For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TTVVDAEVQLTVVSDAAGRMRVQATGFQFDAGRAVAIEDTVGKVAGVQAVHAYPRTASIVIWYSRAICDT AAILSAIIDAETVPAAAVPAYASRSASNRKAGVVQKIIDWSTRTLSGVRRDVAAQPSGETSDACCDGEDN EDREPEQLWQVAKLRRAAFSGVLLTASLVAAWAYPLWPVVLGLKALALAVGASTFVPSSLKRLAEGRVGV GTLMTIAALGAVALGELGEAATLAFLFSISEGLEEYATARTRRGLRALLSLVPDQATVLREGTETIVAST ELHVGDQMIVKPGERLATDGIIRAGRTALDVSAITGESVPVEVGPGDEVFAGSINGLGVLQVGVTATAAN NSLARIVHIVEAEQVRKGASQRLADCIARPLVPSIMIAAALIAGTGSVLGNPLVWIERALVVLVAAAPCA LAIAVPVTVVASIGAASRLGVLIKGGAALETLGTIRAVALDKTGTLTANRPVVIDVATTNGATREEVLAV AAALEARSEHPLAVAVLAATQATTAASDVQAVPGAGLIGRLDGRVVRLGRPGWLDAAELADHVACMQQAG ATAVLVERDQQLLGAIAVRDELRPEAAEVVAGLRTGGYQVTMLTGDNHATAAALAAQAGIEQVHAELRPE DKAHLVAQLRARQPTAMVGDGVNDAPALAAADLGIAMGAMGTDVAIETADVALMGQDLRHLPQALDHARR SRQIMVQNVGLSLSIITVLMPLALFGILGLAAVVLVHEFTEVIVIANGVRAGRIKPLAGPPKTPDRTIPG *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1992c | ctpG | - | 100% (771) | PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE G CTPG |
| M. tuberculosis H37Rv | Rv0969 | ctpV | e-128 | 40.57% (769) | metal cation transporter P-type ATPase CtpV |
| M. tuberculosis H37Rv | Rv3270 | ctpC | e-109 | 35.45% (773) | metal cation-transporting P-type ATPase C CtpC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2015c | ctpG | 0.0 | 100.00% (771) | metal cation transporter P-type ATPase G CtpG |
| M. gilvum PYR-GCK | Mflv_2866 | - | 0.0 | 75.98% (637) | heavy metal translocating P-type ATPase |
| M. leprae Br4923 | MLBr_00747 | ctpC | 1e-111 | 35.69% (765) | putative cation transport ATPase |
| M. abscessus ATCC 19977 | MAB_4853c | - | 0.0 | 72.88% (638) | cation-transporting ATPase G |
| M. marinum M | MMAR_2140 | - | 0.0 | 80.78% (770) | metal cation transporter p-type ATPase |
| M. avium 104 | MAV_4235 | cadA | 1e-117 | 36.84% (760) | cadmium-translocating P-type ATPase |
| M. smegmatis MC2 155 | MSMEG_6058 | - | 1e-118 | 37.53% (762) | cadmium transporting P-type ATPase |
| M. thermoresistible (build 8) | TH_4361 | - | 9e-98 | 35.71% (686) | PUTATIVE heavy metal translocating P-type ATPase |
| M. ulcerans Agy99 | MUL_0423 | ctpV | 1e-121 | 37.09% (790) | metal cation transporter p-type ATPase, CtpV |
| M. vanbaalenii PYR-1 | Mvan_3641 | - | 0.0 | 75.04% (641) | heavy metal translocating P-type ATPase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2866|M.gilvum_PYR-GCK -------------------MSDACG-------------------------
