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SSFVIATPEFLTAAANDLSGIGDAVRAATGAAAPSTTAIAPLAGDEVSAAVTRMFGAYAQEFQTLSARME QFHTDFVRALLTGAGAYSGAEAANASPLQTLEQDLLAGINAPSQMLTGRPLIGNGANGVDGTGAAGGDGG WLVGNGGNGGSGAPGQAGGAGGSAGLWGAGGAGGAGGSATTPGGAGGAGGTGGANGLIGGGNGGVGGAGG AGAAGGAGAVGSTAQAGGAGGDGGAGGANRQLVSLFGAGGAGGAGGAGADGAAGTLGSAGVTGQIGGFGG AGGTGGAGGADQSLIGGSSGGGGAGGLGGAGGLGGNGGDATGFGMTGGDGAMGGAGGAAGAAGAAGAVTV PVNFLAHAGSDGGIGTGGNGGLGGNGGAGSIGTTGTDGTAPTTGGPGGAGGAGGDGGAGGAGIGGVGGGS GGNGGLGGNGGAGGHGGINTGTGGTASASGGTGGNGGAGGNGGAPGAANAIGGQGGQGGIGGNGGNGGNN TSGIDTAVGYAGGGGGGGAGGHGGNGGGNGALGGQGGTGGTGGTGGTASSSNTGPTPSAGTGGGGTGGGG GGGASASGAVGGTGGGGGGGGAGAAAGTGAVGGGGGGGGAAGGAGGTAGNGGAGGNAIAFAGSTSFSSAS GGAGGTGAPGGTGGGGGGGPLASTLSIDAGNGADGVNGGTGGTGTTSGGSGGTGGGAGGQGGNSFQFVPS AAGGAGQSG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2116 | - | - | 100% (710) | PE-PGRS family protein |
| M. marinum M | MMAR_5362 | - | 0.0 | 51.56% (770) | PE-PGRS family protein |
| M. marinum M | MMAR_4602 | - | 0.0 | 51.73% (781) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3538 | PE_PGRS54 | 0.0 | 50.45% (773) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-140 | 49.84% (628) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv3507 | PE_PGRS53 | 0.0 | 47.99% (796) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01183 | - | 5e-15 | 40.40% (99) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 9e-58 | 34.15% (533) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_4827 | - | 6e-26 | 44.32% (176) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-108 | 39.08% (737) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 7e-43 | 39.66% (358) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1721 | - | 0.0 | 73.80% (481) | PE_PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-133 | 46.91% (648) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2116|M.marinum_M ------------------MSSFVIATPEFLTAAANDLSGIGDAVRAATGA
MUL_1721|M.ulcerans_Agy99 ------------------MSSFVIATPEFLTAAANDLSGIGDAVRAATGA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv3507|M.tuberculosis_H37Rv -------------------MSFVLVSPETVAAVATDLKRIGASLAHENAS
Mb3538|M.bovis_AF2122/97 -------------------MSFVLIAPEFVTAAAGDLTNLGSSISAANAS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------MSIIDFILNLFRDPVEAASYVADPEAALANAGLS
MAV_4827|M.avium_104 ----------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAI
MMAR_2116|M.marinum_M AAPSTTAIAPLAGDEVSAAVTRMFGAYAQEFQTLSARMEQFHTDFVRALL
MUL_1721|M.ulcerans_Agy99 AAPSTTAIAPLAGDEVSAAVTRMFGAYAQEFQTLSARMEQFYTDCVRALL
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv3507|M.tuberculosis_H37Rv AAASTTAVVSAAADEVSTAVAALFSQHAQGYQAAAAQVAAFHSRFVQALT
Mb3538|M.bovis_AF2122/97 AASATTQVLAAGADEVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQP
MAV_4827|M.avium_104 DVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAA
MMAR_2116|M.marinum_M TG------------------------------------------------
MUL_1721|M.ulcerans_Agy99 TG------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv3507|M.tuberculosis_H37Rv AG-AGAYAFAEAANASPLQSAMGAVSASAQTLLSRPLIGNGANATTPGGN
