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SYVRTIPEFLSTAAADIGGIGSALTDASSAAAGPTTNLLAAAADEVSAVVSKVFGGYGLSAQAVLTQASA FHDEFTELLANAGGIYAQAEVDNAEALTNAVGEFSEPFIQLWDPSYTYVGSNIATGPNPQPNEPSLTPEF ALIMGGTFDPQPFPLYVTTINNAFIQPFFPGATSVGLSYPAQFWPLTSGLTLNQSVAEGVIDLNNALSVQ INGGQHVINFGFSQSAVVATQEMQRLMALPVGMRPDPSDLSFVLAGNPATPNGGIFTRFPGMHIPFVDLT FTSPTPPDTPYPTTIYATQYDPTSDFPRYPLNILSDLNTLMSLGQHELYPNLDVSNAVQLPTSPDYTGNT TYYMFMTKNLPLLEPVRAIPFIGNPIADFIQPDLRVLVDLGYSDWGSGQDYANVPTPATLFPIPNPFVIG TDLVIGAVHGSTALAVDLGLLPASALPNAYPYLPSLDTDLNFFLGQPGVTDISLVTNAIGPVLQRLPAIN PG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0382 | - | - | 100% (493) | PE-PGRS family protein |
| M. marinum M | MMAR_0384 | - | e-132 | 49.30% (501) | PE family protein, PE4 |
| M. marinum M | MMAR_0383 | - | e-128 | 49.30% (503) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0164c | PE3 | 1e-128 | 50.10% (493) | PE family protein |
| M. gilvum PYR-GCK | Mflv_1918 | - | 5e-30 | 31.47% (375) | hypothetical protein Mflv_1918 |
| M. tuberculosis H37Rv | Rv0159c | PE3 | 1e-128 | 50.10% (493) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 2e-11 | 25.69% (288) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 2e-29 | 32.10% (324) | PE/PPE family protein |
| M. avium 104 | MAV_0534 | - | 3e-14 | 41.84% (98) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5455 | - | 3e-35 | 31.91% (304) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 7e-39 | 36.39% (294) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 1e-130 | 48.90% (501) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_4726 | - | 5e-34 | 34.74% (308) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1918|M.gilvum_PYR-GCK MGKGDFGLKASEFTGRSSTRFADSVRRRPGGATYGLYRHDGLGVGTWAWV
Mvan_4726|M.vanbaalenii_PYR-1 ------------------------MRRRLRSAAWGLLSLVIAVLFAWGSV
Mb0164c|M.bovis_AF2122/97 ------------------MSYVIAAPEMLATAAADVDGIGSAIRAASASA
Rv0159c|M.tuberculosis_H37Rv ------------------MSYVIAAPEMLATTAADVDGIGSAIRAASASA
MUL_1034|M.ulcerans_Agy99 ------------------MSYVLTAPDLLASAATDVDGIAATLQVANSAA
MMAR_0382|M.marinum_M ------------------MSYVRTIPEFLSTAAADIGGIGSALTDASSAA
MAV_0534|M.avium_104 ------------------MSFLMVRPEILDAAARELHGINAAVLQSNSAA
MSMEG_5455|M.smegmatis_MC2_155 ------------------------MGRLLHSLSTAFLVFVAVVVLCVSTS
TH_3724|M.thermoresistible__bu ------------------------------VVAVGALTWGGXGVASPAGQ
MAB_4141|M.abscessus_ATCC_1997 ----------------------MAGQYSVPGKRHSLRRYVATITAVAATC
MLBr_01232|M.leprae_Br4923 ------------------------MKRLLATTLAALTVGTVSGFGSTVAS
Mflv_1918|M.gilvum_PYR-GCK FARSSRSFPRSRRCWRYPRGVPTPVAVLVANTTALVMGGTFHPLTGPRDS