Mvan_3641|M.vanbaalenii_PYR-1 -------------------MSDACG-------------------------
MAB_4853c|M.abscessus_ATCC_199 -------------------MSDACG-------------------------
Rv1992c|M.tuberculosis_H37Rv --MTTVVDA----EVQLTVVSDAAGRMRVQATGFQFDAGRAVAIEDTVGK
Mb2015c|M.bovis_AF2122/97 --MTTVVDA----EVQLTVVSDAAGRMRVQATGFQFDAGRAVAIEDTVGK
MMAR_2140|M.marinum_M -MMTTTTAAPRDGGAALTVVSAAAGRMRVRASGFRFDAGRAVAIEETVGK
MLBr_00747|M.leprae_Br4923 MTLAMAEQIATADNPAFVVVSDAAGRMRIQIEWVRSNPRRAVTVEEAIAK
MAV_4235|M.avium_104 -----------MEDPALQVISDAAGRMRVSVGWVRADSRRAVAVEEAVAK
MSMEG_6058|M.smegmatis_MC2_155 -------------MADLTVVSDAAGRMRVHAPWFRGDAVRAVAIEQAVDQ
TH_4361|M.thermoresistible__bu -------------------MNTGGMNTVTLTVGGMTCASCAARVEKRLNR
MUL_0423|M.ulcerans_Agy99 -------------------MRVHAN-------GFAIDATRAAAIEESVGR
:
Mflv_2866|M.gilvum_PYR-GCK ------------------------CG------------------------
Mvan_3641|M.vanbaalenii_PYR-1 ------------------------CG------------------------
MAB_4853c|M.abscessus_ATCC_199 ------------------------CG------------------------
Rv1992c|M.tuberculosis_H37Rv VAGVQAVHAYPRTASIVIWYSRAICDTAAILSAIIDAETVPAAAVPAYAS
Mb2015c|M.bovis_AF2122/97 VAGVQAVHAYPRTASIVIWYSRAICDTAAILSAIIDAETVPAAAVPAYAS
MMAR_2140|M.marinum_M VTGVRAVQAFPHTASVVVWYSPGRCDTAGILSAIAEAEHIPAASVPARAP
MLBr_00747|M.leprae_Br4923 CNGVRVVHAYPRTGSVVVWYSPRCCDRQS---------------------
MAV_4235|M.avium_104 CDGVRVVHAYPRTGSVVIWYSPRRCDRSA---------------------
MSMEG_6058|M.smegmatis_MC2_155 VPGVRAVHAYPRTGSVVVWYSPRRCDRDA---------------------
TH_4361|M.thermoresistible__bu IDGVVATVNFATEQATVRY--PDHVDPAD---------------------
MUL_0423|M.ulcerans_Agy99 VGGVRAVRAYPRTASVVIWYSPAHCDTAA---------------------
.
Mflv_2866|M.gilvum_PYR-GCK ---------------------------------------------NDEPR
Mvan_3641|M.vanbaalenii_PYR-1 ---------------------------------------------NDEPR
MAB_4853c|M.abscessus_ATCC_199 ---------------------------------------------HDEPA
Rv1992c|M.tuberculosis_H37Rv RSASNRKAGVVQKIIDWSTRTLSGVRRD--------VAAQPSGETSDAC-
Mb2015c|M.bovis_AF2122/97 RSASNRKAGVVQKIIDWSTRTLSGVRRD--------VAAQPSGETSDAC-
MMAR_2140|M.marinum_M HSADGRRAGVMQRILDWSARTLSGPRGDGLGRASAVVAVRRRRAVSDACG
MLBr_00747|M.leprae_Br4923 --------------------------------------------ILAAIS
MAV_4235|M.avium_104 --------------------------------------------VLAAIG
MSMEG_6058|M.smegmatis_MC2_155 --------------------------------------------VRSAMT
