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ERVWQWAWDRCGARYSWAICVVTFAVVLPVYLLLSFWVVAFENSGHYIEAAVVTVAVVSLGLWVIFLPSV VRRRLPEKWAADHDVDRLSALEATYVYGRGAVARGLGSNVVLGAFNLVAVGAVAGASGSRLVQYGIVGAA TGIGIQLIAIHSFVEAALRPARVAIIGDTAIGDSLPRSRPTFAAWSNLSVFGVAFNFAIVGAMLAGLISQ AHTVPLVSLVIGAGMAVVFGVPVIVAPSFSPSMQPIRDLAAGTERVAAGDYSRRLPVVQDDDLGALAASF NHMQAGLVERQRLQAAFGTYVDPGLAARLLVQGDDVFTGERRQVTVMFVDVRDFTPFAEAHTAEDTVSRL NELFEIVVPTVVDAGGHVNKFLGDGALAVFGAPNDLAGHADAAVAAAILIHRRVVERFGEEFRIGIGINT GVVIAGTIGGGGKLEFTLIGDTVNVAARVEQLTKATGDAILLTQQCVDAQGSRPAGLIDRGLHVLKGKSA AIQVFGLHQESDMRADLTH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4438 | - | - | 100% (510) | hypothetical protein MMAR_4438 |
| M. marinum M | MMAR_2550 | - | e-164 | 71.81% (408) | transmembrane protein |
| M. marinum M | MMAR_5137 | - | 2e-39 | 34.85% (330) | adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3669 | - | 1e-40 | 34.22% (374) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1395 | - | 1e-43 | 33.33% (405) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv3645 | - | 1e-40 | 34.22% (374) | transmembrane protein |
| M. leprae Br4923 | MLBr_00201 | - | 7e-42 | 35.85% (371) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_0490c | - | 3e-38 | 34.05% (370) | putative adenylate cyclase |
| M. avium 104 | MAV_0518 | - | 2e-40 | 33.96% (374) | adenylate cyclase, family protein 3 |
| M. smegmatis MC2 155 | MSMEG_6154 | - | 4e-42 | 33.60% (372) | adenylate cyclase, family protein 3 |
| M. thermoresistible (build 8) | TH_0858 | - | 2e-43 | 34.84% (399) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_4617 | - | 0.0 | 98.04% (510) | hypothetical protein MUL_4617 |
| M. vanbaalenii PYR-1 | Mvan_5395 | - | 6e-42 | 32.56% (433) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1395|M.gilvum_PYR-GCK ---------------------MAADPTETGRISAFVRWVARTPWPVFTLG
Mvan_5395|M.vanbaalenii_PYR-1 ---------------------MAAEPIEVGRISAFVRWVARTPWPVFTLG
MSMEG_6154|M.smegmatis_MC2_155 ---------------------MTTEPIPIARIGAFARWVARTPWPVFTLG
TH_0858|M.thermoresistible__bu ---------------------------------------------VFALG
Mb3669|M.bovis_AF2122/97 MDAEAFVGFRQVPAARYGGLMATTAA-LPRRIHAFVRWVVRTPWPLFSLS
Rv3645|M.tuberculosis_H37Rv MDAEAFVGFRQVPAARYGGLMATTAA-LPRRIHAFVRWVVRTPWPLFSLS
MLBr_00201|M.leprae_Br4923 --------------------MATQAAGLPGRIGAFVRWGIRTPWPLFSLS
MAV_0518|M.avium_104 ---------------------MTTAAALPGRISAFARWVVRTPWPLFWLS
MAB_0490c|M.abscessus_ATCC_199 ----------------MTGAEGRPDRRPLARAARYSRWVMRTPWPLFIMG
MMAR_4438|M.marinum_M ----------------------------MERVWQWAWDRCGARYSWAICV
MUL_4617|M.ulcerans_Agy99 ----------------------------MERVWQWAWDRCGARYSWAICV
Mflv_1395|M.gilvum_PYR-GCK MLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLGYLFVSFTVA
Mvan_5395|M.vanbaalenii_PYR-1 MLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLGYLFISFTVA
MSMEG_6154|M.smegmatis_MC2_155 MLQADIIGALFVLGFLRFGLPPEDRIQLQDLPAFNLAIFLAYLFVSFTVG
TH_0858|M.thermoresistible__bu MVQADIIGALFVLGFLRFGLPPGDRLELQDLPAFNLALFLGYLVVSFTVG
Mb3669|M.bovis_AF2122/97 MLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVSTVIILFLAG
Rv3645|M.tuberculosis_H37Rv MLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVSTVIILFLAG
MLBr_00201|M.leprae_Br4923 MLQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLAISTLSVVVAFSTG
MAV_0518|M.avium_104 MMQADIIGALFVLGFLRYALPPEDRIQLQDLPVVNLAVFATSLVVLFLAA
MAB_0490c|M.abscessus_ATCC_199 IAQSNLVGALFVLGFLRFGLPPSDRVELTELGPTRLIILGFSLFILFVVG
MMAR_4438|M.marinum_M VTFAVVLPVYLLLSFWVVAFENSG--HYIEAAVVTVAVVSLGLWVIFLPS
MUL_4617|M.ulcerans_Agy99 VTFAVVLPVYLLLSFWVVAFENSG--HYIEAAVVTVAVVSLGLWVIFLPS
: : :: . ::*.* .: . . : : : : : * .