Mb3538|M.bovis_AF2122/97 TGAG---AYASAEAAAAEQIVLGVINAPTQALLGRPLIGDGANATTPGGA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 DG------------------------------------------------
MAV_4827|M.avium_104 LR------------------------------------------------
MMAR_2116|M.marinum_M ------------------------------------AGAYSGAEAANASP
MUL_1721|M.ulcerans_Agy99 ------------------------------------AGAYSGAEAANASP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ---------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP
Rv3507|M.tuberculosis_H37Rv GGDGGWLFGSGGNGAPGAAGQSGGNGGSAGLWGNGGAGGAGGSGGAAGGN
Mb3538|M.bovis_AF2122/97 GGAGGLLFGNGGAGAAGAPGQAGGPGGPAGLWGNGGPGGAGGSGGGTGGA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------PSILSPSLLSPRDNDFLS
MAV_4827|M.avium_104 -----------------------DALAARRIDNVMLVSAFLAAAALAQNV
MMAR_2116|M.marinum_M LQTLEQDLLAGINAPSQMLT------------------------------
MUL_1721|M.ulcerans_Agy99 LQTLEQDLLAGINAPSQMLT------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFW------------------VVSPIGSTLGGV
Mflv_5091|M.gilvum_PYR-GCK --MVTFGGGATPTPTSLGAA------------------AVDLSGTSCG--
Mvan_1264|M.vanbaalenii_PYR-1 WYVVSFGGSGAPTPNNLAAS------------------LVDLSGTSCG--
Rv3507|M.tuberculosis_H37Rv GGNGGWLFGAGGTGGIGGTG------------------APGAMGGTGG--
Mb3538|M.bovis_AF2122/97 GGAGGWLFGVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAGGVGGAGGGTG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 HNDTDFASHNPIASGNQVMS------------------------------
MAV_4827|M.avium_104 GGAMGYERTAVLLVEPDTAT------------------------------
MMAR_2116|M.marinum_M --------------------------GRPLIGNGANGVDG----------
MUL_1721|M.ulcerans_Agy99 --------------------------GRPLIGNGANGVDG----------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 INTISGQYLIGNGINGTADNP-NGGTGGLLFGDGGHGYDG--------SA
Mflv_5091|M.gilvum_PYR-GCK --------LICNGQDGTGQN------GGILFGNGGSGWNS--------DV
Mvan_1264|M.vanbaalenii_PYR-1 --------LICNGQDGTGQN------GGILFGNGGSGWNS--------EI
Rv3507|M.tuberculosis_H37Rv -NGGNGALLIGGGGLGGAGG--MGGTGGGTGGTGGNGGNG--------AL
Mb3538|M.bovis_AF2122/97 GAGGRAELLFGAGGAGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------------------PSGNVDSFNRG--------PL
MAV_4827|M.avium_104 ----------------------------LAVVETSDGSIP----------
MMAR_2116|M.marinum_M ---TGAAGGDGGWLVGNGGNGGSGAPGQAGGAGGSAG----------LWG
MUL_1721|M.ulcerans_Agy99 ---TGAAGGDGGWLVGNGGNGGSGAPGQAGGAGGSAG----------LWG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 AGLAGGNGGNAGLFG-NGGNGGVGWAGLDGGNGGSGG----LLMGIG--G
Mflv_5091|M.gilvum_PYR-GCK VGMDGGNGGNGGLFGGNGGNGGNGLGGGNGGNGGNAG----AFALFGNGG
Mvan_1264|M.vanbaalenii_PYR-1 AGVSGGNGGNAGLFGGNGGNGGNGLGSGDGGNGGDAG----LFSLFGRGG
Rv3507|M.tuberculosis_H37Rv LIGAGGVGGAGGIGGQGTGAGGAAGAGGTGGNGGAGG----LFMNGGDGG
Mb3538|M.bovis_AF2122/97 AGGAGGQGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 LDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQ------------G
MAV_4827|M.avium_104 --DVYKQQIRAESYGDAAGQLSAMVAGLEKLESLPGG--------LLLVG