TH_4361|M.thermoresistible__bu --------------------------------------------LIAAIE
MUL_0423|M.ulcerans_Agy99 --------------------------------------------IVSAIA
Mflv_2866|M.gilvum_PYR-GCK -GADEEE-REPERLWQIKELQFAAISGVFLLAAVIAGFLDA---------
Mvan_3641|M.vanbaalenii_PYR-1 -GDDDDHDGEPEKLWQIKELQFAALSGVFLLAALITGVLDA---------
MAB_4853c|M.abscessus_ATCC_199 TGDEVDGEREPERLWEVSELRFAAVAGVVLLAGYVVGWTGG---------
Rv1992c|M.tuberculosis_H37Rv CDGEDNEDREPEQLWQVAKLRRAAFSGVLLTASLVAAWAYP---------
Mb2015c|M.bovis_AF2122/97 CDGEDNEDREPEQLWQVAKLRRAAFSGVLLTASLVAAWAYP---------
MMAR_2140|M.marinum_M CDHDDNE-REPQRLWHVRKLRRATLSGALLGASVIVAWVTP---------
MLBr_00747|M.leprae_Br4923 GAAHVAAELIPTRAPHSSDIRNIEVLRMAIGAAALTLLGVR---------
MAV_4235|M.avium_104 EAAHVAAELIPARAPHSSEIRNADVLRMVIGGAALALLGVR---------
MSMEG_6058|M.smegmatis_MC2_155 AAAGVARHLVPGRSPRSADVHNADIVRMAIGAVALILLGIR---------
TH_4361|M.thermoresistible__bu ATGYT--ASLPAPQRDTGGAPAG------------AATGAAGDDHD----
MUL_0423|M.ulcerans_Agy99 EAEHAGDASAPAPAARVAGIADGGVVGRVIGGLARALLGMRTDDNDDDPP
*
Mflv_2866|M.gilvum_PYR-GCK --------------------------------------------AGPVVL
Mvan_3641|M.vanbaalenii_PYR-1 --------------------------------------------AEPVVL
MAB_4853c|M.abscessus_ATCC_199 --------------------------------------------SHPVEI
Rv1992c|M.tuberculosis_H37Rv --------------------------------------------LWPVVL
Mb2015c|M.bovis_AF2122/97 --------------------------------------------LWPVVL
MMAR_2140|M.marinum_M --------------------------------------------LGPVVL
MLBr_00747|M.leprae_Br4923 ----------------------------------------RYVFARPLLL
MAV_4235|M.avium_104 ----------------------------------------RYVFARPPLL
MSMEG_6058|M.smegmatis_MC2_155 ----------------------------------------RYGFARPPLL
TH_4361|M.thermoresistible__bu ---------------------------AEAER-----WRRRLTISAALSI
MUL_0423|M.ulcerans_Agy99 PEIARLRAALDRIGYSPEQDTATQLSPSEQARSGIRFWSRRAWLAWPLGL
. :
Mflv_2866|M.gilvum_PYR-GCK TLEAVALLAG---------------------AYTFVPSTLKRLA-KGKIG
Mvan_3641|M.vanbaalenii_PYR-1 ALEAVALVAG---------------------AYTFVPSTLKRLV-TGKIG
MAB_4853c|M.abscessus_ATCC_199 GLYAAALAIG---------------------AYTFVPSTLRRLA-RGKIG
Rv1992c|M.tuberculosis_H37Rv GLKALALAVG---------------------ASTFVPSSLKRLA-EGRVG
Mb2015c|M.bovis_AF2122/97 GLKALALAVG---------------------ASTFVPSSLKRLA-EGRVG
MMAR_2140|M.marinum_M GMKALALAVG---------------------ASTFVPSTLKRLA-QGRIG
MLBr_00747|M.leprae_Br4923 PTTSRLVASG----------------VTIFTGYPFLRGALR----FGKTG
