For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. marinum M MMAR_2140 (-)

annotation: metal cation transporter p-type ATPase
coordinates: 2578390 - 2580729
length: 779

MMTTTTAAPRDGGAALTVVSAAAGRMRVRASGFRFDAGRAVAIEETVGKVTGVRAVQAFPHTASVVVWYS
PGRCDTAGILSAIAEAEHIPAASVPARAPHSADGRRAGVMQRILDWSARTLSGPRGDGLGRASAVVAVRR
RRAVSDACGCDHDDNEREPQRLWHVRKLRRATLSGALLGASVIVAWVTPLGPVVLGMKALALAVGASTFV
PSTLKRLAQGRIGVGTLMTIAAAGAVALGQVGEAATLAFLFSISEGLEEYAVARTRRGLRALLSLVPDQA
TVLRDGSETVLAPAELRVGDQMIVKPGERLATDGIIRAGRTALDVSAITGESVPVEAGPGDVVFAASING
SGVLQVQVTATAEDNSLARIVHIVEAEQARKGASQRLADRIARPLVPGIMVTGALIAGTGSVLGNPAVWI
ERALVVLVAASPCALAIAVPVSVVAAIGAASKFGVLIKGGAALEALGTIGGIALDKTGTLTANRPAVIDV
ATTNGTTREEVLATAAALEARSEHPLAAAILAATQAPIAAASDVQAVPGTGLTGHLDGHAVRLGRPGWLD
PADLADHVARMQQAGATAVLVERDNQLLGAIAVRDELRPEAAEVIARLRAGRYQVSMLTGDNHATAAALA
AQAGIEHVYAELRPEDKARLVKELRAQRPTAMVGDGVNDAPALAAADLGIAMGAMGTDVAIETADVALMG
QDLRHLPQALDHARRSRQIMLQNVGLSLTIITVLMPLALFGTLGLAAVVLVHEVAEVVVIANGVRAGRIK
PLTGNQARP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_2140--100% (779)metal cation transporter p-type ATPase
M. marinum MMMAR_1431zntAe-13539.33% (806) cation transport ATPase, ZntA
M. marinum MMMAR_2536-e-13338.12% (766) metal cation transporter p-type ATPase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2015cctpG0.080.78% (770) metal cation transporter P-type ATPase G CtpG
M. gilvum PYR-GCKMflv_2866-0.076.54% (635) heavy metal translocating P-type ATPase
M. tuberculosis H37RvRv1992cctpG0.080.78% (770) metal cation transporter P-type ATPase G CtpG
M. leprae Br4923MLBr_00747ctpC1e-10935.10% (775) putative cation transport ATPase
M. abscessus ATCC 19977MAB_4853c-0.074.45% (638) cation-transporting ATPase G
M. avium 104MAV_5246-7e-9934.65% (762) copper-translocating P-type ATPase
M. smegmatis MC2 155MSMEG_6058-1e-11636.38% (767) cadmium transporting P-type ATPase
M. thermoresistible (build 8)TH_4361-3e-9736.17% (669) PUTATIVE heavy metal translocating P-type ATPase
M. ulcerans Agy99MUL_0423ctpV1e-12537.82% (780) metal cation transporter p-type ATPase, CtpV
M. vanbaalenii PYR-1Mvan_3641-0.076.21% (643) heavy metal translocating P-type ATPase

CLUSTAL 2.0.9 multiple sequence alignment


MLBr_00747|M.leprae_Br4923          MTLAMAEQIATADNPAFVVVSDAAGRMRIQIEWVRSNPRRAVTVEEAIAK
MSMEG_6058|M.smegmatis_MC2_155      ----------MAD---LTVVSDAAGRMRVHAPWFRGDAVRAVAIEQAVDQ
Mb2015c|M.bovis_AF2122/97           --MTTVVDA----EVQLTVVSDAAGRMRVQATGFQFDAGRAVAIEDTVGK
Rv1992c|M.tuberculosis_H37Rv        --MTTVVDA----EVQLTVVSDAAGRMRVQATGFQFDAGRAVAIEDTVGK
MMAR_2140|M.marinum_M               -MMTTTTAAPRDGGAALTVVSAAAGRMRVRASGFRFDAGRAVAIEETVGK
Mflv_2866|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3641|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4853c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_5246|M.avium_104                ---------------------MSTPPRHIDEGTFPDHTASTARIELEIT-
TH_4361|M.thermoresistible__bu      -----------------------------------MNTGGMNTVTLTVG-
MUL_0423|M.ulcerans_Agy99           --------------------------MRVHANGFAIDATRAAAIEESVGR
                                                                                      

