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MSYVIAAPEMLATAAADVDGIGSAIRAASASAAGPTTGLLAAAADEVSSAAAALFSEYARECQEVLKQAA AFHGEFTRALAAAGAAYAQAEASNTAAMSGTAGSSGALGSVGMLSGNPLTALMMGGTGEPILSDRVLAII DSAYIRPIFGPNNPVAQYTPEQWWPFIGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYSQSAAVAT NEIRALMALPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLYLTFLDMSFNGATPPDSPYQTYMYTGQY DGYAHNPQYPLNILSDLNAFMGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTHYYMFLTQDLPLLQPIR AIPFVGTPIAELIQPDLRVLVDLGYGYGYADVPTPASLFAPINPIAVASALATGTVQGPQAALVSIGLLP QSALPNTYPYLPSANPGLMFNFGQSSVTELSVLSGALGSVARLIPPIA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0164c | PE3 | - | 100% (468) | PE family protein |
| M. bovis AF2122 / 97 | Mb0165c | PE4 | e-143 | 53.49% (501) | PE family protein |
| M. bovis AF2122 / 97 | Mb0156c | PE1 | 2e-98 | 47.25% (455) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1918 | - | 1e-33 | 36.99% (292) | hypothetical protein Mflv_1918 |
| M. tuberculosis H37Rv | Rv0159c | PE3 | 0.0 | 99.57% (468) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 7e-09 | 25.40% (252) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 2e-23 | 30.66% (287) | PE/PPE family protein |
| M. marinum M | MMAR_0384 | - | 1e-145 | 54.96% (504) | PE family protein, PE4 |
| M. avium 104 | MAV_0534 | - | 6e-15 | 41.84% (98) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5455 | - | 8e-34 | 32.23% (301) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 3e-39 | 35.64% (275) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 1e-143 | 54.56% (504) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_4726 | - | 2e-35 | 34.78% (322) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1918|M.gilvum_PYR-GCK MGKGDFGLKASEFTGRSSTRFADSVRRRPGGATYGLYRHDGLGVGTWAWV
Mvan_4726|M.vanbaalenii_PYR-1 ------------------------MRRRLRSAAWGLLSLVIAVLFAWGSV
Mb0164c|M.bovis_AF2122/97 ------------------MSYVIAAPEMLATAAADVDGIGSAIRAASASA
Rv0159c|M.tuberculosis_H37Rv ------------------MSYVIAAPEMLATTAADVDGIGSAIRAASASA
MMAR_0384|M.marinum_M ------------------MSYVLTAPDLLASAATDVDGIAATLQVANSAA
MUL_1034|M.ulcerans_Agy99 ------------------MSYVLTAPDLLASAATDVDGIAATLQVANSAA
MAV_0534|M.avium_104 ------------------MSFLMVRPEILDAAARELHGINAAVLQSNSAA
MSMEG_5455|M.smegmatis_MC2_155 ------------------------MGRLLHSLSTAFLVFVAVVVLCVSTS
TH_3724|M.thermoresistible__bu ------------------------------VVAVGALTWGGXGVASPAGQ
MAB_4141|M.abscessus_ATCC_1997 ----------------------MAGQYSVPGKRHSLRRYVATITAVAATC
MLBr_01232|M.leprae_Br4923 ------------------------MKRLLATTLAALTVGTVSGFGSTVAS
Mflv_1918|M.gilvum_PYR-GCK FARSSRSFPRSRRCWRYPRGVPTPVAVLVANTTALVMGGTFHPLTGPRDS