Mvan_4726|M.vanbaalenii_PYR-1 VTSTS-----------------------AGAGTALVMGGNGHPLSVPQDT
Mb0164c|M.bovis_AF2122/97 AGPTTGLLAAAADEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAA
Rv0159c|M.tuberculosis_H37Rv AGPTTGLLAAAADEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAA
MUL_1034|M.ulcerans_Agy99 AALTSGLLAAAQDEVSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAA
MMAR_0382|M.marinum_M AGPTTNLLAAAADEVSAVVSKVFGGYGLSAQAVLTQASAFHDEFTELLAN
MAV_0534|M.avium_104 VTPTTALAPAAADVVSLVTAARFSRHGLAFQEVSAQAAQLRDQFATTLGI
MSMEG_5455|M.smegmatis_MC2_155 MPTAAHLLLN--------------------HPHALVIGGTGTPVPPPEYV
TH_3724|M.thermoresistible__bu PERAAALR-------------------LTATADAIIMPGTKIGYIPSQDE
MAB_4141|M.abscessus_ATCC_1997 TVLAP-----------------------LAMESRTIASTLASYVIGIGGN
MLBr_01232|M.leprae_Br4923 SEPGEPWLPPSPVPVRE---------NSPAKIVYALGGARPPTFDWDYYT
Mflv_1918|M.gilvum_PYR-GCK PEFVTAYLDNAVDNQIS------------------------------AAY
Mvan_4726|M.vanbaalenii_PYR-1 PDYINKYVTAADDAFIAP-----------------------------SGL
Mb0164c|M.bovis_AF2122/97 AGAAYAQAEASNTAAMSG-------------------------TAGSSGA
Rv0159c|M.tuberculosis_H37Rv AGAAYAQAEASNTAAMSG-------------------------TAGSSGA
MUL_1034|M.ulcerans_Agy99 AGAAYAQAEAANASLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGA
MMAR_0382|M.marinum_M AGGIYAQAEVDNAEALTNAVG-----EFSEPFIQLWDPSYTYVGSNIATG
MAV_0534|M.avium_104 SAGSYAAAEIANTAAVG---------------------------------
MSMEG_5455|M.smegmatis_MC2_155 NGQTDNYIGAEFPGEYR---------------------------------
TH_3724|M.thermoresistible__bu FTAYATAVIGATAGAPG---------------------------------
MAB_4141|M.abscessus_ATCC_1997 NDGASANIPRKLGGAYS---------------------------------
MLBr_01232|M.leprae_Br4923 IRAGDEFFPDVNRKLIDYP-------------------------------
Mflv_1918|M.gilvum_PYR-GCK GYAVTNAVAVYTPEEFFPLG---GLTFDDSVAEGLANLGRCLRAEPGCVF
Mvan_4726|M.vanbaalenii_PYR-1 CGPQCSLVATYTPAQIRFVNGIFDMTYDESVAVGQANLNDCIQGSD-CTA
Mb0164c|M.bovis_AF2122/97 LGSVG-MLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVA
Rv0159c|M.tuberculosis_H37Rv LGSVG-MLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVA
MUL_1034|M.ulcerans_Agy99 LTAVSSTLMADPVVALIMGGTSVPLPGPGYVSDINNNYIQPLFSGAIPQA
MMAR_0382|M.marinum_M PNPQPNEPSLTPEFALIMGGTFDPQPFPLYVTTINNAFIQPFFPGATSVG
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 -------YAVHTPQNFWPVYG--SMSFDESTVAGLAALQAEMAKEG----
TH_3724|M.thermoresistible__bu -----AVDYLGVPGEFWPATGLDSLTFDASVAXGQAMLTPMVDGAIES--
MAB_4141|M.abscessus_ATCC_1997 ----VDYHPVSYPGAIWPVSGLTAPTFKTSVAQGRTNLNDEIVTAG----
MLBr_01232|M.leprae_Br4923 -----ARAPFRYVPTFLVPGPRDEVTIGEAIAVATKNLNQAIHRGT----
