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TAADGPDDRVQFEAEPGTRIATITLNNPTRRNAYDAAMRDAIAGYLDRVAADDDLTVVILRGTGGVFSAG ADMNNAYGWYGEADAPAADPPTQRRPSQRRRLTVDRRSFSFYHNLMGFPKVTVGEIAGHALGGGFEMALM TDISVIARNARIGMPATRFLGPALGSLHMFFHRLGPVLARRLLLTGDIIEAGDVEHLGIFTDTCDSGAVA ARARYWAEKAAKMPADGIVIAKEAFRLVEQTQAYAGEEVASYLFHAFGTNLQFAPGEFNFVKTRAEHGTK EAFRLRDEHFHVPEPES*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4020 | echA4_2 | - | 100% (298) | enoyl-CoA hydratase, EchA4_2 |
| M. marinum M | MMAR_1002 | echA4 | 5e-23 | 28.67% (286) | enoyl-CoA hydratase, EchA4 |
| M. marinum M | MMAR_2863 | echA13 | 2e-19 | 30.67% (238) | enoyl-CoA hydratase EchA13 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0692 | echA4 | 8e-24 | 29.72% (286) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4357 | - | 1e-139 | 81.08% (296) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv0673 | echA4 | 8e-24 | 29.72% (286) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 2e-18 | 25.95% (262) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3859c | - | 2e-20 | 28.12% (288) | enoyl-CoA hydratase |
| M. avium 104 | MAV_1585 | - | 1e-142 | 83.56% (298) | enoyl-CoA hydratase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_2223 | - | 1e-135 | 80.97% (289) | enoyl-CoA hydratase/isomerase family protein |
| M. thermoresistible (build 8) | TH_1117 | - | 1e-138 | 82.07% (290) | enoyl-CoA hydratase/isomerase family protein |
| M. ulcerans Agy99 | MUL_3885 | echA4_2 | 1e-167 | 96.98% (298) | enoyl-CoA hydratase, EchA4_2 |
| M. vanbaalenii PYR-1 | Mvan_1987 | - | 1e-137 | 80.74% (296) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4020|M.marinum_M ---MTAADGPDDRVQFEAEPGTRIATITLNNPTRRNAYDAAMRDAIAGYL
MUL_3885|M.ulcerans_Agy99 ---MTAADGPDDRVQFEAELGTRIATITLNNPTRRNAYDAAMRDAIAGYL
MAV_1585|M.avium_104 ---MTASSTSDDRVLFDVDAEHRIATITLNNAKQRNSYDAAMREAIARCL
TH_1117|M.thermoresistible__bu ------MPTTDDRVLFDVDRDKRIATITLNNPAQRNSYDAAMRDALERCL
Mflv_4357|M.gilvum_PYR-GCK -----MTTTDDDRVLFDVDRDTRIATITLNNPKQRNSYDAAMRNLLARHL
Mvan_1987|M.vanbaalenii_PYR-1 -----MTTAEDNRVLFEVDRDKRIATITLNNPKQRNSYDASMRNLLARYL
MSMEG_2223|M.smegmatis_MC2_155 -------------MLFEVDDDHRIATITLNNPKQRNSYDAAMRDQLARYL
Mb0692|M.bovis_AF2122/97 MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTPLELSALV
Rv0673|M.tuberculosis_H37Rv MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTPLELSALV
MAB_3859c|M.abscessus_ATCC_199 --------MVDTLKTMTYEVTDRVARITFNRPEQGNAIIADTPLELAALV
MLBr_02402|M.leprae_Br4923 ----------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAA
: : *:. **:*.. *: : :
MMAR_4020|M.marinum_M DRVAADDDLTVVILRGTGGVFSAGADMNNAYG-----------WYG--EA
MUL_3885|M.ulcerans_Agy99 DRVAADDDLTVVILRGTGGVFSAGADMNNAYG-----------WYG--EA
MAV_1585|M.avium_104 DRVAEDDDLTVVLLRGAEGVFSTGADMNNAYG-----------WYG----
TH_1117|M.thermoresistible__bu DQVAEDDDLTVVLLRGADGVFSTGADMNNAYA-----------WYG----
Mflv_4357|M.gilvum_PYR-GCK DEVAEDDDITVVLLRGAEGVFSTGADMNNAYG-----------WYG--PE
Mvan_1987|M.vanbaalenii_PYR-1 DDVAEDDDITVLLLRGADGVFSTGADMNNAYG-----------WYG--PD
MSMEG_2223|M.smegmatis_MC2_155 DIVAEDDDLTVVLLRGAEGVFSTGADMNNAYG-----------WYGSKAE
Mb0692|M.bovis_AF2122/97 ERADLDPGVHVILVSGRGEGFCAGFDLS-AYAEGSSSTGGGGAYQG---T
Rv0673|M.tuberculosis_H37Rv ERADLDPGVHVILVSGRGEGFCAGFDLS-AYAEGSSSTGGGGAYQG---T
MAB_3859c|M.abscessus_ATCC_199 ERADLDPQVHVILVSGRGDGFCGGFDLS-AYAEAND--EGSVRYSG---T
MLBr_02402|M.leprae_Br4923 KELDIDPDVGAILITGSPKVFAAGADIK----------------------
. * : .::: * *. * *:.
