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PIEGAMRSSSLPDGCSDRSADSRGSGEVKDRSSGWFYGHHDREQRSVHDGLLQVIPAALDRGEFFLVYQP IVRLNDKRFIGVEALLRWAHPTLGTLLPARFISLAERNGMIVPLTTFVIEQACRHIRNWRDDSTNPRPFV SVNVSARNIRDPSFLSMVERVLGETGLPAHALRLELTENASLSIDEASITRLQELSALGVGIAIDDFGTG FSSLAYLRNLPVDMVKLAGEFIENLGGDIRGRLADEQITRAMIDLAFKLGIIVCAKRVETPGQAARLRDF GCDAAQGWHFAKALPADFFTE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01752 | - | - | 100% (302) | hypothetical protein MLBr_01752 |
| M. leprae Br4923 | MLBr_01750 | - | 8e-34 | 36.17% (235) | hypothetical protein MLBr_01750 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1392c | - | 1e-106 | 73.95% (261) | hypothetical protein Mb1392c |
| M. gilvum PYR-GCK | Mflv_2073 | - | 3e-40 | 39.75% (244) | diguanylate cyclase/phosphodiesterase |
| M. tuberculosis H37Rv | Rv1357c | - | 1e-106 | 73.95% (261) | hypothetical protein Rv1357c |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1132 | - | 1e-38 | 38.36% (232) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 1e-33 | 34.58% (240) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 6e-33 | 33.90% (236) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4640 | - | 1e-45 | 42.28% (246) | diguanylate cyclase/phosphodiesterase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1392c|M.bovis_AF2122/97 --------------------------------------------------
Rv1357c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01752|M.leprae_Br4923 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1132|M.avium_104 --------------------------------------------------
Mflv_2073|M.gilvum_PYR-GCK MHGGAVSNGRIRPLAGPWLWIPIGLTVALAVLLAVDDSRGLGVRTVDNAI
Mvan_4640|M.vanbaalenii_PYR-1 -----MSGGRPR-LLGSCIAVPVGLTVALAVVLAVGGD-GAWVPVLDDVI
Mb1392c|M.bovis_AF2122/97 --------------------------------------------------
Rv1357c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01752|M.leprae_Br4923 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1132|M.avium_104 --------------------------------------------------
Mflv_2073|M.gilvum_PYR-GCK TLTLSSYATLCAWLAARDARGRARKSWTLMAGALGAYALGDLTWLVRESA
Mvan_4640|M.vanbaalenii_PYR-1 IVALSSCATVCAVLAAKSAEGRQRRAWATMAAAMGAWAVADLIWLVCEYV
Mb1392c|M.bovis_AF2122/97 --------------------------------------------------
Rv1357c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01752|M.leprae_Br4923 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 ---------------------MSESLDVLVTSVATQLMAVEAATSVSVSQ
TH_0811|M.thermoresistible__bu ---------------------VSTELDLLVTGVATKLMAADAATARDVSR
MAV_1132|M.avium_104 ---------------------MPRSLDLVVTSVATALMEATASTARSVSE
Mflv_2073|M.gilvum_PYR-GCK MHTQPFPSPADFFYLVFTILAVLSVLTMARYGAGSTRHSKLRVALDGVTI
Mvan_4640|M.vanbaalenii_PYR-1 LRVEPFPSPADFFYLAFSVLVVPAVLGMAQFDAWSRRQATLRIALDGVTV
Mb1392c|M.bovis_AF2122/97 --------------------------------------------------
Rv1357c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01752|M.leprae_Br4923 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 QVLAELVSFFDVDVSFLRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHF
TH_0811|M.thermoresistible__bu RVLADLVRAFELDFSFLRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHF
MAV_1132|M.avium_104 TVLAQLVEQFDVDASFLHH--HDAAGPVPVAEWPRRTDAAG--PMAALRS
Mflv_2073|M.gilvum_PYR-GCK ALSAPLLAWIVALKDVYADNLGNPASLVIATAYPVLDIVALGVTVSVLVR
Mvan_4640|M.vanbaalenii_PYR-1 ALCSFLLAWIFALDRVYEAYRDDKLALGLAFFYPVADMVILAVAVAVLAR
Mb1392c|M.bovis_AF2122/97 --------------------------------------------------
