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MATATTQRPLKGPAKRMSTWTMTREAITIGFDAGDGFLGRLRGSDITRFRCAGRRFVSISHPDYVDHVLH EARLKYVKSDEYGPIRATAGLNLLTDEGDSWARHRGALNSTFARRHLRGLVGLMIDPIADVTAALVPGAQ FDMHQSMVETTLRVVANALFSQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGV HLPPPLREMQEITLTLDRAINSVIDRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGHETTA NAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRYFSSVWIIAREAVDDDI IDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLRCPTDRPRCAYLPFGGGRRICIGQSFALMEMV LMAAIMSQHFTFDLAPGYHVELEATLTLRPKHGVHVIGRRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1429c | cyp132 | - | 100% (461) | cytochrome P450 132 |
| M. bovis AF2122 / 97 | Mb1694c | cyp139 | 5e-28 | 28.08% (349) | cytochrome P450 139 CYP139 |
| M. bovis AF2122 / 97 | Mb0141 | cyp138 | 7e-26 | 27.08% (373) | cytochrome P450 138 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4801 | - | 3e-37 | 28.34% (434) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1394c | cyp132 | 0.0 | 99.78% (461) | cytochrome P450 132 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-10 | 24.64% (211) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1426 | - | 1e-51 | 31.74% (460) | putative cytochrome P450 |
| M. marinum M | MMAR_0281 | cyp183B1 | 2e-34 | 27.76% (425) | cytochrome P450 183B1 Cyp183B1 |
| M. avium 104 | MAV_5160 | - | 3e-26 | 25.72% (381) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_0968 | - | 4e-32 | 26.60% (406) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3255 | - | 3e-30 | 26.02% (415) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 6e-33 | 28.32% (346) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0245 | - | 4e-34 | 28.06% (392) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1429c|M.bovis_AF2122/97 MATAT---------------------TQRPLKGPAKRMSTWTMTREAITI
Rv1394c|M.tuberculosis_H37Rv MATAT---------------------TQRPLKGPAKRMSTWTMTREAITI
MSMEG_0968|M.smegmatis_MC2_155 MVSDVPAVTAPPGRSADASGANAKPDTGALPLAPRNPLSLRQMARAVR--
TH_3255|M.thermoresistible__bu MVVTT-----------------ERADVATLPPAPRNPLPYWRQVRAVR--
Mvan_0245|M.vanbaalenii_PYR-1 MVGTV-----------------EREDLGALPLAPRNPLPYRQQVRAIR--
MUL_0604|M.ulcerans_Agy99 MVDPP--------------------DIRSLPLAPRNPLPYWQQLKALK--
MAB_1426|M.abscessus_ATCC_1997 MSASALQPEPLSAPVEVAAG---ECPVNHDLYPGGPTFLRWHHTRVGYLK
MMAR_0281|M.marinum_M -------------------------MPTSIPIAPAALPLLGHTLPLLR--
Mflv_4801|M.gilvum_PYR-GCK MVDHR-------------------QPFPPLPHPPRRVPVVGDVFGFSA--
MAV_5160|M.avium_104 -----------------------MSEVATAPLAAVHLPPAVRGPKLLQGI
MLBr_02088|M.leprae_Br4923 MRTCVPTR----------TCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLR
Mb1429c|M.bovis_AF2122/97 GFDAGDGFLGRLRGSDITRFRCAG---------RRFVS----ISHPDYVD
Rv1394c|M.tuberculosis_H37Rv GFDAGDGFLGRLRGSDITRFRCAG---------RRFVS----ISHPDYVD
MSMEG_0968|M.smegmatis_MC2_155 ALDMGQQVIRAAGG-AVTRVQFGP---------RWLVPPLVAVFSPEGIR
TH_3255|M.thermoresistible__bu SFHTGQELLRDAGG-PVK----------------WAIPPIVLVTSPAGIR
Mvan_0245|M.vanbaalenii_PYR-1 TFHTGLETLRDAGG-PVTRLKLAP---------KWLMPPMVVATSPQGAR
MUL_0604|M.ulcerans_Agy99 TLHVGSEALRDAGG-SVTRIWLGP---------KRLVPPMVMVTSPQGAR
MAB_1426|M.abscessus_ATCC_1997 SWRLALGAVWSTYRHTISEYLADLPGQDDVIVARAPMRKAVIVRNPELAR
MMAR_0281|M.marinum_M --NPLSFLLSLPARGDLVRIRIGP-------------ATAVVACTAELTH
Mflv_4801|M.gilvum_PYR-GCK --DILTRPPSDPGLGPVFEFRFLG-------------ARYVVAASADAVA
MAV_5160|M.avium_104 GFAVSRRTMMRRLSRRYGNVFTLR---------LPMWGPVVMVSDPQLAK
MLBr_02088|M.leprae_Br4923 LIDPGTRADPFPVYRALIDYGPMQLPG------MPLTVFSSFSDCDEALR
Mb1429c|M.bovis_AF2122/97 HVLHEAR---LKYVK--SDEYGPIRATAGLNLLTDEGD--SWARHRGALN
Rv1394c|M.tuberculosis_H37Rv HVLHEAR---LKYVK--SDEYGPIRATAGLNLLTDEGD--SWARHRGALN
MSMEG_0968|M.smegmatis_MC2_155 DVLGRND---AFAER--CIVHDEVRHAAGDSLFVLPNE--QWRPRKRALQ
TH_3255|M.thermoresistible__bu DVLNRRD---ALSER--CQVHHEVRHLGGDSLFVLPTD--PWRARRRALA
Mvan_0245|M.vanbaalenii_PYR-1 DILARGG---GHIDK--TRVHHEMRRLLGANLFDLTHE--PWLPRRRALQ
MUL_0604|M.ulcerans_Agy99 DVLGRSG---ALSDRGTLPLLKDLRRAIGESVLNLPHD--TWLPRRRTLQ
MAB_1426|M.abscessus_ATCC_1997 HVLVANQ---DNYIK--SAEYDLLAVGFGRGLVTDLNEG-LWNRNRRLVQ
MMAR_0281|M.marinum_M EILCDDR---IFDKG--GIFFDRFREMLGDGLGTCPRS--QHRRQRRLLQ
Mflv_4801|M.gilvum_PYR-GCK EVNDERR---FCKHVG--PDIDALRIMGGDGLFTAYNEEPNWQRAHDLLM
MAV_5160|M.avium_104 QIFTTSP---DELGN---IQPNLSRLFGSGSVFGLEGD--DHRRRRRLLA
MLBr_02088|M.leprae_Br4923 HPLSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPP--DHTRLRKLVS
. . .. : :
Mb1429c|M.bovis_AF2122/97 STFARRHLRGLVGLMIDPIADVTAALVPGA------QFDMHQSMVETTLR
Rv1394c|M.tuberculosis_H37Rv STFARRHLRGLVGLMIDPIADVTAARVPGA------QFDMHQSMVETTLR
MSMEG_0968|M.smegmatis_MC2_155 PVFTKHSVRAFGGHMSRAAQTLVDEWADQWAQADSLEVDLDAVCRRVTMQ
TH_3255|M.thermoresistible__bu PVFTPTAVRSYGGYMSEAAQRVADGWQAAR------EVDLDAECRRLTMR
Mvan_0245|M.vanbaalenii_PYR-1 PIFTKQHVREFAGHMATAAQTVADSWADGT------ELDLDTECRKLTLR
MUL_0604|M.ulcerans_Agy99 PIFTKQRVAGFAGHMSEAANHILLGWPDGA------EVDLNAASHALVLR
MAB_1426|M.abscessus_ATCC_1997 PIFAKRQVDLFAPQMAEAAARTISRWDELYAEGK--PVDITAEMNYLTMD
MMAR_0281|M.marinum_M PAFHTQRLPGYAQTMTTEVAATVGRWQNGQ------IIDVPAEMMAITGR
Mflv_4801|M.gilvum_PYR-GCK PAFSQQAMRGYHSAMLDAADGLVARWDGKARTG--ASVDVPADATRVTLE
MAV_5160|M.avium_104 PPFHGKSMKNYESIIEEETLRETAGWPEGE------SFPTLPPMMRITLN
MLBr_02088|M.leprae_Br4923 KAFAPKVVQALEGDIAALVDSLLDKGAAAG------QFDVIADLAFPLAV
* : : .