MMAR_2116|M.marinum_M AGGAGGAGGSATTP-----GGAGGAGGTGGANG-----------------
MUL_1721|M.ulcerans_Agy99 AGGAGGAGGSATTP-----GGAGGAGGTGGANG-----------------
TH_3810|M.thermoresistible__bu -----------------VDG----DGGSGGRTG-------------LFSK
MSMEG_0868|M.smegmatis_MC2_155 AGGAGGVGADGTSA--HVDGGTGGTGGTGGGTGGT--GGIGGTGGGLFGL
Mflv_5091|M.gilvum_PYR-GCK NGGNGGVGVVGATG--AVGAP--GVAGATGATG-------------VTSG
Mvan_1264|M.vanbaalenii_PYR-1 NGGNGGVGIAGATG--AVGAP--GVAGATGATG-------------VTSN
Rv3507|M.tuberculosis_H37Rv AGGQGGDGAAGDAA--ASAGGTGGKGGQGGDGG-T--GGAGGAGPVLFGH
Mb3538|M.bovis_AF2122/97 LGGAGGQGGTGGAGGDGVLGGVGGTGGKGGVGGVAGLGGAGGAAGQLFSA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 STAVNGDVRDSNIINADHGSNVGVDQSQTRVGG-------------DYTN
MAV_4827|M.avium_104 SGVDVAPLKQVLQTTTFLDVSVAEEPETALARG------------AALAA
MMAR_2116|M.marinum_M LIGGGNGGVGGAGGAGAAGGAG------AVGSTAQAG-------------
MUL_1721|M.ulcerans_Agy99 LIGGGNGGVGGAGGAGAAGGAG------AVGSTAQAG-------------
TH_3810|M.thermoresistible__bu LSR------------GGDGGDG------GLG-------------------
MSMEG_0868|M.smegmatis_MC2_155 LGHSGSTGAAGAAGNGGDGGNG------GFGYVLIAGPNVTVGSETRGGT
Mflv_5091|M.gilvum_PYR-GCK VVGGNGEDAVGYGATGAAGAAG------AAGAAGAAGAVGSAGAAGEAGE
Mvan_1264|M.vanbaalenii_PYR-1 VTGGNGADAVGYGATGAAGAAG------AAGAAGKAGAVGSAGTAGSAGA
Rv3507|M.tuberculosis_H37Rv GGAGGMGGQGGTGGMGGAGGDGTT--VIAAGTGGEGGTGGAAGAGGAAGA
Mb3538|M.bovis_AF2122/97 GGAAGAVGVGGTGGQGGAGGMGGSGADNASGIGADGGAGGTGGNAGAGGA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VSGHGSADIDKSVTVVDDHSQR-----NTTNINDSFN-------------
MAV_4827|M.avium_104 ANAPLFASSTAALAYAQDPGTG------AVDQYSLPDYLYVPVDPEPGDD
MMAR_2116|M.marinum_M ----------------------GAGGDGGAGGAN------RQLVS-----
MUL_1721|M.ulcerans_Agy99 ----------------------GTGGDGGAGGAN------RQLVS-----
TH_3810|M.thermoresistible__bu ------------------------GNGGHGGGTG-----IISLLS-----
MSMEG_0868|M.smegmatis_MC2_155 GGAGGTGGQS-------TAAGPGKGGGGGGGGGG-----AILIGANGGTV
Mflv_5091|M.gilvum_PYR-GCK TGTWGNAG--------------LPGKAGDAGGAG-----AVGAAGAAGTV
Mvan_1264|M.vanbaalenii_PYR-1 PGVWGNAG--------------LPGAAGAAGGAG-----AIGTAGVAGAA
Rv3507|M.tuberculosis_H37Rv RGALTSGG---------LAGGVGAGGTGGTGGTGGNGADAAAVVGFGANG
Mb3538|M.bovis_AF2122/97 GGAAGTGGTGGVVGAAGKAGIGGTGGQGGAGGAGSAGTDATATGATGGTG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------------TDRSTNIGSGNTTNTEIGSHNQANIG
MAV_4827|M.avium_104 ELAYS-----------------AVGEEDAESPTVVIEKLFLPEDSEPRRR
MMAR_2116|M.marinum_M ----LFGAGGAGGAGGAGADGAAGTLGSAG--------------------
MUL_1721|M.ulcerans_Agy99 ----LFGAGGAGGAD-----------------------------------
TH_3810|M.thermoresistible__bu ----LAGNGGNGGNGYRTTDNN----------------------------
MSMEG_0868|M.smegmatis_MC2_155 DGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRV--IAEGTGSTAE------
Mflv_5091|M.gilvum_PYR-GCK GTAGATGGTGTGANGGAGGVGGVGGTGAAG----AAGGAGGLGE------
Mvan_1264|M.vanbaalenii_PYR-1 GTAGATGGTGVGGNGGAGQAGGIGGTGAAG----AAGQAGTAGE------
Rv3507|M.tuberculosis_H37Rv DPGFAGGKGGNGGIGGAAVTGGVAGDGGTGGKGGTGGAGGAGND------