Mflv_1395|M.gilvum_PYR-GCK SYLTLRMLIPVMRWQRRDMLLGDRDPSDTEVARMRALKMPFYRSLISATN
Mvan_5395|M.vanbaalenii_PYR-1 SYVTLRMLIPVMRWQRREMLLGDRDPAETEVARMRALKMPFYRSLISATN
MSMEG_6154|M.smegmatis_MC2_155 AYLALRLLIPVIRWQRRETVLSEGDPGITELARARALKMPFYRTLISVTN
TH_0858|M.thermoresistible__bu AYVTLRLLLPVIRWQRRDTLLADPDPAATELARARALRMPFYRTLISGTN
Mb3669|M.bovis_AF2122/97 AVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPLYRTLISLAV
Rv3645|M.tuberculosis_H37Rv AVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPLYRTLISLAV
MLBr_00201|M.leprae_Br4923 FAVNLKLLMPVFRWQRRDNRLAEADPAATELARSRALRMPFYHTIISLVT
MAV_0518|M.avium_104 SVVNLTLLMPVFRWQRRDNLLAESDPAATELARIRALRMPFYRTVTSMVI
MAB_0490c|M.abscessus_ATCC_199 AIVSTYLLLPVLRWQYRS---PDFESEGSEAVRVRALQMPFYRTVISVAT
MMAR_4438|M.marinum_M VVRRR----LPEKWAADHDVDRLSALEATYVYGRGAVARGLGSNVVLGAF
MUL_4617|M.ulcerans_Agy99 VVRRR----LPEKWAADHDVDRLSALEATYVYGRDAVVRGLGSNVVLGAF
:* : *: : .: .
Mflv_1395|M.gilvum_PYR-GCK WLLGSVVFIVASWPVASKSAPVVAVATGLGATATAIIGYLQSERVLRPVA
Mvan_5395|M.vanbaalenii_PYR-1 WLLGSVVFIVASWPVASKSAPVVAVATALGATATAIIGYLQSERVLRPVA
MSMEG_6154|M.smegmatis_MC2_155 WCLGSIVFIVASWPVASHSAPVVAVATALGATATAIIGYLQSERVLRPVA
TH_0858|M.thermoresistible__bu WFLGTIVFIVASWPVAGHSAPVIAVATGLGATATAIIGYLQAERVLRPVA
Mb3669|M.bovis_AF2122/97 WATGGGVFILASWSVAKHAAPVVAVATALGATATAIIGYLQSERVLRPVA
Rv3645|M.tuberculosis_H37Rv WATGGGVFILASWSVAKHAAPVVAVATALGATATAIIGYLQSERVLRPVA
MLBr_00201|M.leprae_Br4923 WGIGGAVFIIASWSAARHSAPIVALATALGATATAIIGYLQSERVLRPVA
MAV_0518|M.avium_104 WCIGGVVFIIASWSVARFAAPVVAVATGLGAAATAIIGYLQCERVLRPVA
MAB_0490c|M.abscessus_ATCC_199 WLVGGAIFVAVTWSSTHSSVLVAAFATVLGATTTSIIGYLQSERVLRPVA
MMAR_4438|M.marinum_M NLVAVGAVAGASGSRLVQYG-IVGAATGIGIQLIAIHSFVEA--ALRPAR
MUL_4617|M.ulcerans_Agy99 NLVAVGAVAGASGSRLVQYG-IVGAATGIGIQLIAIHSFVEA--ALRPVR
. . .: . : . ** :* :* .:::. .***.