Mb1429c|M.bovis_AF2122/97 VVANALFSQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLI
Rv1394c|M.tuberculosis_H37Rv VVANALFSQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLI
MSMEG_0968|M.smegmatis_MC2_155 SLGRSVLGIDLNERADVIVEHMH----------------VASSYATDRAL
TH_3255|M.thermoresistible__bu SLGRSVLGLDINERADAISEPMH----------------IASSYTADRAL
Mvan_0245|M.vanbaalenii_PYR-1 ALGRSVLGLDLDEHSDAIAEPLR----------------TALEYIADRAL
MUL_0604|M.ulcerans_Agy99 VVGHSVFGLDLQDKADVITTGVT----------------LAAKWAADRSA
MAB_1426|M.abscessus_ATCC_1997 IVAQTMFGIDLSGDMAERMRIYFARLLKLFGVGFIVGAAPPLRWVVDKLA
MMAR_0281|M.marinum_M TLLATMFSNSLPNPALRQALDDLT---------------AIFAVLYWRML
Mflv_4801|M.gilvum_PYR-GCK TIGQCAAGHPFGCFDTEDPHPFVEH--------------MVAGLKGSDWV
MAV_5160|M.avium_104 AILRAVFGAEGAELDELRRLIPP-----------------WVTLGSRLAA
MLBr_02088|M.leprae_Br4923 AVICRLLGVPYEDAPEFG----------------------RVSALLVQSV
: .
Mb1429c|M.bovis_AF2122/97 WC-------------IYSGVHLPPPLR-EMQEITLTLDRAINSVIDRRLA
Rv1394c|M.tuberculosis_H37Rv WC-------------IYSGVHLPPPLR-EMQEITLTLDRAINSVIDRRLA
MSMEG_0968|M.smegmatis_MC2_155 RP-------------LRAPRWLPTPARRRARAAVAAMRAVTAEILQACRD
TH_3255|M.thermoresistible__bu RP-------------VRAPRWLPTPARRRARAAVATMRRITDEMLQACRA
Mvan_0245|M.vanbaalenii_PYR-1 QP-------------ISAPRWLPTPARRRARAASSTLHKLADKILQACRT
MUL_0604|M.ulcerans_Agy99 RP-------------VRAPHWLPTPARPRARGAYDAMYKIAADMLAACRA
MAB_1426|M.abscessus_ATCC_1997 AHGPDELSSHTPRLAIRALRIGASVAAPRTMKGLRWVERTIDQLIADHRS
MMAR_0281|M.marinum_M TP--------------PPLDRLPTVGNRRYHRASARLRHTIGSAVAGRRA
Mflv_4801|M.gilvum_PYR-GCK GVLR----------ETVLPNFFARRAERRVRRHAVQMHRIADEIVSERLR
MAV_5160|M.avium_104 LP--------------KPQRYPRFGPWGQLDRWRRQYDGVIERLIAAEQA
MLBr_02088|M.leprae_Br4923 DP-------------FITITGEPPEATEERLRAGVWLRDYLEQLVKCRRG
. :
Mb1429c|M.bovis_AF2122/97 E-PTNSADLLNVLLSAD----GGIWPRQRVRDEALTFMLAGHETTANAMS
Rv1394c|M.tuberculosis_H37Rv E-PTNSADLLNVLLSAD----GGIWPRQRVRDEALTFMLAGHETTANAMS
MSMEG_0968|M.smegmatis_MC2_155 D-ADRDAPLVRALMAAEDPETGERLSDEDICNDLLIFMLAGHDTTATALT
TH_3255|M.thermoresistible__bu D-PDRDAPLVHALIRATDPETGRGLSDEDICNDLLIFMLAGHDTTATALT