Mb3538|M.bovis_AF2122/97 FSGGAGGAGGAGGNTGVGGTNGSGGQGGTGGAGGAGGAGGVGADNPTGIG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 TSTSAGGSAAVGGNAGLAGNAG----------------------------
MAV_4827|M.avium_104 PVLLVGSGLAVVGISAVLALEIALAIGIRTTG------------------
MMAR_2116|M.marinum_M ---VTGQIGGFGGAGGTGGAGGADQSLIGGSSGGGG----AGGLGGAGGL
MUL_1721|M.ulcerans_Agy99 ---------------------------------------------GAGGL
TH_3810|M.thermoresistible__bu --ALDGGHGGN------GGNVGFFSLFNLG------------GAGGWGGS
MSMEG_0868|M.smegmatis_MC2_155 -GTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVS----GTATGGRGGD
Mflv_5091|M.gilvum_PYR-GCK -TGTTGGAGGVGGQGTAGGTGGVGGIGGAGSTG---------AVGGVGGK
Mvan_1264|M.vanbaalenii_PYR-1 -TGVTGGVGGIGGQGTEGGTGGVGGVGGVGATG---------GAGGVGGK
Rv3507|M.tuberculosis_H37Rv -AGSTGNPGGKGGDGGIGGAGGAGGAAGTGNGGHAG----NTGDGGDGGT
Mb3538|M.bovis_AF2122/97 GAGGTGGAGGTGGTGGAAGAGGAGGAVGTGGTGGVVGDVGNAGIGGTGGK
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----LAGNAGLAGNAGLAGNAGLAGNAGLAG-----------NAGLAGNA
MAV_4827|M.avium_104 -TVALQPTPNQHLIVPTEQAPAPPPVQASAPQPKIS-----VPEPVAAPK
MMAR_2116|M.marinum_M GGNGG-----------------------------------DATGFGMTG-
MUL_1721|M.ulcerans_Agy99 GGNGG-----------------------------------DATGFGMTG-
TH_3810|M.thermoresistible__bu GVDG-------------------------------------VDVVGGN--
MSMEG_0868|M.smegmatis_MC2_155 GIDGGTGGAGGMGEIYSG----ADGEATGISAGGDGGSATGADSLGGRGG
Mflv_5091|M.gilvum_PYR-GCK GIQGGQGLQGGKG-----------------GDGGAGGKGGDADSMGSAG-
Mvan_1264|M.vanbaalenii_PYR-1 GIQGGQGLQGGQG-----------------GDGGTGGTGGDATSMGEAG-
Rv3507|M.tuberculosis_H37Rv GGNGGNGTGGVNGADNTLNPDTPGGAGEPGGAGGAGGAGGAAGGPGGTGG
Mb3538|M.bovis_AF2122/97 GGAGGTGFAGGAGGAGGQGGSSGAGGTNGSGGAGGTGGQGGAGGAGGAGA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GLAGN------------------------------------AGLAGNAG-
MAV_4827|M.avium_104 PLSPP-----------------------------------VAAPLPAAPP
MMAR_2116|M.marinum_M ----------------------------GDGAMGGAG-------------
MUL_1721|M.ulcerans_Agy99 ----------------------------GDGAMG----------------
TH_3810|M.thermoresistible__bu ----------------------------PDGGTPG---------------
MSMEG_0868|M.smegmatis_MC2_155 TSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGV
Mflv_5091|M.gilvum_PYR-GCK ----------------------------ATGGKGGNG-------------
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------ATGGKGGNG-------------
Rv3507|M.tuberculosis_H37Rv -----------------------TGGNGGNGGNGGNGGNGGNGGNGGNAG
Mb3538|M.bovis_AF2122/97 DNPTGIG---------------GAGGTGGTGGAAGAGGAGGAIGTGGTGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------LAGNAGLAG---------------
MAV_4827|M.avium_104 ---------------------------PAAPPLPEAPP------------
MMAR_2116|M.marinum_M --------------------------------------------------
MUL_1721|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu -------------------------------------------AHG----
MSMEG_0868|M.smegmatis_MC2_155 ATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQ
Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------GNGGRG-
Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------GNGGRG-
