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SPSVAELSQELGEAFRLSSMDDPYPMLAERRRETPVMKGDIMVALGAPSYMGQHAGETHTVFRHDDVMAI LRNHETFSSSIWEISQGPLIGRSILAMDGAEHRQWRGYLQSVFGGKLLSSWDESIFRPLAAKYVADLASK RGADLIAMALEYPLRAIYEILGLEDFKDNYEEFHADVLTILLALWSTPDPAQADQFLLRFQKATEASARS WDRLLPIVQRKRAAGASRNDLISSLIRAEYEGGVLDDEQITSFLRSLLLAATDTTTRQFLNTLTLLLQRP DELDRIRRDRSRLRLALAEGERLEPPALFIPRMITRDVVIRGTELTAGTPLLLAIGSANRDPEAYPPDPD EFRIDRTGPHHATFGFGTHICSGMNTTRREIAALIDAMLDGLPGLRVDPDAPAPLISGIHFRGPSALPVV WD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0272 | cyp226B1 | - | 100% (423) | cytochrome P450 226B1 Cyp226B1 |
| M. marinum M | MMAR_3996 | cyp187A4 | 7e-50 | 32.60% (411) | cytochrome P450 187A4 Cyp187A4 |
| M. marinum M | MMAR_4008 | cyp187A5 | 1e-47 | 30.85% (402) | cytochrome P450 187A5 Cyp187A5 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 1e-27 | 28.57% (406) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_4150 | - | 1e-56 | 34.74% (403) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 1e-27 | 28.57% (406) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-24 | 28.07% (342) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 9e-29 | 27.01% (411) | cytochrome P450 |
| M. avium 104 | MAV_1274 | - | 6e-63 | 36.97% (403) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2240 | - | 2e-52 | 33.33% (402) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_2643 | - | 5e-57 | 34.49% (403) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_3860 | cyp187A4 | 5e-50 | 32.60% (411) | cytochrome P450 187A4 Cyp187A4 |
| M. vanbaalenii PYR-1 | Mvan_2007 | - | 6e-49 | 32.42% (401) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2240|M.smegmatis_MC2_155 --------------------------MDSRIRDDPAVDTA----ALLRDP
Mvan_2007|M.vanbaalenii_PYR-1 --------------------------METPVQD-LAKDEP----IDLRDP
MUL_3860|M.ulcerans_Agy99 ------------------------MTLRTDADGQPVTLDL----TGETSP
TH_2643|M.thermoresistible__bu -------------------------VITAGVKEAQARFDAGMGADGDASP
Mflv_4150|M.gilvum_PYR-GCK -----------------------MSQLFEDLEDFGSFDDAVS--GDVRDP
MAV_1274|M.avium_104 -----------------------MEQLFDDLEDFGAFDDAVS--GDVRDP
MMAR_0272|M.marinum_M --------------------------MSPSVAELSQELGEAFRLSSMDDP
Mb2289|M.bovis_AF2122/97 --------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGA
Rv2266|M.tuberculosis_H37Rv --------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGA
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
..
MSMEG_2240|M.smegmatis_MC2_155 YPIFARYRAQAGVFRGSVMDWSKTPKEL---MPEHQYAAMSFDAVNTVFR
Mvan_2007|M.vanbaalenii_PYR-1 YPMFARRRAEGGVFRGSVMDWSRTPDSL---RPENLYAAVSFDAVNRVFR
MUL_3860|M.ulcerans_Agy99 YPFFEYMRRTDPVWHGALMDHGQMPEEL---RPNDEWVLFGYDGVFQAFR
TH_2643|M.thermoresistible__bu YPMLAELRSKAPVHPG-WPEMSIFENPP---DGPQTFAAYSFDAVKAVFT
Mflv_4150|M.gilvum_PYR-GCK YPELARLRREEPIQR---IDMSAMPGE----EGKPVFIVYRYEDAQQMLR
MAV_1274|M.avium_104 YTELARLRREEPIQR---LDTSGMPHE----ESKPVFIVYRHEDAQQMLR
MMAR_0272|M.marinum_M YPMLAERRRETPVMKGDIMVALGAPSYMGQ-HAGETHTVFRHDDVMAILR
Mb2289|M.bovis_AF2122/97 FATLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYP
Rv2266|M.tuberculosis_H37Rv FATLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYP
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-------MPLTVFSSFSDCDEALRHPLSASDRL
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDD------LKFWALSRHHDVLQGFRNSEALSNAN
:.