MLBr_00747|M.leprae_Br4923          CNGVRVVHAYPRTGSVVVWYSPRCCD------------------------
MSMEG_6058|M.smegmatis_MC2_155      VPGVRAVHAYPRTGSVVVWYSPRRCD------------------------
Mb2015c|M.bovis_AF2122/97           VAGVQAVHAYPRTASIVIWYSRAICDTAAILSAIIDAETVPAAAVPAYAS
Rv1992c|M.tuberculosis_H37Rv        VAGVQAVHAYPRTASIVIWYSRAICDTAAILSAIIDAETVPAAAVPAYAS
MMAR_2140|M.marinum_M               VTGVRAVQAFPHTASVVVWYSPGRCDTAGILSAIAEAEHIPAASVPARAP
Mflv_2866|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3641|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4853c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_5246|M.avium_104                --GMTCASCAARIEKKLNKLD----GVTATVNYATEKAAVSAPASYDPQT
TH_4361|M.thermoresistible__bu      --GMTCASCAARVEKRLNRID----GVVATVNFATEQATVRYPDHVDPAD
MUL_0423|M.ulcerans_Agy99           VGGVRAVRAYPRTASVVIWYSPAHCDTAAIVSAIAEAEHAGDASAPAPAA
                                                                                      

MLBr_00747|M.leprae_Br4923          -------------------------------------RQSILAAISGAAH
MSMEG_6058|M.smegmatis_MC2_155      -------------------------------------RDAVRSAMTAAAG
Mb2015c|M.bovis_AF2122/97           RSASNRKAGVVQKIIDWSTRTLSGVRRD--------VAAQPSGETSDAC-
Rv1992c|M.tuberculosis_H37Rv        RSASNRKAGVVQKIIDWSTRTLSGVRRD--------VAAQPSGETSDAC-
MMAR_2140|M.marinum_M               HSADGRRAGVMQRILDWSARTLSGPRGDGLGRASAVVAVRRRRAVSDACG
Mflv_2866|M.gilvum_PYR-GCK          -------------------------------------MSDACGCGNDEPR
Mvan_3641|M.vanbaalenii_PYR-1       -------------------------------------MSDACGCGNDEPR
MAB_4853c|M.abscessus_ATCC_199      -------------------------------------MSDACGCGHDEPA
MAV_5246|M.avium_104                LITEIENAGYAAAVATP--------------------SPP---------R
TH_4361|M.thermoresistible__bu      LIAAIEATGYTASLPAPQRD--------------TGGAPAGAATGAAGDD
MUL_0423|M.ulcerans_Agy99           RVAGIADGGVVGRVIGG-----------------LARALLGMRTDDNDDD
                                                                                      

MLBr_00747|M.leprae_Br4923          VAAELIPTRAPHSSD-----------------------IRNIEVLRMAIG
MSMEG_6058|M.smegmatis_MC2_155      VARHLVPGRSPRSAD-----------------------VHNADIVRMAIG
Mb2015c|M.bovis_AF2122/97           CDGEDNEDREPEQ-------------------------LWQVAKLRRAAF
Rv1992c|M.tuberculosis_H37Rv        CDGEDNEDREPEQ-------------------------LWQVAKLRRAAF
MMAR_2140|M.marinum_M               CDHDDNE-REPQR-------------------------LWHVRKLRRATL
Mflv_2866|M.gilvum_PYR-GCK          -GADEEE-REPER-------------------------LWQIKELQFAAI
Mvan_3641|M.vanbaalenii_PYR-1       -GDDDDHDGEPEK-------------------------LWQIKELQFAAL
MAB_4853c|M.abscessus_ATCC_199      TGDEVDGEREPER-------------------------LWEVSELRFAAV
MAV_5246|M.avium_104                DDPELASLRRRLVTA----------------------------IALAGPV
TH_4361|M.thermoresistible__bu      HDAEAERWRRRLTIS----------------------------AALSIPV
MUL_0423|M.ulcerans_Agy99           PPPEIARLRAALDRIGYSPEQDTATQLSPSEQARSGIRFWSRRAWLAWPL
                                       .                                              