Rv3507|M.tuberculosis_H37Rv NNSTNAPVGGEGGAGGDGGAGGAGGAANGG--TAGSQGTGGVGGDGGAGG
Mb3538|M.bovis_AF2122/97 AVGSVGNAGIGGTGGTGGVGGAGGAGAAAAAGSSATGGAGFAGGAGGEGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_2116|M.marinum_M ------------GAAGAAGAAGAVTVPVN-------------FLAHAGSD
MUL_1721|M.ulcerans_Agy99 ---------------------GAVTVPVN-------------FLAHAGSD
TH_3810|M.thermoresistible__bu ------------ESHTP----GVYTDRQ-------------------GED
MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGNGWVQAYDPNGPAGTTIDKGK------------AAGGNGGDG
Mflv_5091|M.gilvum_PYR-GCK ------------GLFGKGGNAGNGADGG--------------TGGAGGAG
Mvan_1264|M.vanbaalenii_PYR-1 ------------SLFGRGGNAGNGGNGG--------------TGGNGGNG
Rv3507|M.tuberculosis_H37Rv NGGGGKAGTGNSGNFGVDGEAGFSGGAGGNGGVGGAAGANGGTGGSGGNG
Mb3538|M.bovis_AF2122/97 AGGNSGVG----GTNGSGGAGGAGGKGGTGGAGGSGADNPTGAGFAGGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------NAGLAGNAGLAGNAG--------------LAGNAGLA
MAV_4827|M.avium_104 -----------IPAAPPVVPVPVVVPPVP-------------VPVPVRIP
MMAR_2116|M.marinum_M GGIGTGGNGGLGGN----------GGAGSIGTTGTDGTAPTTGG------
MUL_1721|M.ulcerans_Agy99 GGIGTGGNGGLGGN----------GGAG----------------------
TH_3810|M.thermoresistible__bu GEDGTG--TGIGGR----------GGNGG-----SSSGTHPMAE------
MSMEG_0868|M.smegmatis_MC2_155 GFNGTG--GATGGR----------GGDGAGASVWKANGQHSTGQTDTGGN
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAGGTGGT----------GGTGGIGGAGSTGGTGGTGG------
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGNGGTGGT----------GGTGGIGGAGSTGGTGGTGG------
Rv3507|M.tuberculosis_H37Rv GDGGAGGIGGAGGNGIPGTGTEPAGGTGAKGGDGGDGGAGGAGG-NAGGA
Mb3538|M.bovis_AF2122/97 GTGGAAGAGGAGGATG-------TGGTGGVVGATGSAGIGGAGG--RGGD
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGN----------AGLAGNAGLAGNAGLAGNAG------
MAV_4827|M.avium_104 VPDPVSPPQLLAPPRLS-----VPQPVQPPVRVPQPPSPPQVGG------
MMAR_2116|M.marinum_M ------------------------------------PGGAGGAGGDGGAG
MUL_1721|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu -------------------------------------DGEHVKALDGRPG
MSMEG_0868|M.smegmatis_MC2_155 GGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRGGDGALG
Mflv_5091|M.gilvum_PYR-GCK ------------------------------------TGGTGGTGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------TGGTGGTGGTGGTG
Rv3507|M.tuberculosis_H37Rv GGQGGNAGQGGAGGAGGNAVIPGDGVGKAPHGDAGGSGGDGGKGGQGGSG
Mb3538|M.bovis_AF2122/97 GGDGASGLGLGLSGFDGGQGGQGGDGGSAGAGGINGAGGAGGDGGDGGDG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------------------------LAGNAAVAGNAAVA
MAV_4827|M.avium_104 -------------------------------------TVPQSPPQHQTPP
MMAR_2116|M.marinum_M GAGIGGVGGGSGGNGGLGGNG-----------------------GAGGHG
MUL_1721|M.ulcerans_Agy99 -----------------------------------------------GHG
TH_3810|M.thermoresistible__bu LDG---------GNGSHGGNG-----------------------GHGGRG
MSMEG_0868|M.smegmatis_MC2_155 GNGGTGGVGL--GNGGKGGNG-----------------------GNGGNG
Mflv_5091|M.gilvum_PYR-GCK GTGGTG------GTGGKGGTG-----------------------GTGGAG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTG------GTGGKGGTG-----------------------GTGGDG