Mvan_0245|M.vanbaalenii_PYR-1 D-PTRDAPLVQALIAASDPATGRPLSDDEIRDELIVFMLAGHDTTATTLT
MUL_0604|M.ulcerans_Agy99 D-PSREAPLITALIDATGPNTGESLSDQQICDEMVYFMILGEDTTSTVLT
MAB_1426|M.abscessus_ATCC_1997 GRIARQDNLLALLMAAEDPETGAKYTDLEIRDELMTFLGAGFETTAAALA
MMAR_0281|M.marinum_M AGVDRGDLLSAILASHEVDSSTVAFTDTEVIDQIVSFFIAGTETTALTVA
Mflv_4801|M.gilvum_PYR-GCK DGLGHHDDLLELMLTSD-------LDPANIRYQLINFLVAGHETTSGALS
MAV_5160|M.avium_104 DPNFAERTDVLALLLRSTYDDGAAMSHKEIGDELLTLLAAGHETTASTLA
MLBr_02088|M.leprae_Br4923 T---PGEDLISRLIELD--ESGDQLTEEEIIATCGLLLVAGHETTVNLIA
: : :: * :** ::
Mb1429c|M.bovis_AF2122/97 WFWYLMALNPQARDHMLTELDDVLG-MRRPTADDLGKLAWTTACLQESQR
Rv1394c|M.tuberculosis_H37Rv WFWYLMALNPQARDHMLTELDDVLG-MRRPTADDLGKLAWTTACLQESQR
MSMEG_0968|M.smegmatis_MC2_155 YALWALGHHPEIQDRVAAEARALG--DRELTPADVPQLGYTVQVLHESLR
TH_3255|M.thermoresistible__bu YALWALGHHPEIQDRVAAEVAELP--DREITPHDVPRLGYTVQVLRESLR
Mvan_0245|M.vanbaalenii_PYR-1 YAMWALGHHHDVQDRVRAEVVGIG--DRELTPEDVPALGYTIQVLHEALR
MUL_0604|M.ulcerans_Agy99 YALWALGQHCQLQDRLAAEAAELG--DRPLTPADVPRLGYTIQVLQEAMR
MAB_1426|M.abscessus_ATCC_1997 WTWYLLSRNPDARAKLGQEVDRVLG-GRQPTAADVDNLPWTAAVLNEAMR
MMAR_0281|M.marinum_M WALYLLAEHPAIEQRVHAEIDPVLA-GRAATHADLPRLGLVNRIVTETLR
Mflv_4801|M.gilvum_PYR-GCK FALYFLSRHPEVADRARAEVAEVWGDDERPGFELIAKLRYVRRVLDEALR
MAV_5160|M.avium_104 WAFERISRHPELLARLVEEADNGGN-------------ELRQAAILEVQR
MLBr_02088|M.leprae_Br4923 NAVLAMLRNPSQWKALSSNP------------------QRAPLVVEETLR
: : : : * *
Mb1429c|M.bovis_AF2122/97 YFSSVWIIAREAVDDDIIDG-HRIRRGTTVVIPIHHIHHDPRWWPDPDRF
Rv1394c|M.tuberculosis_H37Rv YFSSVWIIAREAVDDDIIDG-HRIRRGTTVVIPIHHIHHDPRWWPDPDRF
MSMEG_0968|M.smegmatis_MC2_155 MCPPAAGVGRLALRDIAVAG-HRVEAGSLVALGIYAVHHDPQLWPDPEVF
TH_3255|M.thermoresistible__bu LCPPAAGVGRLAMSDLAVDG-YRVEAGTLLAVGIQAIHRDPSLWPDPMVF
Mvan_0245|M.vanbaalenii_PYR-1 LCPPAAATARMAMRDVEVDG-YRIEAGSMMAVGIYALHRDPALWERPLVF
MUL_0604|M.ulcerans_Agy99 LRPPGPTVARRAMQDIEVDG-YRVQAGTYCLVGVYAMHRDPALWDDPLAF
MAB_1426|M.abscessus_ATCC_1997 VYPPILGLARTAKADDVLGD-YPISAGTTVMVLIDSIHHNERVWDDAKTF
MMAR_0281|M.marinum_M LYPPGWIISRVATADVYLGG-HRIPAGATVIFSPYLIHHRPDLYAEPERF