Mflv_1395|M.gilvum_PYR-GCK VAALRGGVPENFRAPGVILRQVLTWVLSTGVPVLAIVLALVASKFEVLTA
Mvan_5395|M.vanbaalenii_PYR-1 VAALRGGVPENFRAPGVILRQVLSWVLSTGVPVLAILLALIASKLEVLTA
MSMEG_6154|M.smegmatis_MC2_155 VAALRGGVPENFRAPGVILRQVLTWVLSTGVPLLAIILALVASKFSILTA
TH_0858|M.thermoresistible__bu VAALRGGVPENFRAPGVVLRQVLTWVLSTGVPVLAIVLALVASKVGILTA
Mb3669|M.bovis_AF2122/97 VAALRSGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIALLHA
Rv3645|M.tuberculosis_H37Rv VAALRSGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIALLHA
MLBr_00201|M.leprae_Br4923 VAALRSGVPENVKTPGVTLRLMLTWVPSTGVPVLAIVLAVVADKIALLHA
MAV_0518|M.avium_104 VAALRSGVPENVKAPGVILRQILTWMLSTAVPVLAIVLAVVADKTSLLHA
MAB_0490c|M.abscessus_ATCC_199 IQALRRGVPENVTAPGVIVRQILTWALSTGVPILAIVLTVVGQRAGYLKS
MMAR_4438|M.marinum_M VAIIG-----DTAIGDSLPRSRPTFAAWSNLSVFGVAFNFAIVGAMLAGL
MUL_4617|M.ulcerans_Agy99 VAIIG-----DTAIGDSLPRSRPTFAAWSNLSVFGVAFNFAIVGAMLAGL
: : : . * :: : :.::.: : .
Mflv_1395|M.gilvum_PYR-GCK PADRLITTILLLAIVA-LIIGLSSTVLVAMSIAD---PLRQLRWALGEVQ
Mvan_5395|M.vanbaalenii_PYR-1 PADRLITTILLLSIVA-LVIGLSSTVLVAMSIAD---PLRQLRWALGEVQ
MSMEG_6154|M.smegmatis_MC2_155 SADRLNTPILLLAVAA-LVIGMSSTVLVAMSIAD---PLRQLRWALGEVQ
TH_0858|M.thermoresistible__bu PAEQLTTPLLVLAIAT-LVIGLSGTVLVAMSIAD---PLRQLRWALGEVQ
Mb3669|M.bovis_AF2122/97 TPEALFNPILMMALAA-LGIGSVSTLLVAMSIAD---PLRQLRWALSEVQ
Rv3645|M.tuberculosis_H37Rv TPEALFNPILMMALAA-LGIGSVSTLLVAMSIAD---PLRQLRWALSEVQ
MLBr_00201|M.leprae_Br4923 VPEQLFSPILLLALAV-LVVGLVSTWLVAMSIAD---PLRQLRWALSEVQ
MAV_0518|M.avium_104 TPEKLFTPILLLAVAA-LGIGLVSTLLVAMSIAD---PLRQLRWALSEVQ
MAB_0490c|M.abscessus_ATCC_199 NADNLTGSILILAIIA-LAIGLMGTLLVATSIAD---PLRQLRWALSEVQ
MMAR_4438|M.marinum_M ISQAHTVPLVSLVIGAGMAVVFGVPVIVAPSFSPSMQPIRDLAAGTERVA
MUL_4617|M.ulcerans_Agy99 ISQAHTVPLVSLVIGAGMAVVFGVPVIVAPSFSPSMQPSRDLAAGTERVA
.: .:: : : . : : . :** *:: * *:* . .*
Mflv_1395|M.gilvum_PYR-GCK RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
Mvan_5395|M.vanbaalenii_PYR-1 RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
MSMEG_6154|M.smegmatis_MC2_155 RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
TH_0858|M.thermoresistible__bu RGNFNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
Mb3669|M.bovis_AF2122/97 RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
Rv3645|M.tuberculosis_H37Rv RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
MLBr_00201|M.leprae_Br4923 RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