Mflv_1918|M.gilvum_PYR-GCK NADPAVAARVG-----------------------TVAPRHDDTFVVFGYS
Mvan_4726|M.vanbaalenii_PYR-1 TLAPYSETGPH-----------------------TVA---DSTYVIYAYS
Mb0164c|M.bovis_AF2122/97 QYTPEQWWPF---IGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYS
Rv0159c|M.tuberculosis_H37Rv QYTPEQWWPF---IGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYS
MUL_1034|M.ulcerans_Agy99 LFTPEQFWPVTPGLGNLTFNQSVAQGVTLLNDAINTQLALGNKVVAFGYS
MMAR_0382|M.marinum_M LSYPAQFWPLT---SGLTLNQSVAEGVIDLNNALSVQINGGQHVINFGFS
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 --------------------------------------HFGSPLVILGYS
TH_3724|M.thermoresistible__bu ----------------------------------------DTPIVVFGHS
MAB_4141|M.abscessus_ATCC_1997 ----------------------------------------NQPITIVGYS
MLBr_01232|M.leprae_Br4923 -----------------------------------------EPAAVVGLS
Mflv_1918|M.gilvum_PYR-GCK QSAAVASLLKRQLIDAPGP---EPAATTFMLAANPMRPNGGVLGRFPALT
Mvan_4726|M.vanbaalenii_PYR-1 QSATVAANQKLQLIAHP-----VASTVSFLLVANPNRPDGGILERFVGAY
Mb0164c|M.bovis_AF2122/97 QSAAVATNEIRALMALPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLY
Rv0159c|M.tuberculosis_H37Rv QSAAVATNEIRALMALPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLY
MUL_1034|M.ulcerans_Agy99 QSATIVNNEILALMAMGTG-APDPGDLSFIMVGAPNNPDGGLLARFPGFY
MMAR_0382|M.marinum_M QSAVVATQEMQRLMALPVGMRPDPSDLSFVLAGNPATPNGGIFTRFPGMH
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 SSTRILTADKNRRIADG----DYAVDINYVLVSDVAKGNGGVMARFPGWH
TH_3724|M.thermoresistible__bu QSAVIATKEKQRLLAEYPD-PDTAPDVTFVMVANPNRPNGGLLARFPGLY
MAB_4141|M.abscessus_ATCC_1997 LGAVVVSKSHSDLLQRYPG---GNPNIQFVLMGSANTPNGGIFARFPWLK
MLBr_01232|M.leprae_Br4923 QGSLALDTEQEQLATDPTA--PPPDQLTFNTFGDPSGYHGFGKSVLASIF
Mflv_1918|M.gilvum_PYR-GCK IPILGITFHGATPTAGVDG-AYRTVDVVRQYDGLGGDFPVRPLNLLATVN
Mvan_4726|M.vanbaalenii_PYR-1 IPLLGITFNGSTPTFSPQPRPLTTVDVARQYDGWA-DFPTNPLNLLADLN
Mb0164c|M.bovis_AF2122/97 LTFLDMSFNGATPPD----SPYQTYMYTGQYDGYA-HNPQYPLNILSDLN
Rv0159c|M.tuberculosis_H37Rv LPFLDMSFNGATPPD----SPYQTYMYTGQYDGYA-HNPQYPLNILSDLN
MUL_1034|M.ulcerans_Agy99 IPFLDVSFNGATPAA----NPYPTSIFTAQYDGIA-HAPQYRLNILSDIN
MMAR_0382|M.marinum_M IPFVDLTFTSPTPPD----TPYPTTIYATQYDPTS-DFPRYPLNILSDLN
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 IPILGVTFDGATRTDS-DGYAFDTKSISFVHDGWS-DFPVYPLNVLALAN
TH_3724|M.thermoresistible__bu IPILGVTFNGATPAPADG--PFDSYDVAREFDGWA-DFPRYPLNLVATAN
MAB_4141|M.abscessus_ATCC_1997 IPLADIESNGAWEPD-----QFKTKVINTEYDTYG-DFPAY-FNPLALAN
MLBr_01232|M.leprae_Br4923 RPGDYIPLIDYTMPQR-MDSQYDSNRVVAAYDGLS-EFPDRADNLLAQLN
Mflv_1918|M.gilvum_PYR-GCK ALLGYGIMHGETVDVPFAQARFQ---------GREGDTDYYLIGTDLLPL