Mflv_4801|M.gilvum_PYR-GCK LQPTVPGYYREAREDTVLAGVHPMRQGDWVLAMTMALHRDPRWGGDPDAF
MAV_5160|M.avium_104 ARTVIDFAGRHVYPDVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPRRF
MLBr_02088|M.leprae_Br4923 YDPAIHLIGRVAAKDMTIGQ-TTLTEGDTMVLLLAAANRDPAVYSRPDEF
. * . * : * : . *
Mb1429c|M.bovis_AF2122/97 DPGRFLR-CPTDRPRCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFT
Rv1394c|M.tuberculosis_H37Rv DPGRFLR-CPTDRPRCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFT
MSMEG_0968|M.smegmatis_MC2_155 DPDRFSPENSRERDRWHFIPFAGGARACIGEHFARLETTLALATIIRSVV
TH_3255|M.thermoresistible__bu DPDRFAPERFKAMDRWQFVPFIGGPRSCIGEHFAMLESTLAIATLIRSVR
Mvan_0245|M.vanbaalenii_PYR-1 DPDRFSAQNSGGRDRWQYLPFGAGPRSCIGDHFAMLEATLALATIIRSAE
MUL_0604|M.ulcerans_Agy99 DPDRFAPKKSKGRDRWQYLPFGGGGRSCLGDHFAMLEASLALATIIREAE
MAB_1426|M.abscessus_ATCC_1997 DPARFLKENLQPEQRKAHMPFGAGKRMCVASGFANLEAIIGIAALAQNYE
MMAR_0281|M.marinum_M DPDRWLPERARAIGRNTYIPFGGGARKCIGDNFGTTEAALALATIAANWR
Mflv_4801|M.gilvum_PYR-GCK DPDRFAPDRVRARPAGLYKPFGTGPRSCIGRQFALHEAVLLLAVLLRRYD
MAV_5160|M.avium_104 DPQRFIDNKPSALS---WIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFT
MLBr_02088|M.leprae_Br4923 DPD---------RPSSRHLAFAVGSHFCLGAALARLEATVTLSAISARFP
** .* * : *:. :. * : :
Mb1429c|M.bovis_AF2122/97 FD-LAPGYH-VELEATLTLRPKHGVHVIGRRR-----------------
Rv1394c|M.tuberculosis_H37Rv FD-LAPGYH-VELEATLTLRPKHGVHVIGRRR-----------------
MSMEG_0968|M.smegmatis_MC2_155 VGSVDAEFP-VDVPFTTVAKGPIRANVAPRGPDHYTL------------
TH_3255|M.thermoresistible__bu IRSLDDDFP-VEVPFTTVARGPIRAVVSARR------------------
Mvan_0245|M.vanbaalenii_PYR-1 IRSSDPHFP-MIVPFTTVAAEPIRARVKSVNRIPAADSGGR--------
MUL_0604|M.ulcerans_Agy99 IHSLDGDFP-VAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDSSASS-
MAB_1426|M.abscessus_ATCC_1997 LDLLPGQQPRREVTFTGGPEGEILMRLRKRHP-----------------
MMAR_0281|M.marinum_M MQRLPGLPVRPAVAASLRPRN-LALRVTARTADRVPGEPGRRLTSREIG
Mflv_4801|M.gilvum_PYR-GCK LVPEPGYQLQVAQRLTLMPKDFRLTLRRRRSE-----------------
MAV_5160|M.avium_104 IETTDAPDEPWHCRGVAFTPKHGGRIVVHRR------------------
MLBr_02088|M.leprae_Br4923 QVQLAGELV---YKPNVAMRGMSALPVQV--------------------