MLBr_00747|M.leprae_Br4923          AAALTLLGVRR--YVFARPLLLPTTSRLVASGVTIFTGYPFLRGALR---
MSMEG_6058|M.smegmatis_MC2_155      AVALILLGIRR--YGFARPPLLGSTSRTLATGATIITGYPFLRGALRTLT
Mb2015c|M.bovis_AF2122/97           SGVLLTASLVAAWAYPLWPVVLGLKALALAVGASTFVPSSLKRLAEG---
Rv1992c|M.tuberculosis_H37Rv        SGVLLTASLVAAWAYPLWPVVLGLKALALAVGASTFVPSSLKRLAEG---
MMAR_2140|M.marinum_M               SGALLGASVIVAWVTPLGPVVLGMKALALAVGASTFVPSTLKRLAQG---
Mflv_2866|M.gilvum_PYR-GCK          SGVFLLAAVIAGFLDAAGPVVLTLEAVALLAGAYTFVPSTLKRLAKG---
Mvan_3641|M.vanbaalenii_PYR-1       SGVFLLAALITGVLDAAEPVVLALEAVALVAGAYTFVPSTLKRLVTG---
MAB_4853c|M.abscessus_ATCC_199      AGVVLLAGYVVGWTGGSHPVEIGLYAAALAIGAYTFVPSTLRRLARG---
MAV_5246|M.avium_104                IAVAMIPALQFQHWHWA---ALALTAPVVGWCGRPFHAAAWANLKHG---
TH_4361|M.thermoresistible__bu      VVLSMIPALQFTHWQWL---ALTLTSPVVVWGAWPFHRAAVANLRHG---
MUL_0423|M.ulcerans_Agy99           GLLASGLTMFFGAYPWAGWLAFAATIPVQFIAGWPFLVGAVQQARAR---
                                                         :             :   .  .       

MLBr_00747|M.leprae_Br4923          -FGKTGTDALVSAATIASLILR----------------------------
MSMEG_6058|M.smegmatis_MC2_155      GNRSAGTDVLVSAATVASLVLR----------------------------
Mb2015c|M.bovis_AF2122/97           ---RVGVGTLMTIAALGAVALG----------------------------
Rv1992c|M.tuberculosis_H37Rv        ---RVGVGTLMTIAALGAVALG----------------------------
MMAR_2140|M.marinum_M               ---RIGVGTLMTIAAAGAVALG----------------------------
Mflv_2866|M.gilvum_PYR-GCK          ---KIGVGTLMTIAAVGAVILG----------------------------
Mvan_3641|M.vanbaalenii_PYR-1       ---KIGVGTLMTIAAVGAVILG----------------------------
MAB_4853c|M.abscessus_ATCC_199      ---KIGVGTLMTIAAIGAVILG----------------------------
MAV_5246|M.avium_104                ---VTTMDTLISIGTLAAFLWSLYALVLGAADRPGMRHDFELTVGHGAHV
TH_4361|M.thermoresistible__bu      ---TATMDTLISLGVTAAYLWSLWALFFTAAGMPGMTMTFTLLPADTGEP
MUL_0423|M.ulcerans_Agy99           ---SANMNTLISLGTLTAFIYSTYQLFAGGP-------------------
                                           ..*:: ..  :                                

