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TTTDDDRVLFDVDRDTRIATITLNNPKQRNSYDAAMRNLLARHLDEVAEDDDITVVLLRGAEGVFSTGAD MNNAYGWYGPEDPAGAGKPRKSRPSQRRRLTVDRKSFGFYHNLMGFPKVTVGEISGYALGGGFEMALMTD ISVIARDTRIGMPATRFLGPALGSLHLFFHRLGPVQARRLLLTGDIIRAADVEHLGVFTETCDADAVTAR ARYWAEKAAKMPADGVVIAKEAFRLVEQSQAYQGEEVASYLFHAYGTNLQFADGEFNFVKTRAQHGTKEA FRLRDEHFHVPEP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4357 | - | - | 100% (294) | enoyl-CoA hydratase/isomerase |
| M. gilvum PYR-GCK | Mflv_2036 | - | 5e-21 | 27.24% (268) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4354 | - | 1e-15 | 30.40% (250) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1099c | echA8 | 2e-23 | 26.97% (267) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1070c | echA8 | 2e-23 | 26.97% (267) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 2e-21 | 26.97% (267) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_1185c | - | 9e-21 | 26.55% (275) | enoyl-CoA hydratase |
| M. marinum M | MMAR_4020 | echA4_2 | 1e-139 | 81.08% (296) | enoyl-CoA hydratase, EchA4_2 |
| M. avium 104 | MAV_1585 | - | 1e-144 | 86.01% (293) | enoyl-CoA hydratase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_2223 | - | 1e-144 | 86.81% (288) | enoyl-CoA hydratase/isomerase family protein |
| M. thermoresistible (build 8) | TH_1117 | - | 1e-141 | 84.88% (291) | enoyl-CoA hydratase/isomerase family protein |
| M. ulcerans Agy99 | MUL_3885 | echA4_2 | 1e-135 | 79.05% (296) | enoyl-CoA hydratase, EchA4_2 |
| M. vanbaalenii PYR-1 | Mvan_1987 | - | 1e-153 | 90.48% (294) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4357|M.gilvum_PYR-GCK --MTTTDDDRVLFDVDRDTRIATITLNNPKQRNSYDAAMRNLLARHLDEV
Mvan_1987|M.vanbaalenii_PYR-1 --MTTAEDNRVLFEVDRDKRIATITLNNPKQRNSYDASMRNLLARYLDDV
MSMEG_2223|M.smegmatis_MC2_155 ----------MLFEVDDDHRIATITLNNPKQRNSYDAAMRDQLARYLDIV
MAV_1585|M.avium_104 MTASSTSDDRVLFDVDAEHRIATITLNNAKQRNSYDAAMREAIARCLDRV
TH_1117|M.thermoresistible__bu ---MPTTDDRVLFDVDRDKRIATITLNNPAQRNSYDAAMRDALERCLDQV
MMAR_4020|M.marinum_M MTAADGPDDRVQFEAEPGTRIATITLNNPTRRNAYDAAMRDAIAGYLDRV
MUL_3885|M.ulcerans_Agy99 MTAADGPDDRVQFEAELGTRIATITLNNPTRRNAYDAAMRDAIAGYLDRV
Mb1099c|M.bovis_AF2122/97 ----MT---YETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATEL
Rv1070c|M.tuberculosis_H37Rv ----MT---YETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATEL
MLBr_02402|M.leprae_Br4923 ----MK---YDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAAKEL
MAB_1185c|M.abscessus_ATCC_199 ----MTSHNFETILTERIDRVAVITLNRPKALNALNSQVMNEVTTAAAEF
: .: *:. ****.. *: :: : : : .