MMAR_4020|M.marinum_M DAPAADPPTQRRPSQRRRLTVDRRSFSFYHN----LMGFPKVTVGEIAGH
MUL_3885|M.ulcerans_Agy99 DAPAADPPTQRRPSQRRRLTVDPRSFSFYHN----LMGFPKVTVGEIAGH
MAV_1585|M.avium_104 TSRNADESTRRRPSQRRRLTVDRKSFGFYHN----FMGFPKVTVGEIAGY
TH_1117|M.thermoresistible__bu EEN--SPQARRRPSQRRRLTVDRRTFGFYHN----FMGFPKVTVGEISGY
Mflv_4357|M.gilvum_PYR-GCK DPAGAGKPRKSRPSQRRRLTVDRKSFGFYHN----LMGFPKVTVGEISGY
Mvan_1987|M.vanbaalenii_PYR-1 KQD---KPAKNRPSQRRRLTVDRKSFGFYHN----LMGFPKVTVGEISGY
MSMEG_2223|M.smegmatis_MC2_155 NGKAEQEQPKSRPSQRRRLTVDRKTFGFYHN----FMGFPKVTVGEISGF
Mb0692|M.bovis_AF2122/97 VLDGKTQAVNHLPNQPWDPMIDYQMMSRFVRGFASLMHADKPTVVKIHGY
Rv0673|M.tuberculosis_H37Rv VLDGKTQAVNHLPNQPWDPMIDYQMMSRFVRGFASLMHADKPTVVKIHGY
MAB_3859c|M.abscessus_ATCC_199 ALDGQVQLRNHLPNINWDPMLDYQMMSRFTRGFSSLLHANKPTVVKVHGY
MLBr_02402|M.leprae_Br4923 ----------EMASLTFTDAFDADFFSAWGK----LAAVRTPMIAAVAGY
.. .* :. : . : . : : *.
MMAR_4020|M.marinum_M ALGGGFEMALMTDISVIARNARIGMPATRFLGPA-LGSLHMFFHRLGPVL
MUL_3885|M.ulcerans_Agy99 ALRGGFEMALMTDISVIARNARIGMPATRFLGPA-LGSLHMFFHRLGPVL
MAV_1585|M.avium_104 ALGGGFEMALMTDISVIARDTKIGMPATRFLGPA-LGSLHMFFHRLGPVL
TH_1117|M.thermoresistible__bu ALGGGFELALMCDIAVIGRDAKIGMPATRFLGPA-LGSLHMFFHRLGPVL
Mflv_4357|M.gilvum_PYR-GCK ALGGGFEMALMTDISVIARDTRIGMPATRFLGPA-LGSLHLFFHRLGPVQ
Mvan_1987|M.vanbaalenii_PYR-1 ALGGGFEMALMTDISVIARDTRIGMPATRFLGPA-LGSLHMFFHRLGPVL
MSMEG_2223|M.smegmatis_MC2_155 ALGGGFEMALMTDISVIARDTRIGMPATRFLGPA-LGSLHMFFHRLGPVL
Mb0692|M.bovis_AF2122/97 CVAGGTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAHRLGDQR
Rv0673|M.tuberculosis_H37Rv CVAGGTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAHRLGDQR
MAB_3859c|M.abscessus_ATCC_199 CVAGGTDIALHADQLIVAADAKIGYPPTRVWG---VPATGLWAHKLGDQR
MLBr_02402|M.leprae_Br4923 ALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAK
.: ** ::*: * : . :::* * :. : . : :*
MMAR_4020|M.marinum_M ARRLLLTGDIIEAGDVEHLGIFTDTCDSGAVAARARYWAEKAAKMPADGI
MUL_3885|M.ulcerans_Agy99 ARRVLLTGDIIEAGDVEHLGIFTDTCDCGAVAARARYWAEKAAKMPADGI
MAV_1585|M.avium_104 ARRLLLTGDIIDAGQVEHLGIFTDTCDPAAVTARARYWAEKAAKMPADGV
TH_1117|M.thermoresistible__bu ARRLLLTGDIIEAGSVEHLGVFTETCDPAMVGPRARYWAEKAAKMPADGV