Rv1357c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01752|M.leprae_Br4923 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 ADADP----------------------------------VFAMAEHLKEP
TH_0811|M.thermoresistible__bu EGADP----------------------------------VFALAEHAKEI
MAV_1132|M.avium_104 EDVES----------------------------------VLAQCERQRRP
Mflv_2073|M.gilvum_PYR-GCK ADVRYRTVLTLVVAAFALTTIGDVGFAHAVVNGTYTTGSWLDVVWAAGLV
Mvan_4640|M.vanbaalenii_PYR-1 VDAAHRAVPALLVFGFAVMTLTDSAFAYGVAVDSYRTGSFIDLGWAVALV
Mb1392c|M.bovis_AF2122/97 --------------------------------------------------
Rv1357c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01752|M.leprae_Br4923 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 AVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGVLGFVKFGDR
TH_0811|M.thermoresistible__bu HIFRPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGVLGFVKYGDR
MAV_1132|M.avium_104 VVSSPDQADGWLRRWLQRDKAAGAPSVAAAPLVSGDATTGVLGFVKFGAR
Mflv_2073|M.gilvum_PYR-GCK CFAAAGQLARSATMPRRRALTVPPNVSVWLPYVPFMIAGTVGPLVVMSGV
Mvan_4640|M.vanbaalenii_PYR-1 AICAAAQLSRENPQFRMPIVLVPSNTALWAPYVPLLLAGTIGPPLVMSGL
Mb1392c|M.bovis_AF2122/97 --------------------------------------------------
Rv1357c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01752|M.leprae_Br4923 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 EWLPAELNALKAIASLFAQVQARIEAEERLRYLADHDHLTGLYNRRALMA
TH_0811|M.thermoresistible__bu QWHPDELNALKAIASLFAQVQARVEAEERLRYLAEHDDLTGLHNRRALLA
MAV_1132|M.avium_104 RWKPEEINTLEAVAALFAQLQARIAAEERLRYLAEHDDLTGVYNRRALVA
Mflv_2073|M.gilvum_PYR-GCK ERFIVPFITAAVCLRQAVAAWENRYLLSLAAERALRDPLTGLANRSLFQD
Mvan_4640|M.vanbaalenii_PYR-1 EQLVVPVIVVAVCLRQVVAAWENRQLLRAAAEQALRDPLTELANQRLFYD
Mb1392c|M.bovis_AF2122/97 --------------------------------------------------
Rv1357c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01752|M.leprae_Br4923 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 HLEARLAPGQPG--PVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQ
TH_0811|M.thermoresistible__bu HLDARLAAGQPG--PVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLR
MAV_1132|M.avium_104 HLTERLAAGNPG--PVAVFYLDLDRLKPINDYLGHTAGDWFIRVFAQRIE
Mflv_2073|M.gilvum_PYR-GCK RLAHALMLRERDNRSVAVISLDLDDFKLVNDSLGHPVADSLLVSAGRRII
Mvan_4640|M.vanbaalenii_PYR-1 RLAHALTLSSREGHSVAVVSLDLDDFKLVNDSVGHPEADSLLVRVGQRIA
Mb1392c|M.bovis_AF2122/97 -----------------------------------------------MDR
Rv1357c|M.tuberculosis_H37Rv -----------------------------------------------MDR
MLBr_01752|M.leprae_Br4923 --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 RGDDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQSVLRERVTVDGE
TH_0811|M.thermoresistible__bu EGAGPDDLIARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQVCVDGE
MAV_1132|M.avium_104 ECAGEQSMIARLGGDEFVVIPHQPMASEAAEAFARRLSTLLCDRLTIGGH
Mflv_2073|M.gilvum_PYR-GCK GCVRTGDTVARVGGDEFALLLEG--DASSPDLIAQRVADAFAEPFIVDGH
Mvan_4640|M.vanbaalenii_PYR-1 DCVRAGDTVARIQGDEFALLLEG--EHDDSKLIAERVVDAFDEPFVLHGE
Mb1392c|M.bovis_AF2122/97 CCQRATAFACALRPTKLIDYE--EMFRGAMQARAMVANP-----DQWADS
Rv1357c|M.tuberculosis_H37Rv CCQRATAFACALRPTKLIDYE--EMFRGAMQARAMVANP-----DQWADS
MLBr_01752|M.leprae_Br4923 -MPIEGAMRSSSLPDGCSDRS--ADSRGSGEVKDRSSG------WFYGHH
MSMEG_2196|M.smegmatis_MC2_155 MLTRTVSIGIAQGIPGKDSTS--DVLNRADHAVLTAKGSGGNRVAVFSDA
TH_0811|M.thermoresistible__bu MLTRTASIGVAQGTPGRDTTS--DLLRRADQAVLTAKSAGGNQITVFTDD
MAV_1132|M.avium_104 VISRTVSIGLAVGTPGADNCT--DLLRRADEAVLTAKRAGGNQTAVSTDD
Mflv_2073|M.gilvum_PYR-GCK QILMHPSIGVAVTPPDEAEVSAQTLITRADMAMYTAKKSRSSRVYTFDAD
Mvan_4640|M.vanbaalenii_PYR-1 HILLRPSVGVAAASPGEAEVAPETMVMRAETAMNVAKRSRSSRVHVFDAT
:. : : .