MAV_4235|M.avium_104 GPSGRLFATG----------------VTVFTGYPFLRGALRSLR-SGRAG
MSMEG_6058|M.smegmatis_MC2_155 GSTSRTLATG----------------ATIITGYPFLRGALRTLTGNRSAG
TH_4361|M.thermoresistible__bu PVVVLSMIPALQFTHWQWLALTLTSPVVVWGAWPFHRAAVANLR-HGTAT
MUL_0423|M.ulcerans_Agy99 LASGLTMFFG-AYPWAGWLAFAATIPVQFIAGWPFLVGAVQQAR-ARSAN
. . . .* .::
Mflv_2866|M.gilvum_PYR-GCK VGTLMTIAAVGAVILGEVG------------------------------E
Mvan_3641|M.vanbaalenii_PYR-1 VGTLMTIAAVGAVILGEVG------------------------------E
MAB_4853c|M.abscessus_ATCC_199 VGTLMTIAAIGAVILGEVG------------------------------E
Rv1992c|M.tuberculosis_H37Rv VGTLMTIAALGAVALGELG------------------------------E
Mb2015c|M.bovis_AF2122/97 VGTLMTIAALGAVALGELG------------------------------E
MMAR_2140|M.marinum_M VGTLMTIAAAGAVALGQVG------------------------------E
MLBr_00747|M.leprae_Br4923 TDALVSAATIASLILREN------------------------------VV
MAV_4235|M.avium_104 TDALVSAATVASLVLREN------------------------------VV
MSMEG_6058|M.smegmatis_MC2_155 TDVLVSAATVASLVLREN------------------------------VV
TH_4361|M.thermoresistible__bu MDTLISLGVTAAYLWSLWALFFTAAGMPGMTMTFTLLPADTGEPHIYLEV
MUL_0423|M.ulcerans_Agy99 MNTLISLGTLTAFIYSTYQLFAGGP--------------------LFFDT
..*:: .. :
Mflv_2866|M.gilvum_PYR-GCK AAMLAFLFSISEGLEEYSLARTRRGLRALLSLVPDEATVLRDGG-----E
Mvan_3641|M.vanbaalenii_PYR-1 AAMLAFLFSISEGLEEYSVARTRRGLRALLSLVPDEATVLRDGT-----E
MAB_4853c|M.abscessus_ATCC_199 AAMLAFLFSISEGLEEYALARTRRGLRALLSLAPEEATVLRDGT-----E
Rv1992c|M.tuberculosis_H37Rv AATLAFLFSISEGLEEYATARTRRGLRALLSLVPDQATVLREGT-----E
Mb2015c|M.bovis_AF2122/97 AATLAFLFSISEGLEEYATARTRRGLRALLSLVPDQATVLREGT-----E
MMAR_2140|M.marinum_M AATLAFLFSISEGLEEYAVARTRRGLRALLSLVPDQATVLRDGS-----E
MLBr_00747|M.leprae_Br4923 ALAVLWLLNIGEYLQDLTLRRTRRAISALLSGTQDTAWIRLTDGPQAGTE
MAV_4235|M.avium_104 ALTVLWLLNIGEYLQDLTLRRTRRAISELLRGSQDTAWIRLEHN-----E
MSMEG_6058|M.smegmatis_MC2_155 ALTVLWLLNIGEYLQDLTLRRTRRAIANLLQGTQDTVWLRLADR----TE
TH_4361|M.thermoresistible__bu AAAVTTFIIAGRYFEARAKRQSGAALRALLDMGANDVAVLRDGA-----E
MUL_0423|M.ulcerans_Agy99 AALIIAFVVLGRYFEATAHGKTREAISKLLDMGAKETRLIVDGE-----E
* : :. .. :: : :: .: ** . . : *
Mflv_2866|M.gilvum_PYR-GCK KTVAPAVLRIGDRMLVKPGERVATDGIIGQGRTALDVSAITGESVPVEAG
Mvan_3641|M.vanbaalenii_PYR-1 KTVAPTDLQIGDRMLVKPGERVATDGIIRHGRTALDVSAITGESVPVEAG
MAB_4853c|M.abscessus_ATCC_199 TTITATELQVGDTMLVRPGERVATDGTITAGRTALNTSAITGESVPVEAG
Rv1992c|M.tuberculosis_H37Rv TIVASTELHVGDQMIVKPGERLATDGIIRAGRTALDVSAITGESVPVEVG