MAV_0518|M.avium_104 RGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVAR
MAB_0490c|M.abscessus_ATCC_199 RGNYNAHVPIYDASELGLLQAGFNDMVRDLGERQRLRDLFGRYVGEDVAR
MMAR_4438|M.marinum_M AGDYSRRLPVVQDDDLGALAASFNHMQAGLVERQRLQAAFGTYVDPGLAA
MUL_4617|M.ulcerans_Agy99 AGDYSRRLPVVQDDDLGALAASFNHMQAGLVERQRLQAAFGTYVDPGLAA
*::. :: : : .:** * *.**.* * *****: ** **. .:*
Mflv_1395|M.gilvum_PYR-GCK RALERG-TELGGQERDVAVLFVDLVGSTHLAATIPASEVVSLLNEFFRVV
Mvan_5395|M.vanbaalenii_PYR-1 RALERG-TELGGQERDVAVLFVDLVGSTHLAATRPAAEVVNLLNEFFRVV
MSMEG_6154|M.smegmatis_MC2_155 RALERG-TELGGQERDVAVLFVDLVGSTHLASTIPAADVVNLLNEFFRVI
TH_0858|M.thermoresistible__bu RALERG-TELGGQERDVAVLFVDLVGSTRLAATTPPADVVNLLNEFFRVV
Mb3669|M.bovis_AF2122/97 RALERG-TELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFRVV
Rv3645|M.tuberculosis_H37Rv RALERG-TELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFRVV
MLBr_00201|M.leprae_Br4923 RALEHG-TELGGQERDVAVLFVDLIGSTQLAETKPPTKVVHLLNEFFRVV
MAV_0518|M.avium_104 RALERG-TELGGQERDVAVLFVDLVGSTQLAATRPPAEVVHLLNEFFRVV
MAB_0490c|M.abscessus_ATCC_199 RALEYG-TELGGQERSVAVLFVDLVGSTQLASTRGPAVVVRVLNEFFRVI
MMAR_4438|M.marinum_M RLLVQGDDVFTGERRQVTVMFVDVRDFTPFAEAHTAEDTVSRLNELFEIV
MUL_4617|M.ulcerans_Agy99 RLLEQGDDVFTGERRQVTVMFVDVRDFTPFAEAHAAEDTVSRLNELFEIV
* * * : *:.*.*:*:***: . * :* : . .* ***:*.::
Mflv_1395|M.gilvum_PYR-GCK VDTVNRHGGFVNKFQGDAALAIFGAPIEHPDASGAALAASRELHDELINV
Mvan_5395|M.vanbaalenii_PYR-1 VDTVNRHGGFVNKFQGDAALAIFGAPIEHPDASGAALAASRELHDELIRV
MSMEG_6154|M.smegmatis_MC2_155 VDTVNKHGGFVNKFQGDAALAIFGAPIEHPDASGGALAASRELHDELIKV
TH_0858|M.thermoresistible__bu VDTVNRHGGFVNKFQGDAALAIFGAPIEHPDACGAALAAARELHDELIAV
Mb3669|M.bovis_AF2122/97 VETVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALSAARELHDELIPV
Rv3645|M.tuberculosis_H37Rv VETVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALSAARELHDELIPV
MLBr_00201|M.leprae_Br4923 VDTVGRHGGFVNKFQGDAALAIFGAPIEHPDSAGAALSAARELHDELLPV
MAV_0518|M.avium_104 VETVGKHGGFVNKFQGDAALAIFGAPIEHPDSPGGALAAARELHDALLPV
MAB_0490c|M.abscessus_ATCC_199 VDTVNKHGGFVNKFQGDAALAIFGAPIDHPDGAAAALAAARELSGELTNV
MMAR_4438|M.marinum_M VPTVVDAGGHVNKFLGDGALAVFGAPNDLAGHADAAVAAAILIHRRVVER
MUL_4617|M.ulcerans_Agy99 VPTVVDAGGHVNKFLGDGALAVFGTPNDLADHADAAVAAAVLIHRRVVER
* ** **.**** **.***:**:* : .. .*::*: : :
Mflv_1395|M.gilvum_PYR-GCK LG-ETEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEP
Mvan_5395|M.vanbaalenii_PYR-1 LG-ETDFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEP
MSMEG_6154|M.smegmatis_MC2_155 LGTETEFGIGVSAGRAIAGHIGAKARFEYTVIGDPVNEAARLTELAKLEE