MSMEG_2240|M.smegmatis_MC2_155 DGKTFNSKIYDSTIGLFIGP-SILAMEGKTHRDHRNLVSAAFKSKSLARW
Mvan_2007|M.vanbaalenii_PYR-1 DGKVFNSHIYDSTIGLFIGP-TILAMEGKTHWEHRNLVSAAFKTRSLARW
MUL_3860|M.ulcerans_Agy99 DGRIFTSAGYDKTIGLVMGH-TILAMGGREHHDHRSLVAKAFRATALERW
TH_2643|M.thermoresistible__bu DNRTFSTRCYEAIVRPLQGP-TILEMQEPEHQTYRRLHEFAFARSSMRRW
Mflv_4150|M.gilvum_PYR-GCK DNVTFSSSGVIAAFGPVLGERVMLGMDEPVHGRLRSLVSKAFSQKGLARW
MAV_1274|M.avium_104 DNETFSSAAVIAAFGPVLGERVMLGMDEPVHGRLRSLVSKAFSQKALARW
MMAR_0272|M.marinum_M NHETFSSSIWEISQGPLIGR-SILAMDGAEHRQWRGYLQSVFGGKLLSSW
Mb2289|M.bovis_AF2122/97 NITINDQTPELAEYFG-----SMIVLDDPRHQRLRSIVSRAFTPKVVARI
Rv2266|M.tuberculosis_H37Rv NITINDQTPELAEYFG-----SMIVLDDPRHQRLRSIVSRAFTPKVVARI
MLBr_02088|M.leprae_Br4923 KATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
MAB_1216c|M.abscessus_ATCC_199 GVSMDKASFGPHAK----LVMSFLAMDDPEHLRLRALVSKGFTPRRIREL
:: : * * * :
MSMEG_2240|M.smegmatis_MC2_155 EPEIARPICEALVDEFVDT--GSADLVRDYTFEFPTRVISKLLGLP--EE
Mvan_2007|M.vanbaalenii_PYR-1 EPEIVRPVVNELIDEFIDD--GRADLVRDFTFEFPTRVISRLLGLP--EE
MUL_3860|M.ulcerans_Agy99 EPSVIGPVCDQLIDEIRAD--GHADLVKALTFEFPTRIISTLLGLP--RE
TH_2643|M.thermoresistible__bu EAELVRPLVERTVDRIRDA--GRADLVEEVFMPIPVRVIAALLGLP--EA
Mflv_4150|M.gilvum_PYR-GCK QDELVGRVGNELIDRFQAD--GKADLVKQFTFDYPSRIIAGLLGLP--EQ
MAV_1274|M.avium_104 EDELVGRVGNSLIDRFAGN--GKADLVKEFTFDYPSRIIAGLLGLP--EQ
MMAR_0272|M.marinum_M DESIFRPLAAKYVADLASK--RGADLI-AMALEYPLRAIYEILGLEDFKD
Mb2289|M.bovis_AF2122/97 EAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIP--KA
Rv2266|M.tuberculosis_H37Rv EAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIP--KA
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAG---QFDVIADLAFPLAVAVICRLLGVP--YE
MAB_1216c|M.abscessus_ATCC_199 EGQVVALARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVP--ES
: : *.: . * ::*:
MSMEG_2240|M.smegmatis_MC2_155 DLPWFRRRAVELIS-------------YSVKYKRAFEASAALKDYFLDQI
Mvan_2007|M.vanbaalenii_PYR-1 DLPWFRKRAVELIS-------------YAVNYKKAFEASAALKDYFLGQI
MUL_3860|M.ulcerans_Agy99 DLDLFRRLSFDLIS-------------IPTDIVAGFNAATELHGYFLDQV
TH_2643|M.thermoresistible__bu DVPEFHRLAIDLLG-------------FHADMDTALKASAELRDYFVGIL
Mflv_4150|M.gilvum_PYR-GCK DYPQFQRWSISLLS-------------WILNPERGLAAAAALCEYFAPIL
MAV_1274|M.avium_104 DYPQFQRWSISLLS-------------WILNPQRGLAASAALCDYFAPIL
MMAR_0272|M.marinum_M NYEEFHADVLTILLALWSTPDPAQADQFLLRFQKATEASARSWDRLLPIV
Mb2289|M.bovis_AF2122/97 DHQRIFHWTNVILGFGDPDLATD--------FDEFMQVSADIGAYATALA
Rv2266|M.tuberculosis_H37Rv DHQRIFHWTNVILGFGDPDLATD--------FDEFMQVSADIGAYATALA
MLBr_02088|M.leprae_Br4923 DAPEFGRVSALLVQSVDPFITITG--EPPEATEERLRAGVWLRDYLEQLV
MAB_1216c|M.abscessus_ATCC_199 DRARIRELADGVMHREDGLADVP---------PEAIQASFDLMTYYIEMV
: : :: ..
