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SFVSVAPSLLDAAARDLAGLGAGLREANLAAAGATMGVLPAAGDEVSAAIAELFGGFGREYQAVGARMAL LHDDFVRALTAGGSAYGQAEALNMWPLQELEQQALGVVNAPSMALFGRPLIGNGVDGVAGTGQAGGAGGI LWGNGGNGGSGAAGANGGAGGSAGLIGTGGVGGAGGVGAVGMAGGSGGAGGSGGWLWGAGGAGGVGGAGG VGAGAGGIGGHGGAGGAGGVARSLLFGTGGAGGAGGVGGGGVAGVDSGTPGGAGGGGGVGGAGGAGGVGG GSRSLLFGAGGVGGEGASGGLGGGGGAGASGVGFDMAGGAGGDGGAGGAAGAGGAGGSGGWLWGNAGQTA GAGVGGAGGAGGAGGAGDHGVSSIAPGEAGAVGFAGGAGGAGGAGGNGVGGGVNGAGGVGGAGGAGGGGG AGASGVGAGVAGGDGGTGGAGGAAGVGGAAGSGGVGGAAGVAGTGGDGGAGGSGGASDQGAAGVNPGEAG AVGFAGGAGGAGGAGGDSGAGGVNGSGGVGGAGGAGGGGGAGASGVGAGVAGGDGGTGGAGGAAGVGGAA GSGGVGGAAGVAGTGGDGGDGGAGGAGSDASVAGQAGFAGGSGGAGGVGGSAGAGGVNGSGGDGGAGAAG GAGGASATVAGSGGVGGDGGAGGAAGGGVGAAGLGGDGGHAGAGGAGGEGLSGGFNTGAAGGIGGAGGAG GTGGDSGGVGGVNGDGGAGGGGGRGGDGGSSTTVAGVGGAGGAGGAGGDSGMVAGAGGTGGQAGDGGFGG FGGAGIDGGGAAGARGGDGGAGGVGGAAEATGTGGAGGSGGAAGGGGSGASAVGAGLAGGAGGDGGIGGA AGAGGSGFVAGADGNGGFGGAGGAGGAGDQGVSGAAPGEAGAVGFAGGAGGAGGAGGNGVGGGVNGAGGV GGAGGAGGGGGAGASGVGAGVAGGDGGAGGAGGAAGVGGAAGSGGVGGAAGVAGTGGDGGAGGSGGASDQ GAAGVNPGEAGAVGFAGGAGGAGGVGGDSGAGGVNGSGGVGGAGGAGGGGGAGASGVGAGVAGGDGGTGG AGGAAGVGGAAGTGGVGGAAGVAGTGGDGGAGGSGGASDQGAAGVNPGEAGAVGFAGGAGGAGGAGGDSG AGGVNGSGGVGGAGGAGGGGGAGASGVGAGVAGGDGGTGGAGGAAGVGGAAGTGGVGGAAGVAGTGGDGG AGGSGGASDQGAAGVNPGEAGTVGFAGGAGGAGGVGGDSGAGGVNGSGGVGGAGGAGGGGGAGASGVGAG VAGGDGGTGGAGGAAGVGGAAGSGGVGGAAGVAGTGGDGGDGGAGGAGSDASVAGQAGFAGGSGGAGGVG GSAGAGGVNGSGGDGGAGGTGGIGGASATTAGVGGAGGAGGAGGTTGGGVGAAGLGGDGGHAGAGGAGGE GLSGGFNTGAAGGIGGAGGAGGTGGDSGGVGGVNGDGGAGGIGGRGGDGGSSTSTSGVGGAGGAGGNGGN AGFGVGAGGTGGSAGDGGAGGFGGAGIDGSGAAGARGGDGGAGGGGGAGGVDGVGGASGNGGAAGAGGAG GSGIGAGIDGGAGGDGGIGGAAGFPGGGGTTGAWGTGGAGGAGGSGGAGDHGGVGVNPGDSGTAGWAGGA GGAGGAGGSAAVNGVNGAGGAGGNGGAGGGGGAGASGIGAGVAGGDGGTGGTGGAAGTGGAAGTGGTGGA AGAAGTAGDGGAGGAGGAGDDGSAGVVSGDPGTAGKAGGAGGAGGAGGNGVAGGANGSGGAGGAGGAGGT GGAGASGVPASVAGGDGGAGGAGGAAGSGGAAGTGGSGGSAGNTGAGGAGGDGGVGGAGGNAEGPGLFGY DGGMGGAGGAGGSAGSTGVNGDGGAGGAGGVGGLGGDSAATAGGGGAGGDGGAGGAAGAGAGIAGSAGDG GHAGAGGAGGAGLSGGFNTGAAGGIGGAGGAGGTGGDSGGVGGVNGDGGAGGIGGHGGDGGSSTSTPGVG GAGGAGGDGGSAGIGVGVAGNGGDAGAGGAGGSGGAGIDGSAATGAHGGAGGSGGVGGQATNSAGVGGDG GAGGAGGNGGAGANGTASPGVPGPGAGGDAGAGGNGGAGGGSGARNGDGGDGGVGGRGGDGHIHPGGSRI NGGDGGVGGAAGLAGVNGASAAGNAGHGGDGGAGGNGSVGAAGADGVGAGATGGFGSQGGDGGKGGAGGA GVNGVGGGDGGKGGSGGTGGAGGAGGAGSDGILPSNGGLGGLGGSGGLGGAGGAGTDGGASGATGTYGNG GTGGAGGAGGNATGGAGEGGGLGGNGGTGGQAFGDGVGGAGGIGGKGGNAAIGTLVVNGGVGGAGGSGGL GGATENGVGGVGGAGGAGGNGGRGDTLFTAGGSGGTGGHGGGGGSASGSGTGGSGGTGGVGGIGGDGKVG GSGGDGGDGGDGGSGVIGGQGGGGGIGGFGGTGAGGAPSDNGTNGEPGNPG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_5294 | - | - | 100% (2432) | PE-PGRS family protein |
M. marinum M | MMAR_1594 | - | 0.0 | 48.26% (2872) | PE-PGRS family protein |
M. marinum M | MMAR_4316 | - | 0.0 | 55.47% (2037) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3541 | PE_PGRS55 | 0.0 | 51.20% (2008) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 0.0 | 48.99% (845) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3508 | PE_PGRS54 | 0.0 | 51.83% (1970) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 9e-13 | 40.22% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 2e-59 | 34.52% (562) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 6e-25 | 46.59% (176) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-169 | 41.97% (1077) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 1e-44 | 41.55% (296) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 58.61% (1133) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 0.0 | 48.97% (829) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_5294|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M -----------------------------------------MSFVSVAPS MUL_4367|M.ulcerans_Agy99 -----------------------------------------MSFVSVGPG Rv3508|M.tuberculosis_H37Rv -----------------------------------------MSFVLIAPE Mb3541|M.bovis_AF2122/97 -----------------------------------------MSFVLISPE Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M LLDAAARDLAGLGAGLREANLAAAGATMGVLPAA---------------- MUL_4367|M.ulcerans_Agy99 LLEAAARDLAGLGAGLREANLAAAGATVGVLPAA---------------- Rv3508|M.tuberculosis_H37Rv