Mvan_4726|M.vanbaalenii_PYR-1 AIMGTILLHPNYSDA--GTPQLQ---------GQYQDSTYYLIPAPITPV
Mb0164c|M.bovis_AF2122/97 AFMGIRWVHNAYPFTAAEVANAVPLP---TSPGYTGNTHYYMFLTQDLPL
Rv0159c|M.tuberculosis_H37Rv AFMGIRWVHNAYPFTAAEVANAVPLP---TSPGYTGNTHYYMFLTQDLPL
MUL_1034|M.ulcerans_Agy99 AIMGYFYVHGNYP--DLMSGQAIQLP---TSPGYTGNTDYYMYLTQDLPL
MMAR_0382|M.marinum_M TLMSLG-QHELYP--NLDVSNAVQLP---TSPDYTGNTTYYMFMTKNLPL
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 AVAGIAVLHPTYP--ELDRPDLVP-------VGSTGDTEYFVIGTDIMPL
TH_3724|M.thermoresistible__bu AILGIYYLHGGYYELLTENPDILDDPE-RTIVQQYGDTTYYLIRTEQLPL
MAB_4141|M.abscessus_ATCC_1997 SIAAIQYAHPDAYYDRIDPAALDDPDNPNVVKTVQGNTTYYLVRAEHLPL
MLBr_01232|M.leprae_Br4923 CFAGGAISHTPSGFFNPEDVPPQNIR--TTVNSRGAKTTTYLIPVNHLPL
Mflv_1918|M.gilvum_PYR-GCK LQPL--LLFVP--RPILSALDAPLRVLVEDAYDRDAG----PGDPTTARW
Mvan_4726|M.vanbaalenii_PYR-1 LVPLTWVPIVG--KPLAIALDPAVRVLVEMGYDRTVN----PGQPTPARY
Mb0164c|M.bovis_AF2122/97 LQPIRAIPFVG--TPIAELIQPDLRVLVDLGYG-YG----YADVPTPASL
Rv0159c|M.tuberculosis_H37Rv LQPIRAIPFVG--TPIAELIQPDLRVLVDLGYG-YG----YADVPTPASL
MUL_1034|M.ulcerans_Agy99 VQPIRDIPYAG--PPLADLIQPQLRVLVDLGYSDYGPGLSYADVPTPAGL
MMAR_0382|M.marinum_M LEPVRAIPFIG--NPIADFIQPDLRVLVDLGYSDWGSGQDYANVPTPATL
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 LMPLETIGVP---RPILLAVDEPLRVLVEAGYRRDIA----PGAPTPARL
TH_3724|M.thermoresistible__bu LRPLRDLGVP---EEFVDALEPYVRRIVDLGYDRNTP----YGEPAPVRV
MAB_4141|M.abscessus_ATCC_1997 LQPLRDLTNPIGASFVLDAIEPTLRVFIDMAYDRDTG----PGTTTQFSF
MLBr_01232|M.leprae_Br4923 TLPLRYLGWSD---ALVDQIDAVLQPKIDAAYAYNDN-------------
Mflv_1918|M.gilvum_PYR-GCK WPVKDFAGTAAKLIASVPVAVDNLTEGFGLG---RVLGTPVPG-VFGVGG
Mvan_4726|M.vanbaalenii_PYR-1 LYVPNLIKAALNFAMAIPTGWDDAISYLTGDPDCRPFHTTVPASPFGVGG
Mb0164c|M.bovis_AF2122/97 FAPINPIAVASALATGTVQGPQAALVSIG----------LLPQSALPNTY
Rv0159c|M.tuberculosis_H37Rv FAPINPIAVASALATGTVQGPQAALVSIG----------LLPQSALPNTY
MUL_1034|M.ulcerans_Agy99 LSVPNPFAVSYYLLKGSLQAPYGAAVEIGVE------AGLLGPESFPDTY
MMAR_0382|M.marinum_M FPIPNPFVIGTDLVIGAVHGSTALAVDLG----------LLPASALPNAY
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 IPIVNPITLTRNFIAAIPVGVDDAMEELGHG----RPLGTQPSGVFGVGG
TH_3724|M.thermoresistible__bu LPPLTPAPGPATQHNAGQGITVASATSTPDK--------RTPVVEAPVEE
MAB_4141|M.abscessus_ATCC_1997 FTPSKNIVDAFNKLPTAIAEGAHNVENGLAGATPKQSASPEKPASPPVPQ
MLBr_01232|M.leprae_Br4923 -PLNKPISVDPVNGMDPIAGIDAELRDSILN-------------------
Mflv_1918|M.gilvum_PYR-GCK P------DLPDVDEGGAVTSDIDEDAVAQRDSASSTERSAPAEESRSAVG
Mvan_4726|M.vanbaalenii_PYR-1 PPVYTGAIDPYGEPTPYLAPPVETHGEAAPGSGSPAAHPAGTEPPETVTF
Mb0164c|M.bovis_AF2122/97 P--------------------------YLPSANPGLMFNFGQSSVTELSV