Mvan_4726|M.vanbaalenii_PYR-1 VTSTS-----------------------AGAGTALVMGGNGHPLSVPQDT
Mb0164c|M.bovis_AF2122/97 AGPTTGLLAAAADEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAA
Rv0159c|M.tuberculosis_H37Rv AGPTTGLLAAAADEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAA
MMAR_0384|M.marinum_M AAPTSGLLAAAQDEVSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAA
MUL_1034|M.ulcerans_Agy99 AALTSGLLAAAQDEVSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAA
MAV_0534|M.avium_104 VTPTTALAPAAADVVSLVTAARFSRHGLAFQEVSAQAAQLRDQFATTLGI
MSMEG_5455|M.smegmatis_MC2_155 MPTAAHLLLN--------------------HPHALVIGGTGTPVPPPEYV
TH_3724|M.thermoresistible__bu PERAAALR-------------------LTATADAIIMPGTKIGYIPSQDE
MAB_4141|M.abscessus_ATCC_1997 TVLAP-----------------------LAMESRTIASTLASYVIGIGGN
MLBr_01232|M.leprae_Br4923 SEPGEPWLPPSP-------------VPVRENSPAKIVYALGGARPPTFDW
Mflv_1918|M.gilvum_PYR-GCK PEFVTAYLDNAVDNQIS------------------------------AAY
Mvan_4726|M.vanbaalenii_PYR-1 PDYINKYVTAADDAFIAP-----------------------------SGL
Mb0164c|M.bovis_AF2122/97 AGAAYAQAEASNTAAMSG-------------------------TAGSSGA
Rv0159c|M.tuberculosis_H37Rv AGAAYAQAEASNTAAMSG-------------------------TAGSSGA
MMAR_0384|M.marinum_M AGAAYAQAEAANASLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGA
MUL_1034|M.ulcerans_Agy99 AGAAYAQAEAANASLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGA
MAV_0534|M.avium_104 SAGSYAAAEIANTAAVG---------------------------------
MSMEG_5455|M.smegmatis_MC2_155 NGQTDNYIGAEFPGEYR---------------------------------
TH_3724|M.thermoresistible__bu FTAYATAVIGATAGAPG---------------------------------
MAB_4141|M.abscessus_ATCC_1997 NDGASANIPRKLGGAYS---------------------------------
MLBr_01232|M.leprae_Br4923 DYYTIRAGDEFFPDVNRK--------------------------------
Mflv_1918|M.gilvum_PYR-GCK GYAVTNAVAVYTPEEFFPLG---GLTFDDSVAEGLANLGRCLRAEPGCVF
Mvan_4726|M.vanbaalenii_PYR-1 CGPQCSLVATYTPAQIRFVNGIFDMTYDESVAVGQANLNDCIQGSD-CTA
Mb0164c|M.bovis_AF2122/97 LGSVG-MLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVA
Rv0159c|M.tuberculosis_H37Rv LGSVG-MLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVA
MMAR_0384|M.marinum_M LTAVSSTLMADPVVALIMGGTSVPLPGPGYVSDINNNYIQPLFSGAIPQA
MUL_1034|M.ulcerans_Agy99 LTAVSSTLMADPVVALIMGGTSVPLPGPGYVSDINNNYIQPLFSGAIPQA
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 -------YAVHTPQNFWPVYG--SMSFDESTVAGLAALQAEMAKEG----
TH_3724|M.thermoresistible__bu -----AVDYLGVPGEFWPATGLDSLTFDASVAXGQAMLTPMVDGAIES--
MAB_4141|M.abscessus_ATCC_1997 ----VDYHPVSYPGAIWPVSGLTAPTFKTSVAQGRTNLNDEIVTAG----
MLBr_01232|M.leprae_Br4923 LIDYPARAPFRYVPTFLVPGPRDEVTIGEAIAVATKNLNQAIHRGT----