MLBr_00747|M.leprae_Br4923          ---------ENVVALAVLWLLNIGEYLQDLTLRRTRRAISALLSGTQDTA
MSMEG_6058|M.smegmatis_MC2_155      ---------ENVVALTVLWLLNIGEYLQDLTLRRTRRAIANLLQGTQDTV
Mb2015c|M.bovis_AF2122/97           ---------ELGEAATLAFLFSISEGLEEYATARTRRGLRALLSLVPDQA
Rv1992c|M.tuberculosis_H37Rv        ---------ELGEAATLAFLFSISEGLEEYATARTRRGLRALLSLVPDQA
MMAR_2140|M.marinum_M               ---------QVGEAATLAFLFSISEGLEEYAVARTRRGLRALLSLVPDQA
Mflv_2866|M.gilvum_PYR-GCK          ---------EVGEAAMLAFLFSISEGLEEYSLARTRRGLRALLSLVPDEA
Mvan_3641|M.vanbaalenii_PYR-1       ---------EVGEAAMLAFLFSISEGLEEYSVARTRRGLRALLSLVPDEA
MAB_4853c|M.abscessus_ATCC_199      ---------EVGEAAMLAFLFSISEGLEEYALARTRRGLRALLSLAPEEA
MAV_5246|M.avium_104                SHVAAPCHVYFEVAAGVTLFVLAGRYFERRSKRTAGAALRALLALGAKDV
TH_4361|M.thermoresistible__bu      -------HIYLEVAAAVTTFIIAGRYFEARAKRQSGAALRALLDMGANDV
MUL_0423|M.ulcerans_Agy99           --------LFFDTAALIIAFVVLGRYFEATAHGKTREAISKLLDMGAKET
                                                 *  :  :.  .. ::  :   :  .:  **    . .

MLBr_00747|M.leprae_Br4923          WIRLTDGPQAGTEIQVPIGTVQIGDEVVVHEHVAIPVDGEVIDGEAVVNQ
MSMEG_6058|M.smegmatis_MC2_155      WLRLADR----TEIEVAVDGVRVGDQVVIHEQVAIVVDGVVCDGEAIVDQ
Mb2015c|M.bovis_AF2122/97           TV-LREG----TETIVASTELHVGDQMIVKPGERLATDGIIRAGRTALDV
Rv1992c|M.tuberculosis_H37Rv        TV-LREG----TETIVASTELHVGDQMIVKPGERLATDGIIRAGRTALDV
MMAR_2140|M.marinum_M               TV-LRDG----SETVLAPAELRVGDQMIVKPGERLATDGIIRAGRTALDV
Mflv_2866|M.gilvum_PYR-GCK          TV-LRDG----GEKTVAPAVLRIGDRMLVKPGERVATDGIIGQGRTALDV
Mvan_3641|M.vanbaalenii_PYR-1       TV-LRDG----TEKTVAPTDLQIGDRMLVKPGERVATDGIIRHGRTALDV
MAB_4853c|M.abscessus_ATCC_199      TV-LRDG----TETTITATELQVGDTMLVRPGERVATDGTITAGRTALNT
MAV_5246|M.avium_104                AVLRAGA-----ETRIPIERLAVGDEFVVRPGERIATDGIVVAGSSAVDA
TH_4361|M.thermoresistible__bu      AVLRDGA-----EKRVPIGELHVGDVFVVRPGEKIATDGEVVAGNSAVDA
MUL_0423|M.ulcerans_Agy99           RLIVDGE-----EHLVPVDRVQVGDLVRVRPGEKIPVDGEVIDGRAAVDE
                                     :          *  :.   : :** . ::    : .** :  * : :: 

MLBr_00747|M.leprae_Br4923          SAITGENLPVSVMAGSHVHAGSVVVRGRLMVRASAVGKHTTIGRIVTRVE
MSMEG_6058|M.smegmatis_MC2_155      SAITGENLPVAVGPGSKVYAGSVVVRGRLVVTAEAVGSHTTIGRIITRVE
Mb2015c|M.bovis_AF2122/97           SAITGESVPVEVGPGDEVFAGSINGLGVLQVGVTATAANNSLARIVHIVE
Rv1992c|M.tuberculosis_H37Rv        SAITGESVPVEVGPGDEVFAGSINGLGVLQVGVTATAANNSLARIVHIVE
MMAR_2140|M.marinum_M               SAITGESVPVEAGPGDVVFAASINGSGVLQVQVTATAEDNSLARIVHIVE
Mflv_2866|M.gilvum_PYR-GCK          SAITGESVPVEAGPGDEVFAGSINGTGVLEVEVTTTAADNSLARIVRIVE
Mvan_3641|M.vanbaalenii_PYR-1       SAITGESVPVEAGPGDEVFAGSINGTGALEVEVSTTAEDNSLARIVRIVE
MAB_4853c|M.abscessus_ATCC_199      SAITGESVPVEAGPGDEVFAGSINGNGVLQVRVSATAADNSLARIVAIVE
MAV_5246|M.avium_104                AMLTGESVPVEVGVGDGVTGGTVNAGGRLVVRATGIGDDTQLARMAQLVE
TH_4361|M.thermoresistible__bu      SMLTGESVPVEVGPGDQVVGATVNVGGHLQVRATRVGADTQLAQMARLVT
MUL_0423|M.ulcerans_Agy99           SMLTGESVPVEKGVGDWVAGATVNTDGLLTVRATAVGADTALAQIVRLVE
                                    : :***.:**    *. * ..::   * * * .   . .. :.::   * 