Mflv_4357|M.gilvum_PYR-GCK AEDDDITVVLLRGAEGVFSTGADMNNAYGWYG--PEDPAGAGKPRKSRPS
Mvan_1987|M.vanbaalenii_PYR-1 AEDDDITVLLLRGADGVFSTGADMNNAYGWYG--PDKQD---KPAKNRPS
MSMEG_2223|M.smegmatis_MC2_155 AEDDDLTVVLLRGAEGVFSTGADMNNAYGWYGSKAENGKAEQEQPKSRPS
MAV_1585|M.avium_104 AEDDDLTVVLLRGAEGVFSTGADMNNAYGWYG----TSRNADESTRRRPS
TH_1117|M.thermoresistible__bu AEDDDLTVVLLRGADGVFSTGADMNNAYAWYG----EEN--SPQARRRPS
MMAR_4020|M.marinum_M AADDDLTVVILRGTGGVFSAGADMNNAYGWYG--EADAPAADPPTQRRPS
MUL_3885|M.ulcerans_Agy99 AADDDLTVVILRGTGGVFSAGADMNNAYGWYG--EADAPAADPPTQRRPS
Mb1099c|M.bovis_AF2122/97 DDDPDIGAIIITGSAKAFAAGADIKEMA---------------------D
Rv1070c|M.tuberculosis_H37Rv DDDPDIGAIIITGSAKAFAAGADIKEMA---------------------D
MLBr_02402|M.leprae_Br4923 DIDPDVGAILITGSPKVFAAGADIKEMA---------------------S
MAB_1185c|M.abscessus_ATCC_199 DADHGIGAIIITGSEKAFAAGADIKEMS---------------------E
* .: .::: *: .*::***::: .
Mflv_4357|M.gilvum_PYR-GCK QRRRLTVDRKSFGFYHNLMGFPKVTVGEISGYALGGGFEMALMTDISVIA
Mvan_1987|M.vanbaalenii_PYR-1 QRRRLTVDRKSFGFYHNLMGFPKVTVGEISGYALGGGFEMALMTDISVIA
MSMEG_2223|M.smegmatis_MC2_155 QRRRLTVDRKTFGFYHNFMGFPKVTVGEISGFALGGGFEMALMTDISVIA
MAV_1585|M.avium_104 QRRRLTVDRKSFGFYHNFMGFPKVTVGEIAGYALGGGFEMALMTDISVIA
TH_1117|M.thermoresistible__bu QRRRLTVDRRTFGFYHNFMGFPKVTVGEISGYALGGGFELALMCDIAVIG
MMAR_4020|M.marinum_M QRRRLTVDRRSFSFYHNLMGFPKVTVGEIAGHALGGGFEMALMTDISVIA
MUL_3885|M.ulcerans_Agy99 QRRRLTVDPRSFSFYHNLMGFPKVTVGEIAGHALRGGFEMALMTDISVIA
Mb1099c|M.bovis_AF2122/97 LTFADAFTADFFATWGKLAAVRTPTIAAVAGYALGGGCELAMMCDVLIAA
Rv1070c|M.tuberculosis_H37Rv LTFADAFTADFFATWGKLAAVRTPTIAAVAGYALGGGCELAMMCDVLIAA
MLBr_02402|M.leprae_Br4923 LTFTDAFDADFFSAWGKLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAA
MAB_1185c|M.abscessus_ATCC_199 QSFSDMFGSDFFSAWGKLGAVRTPTIAAVSGYALGGGCELAMMCDVIIAA
. *. : :: .. . :. ::*.** ** *:*:* *: : .
Mflv_4357|M.gilvum_PYR-GCK RDTRIGMPATRF-LGPALGSLHLFFHRLGPVQARRLLLTGDIIRAADVEH
Mvan_1987|M.vanbaalenii_PYR-1 RDTRIGMPATRF-LGPALGSLHMFFHRLGPVLARRLLLTGDIIRAGEVEH
MSMEG_2223|M.smegmatis_MC2_155 RDTRIGMPATRF-LGPALGSLHMFFHRLGPVLARRLLLTGDVIEAGAIEH
MAV_1585|M.avium_104 RDTKIGMPATRF-LGPALGSLHMFFHRLGPVLARRLLLTGDIIDAGQVEH
TH_1117|M.thermoresistible__bu RDAKIGMPATRF-LGPALGSLHMFFHRLGPVLARRLLLTGDIIEAGSVEH
MMAR_4020|M.marinum_M RNARIGMPATRF-LGPALGSLHMFFHRLGPVLARRLLLTGDIIEAGDVEH
MUL_3885|M.ulcerans_Agy99 RNARIGMPATRF-LGPALGSLHMFFHRLGPVLARRVLLTGDIIEAGDVEH
Mb1099c|M.bovis_AF2122/97 DTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTMDAAEAER
Rv1070c|M.tuberculosis_H37Rv DTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTMDAAEAER
MLBr_02402|M.leprae_Br4923 DTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAER
MAB_1185c|M.abscessus_ATCC_199 ENATFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDMILTGRNMDAAEAER
: :* * :: : *.:*. : : : :* . * ::*** : *. *:
Mflv_4357|M.gilvum_PYR-GCK LGVFTETCDADAVTARARYWAEKAAKMPADGVVIAKEAFRLVEQSQAYQG
Mvan_1987|M.vanbaalenii_PYR-1 LGVFTDTCDAAAVPARARYWAEKAAKMPADGVVIAKEAFRLVEQSQAYQG
MSMEG_2223|M.smegmatis_MC2_155 LGIFTETCDGSQVAARARYWAQKAAKMPADGVVIAKEAFRLVEQSQAYQG
MAV_1585|M.avium_104 LGIFTDTCDPAAVTARARYWAEKAAKMPADGVVIAKEAFRLVEQSQAYQG
TH_1117|M.thermoresistible__bu LGVFTETCDPAMVGPRARYWAEKAAKMPADGVVIAKEAFRLVEQSQAYQG
MMAR_4020|M.marinum_M LGIFTDTCDSGAVAARARYWAEKAAKMPADGIVIAKEAFRLVEQTQAYAG
MUL_3885|M.ulcerans_Agy99 LGIFTDTCDCGAVAARARYWAEKAAKMPADGIVIAKEAFRLVEQTQAYVG
Mb1099c|M.bovis_AF2122/97 SGLVSRVVPADDLLTEARATATTISQMSASAARMAKEAVNRAFESSLSEG
Rv1070c|M.tuberculosis_H37Rv SGLVSRVVPADDLLTEARATATTISQMSASAARMAKEAVNRAFESSLSEG
MLBr_02402|M.leprae_Br4923 SGLVSRVVLADDLLPEAKAVATTISQMSRSATRMAKEAVNRSFESTLAEG
MAB_1185c|M.abscessus_ATCC_199 SGLVSRVVATESLLDEAKAVAKTISEMSLSASMMAKEAVNRAFESSLAEG
*:.: . : .*: * . ::*. .. :****.. :: *
Mflv_4357|M.gilvum_PYR-GCK EEVASYLFHAYGTNLQFADGEFNFVKTRAQHGTKEAFRLRDEHFHVPEP-
Mvan_1987|M.vanbaalenii_PYR-1 EEVASYLFHAYGTNLQFAEGEFNFVKTRAQHGTKEAFRLRDEHFFVPEPG
MSMEG_2223|M.smegmatis_MC2_155 EEVASYLFHAYGTNLQFAPGEFNFVKTRAQHGTKEAFRLRDQHFHVPEPQ
MAV_1585|M.avium_104 EEVASYLFHAFGTNLQFAPGEFNFVKTRAEHGAKEAFRLRDEHFHVPEPE
TH_1117|M.thermoresistible__bu EEVASYLFHAFGTNLQFAPGEFNFVKTRAEHGTKEAFRLRDEHFHVPEPE
MMAR_4020|M.marinum_M EEVASYLFHAFGTNLQFAPGEFNFVKTRAEHGTKEAFRLRDEHFHVPEPE
MUL_3885|M.ulcerans_Agy99 EEVASYLFHAFGANLQFAPGEFNSVKTRAEHGTKEAFRLRDEYFHVPEPE
Mb1099c|M.bovis_AF2122/97 LLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR---------------
Rv1070c|M.tuberculosis_H37Rv LLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR---------------
MLBr_02402|M.leprae_Br4923 LLHERRLFHSTFVTDDQSEGMAAFIEKRAPQFTHR---------------
MAB_1185c|M.abscessus_ATCC_199 LLFERRIFHSAFGTADQSEGMAAFVEKRPANFIHR---------------
:**: . : : * ::.*. : :.
Mflv_4357|M.gilvum_PYR-GCK -------
Mvan_1987|M.vanbaalenii_PYR-1 PRPDPSP
MSMEG_2223|M.smegmatis_MC2_155 -------
MAV_1585|M.avium_104 A------
TH_1117|M.thermoresistible__bu PR-----
MMAR_4020|M.marinum_M S------
MUL_3885|M.ulcerans_Agy99 S------
Mb1099c|M.bovis_AF2122/97 -------
Rv1070c|M.tuberculosis_H37Rv -------
MLBr_02402|M.leprae_Br4923 -------
MAB_1185c|M.abscessus_ATCC_199 -------