIN--GGAGGAGGAGGE-----------GGEGGDGGKGGAGA------ Mvan_1264|M.vanbaalenii_PYR-1 --DIN--GGAGGAGGAGGE-----------GGEGGAGGAGGDGS------ MUL_4367|M.ulcerans_Agy99 -TGVNGDGGAGGAGGVGGLGGDSAATAG-GGGAGGDGGKGGAGG------ TH_4429|M.thermoresistible__bu AHTGAATFSTSGLMPATAALGQAVLQMFPQIREIGGYRQDPHPDHPSGRA MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M AGSFGGGLSG------LLEAGQVLMANLVGGFSLPTLAAELSAALQASFG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GVPGDGGIGG----------TGGAGGAGGAGGAGDAGADGDPSIDGGQGG Rv3508|M.tuberculosis_H37Rv GVPGDGGDGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADGDPSIDGGQGG Mflv_5091|M.gilvum_PYR-GCK --------------------EGGAGGGGGAGGS-------------GAGG Mvan_1264|M.vanbaalenii_PYR-1 --------------------EGGAGGSGGAGGS-------------GTGG MUL_4367|M.ulcerans_Agy99 --------------------AGVNGVGGGDGGKG------------GTGG TH_4429|M.thermoresistible__bu IDIMIPGGTTRGGRNPAGEALGDQIWNWLMSTGIVDPKGSLWKTDVGGDH MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M ASFPEAVAAFTGGLNGLVQAGQTLAANLAGSFGGGLTGLLEAGQVLMANL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 AGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGDGDGFIGGSGG Rv3508|M.tuberculosis_H37Rv AGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGDGDGFIGGSGG Mflv_5091|M.gilvum_PYR-GCK AGGAGGSGG---------------SGGSGGSGGSGGAAGDSDD------- Mvan_1264|M.vanbaalenii_PYR-1 AGGAGGSGG---------------SGGSGGAGGSGGAAGDSD-------- MUL_4367|M.ulcerans_Agy99 AGGAGGAGSDGIIPS---------NGGLGGNGGNGGNGGQAFG-----DG TH_4429|M.thermoresistible__bu FDHIHARIAEGMENAAIQAGLIPAAAGTPAASLGGLSATGGATPVFVTNW MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M VGGFSLPTLAAELSAALQASFGASFPEVVAAFTGGLNGLVQAGQSLAANL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 TGGTGGDAGAGGLANTGGTAGNAGIGGAGGRGGDGGAGDSGALSQDGNGF Rv3508|M.tuberculosis_H37Rv TGGTGGDAGVGGLANTGGTAGNAGIGGAGGRGGDGGAGDSGALSQDGNGF Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 VGGAGGIGGKGGNAAIGTIVINGGVGGAGGSGGLGGATEDG--------- TH_4429|M.thermoresistible__bu PG-TGGMGMPPGLQPILDAAAQGSGEAASNVLGDVMSAVASLGQEDWAKR MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M AGSLGGGFNALVEVGQALAANLVGGFSLPTLAAELSAALQASFGASFPEV MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 AGGQGGQGGAGGNAGAGGINGAGGTGGTGGAGGDGAPATLIGGPDGGDGG Rv3508|M.tuberculosis_H37Rv AGGQGGQGGVGGNAGAGGINGAGGTGGTGGAGGDGQNGTTGVASEGGAGG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 VGGVGCAGGAGGNGGRGDMLFTVG-------------------------- TH_4429|M.thermoresistible__bu DASYATLNKLVRDRNPMALAAALGLDVEDFTRQGGGHGDITANDGPGYDS MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M VAAFTGGLNGLVQAGQSLAANLAGSFGGGFNALIEVGQALAANLVGGFSL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 QGG------------GAGFGSGVAG------------------------- Rv3508|M.tuberculosis_H37Rv QGGDGGQGGIGGAGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADGDPSID Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu SGRLYSDTAALLDRTFTSLNAQLAAMRDQMVSVIEQVSHKLNDAALEPIV MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M PALAAQISAALQASFGASFPEVVAAFTGGLNGLVQAGQTLAANLAGSFGG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -----------------------------------AAGAGGNGGKG---- Rv3508|M.tuberculosis_H37Rv GGQGGAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGDGDGFI Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu KAGVQSALEGLKDSVSHAIGTAMGQAAAPPIADAVRQGMASLPIATSGGD MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M GLSGLLEAGQVLMANLVGGFSLPALAAQISAALQASFGASFPEVVAAFTG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -GDGGTGGTG---------------------------------------- Rv3508|M.tuberculosis_H37Rv GGSGGTGGTGGDAGVGGLANTGGTAGNAGIGGAGGRGGDGGAGDSGALSQ Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu SGGNAFSGLIPGMASGGPVYGGVAGRDSVPALLMPGEHVLTTDDVARLGG MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M GLNGLVQAGQSLAANLAGSFGGGLSGLLQAGQALMANLVGGFSLPTLAAE MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -GTNFAGGQGG------------------AGGRGGAGGNGANG------- Rv3508|M.tuberculosis_H37Rv