TH_0858|M.thermoresistible__bu LG-ETEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEE
Mb3669|M.bovis_AF2122/97 LG-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLED
Rv3645|M.tuberculosis_H37Rv LG-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLED
MLBr_00201|M.leprae_Br4923 LG-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLED
MAV_0518|M.avium_104 IG-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEP
MAB_0490c|M.abscessus_ATCC_199 LG-SNDFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKNEP
MMAR_4438|M.marinum_M FGEEFRIGIGINTGVVIAGTIGGGGKLEFTLIGDTVNVAARVEQLTKATG
MUL_4617|M.ulcerans_Agy99 FGEEFRIGIGINTGVVIAGTIGGG-KLEFTLIGDTVNVAARVEQLTKATG
:* . :***:.:* .*** **. ::*:*:***.** ***: :*:*
Mflv_1395|M.gilvum_PYR-GCK GHVLASSLAVADALDAEALCWNVGEVVELRGRTAPTQLARPVNLIRPPRV
Mvan_5395|M.vanbaalenii_PYR-1 GHVLASAIAVADALDAEALCWDVGEIVELRGRTAPTQLARPVNLVSPDDV
MSMEG_6154|M.smegmatis_MC2_155 GHVLASAIAVSGALDSEALCWDVGEIVELRGRTVPTQLARPINLARPEDL
TH_0858|M.thermoresistible__bu GHVLASAMAVSGALDAEALCWDVGETVELRGRTVPTQLARPVKLAFSNGP
Mb3669|M.bovis_AF2122/97 GHVLASAIAVSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEV
Rv3645|M.tuberculosis_H37Rv GHVLASAIAVSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEV
MLBr_00201|M.leprae_Br4923 GHVLASAIAVSGALDAEALCWNVGEIVELRGRTAPTQLARPLNLAVPEQI
MAV_0518|M.avium_104 GHVLASAIAVSGALDSEALCWDVGEVVELRGRTAPTQLARPVKLATPEEV
MAB_0490c|M.abscessus_ATCC_199 GNVLASASAVMEARDEEALRWDVGETVELRGRTVSTQVARPRHG------
MMAR_4438|M.marinum_M DAILLTQQCVDAQGSRPAGLIDRGLHVLKGKSAAIQVFGLHQESDMRADL
MUL_4617|M.ulcerans_Agy99 DAILLTQQCVDAQGSRPAGLIDRGLHVLKGKSAAIQVFGLHQESDMRADL
. :* : .* . * : * * :. .. .
Mflv_1395|M.gilvum_PYR-GCK EE-KVADDVPSTTR--------------------------
Mvan_5395|M.vanbaalenii_PYR-1 SQ-EVASDRR------------------------------
MSMEG_6154|M.smegmatis_MC2_155 DG-SANGQSTDGSPAETAFQQEKGLFAVEGVEVVGASVPG
TH_0858|M.thermoresistible__bu GP-SNNSDAPGTRTTGSVSRADAETTAPES----------
Mb3669|M.bovis_AF2122/97 S-----SEVRG-----------------------------
Rv3645|M.tuberculosis_H37Rv S-----SEVRG-----------------------------
MLBr_00201|M.leprae_Br4923 T-----SEVTG-----------------------------
MAV_0518|M.avium_104 APQEVSSEVSG-----------------------------
MAB_0490c|M.abscessus_ATCC_199 ----------------------------------------
MMAR_4438|M.marinum_M TH--------------------------------------
MUL_4617|M.ulcerans_Agy99 TH--------------------------------------