Mflv_1918|M.gilvum_PYR-GCK NADP-----------------------AVAARVGTVAPRHDDTFVVFGYS
Mvan_4726|M.vanbaalenii_PYR-1 TLAP-----------------------YSETGPHTVA---DSTYVIYAYS
Mb0164c|M.bovis_AF2122/97 QYTPEQWWPF---IGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYS
Rv0159c|M.tuberculosis_H37Rv QYTPEQWWPF---IGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYS
MMAR_0384|M.marinum_M LFTPEQFWPVTPGLGNLTFNQSVAQGVTLLNDAINTQLALGNKVVAFGYS
MUL_1034|M.ulcerans_Agy99 LFTPEQFWPVTPGLGNLTFNQSVAQGVTLLNDAINTQLALGNKVVAFGYS
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 --------------------------------------HFGSPLVILGYS
TH_3724|M.thermoresistible__bu ----------------------------------------DTPIVVFGHS
MAB_4141|M.abscessus_ATCC_1997 ----------------------------------------NQPITIVGYS
MLBr_01232|M.leprae_Br4923 -----------------------------------------EPAAVVGLS
Mflv_1918|M.gilvum_PYR-GCK QSAAVASLLKRQLIDAPGP---EPAATTFMLAANPMRPNGGVLGRFPALT
Mvan_4726|M.vanbaalenii_PYR-1 QSATVAANQKLQLIAHP-----VASTVSFLLVANPNRPDGGILERFVGAY
Mb0164c|M.bovis_AF2122/97 QSAAVATNEIRALMALPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLY
Rv0159c|M.tuberculosis_H37Rv QSAAVATNEIRALMALPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLY
MMAR_0384|M.marinum_M QSATIVNNEILALMAMGTG-APDPGDLSFIMVGAPNNPDGGLLARFPGFY
MUL_1034|M.ulcerans_Agy99 QSATIVNNEILALMAMGTG-APDPGDLSFIMVGAPNNPDGGLLARFPGFY
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 SSTRILTADKNRRIADGDY----AVDINYVLVSDVAKGNGGVMARFPGWH
TH_3724|M.thermoresistible__bu QSAVIATKEKQRLLAEYPD-PDTAPDVTFVMVANPNRPNGGLLARFPGLY
MAB_4141|M.abscessus_ATCC_1997 LGAVVVSKSHSDLLQRYPG---GNPNIQFVLMGSANTPNGGIFARFPWLK
MLBr_01232|M.leprae_Br4923 QGSLALDTEQEQLATDPTA--PPPDQLTFNTFGDPSGYHGFGKSVLASIF
Mflv_1918|M.gilvum_PYR-GCK IPILGITFHGATPTAGVDG-AYRTVDVVRQYDGLGGDFPVRPLNLLATVN
Mvan_4726|M.vanbaalenii_PYR-1 IPLLGITFNGSTPTFSPQPRPLTTVDVARQYDGWA-DFPTNPLNLLADLN
Mb0164c|M.bovis_AF2122/97 LTFLDMSFNGATPPD----SPYQTYMYTGQYDGYA-HNPQYPLNILSDLN
Rv0159c|M.tuberculosis_H37Rv LPFLDMSFNGATPPD----SPYQTYMYTGQYDGYA-HNPQYPLNILSDLN
MMAR_0384|M.marinum_M IPFLDVSFNGATPAA----NPYPTSIFTAQYDGIA-HAPQYPLNILSDIN
MUL_1034|M.ulcerans_Agy99 IPFLDVSFNGATPAA----NPYPTSIFTAQYDGIA-HAPQYRLNILSDIN
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 IPILGVTFDGATRTDS-DGYAFDTKSISFVHDGWS-DFPVYPLNVLALAN
TH_3724|M.thermoresistible__bu IPILGVTFNGATPAPADG--PFDSYDVAREFDGWA-DFPRYPLNLVATAN
MAB_4141|M.abscessus_ATCC_1997 IPLADIESNGAWEPD-----QFKTKVINTEYDTYG-DFPAY-FNPLALAN
MLBr_01232|M.leprae_Br4923 RPGDYIPLIDYTMPQR-MDSQYDSNRVVAAYDGLS-EFPDRADNLLAQLN
Mflv_1918|M.gilvum_PYR-GCK ALLGYGIMH---------GETVDVPFAQARFQGREGDTDYYLIGTDLLPL