MSMEG_2240|M.smegmatis_MC2_155 ERRRSR--PTEDIIGDLVTAEIDGEKLTDEAIYSFLRLLLPAGLETTYRS
Mvan_2007|M.vanbaalenii_PYR-1 DKRRSA--PTEDIIGDLVSAEIDGERLTDEAIFSFLRLLLPAGLETTFRS
MUL_3860|M.ulcerans_Agy99 EQRRRK--LTDDIIGDLVAAEIDGEKLDDEAIIAFLRLLLPAGLETTYRS
TH_2643|M.thermoresistible__bu AERRRS--PRDDMVSKLAHAEVDGVRMSDEQIYGFMRNLLPAGAETTSRS
Mflv_4150|M.gilvum_PYR-GCK EARRTD--PQDDLISLLAEAEIDGEKLTDEEIFSFLRLLLPAGVETTYRS
MAV_1274|M.avium_104 AARRTE--PKDDLISGLAQAEIDGEKLEDEEIYSFLRLLLPAGVETTYRA
MMAR_0272|M.marinum_M QRKRAAGASRNDLISSLIRAEYEGGVLDDEQITSFLRSLLLAATDTTTRQ
Mb2289|M.bovis_AF2122/97 EDRRVN--HHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNA
Rv2266|M.tuberculosis_H37Rv EDRRVN--HHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNA
MLBr_02088|M.leprae_Br4923 KCRRGT--PGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNL
MAB_1216c|M.abscessus_ATCC_199 RERRRR--PTEDLTSALLQAEIDGDRLTDEEVLAFLFLMVIAGNETTTKL
:* :*: . * : .* : .. : . :: *. :** .
MSMEG_2240|M.smegmatis_MC2_155 SGNLLYLLLTHPDQFAAVQNDHD-LIGAAIEEGLRYETPLTTVQRSATKD
Mvan_2007|M.vanbaalenii_PYR-1 SGNLLYLLLTHRDQFEAVNADHA-LIGAAIEEGLRYETPLTTVQRFANED
MUL_3860|M.ulcerans_Agy99 SGNLLYLLLTHPEQLTMVQRDRS-LIPIAIEEGLRFETPLTMVMRTTTEE
TH_2643|M.thermoresistible__bu TASLAYGLLTHPDQLTAVKADRD-LLPQAIEEGIRWETPLLNFMREVTED
Mflv_4150|M.gilvum_PYR-GCK LGNLLFALLSDTAQLDAVRADRS-LLPQAIEEGVRWNPPLLTITRTTTCD
MAV_1274|M.avium_104 LGSLLLALLSDPEQLDAIRGDRS-LLPQAIEEGVRWEPPLLTITRVATRD
MMAR_0272|M.marinum_M FLNTLTLLLQRPDELDRIRRDRS-RLRLALAEGERLEPPALFIPRMITRD
Mb2289|M.bovis_AF2122/97 ITHGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQD
Rv2266|M.tuberculosis_H37Rv ITHGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQD
MLBr_02088|M.leprae_Br4923 IANAVLAMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKD
MAB_1216c|M.abscessus_ATCC_199 LANAVYWGHRNPDQLATVHADHD-RIPLWVEESLRYDTSSQILARTVAED
: : : * * .. . * :
MSMEG_2240|M.smegmatis_MC2_155 TELEGVQIPAGAVIDVCIGSANRDENRWE-RPEEFDIFRKR-IPHITFAA
Mvan_2007|M.vanbaalenii_PYR-1 TEIDGVEIPAGSVIDVCIGSANRDESRWE-RAEQFDIFRTR-TPHISFAA
MUL_3860|M.ulcerans_Agy99 VDIGGKTIPPDAQIDLCMGSANRDESRWP-DPNRFDIRRTR-HAHIAFAG