Rv3507|M.tuberculosis_H37Rv GTGGSGAPIGG-GAGGTGGSGGHAGKGGAGGI--GAQGTTITVPGNGGNA
Mb3538|M.bovis_AF2122/97 ATGAAGLGDNG-GVGGDGGAGGAAGNGGNAGVGLTAKAGDGGAAGNGGNG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GNAAVAGNAAVGGVLNTGVSG-----------------------AIGGSS
MAV_4827|M.avium_104 GEGTPP------KPDGPGNYG-------------------------GGHV
MMAR_2116|M.marinum_M GIN--------------TGTGGTASASG-------------------GTG
MUL_1721|M.ulcerans_Agy99 GIN--------------TGTRGTASASG-------------------GTG
TH_3810|M.thermoresistible__bu G---------------FLGIGGSGGWG-----------------------
MSMEG_0868|M.smegmatis_MC2_155 GTYVDP---------SHTGAGGNGGNGGAGRIRVN-----NGTATGTATG
Mflv_5091|M.gilvum_PYR-GCK GTGGDG---------GTGGTGGTGGTGG--------------------TG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTG---------GTGGTGGTGGTGG--------------------TG
Rv3507|M.tuberculosis_H37Rv GDGGNG---------GNAGAGGNGGSGDFGGNTTSGASGSGGNGGNAGTA
Mb3538|M.bovis_AF2122/97 GAGGAGGAGDNNFNGGQGGAGGQGGQGGLGGASTTSINANGGAGGNGGTG
MLBr_01183|M.leprae_Br4923 ------------------------------------------------MP
MAB_4284c|M.abscessus_ATCC_199 HVGGAIN----------ESLGGSGSVGG------------------STAV
MAV_4827|M.avium_104 PT---------------PGAGGSGGSGG----------------GHVPTP
MMAR_2116|M.marinum_M GNGGAGGNG-----------GAPGAANAIGGQGGQG--------------
MUL_1721|M.ulcerans_Agy99 GNGGAGGNG-----------GAPGAANAIGGQGGQG--------------
TH_3810|M.thermoresistible__bu GHGGNGGDT-----------DADGGNGGDGGNGG----------------
MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGNG-----------DADGHRGGKGGDGGEALIRATV-IGSNASG
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAG-----------DGTGGTGGTGGTGGQG--------------
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGAG-----------DGLGGTGGTGGTGGFG--------------
Rv3507|M.tuberculosis_H37Rv GSGGAGGTGGTGLSGGNGGNGGNGGNGGDGGNGAHGTVGAQF-VPATSLP
Mb3538|M.bovis_AF2122/97 GKGGAGGAGTLG-------VGGSGGTGGDGGDAGAGGGGGFGGAAGKAGG
MLBr_01183|M.leprae_Br4923 LFLNAEPQA------------LTAAANTLEGLSAAT--------------
MAB_4284c|M.abscessus_ATCC_199 GGGAHTGVG-----------GGVSTGVGVGSHVGGG--------------
MAV_4827|M.avium_104 GAGGSGGSG--------------GGHVPTPGTGGPG--------------
. . .
MMAR_2116|M.marinum_M -GIGGNGGNGGNNTSGID----------------------TAVGYAGGGG
MUL_1721|M.ulcerans_Agy99 -GIGGNGGNGGN--------------------------------------
TH_3810|M.thermoresistible__bu --SAGRGGTGGLRGVF--------------------------------GI
MSMEG_0868|M.smegmatis_MC2_155 TATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGI
Mflv_5091|M.gilvum_PYR-GCK -GQGGQGGTGGTGGQG------------------------GLGGGGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 -GQGGQGGTGGTGGQG------------------------GLGGVGGTGG
Rv3507|M.tuberculosis_H37Rv TPNGGAGGNGGTGSNGGAPGPAG-------APGPTTGGNAGSQGIGGDGG
Mb3538|M.bovis_AF2122/97 GGNGGVGGDGGEGATGLGLDLSG--FAGGQGGQGGAGGNAGAGGINGAGG
MLBr_01183|M.leprae_Br4923 --VASNAAAAQLTTEI----------------------------------
MAB_4284c|M.abscessus_ATCC_199 -ISESLGGSGSVGGST----------------------------------
MAV_4827|M.avium_104 ----GTGGSGGGHVPT----------------------------------
. .. .