Mb2015c|M.bovis_AF2122/97 TIVASTELHVGDQMIVKPGERLATDGIIRAGRTALDVSAITGESVPVEVG
MMAR_2140|M.marinum_M TVLAPAELRVGDQMIVKPGERLATDGIIRAGRTALDVSAITGESVPVEAG
MLBr_00747|M.leprae_Br4923 IQVPIGTVQIGDEVVVHEHVAIPVDGEVIDGEAVVNQSAITGENLPVSVM
MAV_4235|M.avium_104 IQVATDTLQIGDEVVVHDHVAIPVDGEVIDGEAIVDQSAITGENLPVSVV
MSMEG_6058|M.smegmatis_MC2_155 IEVAVDGVRVGDQVVIHEQVAIVVDGVVCDGEAIVDQSAITGENLPVAVG
TH_4361|M.thermoresistible__bu KRVPIGELHVGDVFVVRPGEKIATDGEVVAGNSAVDASMLTGESVPVEVG
MUL_0423|M.ulcerans_Agy99 HLVPVDRVQVGDLVRVRPGEKIPVDGEVIDGRAAVDESMLTGESVPVEKG
:. :::** . :: : .** : *.: :: * :***.:**
Mflv_2866|M.gilvum_PYR-GCK PGDEVFAGSINGTGVLEVEVTTTAADNSLARIVRIVEAEQSRKGASQRLA
Mvan_3641|M.vanbaalenii_PYR-1 PGDEVFAGSINGTGALEVEVSTTAEDNSLARIVRIVEAEQSRKGASQRLA
MAB_4853c|M.abscessus_ATCC_199 PGDEVFAGSINGNGVLQVRVSATAADNSLARIVAIVEAEQSRKGASQRLA
Rv1992c|M.tuberculosis_H37Rv PGDEVFAGSINGLGVLQVGVTATAANNSLARIVHIVEAEQVRKGASQRLA
Mb2015c|M.bovis_AF2122/97 PGDEVFAGSINGLGVLQVGVTATAANNSLARIVHIVEAEQVRKGASQRLA
MMAR_2140|M.marinum_M PGDVVFAASINGSGVLQVQVTATAEDNSLARIVHIVEAEQARKGASQRLA
MLBr_00747|M.leprae_Br4923 AGSHVHAGSVVVRGRLMVRASAVGKHTTIGRIVTRVEEAQHDRAPIQTVG
MAV_4235|M.avium_104 VGMPVHAGSVVVRGRLVVRARAVGNQTTIGRIITRVEEAQHDRAPIQTVG
MSMEG_6058|M.smegmatis_MC2_155 PGSKVYAGSVVVRGRLVVTAEAVGSHTTIGRIITRVEEAQQHRAPIQTVG
TH_4361|M.thermoresistible__bu PGDQVVGATVNVGGHLQVRATRVGADTQLAQMARLVTEAQSGKAEVQRLA
MUL_0423|M.ulcerans_Agy99 VGDWVAGATVNTDGLLTVRATAVGADTALAQIVRLVEEAQGGKAPVQRLA
* * ..:: * * * . .. .. :.:: * * :. * :.
Mflv_2866|M.gilvum_PYR-GCK DRIAKPLVPGVMIVAALIAVIGSLLG--DPATWIERALVVLVAASPCALA
Mvan_3641|M.vanbaalenii_PYR-1 DRIAKPLLPGIMIVAALIAVIGSLLG--DPATWIERALVVLVAASPCALA
MAB_4853c|M.abscessus_ATCC_199 DRIAKPLVPAIMITAAAIAVLGSVFG--DPLVWIERALVVLVAASPCALA
Rv1992c|M.tuberculosis_H37Rv DCIARPLVPSIMIAAALIAGTGSVLG--NPLVWIERALVVLVAAAPCALA
Mb2015c|M.bovis_AF2122/97 DCIARPLVPSIMIAAALIAGTGSVLG--NPLVWIERALVVLVAAAPCALA
MMAR_2140|M.marinum_M DRIARPLVPGIMVTGALIAGTGSVLG--NPAVWIERALVVLVAASPCALA
MLBr_00747|M.leprae_Br4923 ENFSRCFVPTSFVVSAITLA---------ITKDVRRTMTVLLIACPCAVG
MAV_4235|M.avium_104 ENFSRRFVPTSFIVSAITLA---------VTGDVRRAMTMLLIACPCAVG
MSMEG_6058|M.smegmatis_MC2_155 ENFSRRFVPASFLLSAATLV---------VTRDVRRAMTMLLVACPCAVG
TH_4361|M.thermoresistible__bu DRVSAVFVPIVIALSALTLAGWLLLTDAPVSAAFTAAVAVLIIACPCALG
MUL_0423|M.ulcerans_Agy99 DRVSAVFVPVVVRIAAATFAGWTLLAANPV-AGMTAAVSVLIIACPYALG
: .: ::* . .* . :: :*: *.* *:.