MLBr_00747|M.leprae_Br4923          EAQHDRAPIQTVGENFSRCFVPTSFVVSAITLA--ITKDVR-------RT
MSMEG_6058|M.smegmatis_MC2_155      EAQQHRAPIQTVGENFSRRFVPASFLLSAATLV--VTRDVR-------RA
Mb2015c|M.bovis_AF2122/97           AEQVRKGASQRLADCIARPLVPSIMIAAALIAG--TGSVLGNPLVWIERA
Rv1992c|M.tuberculosis_H37Rv        AEQVRKGASQRLADCIARPLVPSIMIAAALIAG--TGSVLGNPLVWIERA
MMAR_2140|M.marinum_M               AEQARKGASQRLADRIARPLVPGIMVTGALIAG--TGSVLGNPAVWIERA
Mflv_2866|M.gilvum_PYR-GCK          AEQSRKGASQRLADRIAKPLVPGVMIVAALIAV--IGSLLGDPATWIERA
Mvan_3641|M.vanbaalenii_PYR-1       AEQSRKGASQRLADRIAKPLLPGIMIVAALIAV--IGSLLGDPATWIERA
MAB_4853c|M.abscessus_ATCC_199      AEQSRKGASQRLADRIAKPLVPAIMITAAAIAV--LGSVFGDPLVWIERA
MAV_5246|M.avium_104                RAQSGKADAQRLADRVSGVFVPVVLLLAVATLAGWLAAG-GTLATALTAA
TH_4361|M.thermoresistible__bu      EAQSGKAEVQRLADRVSAVFVPIVIALSALTLAGWLLLTDAPVSAAFTAA
MUL_0423|M.ulcerans_Agy99           EAQGGKAPVQRLADRVSAVFVPVVVRIAAATFAGWTLLAANPVAG-MTAA
                                      *  :.  * :.: .:  ::*  .  ..                    :

MLBr_00747|M.leprae_Br4923          MTVLLIACPCAVGLATPTAISAAIGNGARRGILIKGGSHLEQAGRVDAIL
MSMEG_6058|M.smegmatis_MC2_155      MTMLLVACPCAVGLATPTVISAAIGNGARRGILIKGGSHLEQAGRVDAMV
Mb2015c|M.bovis_AF2122/97           LVVLVAAAPCALAIAVPVTVVASIGAASRLGVLIKGGAALETLGTIRAVA
Rv1992c|M.tuberculosis_H37Rv        LVVLVAAAPCALAIAVPVTVVASIGAASRLGVLIKGGAALETLGTIRAVA
MMAR_2140|M.marinum_M               LVVLVAASPCALAIAVPVSVVAAIGAASKFGVLIKGGAALEALGTIGGIA
Mflv_2866|M.gilvum_PYR-GCK          LVVLVAASPCALAISVPVTVVAAIGAASKLGALVKGGAALEGLGKIRGVA
Mvan_3641|M.vanbaalenii_PYR-1       LVVLVAASPCALAISVPVTVVAAIGAASKLGVLVKGGAALEGLGRIRGVA
MAB_4853c|M.abscessus_ATCC_199      LVVLVAASPCALAISVPVTVVAAIGAASKLGVLVKGGAALEALGVVRTIA
MAV_5246|M.avium_104                VAVLIIACPCALGLATPTALLVGTGRAAQLGVLIKGPEVLETTRAVDTVV
TH_4361|M.thermoresistible__bu      VAVLIIACPCALGLATPTALLVGTGRGAQLGILIKGPQVLESTRRIDTVV
MUL_0423|M.ulcerans_Agy99           VSVLIIACPYALGLATPTAIIVGTGRGADMGILVKGGEVLEASKKIDTVV
                                    : :*: *.* *:.::.*. : .. * .:  * *:**   **    :  : 