Rv0159c|M.tuberculosis_H37Rv P--------------------------YLPSANPGLMFNFGQSSVTELSV
MUL_1034|M.ulcerans_Agy99 P--------------------------WVPSLNPGLNFYLGQPSVTLLSL
MMAR_0382|M.marinum_M P--------------------------YLPSLDTDLNFFLGQPGVTDISL
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 E------------DTELKGLPAGVISLAKPTLPVSSHTTVVEKTERKDLA
TH_3724|M.thermoresistible__bu P--------------------------PVQTGRSTLKREKPVSARHLVRN
MAB_4141|M.abscessus_ATCC_1997 PGPTNPGSATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAADPTAISVST
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK GADSDGRDDVVDPEPAAP---------EAETSEAETVT-ETEADDADDAD
Mvan_4726|M.vanbaalenii_PYR-1 SPTTESTPSTLLPETPAESEDMPPDFVENDTPDSDEVS-PTEDDALKDTE
Mb0164c|M.bovis_AF2122/97 LSGALGSVARLIPPIA----------------------------------
Rv0159c|M.tuberculosis_H37Rv LSGALGSVARLIPPIA----------------------------------
MUL_1034|M.ulcerans_Agy99 LSGGLGDIFHLIPPPVFP--------------------------------
MMAR_0382|M.marinum_M VTNAIGPVLQRLPAINPG--------------------------------
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 KPAAEPEPVVEDEPAVEDETPVADTKKASPKPLRPKVRGPISFDAPKLPT
TH_3724|M.thermoresistible__bu SLRAVPGLRRGEPAATPTPDVTPDVTPDAPAGQP----------------
MAB_4141|M.abscessus_ATCC_1997 AGASTARDQDFQPDTKPDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLP
MLBr_01232|M.leprae_Br4923 ---VFAQLRSILPPPPG---------------------------------
Mflv_1918|M.gilvum_PYR-GCK -------------------DGADADDEDIDADGADADGEDTAGNTAEAA-
Mvan_4726|M.vanbaalenii_PYR-1 TINESQDGPTESASGVSGEDAADADSRSADADSLSADAGDSAPADAAAAD
Mb0164c|M.bovis_AF2122/97 --------------------------------------------------
Rv0159c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1034|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0382|M.marinum_M --------------------------------------------------
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 IRKATGDRPLKRLLSALTPKRPKPASSHDAGPAAGNKDTDNADKPAARAD
TH_3724|M.thermoresistible__bu ---------------------EPAEPNESAAPPAAAEADDASE-------
MAB_4141|M.abscessus_ATCC_1997 VAQPGTAPKSPKFPSLKNHLKSVPGLSEKKNPAADASSKHSQPANAPAHT
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK ----------------
Mvan_4726|M.vanbaalenii_PYR-1 TAA-------------
Mb0164c|M.bovis_AF2122/97 ----------------
Rv0159c|M.tuberculosis_H37Rv ----------------
MUL_1034|M.ulcerans_Agy99 ----------------
MMAR_0382|M.marinum_M ----------------
MAV_0534|M.avium_104 ----------------
MSMEG_5455|M.smegmatis_MC2_155 DAA-------------
TH_3724|M.thermoresistible__bu ----------------
MAB_4141|M.abscessus_ATCC_1997 SDKTSDHASETGRGAA
MLBr_01232|M.leprae_Br4923 ----------------