FVTAAAGDLTNLGSSISAANASAASATTQVLAAG---------------- Mb3541|M.bovis_AF2122/97 VVSAAAGDLANVGSTISAANKAAAAATTQVLAAG---------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------MMFLAPPGGPGPISAAIQLTSTG---------------- MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --MSIIDFILNLFRDPVEAASYVADPEAALANAG---------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------MNIVLGVSMAPSSIQMVVLEGEYADG--------------- MMAR_5294|M.marinum_M ----GDEVSAAIAELFGGFGREYQAVGARMALLHDDFVRALTAGGSAYGQ MUL_4367|M.ulcerans_Agy99 ----GDEVSAAIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQ Rv3508|M.tuberculosis_H37Rv ----ADEVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYAS Mb3541|M.bovis_AF2122/97 ----ADEVSARIAALFGMYGLEYQAISAQVAAYHQQFVQTLRTGAASYML Mflv_5091|M.gilvum_PYR-GCK ------------MVTFGGGA---TPTPTSLGAAAVDLSGTSCG------- Mvan_1264|M.vanbaalenii_PYR-1 ----SEATEPWYVVSFGGSG---APTPNNLAASLVDLSGTSCG------- MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------LSAVSAAQVGAVMPVVAESVASNYGYQSQWVN----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------ATVEEDAIDVTGADDAATASAPDRVISAILGTREG------- MMAR_5294|M.marinum_M AEALNMWPLQ---------ELEQQALGVVNAPSMALFGRPLIGNGVDGVA MUL_4367|M.ulcerans_Agy99 AEALNMWPLQ---------ELEQQALGVVNAPSMALFGRPSIGNGVDGVA Rv3508|M.tuberculosis_H37Rv AEAA---------------AAEQIVLGVINAPTQALLGRPLIGDGAN-AT Mb3541|M.bovis_AF2122/97 AEATN---------------VEQNLLNLINAPTQTLLGRPLIGDGAN-AT Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------LICNGQD--- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------LICNGQD--- MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGIN-GT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M GTGQAGGAGGILWGNGGNGG-SGAAGANGGAGGSAGLIGTGGVGGAGG-- MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGG-- Rv3508|M.tuberculosis_H37Rv TPGGAGGAGGLLFGNGGAGA-AGAPGQAGGPGGPAGLWGNGGPGGAGGSG Mb3541|M.bovis_AF2122/97 TPGGAGGDGGLLFGSGGNGA-PGAPGQAGGAGGSAGLLGNGGSGGAGG-- Mflv_5091|M.gilvum_PYR-GCK ---GTGQNGGILFGNGGSGWNSDVVGMDGGNGGNGGLFG----------- Mvan_1264|M.vanbaalenii_PYR-1 ---GTGQNGGILFGNGGSGWNSEIAGVSGGNGGNAGLFG----------- MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFGNGGNGGVGW-- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------TGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSHN- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----AADAGLQLSSIGVTWTDQLEAAALRDALAARRIDN---------- MMAR_5294|M.marinum_M ---------------VGAVG----MAGGSGGAGGSGGWLWGAGGAGGVGG MUL_4367|M.ulcerans_Agy99 ---------------VGAAG----MTGGSGGAGGGGGWLWGAGGSG---- Rv3508|M.tuberculosis_H37Rv GGTGGAGGAGGWLFGVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAGGVGG Mb3541|M.bovis_AF2122/97 -------------------------TGAPGGNGGNAGWLYGRGGVGGAGG Mflv_5091|M.gilvum_PYR-GCK ---------------------------GNGGNGGNG-------------- Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------GNGGNGGNG-------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------AGLDGGNGGSGGLLMGIGGAGGAGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M AGGVGAGAG-------GIGGHGGAGGAGGVARSL-------------LFG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv AGGGTGGAGGRAELLFGAGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLA Mb3541|M.bovis_AF2122/97 IGGGTGGAGG---HAWLFGHGGTGGIGGGPGGNGG-----------WLLG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 VGADG--------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M TGGAGGAGGVGGG-GVAGVDSGTPGGAGGGGGVGGAGGAGGVGGGSRSLL MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv PGGAGGAGGQGGA-GGAGSDGGALGGTGGTGGTGGAGGAGGRG----ALL Mb3541|M.bovis_AF2122/97 NGGHGGAGGIGGGSGGAGGNGGWLLGNGGIGGAGGTGGGAGGTGGNAAWL Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M FGAGGVGGEGASGG-LGGGGGAGASGVGFDMAGGAGGDGGAGGAAGAGGA MUL_4367|M.ulcerans_Agy99 ------------------------------------------GAAGAGGS Rv3508|M.tuberculosis_H37Rv LGAGGQGGLGGAGG-QGGTGGAGGDGVLGG-VGGTGGKGGVGGVAGLGGA Mb3541|M.bovis_AF2122/97 LGGGGTGGAGGIGGGNGGHGGNGGWLLGNGGNGGLGGDGDGGTGGGHGGN Mflv_5091|M.gilvum_PYR-GCK ------------------------------------------LGGGNGGN Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------------LGSGDGGN MSMEG_0868|M.smegmatis_MC2_155 -----------------------------------TSAHVDGGTGGTGGT TH_3810|M.thermoresistible__bu ---------------------------------------VD----GDGGS MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------DTDFASHN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------VMLVSAF MMAR_5294|M.marinum_M GGSGGWLWGNAG----------QTAGAGVGGAGGAGGAGGAG----DHGV MUL_4367|M.ulcerans_Agy99 GGSGGWLWGNAG----------QTAGAGVGGAGGAGGAGDAG----DQGV Rv3508|M.tuberculosis_H37Rv GGAAGQLFSAGG----------AAGAVGVGGTGGQGGAGGAG----AAGA Mb3541|M.bovis_AF2122/97 GGNPGWLLGTAGGGGNGGAGSTGTAGGGSGGTGGDGGTGGRGGLLMGAGA Mflv_5091|M.gilvum_PYR-GCK GGNAGAFALFGN-----------------GGNGGNGGVGVVG----ATGA Mvan_1264|M.vanbaalenii_PYR-1 GGDAGLFSLFGR-----------------GGNGGNGGVGIAG----ATGA MSMEG_0868|M.smegmatis_MC2_155 GGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNG----GFGY TH_3810|M.thermoresistible__bu GGRTG-----------LFSKLSR------------GGDGGDG----GLG- MAB_4284c|M.abscessus_ATCC_199 PIASGNQVMSPS---------------------GNVDSFNRG-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 LAAAALAQNVGG----------------------------------AMGY MMAR_5294|M.marinum_M SS-IAPGEAGAVGFAGG-AGGAGGAGGNGVGGG----VNGAGGVGGAGGA MUL_4367|M.ulcerans_Agy99 SG-VAPGEAGAVGFAGG-AGGAGGAGGNGVGGG----VNGAGGAGGAGGV Rv3508|M.tuberculosis_H37Rv DAPASTGLTGGTGFAGG-AGGVGGQGGNAIAGG----INGSGGAGGTGGQ Mb3541|M.bovis_AF2122/97 GGHGGTGGAGGAGVDGGGAGGAGGAGGNGGAGGQAALLFGRGGTGGAGGY Mflv_5091|M.gilvum_PYR-GCK VG--APGVAGATGATGVTSGVVGGNGEDAVGYG---------ATGAAGAA Mvan_1264|M.vanbaalenii_PYR-1 VG--APGVAGATGATGVTSNVTGGNGADAVGYG---------ATGAAGAA MSMEG_0868|M.smegmatis_MC2_155 VLIAGPNVTVGSETRGG-TGGAGGTGGQSTAAG--------PGKGGGGGG TH_3810|M.thermoresistible__bu --------------------------------------------GNGGHG MAB_4284c|M.abscessus_ATCC_199 -----PLLDLSFGDLQFGNRDTTAIGDGAVAVG---------GSNSGPIA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIR---------AESYGDA MMAR_5294|M.marinum_M GGGGGAGASGVG----AGVAGGDGGTGGAGGAAGVGGAAGSGGVGGAAGV MUL_4367|M.ulcerans_Agy99 GGGGGAGASGVG----AGVAGGDGGTGGAGGAAGVGGAAGTGGTG----- Rv3508|M.tuberculosis_H37Rv GGAGGMGGSGADNASGIGADGGAGGTGGNAGAGGAGGAAGTGGTGGVVG- Mb3541|M.bovis_AF2122/97 GGDGGGGGDGFD-----GTMAGLGGTGGSGGTGGDGGAPGNGGAGGAGQL Mflv_5091|M.gilvum_PYR-GCK GAAGAAGAAG---------AVGSAGAAGEAGETGTWGNAG---------- Mvan_1264|M.vanbaalenii_PYR-1 GAAGAAGKAG---------AVGSAGTAGSAGAPGVWGNAG---------- MSMEG_0868|M.smegmatis_MC2_155 GGGGAILIGANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGG------- TH_3810|M.thermoresistible__bu GGTGIISLLS---------LAGNGGNGGNGYRTTDNN------------- MAB_4284c|M.abscessus_ATCC_199 SGQGSTAVNGDVRDSNIINADHGSNVGVDQSQTRVGGDYTN--------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AGQLSAMVAG---------LEKLESLPGGLLLVGSGVDVAP--------- MMAR_5294|M.marinum_M AGTGGDGGAGGSGGASDQGAAGVNPGEAGAVGFAGGAGGAGGAGGDSGAG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mb3541|M.bovis_AF2122/97 LSHSG--------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M GVNGSGGVGGAGGAGGGGGAGASGVGAGVAGGDGGTGGAGGAAGVGGAAG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M SGGVGGAAGVAGTGGDGGDGGAGGAGSDASV-AGQAG---FAGGSGGAGG MUL_4367|M.ulcerans_Agy99 -----GAAGVAGTGGDGGDGGAGGAGSDASL-AGQAG---FAGGSGGAGG Rv3508|M.tuberculosis_H37Rv ---AAGKAGIGGTGGQGGAGGAGSAGTDATA-TGATGGTGFSGGAGGAGG Mb3541|M.bovis_AF2122/97 ---VAGASGKGGAGGTGGNGGAGSAGADAPAGSGAMGSTGFAGGAGGDGG Mflv_5091|M.gilvum_PYR-GCK ---LPGKAG--DAGGAGAVGAAGAAGTVGTA------------GATGGTG Mvan_1264|M.vanbaalenii_PYR-1 ---LPGAAG--AAGGAGAIGTAGVAGAAGTA------------GATGGTG MSMEG_0868|M.smegmatis_MC2_155 ----TGRVIAEGTGSTAEGTATGGDGGHSTG-----------TGIGGNGG TH_3810|M.thermoresistible__bu -------------------ALDGGHGGN-----------------GGNVG MAB_4284c|M.abscessus_ATCC_199 ------VSGHGSADIDKSVTVVDDHSQRNTT------------NINDSFN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------LKQVLQTTTFLDVSVAEEPETALAR------------GAALAAA MMAR_5294|M.marinum_M VGGSAGAG-----GVNGSGGDGGAGAAGGAGGASAT------------VA MUL_4367|M.ulcerans_Agy99 VGGSAGAG-----GVNGSGGDGGAGAAGGAGGASAT------------VA Rv3508|M.tuberculosis_H37Rv AGGNTGVG-----GTNGSGGQGGTGGAGGAGGAGGVGAD-----NPTGIG Mb3541|M.bovis_AF2122/97 NGGGSGASQ----GNGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQG Mflv_5091|M.gilvum_PYR-GCK TGANGGAG-----GVGGVGGTGAAGAAGGAGGLGETG----------TTG Mvan_1264|M.vanbaalenii_PYR-1 VGGNGGAG-----QAGGIGGTGAAGAAGQAGTAGETG----------VTG MSMEG_0868|M.smegmatis_MC2_155 IGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEI--------YSG TH_3810|M.thermoresistible__bu FFSLFNLG--------GAGGWGGSGVDG---------------------- MAB_4284c|M.abscessus_ATCC_199 TDRSTNIG-----SGNTTNTEIGSHNQANIGTSTSAG------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 NAPLFASS----TAALAYAQDPGTGAVDQYSLPDYLYVP----------- MMAR_5294|M.marinum_M GSGGVGGDGGAGGAAG--GGVGAAGLGGDGGHAGAGGAGGEGLSGGFN-- MUL_4367|M.ulcerans_Agy99 GSGGVGGDGGAGGAAG--GGVGAASLGGDGGHAGAGGAGGEGLSGGFN-- Rv3508|M.tuberculosis_H37Rv GTGGTGGKGGAGGAGGQGGSSGAGGTNGSGGAGGTGGQGGAGGAGGAG-- Mb3541|M.bovis_AF2122/97 GTGGTGGNAGAGGTGFTQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGT Mflv_5091|M.gilvum_PYR-GCK GAGGVGGQGTAGGTGGVGGIGGAGSTGAVGGVGGKGIQGGQGLQ------ Mvan_1264|M.vanbaalenii_PYR-1 GVGGIGGQGTEGGTGGVGGVGGVGATGGAGGVGGKGIQGGQGLQ------ MSMEG_0868|M.smegmatis_MC2_155 ADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA-- TH_3810|M.thermoresistible__bu -------------------VDVVGGN------------------------ MAB_4284c|M.abscessus_ATCC_199 GSAAVGGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGN------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VDPEPGDDELAYSAVGEEDAESPTVVIEKLFLPEDSEPRRRPVLLVGS-- MMAR_5294|M.marinum_M TGAAGGIGGAGGAGGTGGDS--GGVGGVNGDGGAGGGGGRGGDGGSSTTV MUL_4367|M.ulcerans_Agy99 TGAAGGIGGAGGAGGTGGDS--GGVGGVNGDGGAGGGGGRGGDGGS---- Rv3508|M.tuberculosis_H37Rv ADNPTGIGGAGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSVGNAGIG--- Mb3541|M.bovis_AF2122/97 TGGAGGAGGAGGTGGTGGAAG-TGTGGQQGNGGNGGNGGTGGKGGTG--- Mflv_5091|M.gilvum_PYR-GCK ----GGKGGDGGAGGKGGDADSMGSAG--ATGGKGGNGGNGGRGGLF--- Mvan_1264|M.vanbaalenii_PYR-1 ----GGQGGDGGTGGTGGDATSMGEAG--ATGGKGGNGGNGGRGSLF--- MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASAN--- TH_3810|M.thermoresistible__bu --------PDGGTPG----------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----AGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------GLAVVGISAVLALEIALAIGIRTTGTVALQPTPNQHLIVP-- MMAR_5294|M.marinum_M AGVGGAGGAGGAGGDSGMVAGAGGTGGQAGDGGFGGFGGAGIDGGGAAGA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M RGGDGGAGGVGGAAEATGTGGAGGSGGAAGGGGSGASAVGAGLAGGAGGD MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M GGIGGAAGAGGSGFVAGADGNGGFGGAGGAGGAGDQGVSGAAPGEAGAVG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M FAGGAGGAGGAGGNGVGGGVNGAGGVGGAGGAGGGGGAGASGVGAGVAGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv ------------------GTGGTGGVGGAGGAGAAAAAGSSATGG----- Mb3541|M.bovis_AF2122/97 ----------------------GAGMNSLDPLLAAQDGGQGGTGG----- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M DGGAGGAGGAAGVGGAAGSGGVGGAAGVAGTGGDGGAGGSGGASDQGAAG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M VNPGEAGAVGFAGGAGGAGGVGGDSGAGGVNGSGGVGGAGGAGGGGGAGA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv --------AGFAGGAGGEGGAGGNSGVGGTNGSGGAGGAGGKGGTGGAGG Mb3541|M.bovis_AF2122/97 -----------TGGNAGAGGTGFTQGADGNAGNGGDGGVGGNGGNGADNT Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M SGVGAGV-AGGDGGTGGAGGAAGVGGAAGTGGVGGAAGVAGTGGDGGAGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv SGADNPTGAGFAGGAGGTGGAAGAGGAGGATGTGGTGGVVGATGSAGIGG Mb3541|M.bovis_AF2122/97 TTAAAGT----TGGAGGAGGAGGTGGTGGAAGTG-TGGQQGNGGNGGNGG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M SGGASDQGAAGVNPGEAGAVGFAGGAGGAGGAGGDSGAGGVNGSGGVGGA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv AGGRGGDGGDGASGLGLGLSGFDGGQGGQGGAGGSAGAGGINGAGGAGGN Mb3541|M.bovis_AF2122/97 TGGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGGNAGAGGTGFTQGADGN Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M GGAGGGGGAGASG--------VGAGVAGGDGGTGGAGGAAGVGGAAGTGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GGDGGDGATGAAG--------LGDNGGVGGDGGAGGAAGNGGNAGVGLTA Mb3541|M.bovis_AF2122/97 AGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGGTGGAAGTG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M VGGAAGVAGTGGDGGAGGSGGASDQGAAGVNPGEAGTVGFAGGAGGAGGV MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv KAGDGGAAGNGGNGGAGGAGG-------------AGDNNFNGGQGGAGGQ Mb3541|M.bovis_AF2122/97 TGGQQGNGGNGGNGGTGGKGG------------TGGDGALAGSSGGAGGK Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M GGDSGAGGVNGS-GGVGGAGGAGGGGGAGASGVGAGVAGGDGGTGGAGGA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GGQGGLGGASTT-SINANGGAGGNGGTGGKGGAGGAGTLGVGGSGGTGGD Mb3541|M.bovis_AF2122/97 GGNGGDAGKAGTGSAPGTAGTGGDGGKGGNGGIGAAGTTGPVGTGASGGT Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M AGVGGAAGSGGVGGAA-----GVAGTGGDGGDGGAGGAGSDASVAGQAGF MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GGDAGSGGGGGFGGAA-----GKAGGGGNGGRGGDGGDGASGLGLGLSGF Mb3541|M.bovis_AF2122/97 GGSGGAGGTGGDGGAANGGTAGAGGAGGNGGKGGDGGAGVTSSTAGNSGG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M AGGSGGAGGVGGSAGAGGVNGSGGDGGAGGTGGIGGASATTAGVGGAGGA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv DGGQGGQGGAGGSAGAGGINGAGGAGGNGGDGGDGATGAAG--------- Mb3541|M.bovis_AF2122/97 AGGSGGKGGDAGAGGAGATPGANGIAGNGGDGGDGAAGAVG--------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M GGAGGTTGGGVGAAGLGGDGGHAGAGGAGGEGLSGGFNTGAAGGIGGAGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M AGGTGGDSGGVGGVNGDGGAGGIGGRGGDGGSSTSTSGVGGAGGAGGNGG MUL_4367|M.ulcerans_Agy99 --------------------------------STSTSGVGGAGGAGGNGG Rv3508|M.tuberculosis_H37Rv -----------------------------LGDNGGVGGDGGAGGAAGNGG Mb3541|M.bovis_AF2122/97 ---------------------------ISGATGAGDGGHGGTGGAGGNGG Mflv_5091|M.gilvum_PYR-GCK ----------------------------------GKGGNAGNGADGGTGG Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------GRGGNAGNGGNGGTGG MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------GAVGGNGGFTNIAAIHG TH_3810|M.thermoresistible__bu -----------------------------------------------AHG MAB_4284c|M.abscessus_ATCC_199 -----------------------------------LAGNAGLAGNAGLAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M NAGFG----VGAG-GTGGSAGDGGAGGFGGAGIDGSGAAGARGGDGGAGG MUL_4367|M.ulcerans_Agy99 NAGFG----VSAG-GTGGSAGDGGAG------------------------ Rv3508|M.tuberculosis_H37Rv NAGVG----LTAKAGDGGAAGNGGNGGAGGAG-----GAGDNNFNGGQGG Mb3541|M.bovis_AF2122/97 TGGAGGSGIDGVGGGTGGTGGNGGNGAIGGAG----GDAGGSGNSGGNGG Mflv_5091|M.gilvum_PYR-GCK AGGAG---------GTGGTGGAGGTG------------------------ Mvan_1264|M.vanbaalenii_PYR-1 NGGNG---------GTGGTGGNGGTG------------------------ MSMEG_0868|M.smegmatis_MC2_155 SITDSSATSGHGGAAQGGNGGNGGNGWV---------------------Q TH_3810|M.thermoresistible__bu -------------------------------------------------E MAB_4284c|M.abscessus_ATCC_199 NAGLAG-------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M GGGAGGVDGVGGAS-----GNGGAAGAGGAGG-SGIGAGIDGGAGGDGGI MUL_4367|M.ulcerans_Agy99 -GGAGGVDGVGGAS-----GNGGAAGAGGAGG-SGIGAGIDGGAGGAGGT Rv3508|M.tuberculosis_H37Rv AGGQGGQGGLGGASTTSINANGGAGGNGGTGGKGGAGGAGTLGVGGSGGT Mb3541|M.bovis_AF2122/97 TGGKGGNAGAGGAAGSN-GGTVGANGTGGDGGNGGAAGAATAGSNGGAGT Mflv_5091|M.gilvum_PYR-GCK --GTGGTGGIGGAG-----STGGTGGTGGTGG--------TGGTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 --GTGGTGGIGGAG-----STGGTGGTGGTGG--------TGGTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 AYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGG-------ATGGRGGDGAG TH_3810|M.thermoresistible__bu SHTP----GVYTDRQ-------GEDGEDGTGT-------GIGGRGGNGG- MAB_4284c|M.abscessus_ATCC_199 --------------------NAGLAGNAGLAG--------NAGLAGNAGL MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------TEQAPAPPP--------VQASAPQPKI MMAR_5294|M.marinum_M GGAAGFPGGGGTTGA--WGTGG---------AGGAGGSGGAGDHGGVGVN MUL_4367|M.ulcerans_Agy99 GGAAGFPGGGGTTGA--WGTGG---------AGGAGGAGGAGDHGGVGVN Rv3508|M.tuberculosis_H37Rv GGDGGDAGSGGGGGF--GGAAG---------KAGGGGNGGVGGDGGEGAS Mb3541|M.bovis_AF2122/97 GSAGGNGGTGGRGGS--GGAGGDGIGGVGGGKGGNGADGEVGGAGGAGGS Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGTGGKGGT--GGTGG---------AGGTGGDGGTGGTGGTG-- Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGTGGKGGT--GGTGG---------DGGTGGTGGTGGTGGTG-- MSMEG_0868|M.smegmatis_MC2_155 ASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEG TH_3810|M.thermoresistible__bu ----SSSGTHPMAE------------------------------------ MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAAVAGN----------------------------------- MLBr_01183|M.leprae_Br4923 -----MPLFLN--------------------------------------- MAV_4827|M.avium_104 SVPEPVAAPKPLSPP----------------------------------- MMAR_5294|M.marinum_M PGDS--GTAGWAGGAGGAGGAGGSAAVN----GVNGAGGAGGNGGAGGGG MUL_4367|M.ulcerans_Agy99 PGDS--GTAGWAGGAGGAGGAGGSAAFN----GVNGAGGAGGNGGAGGGG Rv3508|M.tuberculosis_H37Rv GLGL--GLSGFDGGQGGQGGAGGSAGAG----GINGAGGAGGTGGAGGDG Mb3541|M.bovis_AF2122/97 GPNTSPGGNGGQGGQGGSGGAGGAAGAGGAGGGANGTAGNGGQGGAGGTG Mflv_5091|M.gilvum_PYR-GCK -------------GTGGTGGTGGTGGAG------DGTGGTGGTGGTGGQG Mvan_1264|M.vanbaalenii_PYR-1 -------------GTGGTGGTGGTGGAG------DGLGGTGGTGGTGGFG MSMEG_0868|M.smegmatis_MC2_155 EGGT-----GGHGGDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNG TH_3810|M.thermoresistible__bu ------------DGEHVKALDGRPGLDG-------GNGSHGGNGGHGGRG MAB_4284c|M.abscessus_ATCC_199 ------------AAVAGNAAVAGNAAVG----GVLNTGVSGAIGGSSHVG MLBr_01183|M.leprae_Br4923 -------------AEPQALTAAANTLEG------LSAATVASNAAAAQLT MAV_4827|M.avium_104 --------------VAAPLPAAPPPAAP-------PLPEAPPIPAAPPVV . . MMAR_5294|M.marinum_M GAGASGIG--AGVAGGDGGTGGTGGAAGTGG-AAGTGGTGGAAG-AAGTA MUL_4367|M.ulcerans_Agy99 GAGASGIG--AGVAGGDGGTGGTGGAAGTGG-AAGTGGTGGAAG-AAGSA Rv3508|M.tuberculosis_H37Rv -APATLIGGPDGGDGGQGGIGGDGGNAGFGAGVPGDGGDGGNAGFGAGVP Mb3541|M.bovis_AF2122/97 GAGAASSAT-NGGSGGAGGTGGAGGTGGAGG--DGVGGAGGGNGGHGGDA Mflv_5091|M.gilvum_PYR-GCK ------------GQGGQGGTGGTGGQGGLGG------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------GQGGQGGTGGTGGQGGLGG------------------- MSMEG_0868|M.smegmatis_MC2_155 GTY---------VDPSHTGAGGNGGNGGAGRIRVNNGTATGTAT------ TH_3810|M.thermoresistible__bu G---------------FLGIGGSGGWG----------------------- MAB_4284c|M.abscessus_ATCC_199 G----------AINESLGGSGSVGGSTAVGG------------------- MLBr_01183|M.leprae_Br4923 --------------TEIAPPAADDVSILLAH------------------- MAV_4827|M.avium_104 PVPVVVPPVPVPVPVRIPVPDPVSPPQLLAP------------------- . MMAR_5294|M.marinum_M GDGG---------------AGGAGGAGDDGSAGVVSGDPGTAGKAGGAGG MUL_4367|M.ulcerans_Agy99 GDGG---------------AGGAGGAGDDGSAGVVSGDPGTAGKAGGAGG Rv3508|M.tuberculosis_H37Rv GDGG---------------IGGTGGAGGAGGAGAD-GDPSIDGGQGGAGG Mb3541|M.bovis_AF2122/97 GDGGNGANGNNRSSGSFLAAGGTGGAAGDGGQGGQGGAGGGAGGQGGAGG Mflv_5091|M.gilvum_PYR-GCK -------------------GGGTGGQGGTGG----------TGGQGGTGG Mvan_1264|M.vanbaalenii_PYR-1 -------------------VGGTGGTGGTGG----------TGGQGGTGG MSMEG_0868|M.smegmatis_MC2_155 --------------------GGNGGNGGNGD---------ADGHRGGKGG TH_3810|M.thermoresistible__bu ---------------------GHGGNGGDTD---------ADGGNGGDGG MAB_4284c|M.abscessus_ATCC_199 --------------------GAHTGVGGGVS----------TGVGVGSHV MLBr_01183|M.leprae_Br4923 ---------------------FFSGHGRQYQ----------AHASQGATN MAV_4827|M.avium_104 ---------------------PRLSVPQPVQPPVRVPQPPSPPQVGGTVP . * MMAR_5294|M.marinum_M AGGAGGNGV--AGGANGSGGAGGAGGAGGTGGAG-ASGVPAS-VAGGDGG MUL_4367|M.ulcerans_Agy99 AGGVGGNGV--AGGVNGSGGAGGAGGAGGTGGAG-ASGVPAS-VDGGDGG Rv3508|M.tuberculosis_H37Rv HGGQGGKGG--LNSTGLASAASGDGGNGGAGGAG-GNGGDGDGFIGGSGG Mb3541|M.bovis_AF2122/97 AGGTGGNGGNITGGTAGTAGAAGNGGAAGKGGAG-GQGGTGG-GTGGQGG Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGG--------TGGAGGDGGLGGLGGFG-GSGGTGG--QGGLGG Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGG--------TGGAGGDGGLGGLGGFG-GVGGTGG--QGGQGG MSMEG_0868|M.smegmatis_MC2_155 DGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQ TH_3810|M.thermoresistible__bu NGG-----------------SAGRGGTGGLRGVF---------------- MAB_4284c|M.abscessus_ATCC_199 GGGISESLG-------------GSGSVGGSTAVG---------------- MLBr_01183|M.leprae_Br4923 HQDLIQS------------LLTSSSAYAGTETAN---------------- MAV_4827|M.avium_104 QSPPQHQTP------------PGEGTPPKPDGPG---------------- . . MMAR_5294|M.marinum_M AGGAGGAAGSGGAAGTGGSGGSAGNTGAGGAGGDGGVGGAGGNAEGPGLF MUL_4367|M.ulcerans_Agy99 AGGAG------GAAGTGGSGGSAGNTGAGGAGG----------------- Rv3508|M.tuberculosis_H37Rv TGGTGGDAGVGGLANTGGTAGNAGIGGAGGRGGDGGAGDSGALSQDGN-- Mb3541|M.bovis_AF2122/97 AGGDGGAGGTGGDRTVGGGTVPAGSGGQGGNAGGGGAGGQGGADGGSGGD Mflv_5091|M.gilvum_PYR-GCK