MMAR_2116|M.marinum_M GGGAGGHGGNG---------------------------------------
MUL_1721|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu NGGNGR--------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 NGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGID--------------
Mflv_5091|M.gilvum_PYR-GCK QGGTGGTGGQG--------------GTGGTGGTGGT--------------
Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGQG--------------GTGGTGGTGGT--------------
Rv3507|M.tuberculosis_H37Rv NGGDGGKGGDGADAVNVVFMPTEPQAATGTAGSAGDP-------------
Mb3538|M.bovis_AF2122/97 TGGTGGAGGDGAPATLIGGPDGGDGGQGGIGGDGGNAGFGAGVPGDGGIG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_2116|M.marinum_M --GGNGALGGQG------------------GTGGTGGT------------
MUL_1721|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --AGLGGRGXX----------------------XXGGG------------
MSMEG_0868|M.smegmatis_MC2_155 --GGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKA------------
Mflv_5091|M.gilvum_PYR-GCK --GGTGGAGGDG---------------GLGGLGGFGGS------------
Mvan_1264|M.vanbaalenii_PYR-1 --GGTGGAGGDG---------------GLGGLGGFGGV------------
Rv3507|M.tuberculosis_H37Rv -TGGNGGPGTPGSPMVAPPPPTPITQVQQGGDGGAGGTGSTNAN----DG
Mb3538|M.bovis_AF2122/97 GTGGAGGAGGAGGAGDAGADGDPSIDGGQGGAGGHGGQGGKGGLNSTGLA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_2116|M.marinum_M GGTASSSNTGPTPSAGTGGG---------------GTGGGGGGGASASGA
MUL_1721|M.ulcerans_Agy99 GGTASSSNTGPTPSAGTGGG---------------GTGGGGGG-------
TH_3810|M.thermoresistible__bu VGAAVRSGNG----VFSGGG---------------GTPSAGFGVPTT---
MSMEG_0868|M.smegmatis_MC2_155 TGTASQGGNGGPSWVQSGYGS-------TLGGNATGTATAGKGGEASNGG
Mflv_5091|M.gilvum_PYR-GCK GGTGGQGGLGGPGGSTGGAG-----------GAGGQAGTAGKGGLFGGSG
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGQGGQGGPGGSTGGAG-----------GAGGQAGVAGKGGLFGGSG
Rv3507|M.tuberculosis_H37Rv TATGGKGGEGGVGSILGGPGGNGGTGGNASATGTNGVANAGNGGKGGDGG
Mb3538|M.bovis_AF2122/97 SAASGDGGNGGAGGAGGNGGDGDGFIG-GSGGTGGTGGDAGAGGLANTGG
MLBr_01183|M.leprae_Br4923 APPAADDVSILLAHFFSGHG-------------RQYQAHASQG-------
MAB_4284c|M.abscessus_ATCC_199 -AVGGGAHTGVGGGVSTGVG---------------VGSHVGGGISESLGG
MAV_4827|M.avium_104 PGAGTPGGSGGGHLPFPGAG---------------STPGGSGGGHLPTPG
. . * . *
MMAR_2116|M.marinum_M VGGTGGGGGGGGAGAAAGTG--------------AVGGGGGGGGAAG---
MUL_1721|M.ulcerans_Agy99 ----GGGGGGGGASASGAVG--------------GTGGGGGGGGAGA---
TH_3810|M.thermoresistible__bu IQFPAGSCTSRAVSREGIMP--------------SSRAASARAGAAC---
MSMEG_0868|M.smegmatis_MC2_155 VAGNGGNALVMAAGTTGVAT--------------GNTATGGDGGAAT---
Mflv_5091|M.gilvum_PYR-GCK SAGKAGATGAAGASGGKGAQ--------------GATGAQGATGAQG---
Mvan_1264|M.vanbaalenii_PYR-1 SAGTAGVTGASGASGGKGAQ--------------GATGAQGATGAQG---
Rv3507|M.tuberculosis_H37Rv QFGAGGNGGAGGSVTDGSAG--------------STAGNGGNGGNATNGT
Mb3538|M.bovis_AF2122/97 TAGNAGIGGAGGRGGDGGAGDSGALSQDGNGFAGGQGGQGGAGGNAGAGG
MLBr_01183|M.leprae_Br4923 ATNHQDLIQSLLTSSSAYAG----------------TETANHDSL-----
MAB_4284c|M.abscessus_ATCC_199 SGSVGGSTAVGGGAHTGVGG--------------GVNTGVGVGSHVGGG-
MAV_4827|M.avium_104 AGTPGGGLGGFGGGHAPAPG----------------GGLGGGGGHAP---
. .