Mvan_4726|M.vanbaalenii_PYR-1 AIMGTILLH---------PNYSDA--GTPQLQGQYQDSTYYLIPAPITPV
Mb0164c|M.bovis_AF2122/97 AFMGIRWVHN---AYPFTAAEVANAVPLPTSPGYTGNTHYYMFLTQDLPL
Rv0159c|M.tuberculosis_H37Rv AFMGIRWVHN---AYPFTAAEVANAVPLPTSPGYTGNTHYYMFLTQDLPL
MMAR_0384|M.marinum_M AIMGYFYVHG---NYP--DLMSGQAIQLPTSPGYTGNTDYYMYLTQDLPL
MUL_1034|M.ulcerans_Agy99 AIMGYFYVHG---NYP--DLMSGQAIQLPTSPGYTGNTDYYMYLTQDLPL
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 AVAGIAVLH---------PTYPELDRPDLVPVGSTGDTEYFVIGTDIMPL
TH_3724|M.thermoresistible__bu AILGIYYLHGGY-YELLTENPDILDDPERTIVQQYGDTTYYLIRTEQLPL
MAB_4141|M.abscessus_ATCC_1997 SIAAIQYAHPDAYYDRIDPAALDDPDNPNVVKTVQGNTTYYLVRAEHLPL
MLBr_01232|M.leprae_Br4923 CFAGGAISHTP--SGFFNPEDVPPQNIRTTVNSRGAKTTTYLIPVNHLPL
Mflv_1918|M.gilvum_PYR-GCK LQPL--LLFVP--RPILSALDAPLRVLVEDAYDRDAG----PGDPTTARW
Mvan_4726|M.vanbaalenii_PYR-1 LVPLTWVPIVG--KPLAIALDPAVRVLVEMGYDRTVN----PGQPTPARY
Mb0164c|M.bovis_AF2122/97 LQPIRAIPFVG--TPIAELIQPDLRVLVDLGYG-YG----YADVPTPASL
Rv0159c|M.tuberculosis_H37Rv LQPIRAIPFVG--TPIAELIQPDLRVLVDLGYG-YG----YADVPTPASL
MMAR_0384|M.marinum_M VQPIRDIPYAG--PPLADLIQPQLRVLVDLGYSDYGPGLSYADVPTPAGL
MUL_1034|M.ulcerans_Agy99 VQPIRDIPYAG--PPLADLIQPQLRVLVDLGYSDYGPGLSYADVPTPAGL
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 LMPLETIGVP---RPILLAVDEPLRVLVEAGYRRDIA----PGAPTPARL
TH_3724|M.thermoresistible__bu LRPLRDLGVP---EEFVDALEPYVRRIVDLGYDRNTP----YGEPAPVRV
MAB_4141|M.abscessus_ATCC_1997 LQPLRDLTNPIGASFVLDAIEPTLRVFIDMAYDRDTG----PGTTTQFSF
MLBr_01232|M.leprae_Br4923 TLPLRYLGWSD---ALVDQIDAVLQPKIDAAYAYNDN-----PLNKPISV
Mflv_1918|M.gilvum_PYR-GCK WPVKD-FAGTAAKLIASVPVAVDNLTEGFGLG---RVLGTPVPG-VFGVG
Mvan_4726|M.vanbaalenii_PYR-1 LYVPN-LIKAALNFAMAIPTGWDDAISYLTGDPDCRPFHTTVPASPFGVG
Mb0164c|M.bovis_AF2122/97 FAPIN-PIAVASALATGTVQGPQAALVSIG----LLPQSALPNTYPYLPS
Rv0159c|M.tuberculosis_H37Rv FAPIN-PIAVASALATGTVQGPQAALVSIG----LLPQSALPNTYPYLPS
MMAR_0384|M.marinum_M LSVPN-PFAVSYYLLKGSLQAPYGAAVEIGVEAGLLGPESFPDTYPWVPS
MUL_1034|M.ulcerans_Agy99 LSVPN-PFAVSYYLLKGSLQAPYGAAVEIGVEAGLLGPESFPDTYPWVPS
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 IPIVN-PITLTRNFIAAIPVGVDDAMEELGHG---RPLG-TQPSGVFGVG
TH_3724|M.thermoresistible__bu LPPLT-PAPGPATQHN-AGQGITVASATSTPDKRTPVVEAPVEEPPVQTG
MAB_4141|M.abscessus_ATCC_1997 FTPSKNIVDAFNKLPTAIAEGAHNVENGLAGATPKQSASPEKPASPPVPQ
MLBr_01232|M.leprae_Br4923 DPVNG---------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK GP------DLPDVDEGGAVTSDIDEDAVAQRDSASSTERSAPAEESRSAV
Mvan_4726|M.vanbaalenii_PYR-1 GPPVYTGAIDPYGEPTPYLAPPVETHGEAAPGSGSPAAHPAGTEPPETVT
Mb0164c|M.bovis_AF2122/97 AN--------------PGLMFNFGQSSVTELSVLSGALGSVARLIPPIA-