PGGSTG--------GAGGAGGQAGTAGKGGLFG----------------- Mvan_1264|M.vanbaalenii_PYR-1 PGGSTG--------GAGGAGGQAGVAGKGGLFG----------------- MSMEG_0868|M.smegmatis_MC2_155 ANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGI------- TH_3810|M.thermoresistible__bu ----------------GINGGNGR-------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------GGAHTGVGGGVSTGVGVGSHVG----------------- MLBr_01183|M.leprae_Br4923 ------------------HDSL---------------------------- MAV_4827|M.avium_104 ----------------NYGGGHVPTPGAGGSGG----------------- MMAR_5294|M.marinum_M GYDGGMGGAGGAGGSAGSTGVNGDGGAGGAGGVGGLGGD----SAATAGG MUL_4367|M.ulcerans_Agy99 --------AGGAGGSAASTGVNGDGGAGGAGGVGGLGGD----SAATAGG Rv3508|M.tuberculosis_H37Rv GFAGGQGGQGGVGGNAGAGGINGAGGTGGTGGAGGDGQNGTTGVASEGGA Mb3541|M.bovis_AF2122/97 GGDAGTGGNGGNGGNRNSG--NGTGGAGGNGGGGANGGAG----GAGGSG Mflv_5091|M.gilvum_PYR-GCK ----------------------GSGSAGKAGATG-----------AAGAS Mvan_1264|M.vanbaalenii_PYR-1 ----------------------GSGSAGTAGVTG-----------ASGAS MSMEG_0868|M.smegmatis_MC2_155 ----------GAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTAT TH_3810|M.thermoresistible__bu ---------------------AGLGGRGXX-------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------------GGIS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------------------------------------------SG MMAR_5294|M.marinum_M GGAGGDGGAGGAAGAGAGIAGSAGDGGHAGAGGAGGAGLSGGFNTGAAGG MUL_4367|M.ulcerans_Agy99 GGAGGDG------------------------------------------- Rv3508|M.tuberculosis_H37Rv GGQGGDGGQGGIGGAGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADGDPS Mb3541|M.bovis_AF2122/97 GGTGGNGGAGGDAGDAGNGGNGNG-TGNGGNGGNGGIAGMGGNGGAGTGS Mflv_5091|M.gilvum_PYR-GCK GGKGAQG------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GGKGAQG------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGDGGKA------------------------------------------- TH_3810|M.thermoresistible__bu --XXGGG------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ESLGGSG------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GGHVPTP------------------------------------------- MMAR_5294|M.marinum_M IGGAGGAGGTGGDSGGVGGVNGDGGAGGIGGHGGDGGSSTSTPGVGGAGG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv IDGGQGGAGGHGGQGGKGGLN----------------------------- Mb3541|M.bovis_AF2122/97 GNGGNGGSGGNGGNAGMGGNS----------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M AGGDGGSAGIGVGVAGNGGDAGAGGAGGSGGAG-IDGSAATGAHGGAGGS MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv ------STGLASAASGDGGNGGAGGAGGNGGDG-DGFIGGSGGTGGTGGD Mb3541|M.bovis_AF2122/97 --------GTGSGDGGAGGNGGAAGTGGTGGDGGLTGTGGTGGSGGTGGD Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M GGVGGQATNSAGVGGDGGAGGAGGNGGAGANGTASPGVPGPGAGGDAGAG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv AGVGGLAN------------------------------------------ Mb3541|M.bovis_AF2122/97 GGNGGNGGN--------------------------------------GAD Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M GNGGAGGGSGARNGDGGDGGVGG-RGGDGHIHPGGSRINGGDGGVGGAAG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv --------TGGTAGNAGIGGAGG-RGGDGGAGDSGALSQDGNGFAGGQGG Mb3541|M.bovis_AF2122/97 NTANMTAQAGGDGGNGGDGGFGGGAGAGGGGLTAGANGTGGQGGAGGDGG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M LAGVNGASAAGNAGHGGDGGAGGNGSVGAAGADGVGAGATGGFGSQGGDG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv QGGVGGNAGAG------------------------------GINGAGGTG Mb3541|M.bovis_AF2122/97 NGAIGGHGPLTD-----------------------------DPGGNGGTG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------T TH_3810|M.thermoresistible__bu -------------------------------------------------V MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5294|M.marinum_M GKGGAGGAG-----VNGVG-----GGDGGKGGSGGTGGAGGAGG-AGSDG MUL_4367|M.ulcerans_Agy99 GKGGAGGAG-----VNGVG-----GGDGGKGG---TGGAGGAGG-AGSDG Rv3508|M.tuberculosis_H37Rv GTGGAGGDG-----QNGTTGVASEGGAGGQGGDGGQGGIGGAGGNAGFGA Mb3541|M.bovis_AF2122/97 GNGGTGGTG-----GAGIG-----SLGGGTGGDGGNGGTGGNGGTGGEGG Mflv_5091|M.gilvum_PYR-GCK ATGAQGATG-----AQGAT------GATGAAGKAGATGAAGAAGAAGSAG Mvan_1264|M.vanbaalenii_PYR-1 ATGAQGATG-----AQGAT------GATGASGAQGSAGSAGSAGVAGSAG