Mflv_2866|M.gilvum_PYR-GCK ISVPVTVVAAIGAASKLGALVKGGAALEGLGKIRGVALDKTGTLTANRPA
Mvan_3641|M.vanbaalenii_PYR-1 ISVPVTVVAAIGAASKLGVLVKGGAALEGLGRIRGVALDKTGTLTANRPA
MAB_4853c|M.abscessus_ATCC_199 ISVPVTVVAAIGAASKLGVLVKGGAALEALGVVRTIALDKTGTLTANRPT
Rv1992c|M.tuberculosis_H37Rv IAVPVTVVASIGAASRLGVLIKGGAALETLGTIRAVALDKTGTLTANRPV
Mb2015c|M.bovis_AF2122/97 IAVPVTVVASIGAASRLGVLIKGGAALETLGTIRAVALDKTGTLTANRPV
MMAR_2140|M.marinum_M IAVPVSVVAAIGAASKFGVLIKGGAALEALGTIGGIALDKTGTLTANRPA
MLBr_00747|M.leprae_Br4923 LATPTAISAAIGNGARRGILIKGGSHLEQAGRVDAILFDKTGTLTVGRPV
MAV_4235|M.avium_104 LATPTAISAAIGNGARRGILIKGGSHLEQAGQVDAIVFDKTGTLTVGRPV
MSMEG_6058|M.smegmatis_MC2_155 LATPTVISAAIGNGARRGILIKGGSHLEQAGRVDAMVFDKTGTLTLGRPI
TH_4361|M.thermoresistible__bu LATPTALLVGTGRGAQLGILIKGPQVLESTRRIDTVVLDKTGTVTTGQMS
MUL_0423|M.ulcerans_Agy99 LATPTAIIVGTGRGADMGILVKGGEVLEASKKIDTVVFDKTGTLTRAQME
::.*. : .. * .: * *:** ** : : :*****:* :
Mflv_2866|M.gilvum_PYR-GCK VIDVATT-NGATREEVLDLAASLEARSEHPLAAAILAAVDD----VTPAT
Mvan_3641|M.vanbaalenii_PYR-1 VIDVATT-NGATREQVLDVAAALESRSEHPLAAAILAATDD----VIPAT
MAB_4853c|M.abscessus_ATCC_199 VIEVAAT-AGATGERVLSAAAALESRSEHPLAAAILAAAGS----VDPAD
Rv1992c|M.tuberculosis_H37Rv VIDVATT-NGATREEVLAVAAALEARSEHPLAVAVLAATQA----TTAAS
Mb2015c|M.bovis_AF2122/97 VIDVATT-NGATREEVLAVAAALEARSEHPLAVAVLAATQA----TTAAS
MMAR_2140|M.marinum_M VIDVATT-NGTTREEVLATAAALEARSEHPLAAAILAATQAP---IAAAS
MLBr_00747|M.leprae_Br4923 VTNIVAMHKDWSPEQVLAYAASSEIHSRHPLAEAVIRSTEERHISIPPHE
MAV_4235|M.avium_104 VTNIVAMHKDWEPEQVLAYAASSEIHSRHPLAEAVIRSTEERHITIPPHE
MSMEG_6058|M.smegmatis_MC2_155 VTNVVAFHKDWEPEQVLAYAASSEIHARHPLAEAVIRSTRERHIVIPPHE
TH_4361|M.thermoresistible__bu VTSVHVA-DGLSETELLRLAGAVEHASEHPIARAVATHAAQTVPPLPEVS
MUL_0423|M.ulcerans_Agy99 LTDVIAG-KRRQPDVVLRIAAAVESGSEHPIGAAIVAGARERELEVPPAT
: .: . :* *.: * :.**:. *: .
Mflv_2866|M.gilvum_PYR-GCK DVEAVTGAGLNGRRDGRTIRLGRPGWLDPG------PLADGVARMQHAGA
Mvan_3641|M.vanbaalenii_PYR-1 DVEAVTGTGLTGHRDGHTLRLGRPGWLDPG------PLAGDVTRMQQAGA
MAB_4853c|M.abscessus_ATCC_199 DVEAVTSAGLTGRRGGHTLRLGRPGWIDPG------SLAPDVARMQQGGA
Rv1992c|M.tuberculosis_H37Rv DVQAVPGAGLIGRLDGRVVRLGRPGWLDAA------ELADHVACMQQAGA
Mb2015c|M.bovis_AF2122/97 DVQAVPGAGLIGRLDGRVVRLGRPGWLDAA------ELADHVACMQQAGA
MMAR_2140|M.marinum_M DVQAVPGTGLTGHLDGHAVRLGRPGWLDPA------DLADHVARMQQAGA
MLBr_00747|M.leprae_Br4923 ECEVLVGLGMRTWADGRTLLLGSPSLLCAEKVKVSKTASEWVDKLRHQTE
MAV_4235|M.avium_104 ECEVLVGLGMRTWADGRTLLLGSPSLLQAEKVKVSKKAKEWVDKLRRQAE
MSMEG_6058|M.smegmatis_MC2_155 ECEVLVGLGMRTRADGRTLLLGSPSLLRQEKVRVTSRAAAWVDKLRKRAE
TH_4361|M.thermoresistible__bu DFENHGGNGVSGRVDGHDVRVGR---LAWLGLSAGDRLRNAAAQAEAAGH
MUL_0423|M.ulcerans_Agy99 EFTNLAGHGVRGEVGGKSVLVGRRKLVDEQHLRLPEQLAAAAADLEERGR
: . *: .*: : :* : . .