MMAR_2116|M.marinum_M ------------------------GAGGTAGNGGAGGNAIAFAGSTSFSS
MUL_1721|M.ulcerans_Agy99 ------------------------AAG-----------------------
TH_3810|M.thermoresistible__bu ----------------------ASSTSRSRRSFCCSRA------------
MSMEG_0868|M.smegmatis_MC2_155 ----------------------TAGATGGAGGFSNIAAIH-GAITDSTAI
Mflv_5091|M.gilvum_PYR-GCK ----------------------ATGATGAAGKAGATGAAG-AAGAAGSAG
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------ATGATGASGAQGSAGSAG-SAGVAGSAG
Rv3507|M.tuberculosis_H37Rv IAGQPAGGNGSAGGKGGDGGNIAAGATGTAGNGGNGGNGNDGAVNAGTGG
Mb3538|M.bovis_AF2122/97 INGAGGTGGTGGAGGDGAPATLIGGPDGGDGGQGGGAGFGSGVAGAAGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------------ISESLGGSGSVGGSTAVGGGAHTSAIND
MAV_4827|M.avium_104 ------------------------APGGGLGGFGGGHS------------
MMAR_2116|M.marinum_M ASGGAGGTGAPGGTGGGGGGGPLAST--------------------LSID
MUL_1721|M.ulcerans_Agy99 -------TGAVG--GGGGGAAPPAAP--------------------VAPP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 SGHGGAGNGGNGGKGADGWVQAYDPAGPVGSK--------------IANS
Mflv_5091|M.gilvum_PYR-GCK TTGAQGSAGTNGANGANGSQGAAGKAGATG----------------TTGA
Mvan_1264|M.vanbaalenii_PYR-1 TTGAQGSAGTNGANGANGSQGAAGKAGATG----------------TTGA
Rv3507|M.tuberculosis_H37Rv SGGNGGNAGGGGANGGDGGAGGAGGAGGRGGKGIDGGFGGDGGNGGSNNG
Mb3538|M.bovis_AF2122/97 GNGGKGGDGGTGGTGGTNFAGGQGGAGGRGGAG-----------GNGANG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ALGGSGSVGGSTAVGGGAHTSAINES----------------------MN
MAV_4827|M.avium_104 -------GGGLGGLGGGHK-------------------------------
MMAR_2116|M.marinum_M AGNGADGVNGGTGGTGTTSGGSGGTGG-------------GAGGQGGNSF
MUL_1721|M.ulcerans_Agy99 EMEAREATP-----------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 SAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGG
Mflv_5091|M.gilvum_PYR-GCK TGAAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEGGDGG
Mvan_1264|M.vanbaalenii_PYR-1 TGAAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEGGAGG
Rv3507|M.tuberculosis_H37Rv TGAGGNGGNGGTGGVGSVGAAGGDGGNGGTGGFAGFGGTAGNGGSGGTGG
Mb3538|M.bovis_AF2122/97 VGDNAAGGDGGNGGAGGLGGGGGTGGTNGNGGLGGGGGNGGAGGAGGTPT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SSINASHSSSMNESFGSSMGSHGAAGTG----------FEAQGHAQGHAS
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_2116|M.marinum_M QFVPSAAGGAGQSG------------------------------------
MUL_1721|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 NGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTP
Mflv_5091|M.gilvum_PYR-GCK KGGAGAEGGAGGGGGAGGSGAGGAG-------GAGGSGGSGGSGGSGGSG
Mvan_1264|M.vanbaalenii_PYR-1 AGGDGSEGGAGGSGGAGGSGTGGAG-------GAGGSGGSGGSGGAGGSG
Rv3507|M.tuberculosis_H37Rv AGGDGGTGGDGGNGVIAGGGGTGGNGGASGAGGAGGTGGFAGNGNAGGNG
Mb3538|M.bovis_AF2122/97 GSGTEGTGGDGGDAGAGGNGGSATGVGNGGNGGDGGNGGDGGNGAPGGFG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ETAHTTLPGAEHH-------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_2116|M.marinum_M -----------------------------------------
MUL_1721|M.ulcerans_Agy99 -----------------------------------------
TH_3810|M.thermoresistible__bu -----------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 GTAGTTGANNP------------------------------
Mflv_5091|M.gilvum_PYR-GCK GAAGDSDD---------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 GAAGDSD----------------------------------
Rv3507|M.tuberculosis_H37Rv GTGGASEDGDNGNAGSGATGGTGGNGGTGGDGGAAGLGGVA
Mb3538|M.bovis_AF2122/97 GGAGAGGLGGSGAG--GGTDGDDGNGGSPGTDGS-------
MLBr_01183|M.leprae_Br4923 -----------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------------------------------
MAV_4827|M.avium_104 -----------------------------------------