DGNGFAGGQGGQGGVGGNAGAGGINGAGGTGGTGGAGGDGQNGTTGVASE Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu QSGVYAFRAALARTGGVRGFATGGAVVNDVVGAEFFGVSQIPIIGLVVNI MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M LSAALQASFGASFPEAVAAFTGGLNGLVQAGQSLAANLAGSLGGGFNALI MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GGAGGQGGDGGQGGIGGAGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu LIRVLLSVLGVQIQARDTLLQMTDEFRQFRGDFQAFDASGRLLNDTSALV MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M EVGQALAANLVGGFSLPALAAQISAALQASFGASFPEAVAAFTGGLNGLV MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -----------------------------------VGDNAAGGDGGNGGA Rv3508|M.tuberculosis_H37Rv DPSIDGGQGGAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGA Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 ---------------------------------------GSGGTGGDGGG TH_4429|M.thermoresistible__bu DRAQSSEEMAAQERIRILKIVIEALIRYIIEKVIVPIGKAVANAAISAGA MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M QAGQSLAANLAGSFGGGLTGLLEAG--QVLMANLAGGFSLPTLAAQISAA MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GGLGGGGGTGGTNGNGGLGGGGGNG--GAGGAGGTPTGSGTEGTGGDGGD Rv3508|M.tuberculosis_H37Rv GGLGGGGGTGGTNGNGGLGGGGGNG--GAGGAGGTPTGSGTEGTGGDGGD Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 GGSASGSGTGGSGGTGGVGGIGGDG--KLG-------------------- TH_4429|M.thermoresistible__bu SAAGAAINTQAPGVGGIVSSLITAAGQAGVDIIADVGTDLALAISETVIA MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M LQASFGASFPEAVAAFTGGLNGLVQAGQSLAANLAGSLGGGFNALIEVGQ MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 AGAGGNGGSATGVGNGGNGGDGGNGGDGGNGAPGGFGGGAGAGGLGGSGA Rv3508|M.tuberculosis_H37Rv AGAGGNGGSATGVGNGGNGGDGGNGGDGGNGAPGGFGGGAGAGGLGGSGA Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 ----------------GFGGDGGDGGDGGFGVIGGQGGGGGFGGLGGTGA TH_4429|M.thermoresistible__bu VVAEGLQSLFPDLMTTIFGGGLLSVLLDPIGNILGNTFGGLLGGITSLLA MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M ALAANLVGGFSLPALAAQISAALQASFGASFPEAVAAFTGGLNGLVQAGQ MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 GGGTDGDDGNGGSPGTDGS------------------------------- Rv3508|M.tuberculosis_H37Rv GGGTDGDDGNGGSPGTDGS------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 GG-APSDKGINGEPGNPG-------------------------------- TH_4429|M.thermoresistible__bu GLFGGAATLIPGLPFDRGGIAYGTGLMPKATIAPERVLSPRQTELFERMV MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M TLAANLAGSLGGGFNALIEVGQALAANLAGGFSLPTLAAELSAALQASFG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu AALERNPRAATGSTTIVDVGGITVAGGPEAGERVRAGLMELMH------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M ASFPEVVAAFTGGLNGLVQAGQTLAANLAGSLGGGFNALVEVGQALAANL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M VGGFSLPALAAQISAALQASFGASFPEAVAAFTGGLNGLVQAGQSLAANL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M AGSLGGGFNALIEVGQALAANLVGGFSLPTLAAQISAALQASLGTSFPEL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M MAGFTGGFTGLLQTGQSLAGNLVGSFGGGLDALIQTGQNVAANLVGAFNA MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M PALLAGLNSGLNGLVQTGASLAGNLAGAFGAGLPELATQLSAALSASLSG MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M DLSAELSAALTASLANTASGLLSGLAQTGATLAGGIGGGLLGLIGTGETL MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M ASSLAGGVSGLLGTGESLLMIWQNATAEVTGALSDAVVASIGVGLPGLSQ MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M AAVTLSTGIANASVGLTQTGGVIVSALDNAALGITGDISAALANLQLAIQ MAV_0534|M.avium_104 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Mb3538|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- TH_4429|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2461|M.marinum_M AALNASFGVQVAA MAV_0534|M.avium_104 ------------- MLBr_01183|M.leprae_Br4923 ------------- Mb3538|M.bovis_AF2122/97 ------------- Rv3508|M.tuberculosis_H37Rv ------------- Mflv_5091|M.gilvum_PYR-GCK ------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------- MUL_4367|M.ulcerans_Agy99 ------------- TH_4429|M.thermoresistible__bu ------------- MAB_4284c|M.abscessus_ATCC_199 ------------- MSMEG_2991|M.smegmatis_MC2_155 -------------