Mb1392c|M.bovis_AF2122/97 DRDQV-----------------NTRHYLSTSMRVALDRGEFFLVYQPIIR
Rv1357c|M.tuberculosis_H37Rv DRDQV-----------------NTRHYLSTSMRVALDRGEFFLVYQPIIR
MLBr_01752|M.leprae_Br4923 DREQR-----------------SVHDGLLQVIPAALDRGEFFLVYQPIVR
MSMEG_2196|M.smegmatis_MC2_155 MAMEI-----------------DFRNDIELHLQSVIEGGALVLHYLPEID
TH_0811|M.thermoresistible__bu MSLEA-----------------EFRNDIELHLQSVIQDEALLLHFLPEVD
MAV_1132|M.avium_104 MSLKR-----------------AFRNDIELHLQGDIESEGLLLHYLPEVD
Mflv_2073|M.gilvum_PYR-GCK MTLPGPDADSMTESPDRKPGAGAAKVQLLGELRRAIDAAELEMVYQPKVA
Mvan_4640|M.vanbaalenii_PYR-1 LESAAPDVVAPERGSPQNWPDGAAKVRLLGELRRAIDNGEFHMVYQPIVD
: : : :: : : : * :
Mb1392c|M.bovis_AF2122/97 LADNRIIGAEALLRWEHPTLGTLLPGRFIDRAENNGLMVPLTAFVLEQAC
Rv1357c|M.tuberculosis_H37Rv LADNRIIGAEALLRWEHPTLGTLLPGRFIDRAENNGLMVPLTAFVLEQAC
MLBr_01752|M.leprae_Br4923 LNDKRFIGVEALLRWAHPTLGTLLPARFISLAERNGMIVPLTTFVIEQAC
MSMEG_2196|M.smegmatis_MC2_155 MRTGEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAGELGRWVLRTAC
TH_0811|M.thermoresistible__bu MRTGEILATEALVRWHHPTRGLLAPDTFIGVAESVNLAGELGRWVMRTAC
MAV_1132|M.avium_104 LWTGAVVGAEALVRWRHPIWGLLLPDSFIGVAESTNLGAELGGWVMRSAC
Mflv_2073|M.gilvum_PYR-GCK LRTGRIIGVEALLRWPHPRLGLLYPGAFMSLVRQHGLMRPVSDLVVDKVL
Mvan_4640|M.vanbaalenii_PYR-1 LRSGFIVGVEALLRWPHPRLGMLSPDAFLPLVRQHGLMRPVTEVVLDNVL
: .:..***:** ** * * * *: .. .: : *: .