MLBr_00747|M.leprae_Br4923          FDKTGTLTVGRPVVTNIVAMHKDWSPEQVLAYAASSEIHSRHPLAEAVIR
MSMEG_6058|M.smegmatis_MC2_155      FDKTGTLTLGRPIVTNVVAFHKDWEPEQVLAYAASSEIHARHPLAEAVIR
Mb2015c|M.bovis_AF2122/97           LDKTGTLTANRPVVIDVATTNGATR-EEVLAVAAALEARSEHPLAVAVLA
Rv1992c|M.tuberculosis_H37Rv        LDKTGTLTANRPVVIDVATTNGATR-EEVLAVAAALEARSEHPLAVAVLA
MMAR_2140|M.marinum_M               LDKTGTLTANRPAVIDVATTNGTTR-EEVLATAAALEARSEHPLAAAILA
Mflv_2866|M.gilvum_PYR-GCK          LDKTGTLTANRPAVIDVATTNGATR-EEVLDLAASLEARSEHPLAAAILA
Mvan_3641|M.vanbaalenii_PYR-1       LDKTGTLTANRPAVIDVATTNGATR-EQVLDVAAALESRSEHPLAAAILA
MAB_4853c|M.abscessus_ATCC_199      LDKTGTLTANRPTVIEVAATAGATG-ERVLSAAAALESRSEHPLAAAILA
MAV_5246|M.avium_104                LDKTGTVTTGAMTVLDVVAADGTDR-ATLLRYAGALEAASEHPIAHAIAR
TH_4361|M.thermoresistible__bu      LDKTGTVTTGQMSVTSVHVADGLSE-TELLRLAGAVEHASEHPIARAVAT
MUL_0423|M.ulcerans_Agy99           FDKTGTLTRAQMELTDVIAGKRRQP-DVVLRIAAAVESGSEHPIGAAIVA
                                    :*****:*     : .: .         :*  *.: *  :.**:. *:  

MLBr_00747|M.leprae_Br4923          STEERHISIPPHEECEVLVGLGMRTWADGRTLLLGSPSLLCAEKVKVSKT
MSMEG_6058|M.smegmatis_MC2_155      STRERHIVIPPHEECEVLVGLGMRTRADGRTLLLGSPSLLRQEKVRVTSR
Mb2015c|M.bovis_AF2122/97           ATQA----TTAASDVQAVPGAGLIGRLDGRVVRLGRPGWLDA------AE
Rv1992c|M.tuberculosis_H37Rv        ATQA----TTAASDVQAVPGAGLIGRLDGRVVRLGRPGWLDA------AE
MMAR_2140|M.marinum_M               ATQAP---IAAASDVQAVPGTGLTGHLDGHAVRLGRPGWLDP------AD
Mflv_2866|M.gilvum_PYR-GCK          AVDD----VTPATDVEAVTGAGLNGRRDGRTIRLGRPGWLDP------GP
Mvan_3641|M.vanbaalenii_PYR-1       ATDD----VIPATDVEAVTGTGLTGHRDGHTLRLGRPGWLDP------GP
MAB_4853c|M.abscessus_ATCC_199      AAGS----VDPADDVEAVTSAGLTGRRGGHTLRLGRPGWIDP------GS
MAV_5246|M.avium_104                DAKAELGPLPTPTGFRAVGGGGVHGRVDGHAVAIGRPSWLAERGLRPDAA
TH_4361|M.thermoresistible__bu      HAAQTVPPLPEVSDFENHGGNGVSGRVDGHDVRVGRLAWL---GLSAGDR
MUL_0423|M.ulcerans_Agy99           GARERELEVPPATEFTNLAGHGVRGEVGGKSVLVGRRKLVDEQHLRLPEQ
                                     .                 . *:    .*: : :*    :          