TH_2643|M.thermoresistible__bu IEFFGVQIPAGSTIAVNLGSANHDETRWE-RPEEFDIFRER-KPHIGFGH
Mflv_4150|M.gilvum_PYR-GCK TELGGVPIPAGCSVLPMLGSTNRQEDRWE-DPDEFNLFRAQ-KANLGWGY
MAV_1274|M.avium_104 TELGGVPIPAGSTVMPMLGAANRQEDRYP-DPDRFDIFRAP-KSHLGWGH
MMAR_0272|M.marinum_M VVIRGTELTAGTPLLLAIGSANRDPEAYPPDPDEFRIDRTG-PHHATFGF
Mb2289|M.bovis_AF2122/97 IELRGTKMAAGDKVSLWYCSANRDESKFA-DPWTFDLARNPNPHLGFGGG
Rv2266|M.tuberculosis_H37Rv IELRGTKMAAGDKVSLWYCSANRDESKFA-DPWTFDLARNPNPHLGFGGG
MLBr_02088|M.leprae_Br4923 MTIGQTTLTEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPS-SRHLAFAV
MAB_1216c|M.abscessus_ATCC_199 ITVYDTKIPAGDILLLLPGSANRDDRVFD-DADQYRIGREIGAKLVSFGS
. :. . : ::*:: : . : * .
MSMEG_2240|M.smegmatis_MC2_155 GEHTCMGLHLARMETRVAMETLLNRVTDLRLIADD----DPHIFGQPFRS
Mvan_2007|M.vanbaalenii_PYR-1 GEHTCMGLHLARMETRVAAETLLSRLSAIELLTDG----DPHIHGQPFRS
MUL_3860|M.ulcerans_Agy99 GIHMCLGMHLARLETRVMLNSLFDRVTNLAFTPDDGTGVQSRIIGLTFRS
TH_2643|M.thermoresistible__bu GAHVCLGMHLARLESTVIFNTLLDRLPGLRLDPDA---AAPYVAGMYFRS
Mflv_4150|M.gilvum_PYR-GCK GVHVCLGMHLARLEMRTAVNLLLDRLPGLRLDPDG---DDPHIRGQVFRS
MAV_1274|M.avium_104 GVHVCLGMHLARLEMRTAVNLLLDRLPNLRLDPDA---DDPHIRGQVFRS
MMAR_0272|M.marinum_M GTHICSGMNTTRREIAALIDAMLDGLPGLRVDPDAP---APLISGIHFRG
Mb2289|M.bovis_AF2122/97 GAHFCLGANLARREIRVAFDELRRQMP-DVVATEEP----ARLLSQFIHG
Rv2266|M.tuberculosis_H37Rv GAHFCLGANLARREIRVAFDELRRQMP-DVVATEEP----ARLLSQFIHG
MLBr_02088|M.leprae_Br4923 GSHFCLGAALARLEATVTLSAISARFPQVQLAG-EL----VYKPNVAMRG
MAB_1216c|M.abscessus_ATCC_199 GAHFCLGAHLARMEAKVALTELFTRISGYEIDERNS----VRVHSSNVRG
* * * * :* * . : .. . . .:.
MSMEG_2240|M.smegmatis_MC2_155 PTAIPVTFRPAG---
Mvan_2007|M.vanbaalenii_PYR-1 PTALPVTFTPSRARP
MUL_3860|M.ulcerans_Agy99 PNKLPVTFTPAA---
TH_2643|M.thermoresistible__bu PPYLHVVWD------
Mflv_4150|M.gilvum_PYR-GCK PTSLPVLFDAVGSDA
MAV_1274|M.avium_104 PTSVPVLFDPQ----
MMAR_0272|M.marinum_M PSALPVVWD------
Mb2289|M.bovis_AF2122/97 IKTLPVTWS------
Rv2266|M.tuberculosis_H37Rv IKTLPVTWS------
MLBr_02088|M.leprae_Br4923 MSALPVQV-------
MAB_1216c|M.abscessus_ATCC_199 FAHLPMTVQLREGR-
: :