MSMEG_0868|M.smegmatis_MC2_155 GTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNA TH_3810|M.thermoresistible__bu GAAVRSGNG----VFSGGG--------GTPSAGFGVPTT---IQFPAGSC MAB_4284c|M.abscessus_ATCC_199 SVGGSTAVG-----------------GGAHTGVGGGVNTGVGVGSHVGGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GAGGSGGSG------------------GGHVPTPGTGGPGGTGGSGGGHV MMAR_5294|M.marinum_M ILPSNGGLGGLGGSGGLGGAGGAGTDGGASGATGTYGNGGTGGAGGAGGN MUL_4367|M.ulcerans_Agy99 IIPSNGGLG----------------------------------------- Rv3508|M.tuberculosis_H37Rv GVPGDGGIGGTGGAG----------------------------------- Mb3541|M.bovis_AF2122/97 EVGGAGGTG----------------------------------------- Mflv_5091|M.gilvum_PYR-GCK TTGAQGSAG----------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 TTGAQGSAG----------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 LVMAAGTTGVAT-------------------------------------- TH_3810|M.thermoresistible__bu TSRAVSREGIMP-------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ISESLGGSGSVG-------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PTPGAGTPG----------------------------------------- MMAR_5294|M.marinum_M ATGGAGEGGGLGGNGGTGGQA-FGDGVGGAGGIGGKGGNAAIGTLVVNGG MUL_4367|M.ulcerans_Agy99 ---------GNGGNGGNGGQA-FGDGVGGAGGIGGKGGNAAIGTIVINGG Rv3508|M.tuberculosis_H37Rv ---------GAGGAGADGDPS-IDGGQGGAGGHGGQGGKGGLNSTGLASA Mb3541|M.bovis_AF2122/97 ---------GAAGNGGDGGTGGTGGGDGGAGGTGGTGGTGGLGDPRVG-G Mflv_5091|M.gilvum_PYR-GCK ---------TNGANGANGSQG----AAGKAGATGTTGATG---------- Mvan_1264|M.vanbaalenii_PYR-1 ---------TNGANGANGSQG----AAGKAGATGTTGATG---------- MSMEG_0868|M.smegmatis_MC2_155 ---------GNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAIS TH_3810|M.thermoresistible__bu ---------SSRAASARAGAACASSTSRSRRSFCCSRA------------ MAB_4284c|M.abscessus_ATCC_199 ---------GSTAVGGGAHTSAINDALGGSGSVGGSTAVG---------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------GSGGGHLPFPGAGSTPGGSGG--------------- MMAR_5294|M.marinum_M VGGAGGSGGLGGATENG-VGGVGGAGGAG--GNGGRGDTLFTAGGSGGTG MUL_4367|M.ulcerans_Agy99 VGGAGGSGGLGGATEDG-VGGVGCAGGAG--GNGGRGDMLFTVGGSGGTG Rv3508|M.tuberculosis_H37Rv ASGDGGNGGAGGAGGNGGAGGLGGGGGTG--GTNGNG----GLGGGGGNG Mb3541|M.bovis_AF2122/97 SGGDGGTGGSGGAAGNGGNGGNAGAGGNGNGGTGGAG----GIGGTGGNG Mflv_5091|M.gilvum_PYR-GCK AAGEDGDAGSGGSGINGGAGGAGGAGGEG--GEGGDG----GKGGAGAEG Mvan_1264|M.vanbaalenii_PYR-1 AAGDAGDPGSEAVDINGGAGGAGGAGGEG--GEGGAG----GAGGDGSEG MSMEG_0868|M.smegmatis_MC2_155 GHGGAGNGGNGGKGADGWVQAYDPAGPVG--SKIANSSAVAGNGGDGGVN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --GGAHTSAINESMNSSINASHSSSMNES-------------FGSSMGSH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----GHLPTPGAGTPGGGLGGFGGGHAPAP-------------GGGLGGG MMAR_5294|M.marinum_M GHGGGGGSASGSGTGGSGGTGGVGGIGGDGK------VGGSGGDGGDGGD MUL_4367|M.ulcerans_Agy99 GDGGGGGSASGSGTGGSGGTGGVGGIGGDGK------LGGFGGDGGDGGD Rv3508|M.tuberculosis_H37Rv GAGGAGGTPTGSGTEGTGGDGGDAGAGGNGGSATGVGNGGNGGDGGNGGD Mb3541|M.bovis_AF2122/97 GDAEPGVPPGAGGAGGAGTTGGKGGTGGNGSGTGSGGTGGDGGTGGGGGN Mflv_5091|M.gilvum_PYR-GCK GAGGGGG-AGGSGAGGAGGAGGSGGSGGSGG------SGGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 GAGGSGG-AGGSGTGGAGGAGGSGGSGGSGG------AGGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 GTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GAAGTGFEAQGHAQGHASETAHTTLPGAEHH------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK------------------- MMAR_5294|M.marinum_M GGSGVIGGQG------GGGGIGGFGGTGAGG-APSDNGTNGEPGNPG- MUL_4367|M.ulcerans_Agy99 GGFGVIGGQG------GGGGFGGLGGTGAGG-APSDKGINGEPGNPG- Rv3508|M.tuberculosis_H37Rv GGNGAPGGFG------GGAGAGGLGGSGAGGGTDGDDGNGGSPGTDGS Mb3541|M.bovis_AF2122/97 GGTGWNGGKGDT-GSGGGAGDGGKAPAGGTGGAGGDGGAGGKGGSGGV Mflv_5091|M.gilvum_PYR-GCK ------------------------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------------------ MSMEG_0868|M.smegmatis_MC2_155 GAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP TH_3810|M.thermoresistible__bu ------------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------------ MLBr_01183|M.leprae_Br4923 ------------------------------------------------ MAV_4827|M.avium_104 ------------------------------------------------