Mb1392c|M.bovis_AF2122/97 RHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVLVEGVLGETGLPAHALQ
Rv1357c|M.tuberculosis_H37Rv RHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVLVEGVLGETGLPAHALQ
MLBr_01752|M.leprae_Br4923 RHIRNWRDDSTNPRPFVSVNVSARNIRDPSFLSMVERVLGETGLPAHALR
MSMEG_2196|M.smegmatis_MC2_155 AEFSRWRANGVGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGSVC
TH_0811|M.thermoresistible__bu GEFAKWRAEGIGLDAVLRINVSPVQLVTDGFVASVADIIDEFGLDGSSVC
MAV_1132|M.avium_104 ADFSRWRANGVGHGAMLRINVSPIQLISRGFVETVADTIGEFGIDAGSVC
Mflv_2073|M.gilvum_PYR-GCK DAATAWKAEGVRIP--VAVNLFAPTLRDAQLPDRLLGALEKRGLTADMLT
Mvan_4640|M.vanbaalenii_PYR-1 DDAARWMADGVPMP--VAVNLFAPFLRDAQLPSALCQALERRGLPTDLLT
* .. : :*: . : : : : . *: :
Mb1392c|M.bovis_AF2122/97 LELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAYLPRLPVD
Rv1357c|M.tuberculosis_H37Rv LELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAYLPRLPVD
MLBr_01752|M.leprae_Br4923 LELTENASLSIDEASITRLQELSALGVGIAIDDFGTGFSSLAYLRNLPVD
MSMEG_2196|M.smegmatis_MC2_155 LEITESVVVQDIETTRTTLTGLHNVGVQVAIDDFGTGYSVLSLLKSLPVD
TH_0811|M.thermoresistible__bu LEITESVVVQDIKTTRITLEGLNEVGVQVAIDDFGTGYSVLSHLKTLPVD
MAV_1132|M.avium_104 LEITERAVVHDTETTRKTLSELKEVGVQIAIDDFGTGYAVLSHLKSLPVD
Mflv_2073|M.gilvum_PYR-GCK VEITEDLVVDDLGTVTDVLQQLRHCGIRVAIDDFGSGYSALSYLRDLPID
Mvan_4640|M.vanbaalenii_PYR-1 VEITEDLVLHDFDVVTGVLGQLREQGIRVAIDDFGSGFSALSYLRELRID
:*::* : * * *: :****** *:: *: * * :*
Mb1392c|M.bovis_AF2122/97 VVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQ
Rv1357c|M.tuberculosis_H37Rv VVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQ
MLBr_01752|M.leprae_Br4923 MVKLAGEFIENLGGDIRGRLADEQITRAMIDLAFKLGIIVCAKRVETPGQ
MSMEG_2196|M.smegmatis_MC2_155 TLKIDRSFVAELG----SNPGDLPIVRAVIALAGAFGLQLVAEGVETERA
TH_0811|M.thermoresistible__bu TLKIDKGFVQDLG----NSPGDLAIVRAIIALAEAFGLQLVAEGVETEAA
MAV_1132|M.avium_104 MLKIDAGFVREVG----TDAGDLAIVRAIIGLAEAFGLEVVAEGVETPAA
Mflv_2073|M.gilvum_PYR-GCK EIKLDRYFVAPVTE----DPRAAAVVSAVIDLAHDLGIVVVAEGVEEPVT
Mvan_4640|M.vanbaalenii_PYR-1 EIKLDRHFIATVAS----DPRAAAVVRAVIDLTHDLGSVVVAEGVEEPAT
:*: *: : :. *:* * :* : *: **
Mb1392c|M.bovis_AF2122/97 AARLRAFGCKAAQGWHFAKALPVDFFRE----------------------
Rv1357c|M.tuberculosis_H37Rv AARLRAFGCKAAQGWHFAKALPVDFFRE----------------------
MLBr_01752|M.leprae_Br4923 AARLRDFGCDAAQGWHFAKALPADFFTE----------------------
MSMEG_2196|M.smegmatis_MC2_155 ALTLLRHGCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM-----
TH_0811|M.thermoresistible__bu ALTLLRHGCHRAQGFLLSRPIPSNEMRELLARGRIPMRFSATP-------
MAV_1132|M.avium_104 ALTLMQHGCHRAQGFLLSRPIPGEAMEALLSARWMPMPFLADREASSMGS
Mflv_2073|M.gilvum_PYR-GCK AHWLRGKQCDIAQGYYFGRPTDRAHLPGLVEAAALPRLDVVAD-------
Mvan_4640|M.vanbaalenii_PYR-1 AAWLRDRGCDMAQGYYFGKPIEAADVPGLVRMAKDPA-------------
* * * ***: :.:. .
Mb1392c|M.bovis_AF2122/97 -
Rv1357c|M.tuberculosis_H37Rv -
MLBr_01752|M.leprae_Br4923 -
MSMEG_2196|M.smegmatis_MC2_155 -
TH_0811|M.thermoresistible__bu -
MAV_1132|M.avium_104 I
Mflv_2073|M.gilvum_PYR-GCK -
Mvan_4640|M.vanbaalenii_PYR-1 -