Mflv_4357|M.gilvum_PYR-GCK ARRLLLTGDIIRAADVEHLGVFTETCDADAVTARARYWAEKAAKMPADGV
Mvan_1987|M.vanbaalenii_PYR-1 ARRLLLTGDIIRAGEVEHLGVFTDTCDAAAVPARARYWAEKAAKMPADGV
MSMEG_2223|M.smegmatis_MC2_155 ARRLLLTGDVIEAGAIEHLGIFTETCDGSQVAARARYWAQKAAKMPADGV
Mb0692|M.bovis_AF2122/97 AKRLLFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIAALPVNQL
Rv0673|M.tuberculosis_H37Rv AKRLLFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIAALPVNQL
MAB_3859c|M.abscessus_ATCC_199 AKRLLLTGDCLSGRQAYDWGLAVEAPEPDELDERTERLVERIAAMPLNQL
MLBr_02402|M.leprae_Br4923 AMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQMSRSAT
* :::** : . *: . : .:. . : :. .
MMAR_4020|M.marinum_M VIAKEAFRLVEQTQAYAGEEVASYLFHAFGTNLQFAPGEFNFVKTRAEHG
MUL_3885|M.ulcerans_Agy99 VIAKEAFRLVEQTQAYVGEEVASYLFHAFGANLQFAPGEFNSVKTRAEHG
MAV_1585|M.avium_104 VIAKEAFRLVEQSQAYQGEEVASYLFHAFGTNLQFAPGEFNFVKTRAEHG
TH_1117|M.thermoresistible__bu VIAKEAFRLVEQSQAYQGEEVASYLFHAFGTNLQFAPGEFNFVKTRAEHG
Mflv_4357|M.gilvum_PYR-GCK VIAKEAFRLVEQSQAYQGEEVASYLFHAYGTNLQFADGEFNFVKTRAQHG
Mvan_1987|M.vanbaalenii_PYR-1 VIAKEAFRLVEQSQAYQGEEVASYLFHAYGTNLQFAEGEFNFVKTRAQHG
MSMEG_2223|M.smegmatis_MC2_155 VIAKEAFRLVEQSQAYQGEEVASYLFHAYGTNLQFAPGEFNFVKTRAQHG
Mb0692|M.bovis_AF2122/97 IMVKLALNSALLQQGVATSRMVSTVFDGAAR---HTPEGHAFVADAVEHG
Rv0673|M.tuberculosis_H37Rv IMVKLALNSALLQQGVATSRMVSTVFDGAAR---HTPEGHAFVADAVEHG
MAB_3859c|M.abscessus_ATCC_199 MMIKLACNSVLINQGIANSAMIGTVFDGISR---HTPEAHAFTADAIANG
MLBr_02402|M.leprae_Br4923 RMAKEAVNRSFESTLAEGLLHERRLFH------------STFVTDDQSEG
: * * . :*. . .*
MMAR_4020|M.marinum_M TKEAFRLRDEHFHVPEPES------
MUL_3885|M.ulcerans_Agy99 TKEAFRLRDEYFHVPEPES------
MAV_1585|M.avium_104 AKEAFRLRDEHFHVPEPEA------
TH_1117|M.thermoresistible__bu TKEAFRLRDEHFHVPEPEPR-----
Mflv_4357|M.gilvum_PYR-GCK TKEAFRLRDEHFHVPEP--------
Mvan_1987|M.vanbaalenii_PYR-1 TKEAFRLRDEHFFVPEPGPRPDPSP
MSMEG_2223|M.smegmatis_MC2_155 TKEAFRLRDQHFHVPEPQ-------
Mb0692|M.bovis_AF2122/97 FRDAVRRRDEPFGDYGRQASRV---
Rv0673|M.tuberculosis_H37Rv FRDAVRRRDEPFGDYGRQASRV---
MAB_3859c|M.abscessus_ATCC_199 YRQAVRHRDEPFGDYGRKPTEL---
MLBr_02402|M.leprae_Br4923 MAAFIEKRAPQFTHR----------
.. * *