Mflv_2866|M.gilvum_PYR-GCK TAVLVEDNGQVIGAIAVRDELRPEAAEVVAQLRRDGYH-VAMLTGDNQAT
Mvan_3641|M.vanbaalenii_PYR-1 TAVLVEHNGQVIGAIAVRDELRPEAAEVVAQLRRDGYH-VAMLTGDNHAT
MAB_4853c|M.abscessus_ATCC_199 TAVLVEEDGQLLGAIAVRDELRPEAAHVIAALHRSGYR-VAMLTGDNAAT
Rv1992c|M.tuberculosis_H37Rv TAVLVERDQQLLGAIAVRDELRPEAAEVVAGLRTGGYQ-VTMLTGDNHAT
Mb2015c|M.bovis_AF2122/97 TAVLVERDQQLLGAIAVRDELRPEAAEVVAGLRTGGYQ-VTMLTGDNHAT
MMAR_2140|M.marinum_M TAVLVERDNQLLGAIAVRDELRPEAAEVIARLRAGRYQ-VSMLTGDNHAT
MLBr_00747|M.leprae_Br4923 TPLLFAVDGTLVGLISLRDEVRPEAAEVLTKLRASGVRRIVMLTGDHPDI
MAV_4235|M.avium_104 TPLLLAVDGTLVGLISLRDEVRPEAAGVLKKLRANGIRRIVMLTGDHPDI
MSMEG_6058|M.smegmatis_MC2_155 TPLLLAVDGKLVGLISLRDEVRPEAAEVLRALRTAGVRRMVMLTGDHPDA
TH_4361|M.thermoresistible__bu TPVWVAVDGRIAGVIVVSDTVKDHAAEAIAELRALGAT-PVLLTGDNDRA
MUL_0423|M.ulcerans_Agy99 TAVYVGQDGQVVGVLAVADTVKDDAADVVSQLHAMGLQ-VALITGDNART
*.: . : : * : : * :: .** .: *: ::***:
Mflv_2866|M.gilvum_PYR-GCK AAALARDVGIEAVHAELRPEDKARLIEQLR-AQRPTAMVGDGVNDAPALA
Mvan_3641|M.vanbaalenii_PYR-1 AAALARDVGIEDVHAELRPEDKARLIEQLR-AQRPTAMVGDGVNDAPALA
MAB_4853c|M.abscessus_ATCC_199 ATTLARQVGIDTVHADLRPEDKARIITELR-QQHPTAMVGDGVNDAPALA
Rv1992c|M.tuberculosis_H37Rv AAALAAQAGIEQVHAELRPEDKAHLVAQLR-ARQPTAMVGDGVNDAPALA
Mb2015c|M.bovis_AF2122/97 AAALAAQAGIEQVHAELRPEDKAHLVAQLR-ARQPTAMVGDGVNDAPALA
MMAR_2140|M.marinum_M AAALAAQAGIEHVYAELRPEDKARLVKELR-AQRPTAMVGDGVNDAPALA
MLBr_00747|M.leprae_Br4923 AKAVATELGIDEWRAEVMPEDKLKVVRDLQNEGYVVGMVGDGVNDAPALA
MAV_4235|M.avium_104 AAVVADELGIDEWRAEVMPEDKLAAVRDLQEEGFVVGMVGDGINDAPALA
MSMEG_6058|M.smegmatis_MC2_155 AAAVADELGITEWRAEVLPEDKLAVVRRLHAEGHTVAVIGDGVNDAPALA
TH_4361|M.thermoresistible__bu ARTVAAQVGIDDVIAGVLPAEKVDHIKQLQDRGRVVAMIGDGVNDAAALA
MUL_0423|M.ulcerans_Agy99 AAAIAAQVGIDRVLAEVLPADKVNEVRRLQDEGRIVAMVGDGVNDAPALV
* .:* : ** * : * :* : *: ..::***:***.**.