Rv0159c|M.tuberculosis_H37Rv AN--------------PGLMFNFGQSSVTELSVLSGALGSVARLIPPIA-
MMAR_0384|M.marinum_M LN--------------PGLNFYLGQPSVTLLSLLSGGLGDIFHLIPPPVF
MUL_1034|M.ulcerans_Agy99 LN--------------PGLNFYLGQPSVTLLSLLSGGLGDIFHLIPPPVF
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 GEDTELKGLPAGVISLAKPTLPVSSHTTVVEKTERKDLAKPAAEPEPVVE
TH_3724|M.thermoresistible__bu RS------------------TLKREKPVSARHLVRNSLRAVPGLRRGEPA
MAB_4141|M.abscessus_ATCC_1997 PGPTNPGSATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAADPTAISVST
MLBr_01232|M.leprae_Br4923 -------------------MDPIAGIDAELRDSILNVFAQLRSILPPPPG
Mflv_1918|M.gilvum_PYR-GCK GGADSDGRDDVVDPEPAAP---------EAETSEAETVTETEADDADDAD
Mvan_4726|M.vanbaalenii_PYR-1 FSPTTESTPSTLLPETPAESEDMPPDFVENDTPDSDEVSPTEDDALKDTE
Mb0164c|M.bovis_AF2122/97 --------------------------------------------------
Rv0159c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0384|M.marinum_M P-------------------------------------------------
MUL_1034|M.ulcerans_Agy99 P-------------------------------------------------
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 DEPAVEDETPVADTKKASPKPLRPKVRGPISFDAPKLPTIRKATGDRPLK
TH_3724|M.thermoresistible__bu ATPTPDVTPDVTPDAPAGQ-------------------------------
MAB_4141|M.abscessus_ATCC_1997 AGASTARDQDFQPDTKPDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLP
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK -------------------DGADADDEDIDADGADADGEDTAGNTAEAA-
Mvan_4726|M.vanbaalenii_PYR-1 TINESQDGPTESASGVSGEDAADADSRSADADSLSADAGDSAPADAAAAD
Mb0164c|M.bovis_AF2122/97 --------------------------------------------------
Rv0159c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0384|M.marinum_M --------------------------------------------------
MUL_1034|M.ulcerans_Agy99 --------------------------------------------------
MAV_0534|M.avium_104 --------------------------------------------------
MSMEG_5455|M.smegmatis_MC2_155 RLLSALTPKRPKPASSHDAGPAAGNKDTDNADKPAARADDAA--------
TH_3724|M.thermoresistible__bu --------------------PEPAEPNESAAPPAAAEADDASE-------
MAB_4141|M.abscessus_ATCC_1997 VAQPGTAPKSPKFPSLKNHLKSVPGLSEKKNPAADASSKHSQPANAPAHT
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK ----------------
Mvan_4726|M.vanbaalenii_PYR-1 TAA-------------
Mb0164c|M.bovis_AF2122/97 ----------------
Rv0159c|M.tuberculosis_H37Rv ----------------
MMAR_0384|M.marinum_M ----------------
MUL_1034|M.ulcerans_Agy99 ----------------
MAV_0534|M.avium_104 ----------------
MSMEG_5455|M.smegmatis_MC2_155 ----------------
TH_3724|M.thermoresistible__bu ----------------
MAB_4141|M.abscessus_ATCC_1997 SDKTSDHASETGRGAA
MLBr_01232|M.leprae_Br4923 ----------------