MLBr_00747|M.leprae_Br4923          ASEWVDKLRHQTETPLLFAVDGTLVGLISLRDEVRPEAAEVLTKLRASGV
MSMEG_6058|M.smegmatis_MC2_155      AAAWVDKLRKRAETPLLLAVDGKLVGLISLRDEVRPEAAEVLRALRTAGV
Mb2015c|M.bovis_AF2122/97           LADHVACMQQAGATAVLVERDQQLLGAIAVRDELRPEAAEVVAGLRTGGY
Rv1992c|M.tuberculosis_H37Rv        LADHVACMQQAGATAVLVERDQQLLGAIAVRDELRPEAAEVVAGLRTGGY
MMAR_2140|M.marinum_M               LADHVARMQQAGATAVLVERDNQLLGAIAVRDELRPEAAEVIARLRAGRY
Mflv_2866|M.gilvum_PYR-GCK          LADGVARMQHAGATAVLVEDNGQVIGAIAVRDELRPEAAEVVAQLRRDGY
Mvan_3641|M.vanbaalenii_PYR-1       LAGDVTRMQQAGATAVLVEHNGQVIGAIAVRDELRPEAAEVVAQLRRDGY
MAB_4853c|M.abscessus_ATCC_199      LAPDVARMQQGGATAVLVEEDGQLLGAIAVRDELRPEAAHVIAALHRSGY
MAV_5246|M.avium_104                LAAAAARAEHDGKTVVAVGWDGRARGILALADTVKPSSAAAVRQFTRLGL
TH_4361|M.thermoresistible__bu      LRNAAAQAEAAGHTPVWVAVDGRIAGVIVVSDTVKDHAAEAIAELRALGA
MUL_0423|M.ulcerans_Agy99           LAAAAADLEERGRTAVYVGQDGQVVGVLAVADTVKDDAADVVSQLHAMGL
                                        .   .    * : .  :    * : : * ::  :* .:  :     

MLBr_00747|M.leprae_Br4923          RRIVMLTGDHPDIAKAVATELGIDEWRAEVMPEDKLKVVRDLQNEGYVVG
MSMEG_6058|M.smegmatis_MC2_155      RRMVMLTGDHPDAAAAVADELGITEWRAEVLPEDKLAVVRRLHAEGHTVA
Mb2015c|M.bovis_AF2122/97           Q-VTMLTGDNHATAAALAAQAGIEQVHAELRPEDKAHLVAQLRAR-QPTA
Rv1992c|M.tuberculosis_H37Rv        Q-VTMLTGDNHATAAALAAQAGIEQVHAELRPEDKAHLVAQLRAR-QPTA
MMAR_2140|M.marinum_M               Q-VSMLTGDNHATAAALAAQAGIEHVYAELRPEDKARLVKELRAQ-RPTA
Mflv_2866|M.gilvum_PYR-GCK          H-VAMLTGDNQATAAALARDVGIEAVHAELRPEDKARLIEQLRAQ-RPTA
Mvan_3641|M.vanbaalenii_PYR-1       H-VAMLTGDNHATAAALARDVGIEDVHAELRPEDKARLIEQLRAQ-RPTA
MAB_4853c|M.abscessus_ATCC_199      R-VAMLTGDNAATATTLARQVGIDTVHADLRPEDKARIITELRQQ-HPTA
MAV_5246|M.avium_104                T-PILLTGDNHTVARRTAGELGIGEVISGALPADKVEAVKRLQSAGRVVA
TH_4361|M.thermoresistible__bu      T-PVLLTGDNDRAARTVAAQVGIDDVIAGVLPAEKVDHIKQLQDRGRVVA
MUL_0423|M.ulcerans_Agy99           Q-VALITGDNARTAAAIAAQVGIDRVLAEVLPADKVNEVRRLQDEGRIVA
                                        ::***:   *   * : **    :   * :*   :  *:     ..