Mflv_2866|M.gilvum_PYR-GCK TADLGIAMGAMGTDVAIETADVALMGEDLRHLPQTFTHARRARRIMLQNV
Mvan_3641|M.vanbaalenii_PYR-1 TADIGIAMGAMGTDVAIETADVALMGEDLRHLPQAFTHARRARRIMLQNV
MAB_4853c|M.abscessus_ATCC_199 TADLGIAMGAMGTDVAIETADVALMGEDLRHLTQALAHARRARTIMLQNV
Rv1992c|M.tuberculosis_H37Rv AADLGIAMGAMGTDVAIETADVALMGQDLRHLPQALDHARRSRQIMVQNV
Mb2015c|M.bovis_AF2122/97 AADLGIAMGAMGTDVAIETADVALMGQDLRHLPQALDHARRSRQIMVQNV
MMAR_2140|M.marinum_M AADLGIAMGAMGTDVAIETADVALMGQDLRHLPQALDHARRSRQIMLQNV
MLBr_00747|M.leprae_Br4923 AADIGIAMGLAGTDVAVETADVALANDDLNRLLDVRDLGGRAVEVIRENY
MAV_4235|M.avium_104 AADIGIAMGLAGTDVAVETADVALSNDDLHRLLDVRDLGSRAVDVIRENY
MSMEG_6058|M.smegmatis_MC2_155 AADIGIAMGLGGTDVAVETADVALASDDLRRLLDVRDLGARAVDVIQQNY
TH_4361|M.thermoresistible__bu QADLGLAIGTG-TDVAIEASDLTLVTGDLRAAPDAIRLGRATLRTIKGNL
MUL_0423|M.ulcerans_Agy99 QADLGIAIGTG-TDVAIEASDITLMSGRLDGVVSAIELSRRTLRTIYQNL
**:*:*:* ****:*::*::* * .. . : : *
Mflv_2866|M.gilvum_PYR-GCK DLSLGLILALVPLALFGILGLAAVVLVHELAEIVVIANGVRAGRTKPLAI
Mvan_3641|M.vanbaalenii_PYR-1 GLSLGLIVVLMPLALFGVLGLAAVVLVHELAEIVVIANGVRAGRTTPLAA
MAB_4853c|M.abscessus_ATCC_199 GLSLALIAVLIPLALLGILGLAAVVAVHELAEIVVIANGVRAGRTQPLTA
Rv1992c|M.tuberculosis_H37Rv GLSLSIITVLMPLALFGILGLAAVVLVHEFTEVIVIANGVRAGRIKPLAG
Mb2015c|M.bovis_AF2122/97 GLSLSIITVLMPLALFGILGLAAVVLVHEFTEVIVIANGVRAGRIKPLAG
MMAR_2140|M.marinum_M GLSLTIITVLMPLALFGTLGLAAVVLVHEVAEVVVIANGVRAGRIKPLTG
MLBr_00747|M.leprae_Br4923 GMSIAVNAAGLFIGAGGALSPVLAAVLHNASSVAVVANSSRLIRYRLD--
MAV_4235|M.avium_104 GMSIAVNAAGLIIGAGGALSPVLAAILHNASSVAVVANSSRLIRYRLN--
MSMEG_6058|M.smegmatis_MC2_155 AMSIAVNAIGLAVGAGGALSPVLAAVLHNASSVAVVANSARLIRYEID--
TH_4361|M.thermoresistible__bu FWAFAYNVAALPLAAAGLLNPLIAGAAMAFSSVFVVSNSLRLRRFTPSR-
MUL_0423|M.ulcerans_Agy99 GWAFGYNTAAIPLAALGVLNPVVAGAAMGLSSVSVVTNSLRLRRFGRDV-
:: : :. * *. . :.: *::*. * *
Mflv_2866|M.gilvum_PYR-GCK TPIERPASHNRAAAVGAPS
Mvan_3641|M.vanbaalenii_PYR-1 TPVDPAASHSGVAPVGAPS
MAB_4853c|M.abscessus_ATCC_199 P----EHANTPAAQLAQQE
Rv1992c|M.tuberculosis_H37Rv P------PKTPDRTIPG--
Mb2015c|M.bovis_AF2122/97 P------PKTPDRTIPG--
MMAR_2140|M.marinum_M N------QARP--------
MLBr_00747|M.leprae_Br4923 -------------------
MAV_4235|M.avium_104 -------------------
MSMEG_6058|M.smegmatis_MC2_155 -------------------
TH_4361|M.thermoresistible__bu -------------------
MUL_0423|M.ulcerans_Agy99 -------------------