MLBr_00747|M.leprae_Br4923          MVGDGVNDAPALAAADIGIAMGLAGTDVAVETADVALANDDLNRLLDVRD
MSMEG_6058|M.smegmatis_MC2_155      VIGDGVNDAPALAAADIGIAMGLGGTDVAVETADVALASDDLRRLLDVRD
Mb2015c|M.bovis_AF2122/97           MVGDGVNDAPALAAADLGIAMGAMGTDVAIETADVALMGQDLRHLPQALD
Rv1992c|M.tuberculosis_H37Rv        MVGDGVNDAPALAAADLGIAMGAMGTDVAIETADVALMGQDLRHLPQALD
MMAR_2140|M.marinum_M               MVGDGVNDAPALAAADLGIAMGAMGTDVAIETADVALMGQDLRHLPQALD
Mflv_2866|M.gilvum_PYR-GCK          MVGDGVNDAPALATADLGIAMGAMGTDVAIETADVALMGEDLRHLPQTFT
Mvan_3641|M.vanbaalenii_PYR-1       MVGDGVNDAPALATADIGIAMGAMGTDVAIETADVALMGEDLRHLPQAFT
MAB_4853c|M.abscessus_ATCC_199      MVGDGVNDAPALATADLGIAMGAMGTDVAIETADVALMGEDLRHLTQALA
MAV_5246|M.avium_104                MVGDGVNDAAALAAADLGLAMGTG-TDVAIEAADVTVVRGDLRAAVDAIR
TH_4361|M.thermoresistible__bu      MIGDGVNDAAALAQADLGLAIGTG-TDVAIEASDLTLVTGDLRAAPDAIR
MUL_0423|M.ulcerans_Agy99           MVGDGVNDAPALVQADLGIAIGTG-TDVAIEASDITLMSGRLDGVVSAIE
                                    ::*******.**. **:*:*:*   ****:*::*:::    *    ..  

MLBr_00747|M.leprae_Br4923          LGGRAVEVIRENYGMSIAVNAAGLFIGAGGALSPVLAAVLHNASSVAVVA
MSMEG_6058|M.smegmatis_MC2_155      LGARAVDVIQQNYAMSIAVNAIGLAVGAGGALSPVLAAVLHNASSVAVVA
Mb2015c|M.bovis_AF2122/97           HARRSRQIMVQNVGLSLSIITVLMPLALFGILGLAAVVLVHEFTEVIVIA
Rv1992c|M.tuberculosis_H37Rv        HARRSRQIMVQNVGLSLSIITVLMPLALFGILGLAAVVLVHEFTEVIVIA
MMAR_2140|M.marinum_M               HARRSRQIMLQNVGLSLTIITVLMPLALFGTLGLAAVVLVHEVAEVVVIA
Mflv_2866|M.gilvum_PYR-GCK          HARRARRIMLQNVDLSLGLILALVPLALFGILGLAAVVLVHELAEIVVIA
Mvan_3641|M.vanbaalenii_PYR-1       HARRARRIMLQNVGLSLGLIVVLMPLALFGVLGLAAVVLVHELAEIVVIA
MAB_4853c|M.abscessus_ATCC_199      HARRARTIMLQNVGLSLALIAVLIPLALLGILGLAAVVAVHELAEIVVIA
MAV_5246|M.avium_104                LSRRTLATIKTNLVWAFGYNLAAIPLAALGMLNPMLAGAAMALSSVLVVG
TH_4361|M.thermoresistible__bu      LGRATLRTIKGNLFWAFAYNVAALPLAAAGLLNPLIAGAAMAFSSVFVVS
MUL_0423|M.ulcerans_Agy99           LSRRTLRTIYQNLGWAFGYNTAAIPLAALGVLNPVVAGAAMGLSSVSVVT
                                     .  :   :  *   ::      : :.  * *.   .      :.: *: 

MLBr_00747|M.leprae_Br4923          NSSRLIRYRLD---------------------
MSMEG_6058|M.smegmatis_MC2_155      NSARLIRYEID---------------------
Mb2015c|M.bovis_AF2122/97           NGVRAGRIKPLAGPPKTPDRTIPG--------
Rv1992c|M.tuberculosis_H37Rv        NGVRAGRIKPLAGPPKTPDRTIPG--------
MMAR_2140|M.marinum_M               NGVRAGRIKPLTGNQARP--------------
Mflv_2866|M.gilvum_PYR-GCK          NGVRAGRTKPLAITPIERPASHNRAAAVGAPS
Mvan_3641|M.vanbaalenii_PYR-1       NGVRAGRTTPLAATPVDPAASHSGVAPVGAPS
MAB_4853c|M.abscessus_ATCC_199      NGVRAGRTQPLTAP----EHANTPAAQLAQQE
MAV_5246|M.avium_104                NSLRLRSFASIIPGA-----------------
TH_4361|M.thermoresistible__bu      NSLRLRRFTPSR--------------------
MUL_0423|M.ulcerans_Agy99           NSLRLRRFGRDV--------------------
                                    *. *