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MTGPPPMAIDAKHLTYRYGQFTAVDDVTLQVRPGETMGLLGPNGAGKTTMVRMLTTLAPVQQGELHIFGL DARRRTTDIRANIGYVPQQLSVEPALTGRQNVAWFARLYGVPRAERAERVDQALAAMDLLDVADRLASAY SGGMIRRLEVAQALVNRPSLLVLDEPTVGLDPIARDGVWEHVQKMQARFAMTVLLTTHYMEEADALCDRV ALMHRGALRAVGAPDELKARISRVSQHATLEDVFRHYAASDLGGDDAAHPRPSGSIRQVRSSRKVARRVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5181 | - | - | 100% (280) | daunorubicin resistance ABC transporter ATPase subunit |
| M. avium 104 | MAV_3250 | - | 4e-45 | 43.11% (225) | daunorubicin resistance ATP-binding protein DrrA |
| M. avium 104 | MAV_3085 | - | 4e-33 | 36.07% (244) | ABC transporter ATP-binding subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2961 | drrA | 9e-46 | 41.96% (224) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. gilvum PYR-GCK | Mflv_1936 | - | 5e-50 | 43.93% (239) | daunorubicin resistance ABC transporter ATPase subunit |
| M. tuberculosis H37Rv | Rv2936 | drrA | 9e-46 | 41.96% (224) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. leprae Br4923 | MLBr_02352 | - | 4e-45 | 42.86% (217) | putative antibiotic resistance efflux protein |
| M. abscessus ATCC 19977 | MAB_1689 | - | 2e-30 | 36.76% (204) | daunorubicin resistance ABC transporter ATP-binding subunit |
| M. marinum M | MMAR_1771 | drrA | 6e-46 | 41.07% (224) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. smegmatis MC2 155 | MSMEG_6509 | - | 1e-105 | 72.10% (276) | ABC-type drug export system, ATP-binding protein |
| M. thermoresistible (build 8) | TH_2424 | - | 5e-30 | 34.53% (223) | PUTATIVE sulfate ABC transporter, ATPase subunit |
| M. ulcerans Agy99 | MUL_2014 | drrA | 3e-46 | 41.07% (224) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. vanbaalenii PYR-1 | Mvan_4796 | - | 2e-49 | 41.42% (268) | daunorubicin resistance ABC transporter ATPase subunit |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5181|M.avium_104 ------MTG--PPP------MAIDAKHLTYRYG---QFTAVDDVTLQVRP
MSMEG_6509|M.smegmatis_MC2_155 ------MTDHMPEPTLPDRTPAIDCDGLTHRYG---QFTAVEDLTLQVRA
Mb2961|M.bovis_AF2122/97 ---------------MRNDDMAVVVNGVRKTYGKG-KIVALDDVSFKVRR
Rv2936|M.tuberculosis_H37Rv ---------------MRNDDMAVVVNGVRKTYGKG-KIVALDDVSFKVRR
MLBr_02352|M.leprae_Br4923 ---------------MRNNDKAVMVRGVRKTYGKG-KIIALDDVSFDVDR
MMAR_1771|M.marinum_M ---------------MRNNDLAVEVRGVRKAFG---DVVALNDISFEVGR
MUL_2014|M.ulcerans_Agy99 ---------------MRNNDLAVEVRGVRKAFG---DVVALNDISFEVGR
Mflv_1936|M.gilvum_PYR-GCK ----------------MPFPPAIEALDLVKRFG---DQTAVAGVSFVVPP
Mvan_4796|M.vanbaalenii_PYR-1 MADKSVGPMSVCAYTVDAMESAIEAIDLVKRFGDTLDNPAVDGVSFAVPP
MAB_1689|M.abscessus_ATCC_1997 -------------MTTDTQIPALRAAELVKAYPGS-DARAVDGLDLTIPQ
TH_2424|M.thermoresistible__bu ------------------MTDAITVRGANKRYG---DFAALDNVDFAVPA
*: : . *: .: : :
MAV_5181|M.avium_104 GETMGLLGPNGAGKTTMVRMLTTLAPVQQGELHIFGLDARRRTTDIRANI
MSMEG_6509|M.smegmatis_MC2_155 GETLGLLGPNGAGKTTAVRVLTTLTPVQQGRVRIFGLDTRAHTMDIRHNI
Mb2961|M.bovis_AF2122/97 GEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSI
Rv2936|M.tuberculosis_H37Rv GEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSI
MLBr_02352|M.leprae_Br4923 GEVIGLLGPNGAGKTTMVDILSTLTRPDRGLATVAGYDVVSEPAGVRRSI
MMAR_1771|M.marinum_M GEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAHVAGSDVVAQPAGVRRSI
MUL_2014|M.ulcerans_Agy99 GEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAHVAGYDVVAQPAGVRRSI
Mflv_1936|M.gilvum_PYR-GCK GTVLGLLGPNGAGKTTTVRMMTTLTEPTSGTARVAGFDVRTHPDEVRRHM
Mvan_4796|M.vanbaalenii_PYR-1 GTVLGLLGPNGAGKTTTVRMMTTLTEPTSGTARVAGYDVRAQPDDVRRHM
MAB_1689|M.abscessus_ATCC_1997 GIVYCLLGRNGAGKTTTIRMATTLLAPTRGELEVLGVPVDN-TKELRPLI
TH_2424|M.thermoresistible__bu GSLTALLGPSGSGKSTLLRAIAGLDRPDTGTITINGRDVTDVPPQRR-GI
* *** .*:**:* : : * * : * . . * :
MAV_5181|M.avium_104 GYVPQQLSVEPALTGRQNVAWFARLYGVPRAERAERVDQALAAMDLLDVA
MSMEG_6509|M.smegmatis_MC2_155 GYVPQQLSIEAALTGRQNVELFARLYDVPRSERADRVAAALEAMQLLDVA
Mb2961|M.bovis_AF2122/97 MVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAG
Rv2936|M.tuberculosis_H37Rv MVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAG
MLBr_02352|M.leprae_Br4923 MVTGQQVAVDDQLSGEQNLILFGRLYGLSKSVARVRTQELLEQFDLLHAG
MMAR_1771|M.marinum_M MVTGQQVAVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAG
MUL_2014|M.ulcerans_Agy99 MVTGQQVAVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAG
Mflv_1936|M.gilvum_PYR-GCK GLTGQVATVDELLTGRENIRMIGGLYGIRRRDLKNLGDQLLHQFSLTDAA
Mvan_4796|M.vanbaalenii_PYR-1 GLTGQVATVDELLTGRENIRMIGGLYGIRRKDLDRLGDQLLHQFSLTDAA
MAB_1689|M.abscessus_ATCC_1997 GVALQEVALDLWMSPVEQIRMSLAIAGWPKARRKAREDELVEQFGLSTYV
TH_2424|M.thermoresistible__bu GFVFQHYAAFKHLTVRDNVAFGLKIRRRPKREIAEKVDNLLEVVGLAGFQ
. * : :: ::: : : : . *
MAV_5181|M.avium_104 DRLASAYSGGMIRRLEVAQALVNRPSLLVLDEPTVGLDPIARDGVWEHVQ
MSMEG_6509|M.smegmatis_MC2_155 DTVAGTYSGGMVRRLELAQALVNRPLLLILDEPTVGLDPIARDSVWTQVR
Mb2961|M.bovis_AF2122/97 KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
Rv2936|M.tuberculosis_H37Rv KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
MLBr_02352|M.leprae_Br4923 KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
MMAR_1771|M.marinum_M KRLVRTYSGGMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVT
MUL_2014|M.ulcerans_Agy99 KRLVRTYSGGMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVT
Mflv_1936|M.gilvum_PYR-GCK DRPVRSYSGGMRRRLDLAVSLLASPPVLFLDEPTTGLDPRSRSELWDVLR
Mvan_4796|M.vanbaalenii_PYR-1 DRVVRSYSGGMRRRLDLAVSLLASPPVLFLDEPTTGLDPRSRSELWDVLR
MAB_1689|M.abscessus_ATCC_1997 NRKVGALSGGMRRRVDVALAVAHNPQMLFLDEPSSGLDIEGKQEVWNAIR
TH_2424|M.thermoresistible__bu NRYPNQLSGGQRQRMALARALAVDPEVLLLDEPFGALDAKVREDLRTWLR
. *** :*: :* .: * : .**** .** :. : :
MAV_5181|M.avium_104 KMQARFAMTVLLTTHYMEEADALCDRVALMHRGALRAVGAPDELKARIS-
MSMEG_6509|M.smegmatis_MC2_155 AMQAEFGMTVLLTTHYMGEADALCDRVALMHHGRLQAVGSPDELKRAVSS
Mb2961|M.bovis_AF2122/97 SFKK-LGIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGD
Rv2936|M.tuberculosis_H37Rv SFKK-LGIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGD
MLBr_02352|M.leprae_Br4923 SFKQ-IGIATLLTTQYLEEADELSDRIILIDHGTVIAEGTASELKHRVGE
MMAR_1771|M.marinum_M SFKK-LGIATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGD
MUL_2014|M.ulcerans_Agy99 SFKK-LGIATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGD
Mflv_1936|M.gilvum_PYR-GCK GLVA-QGTTLLLTTQYLEEADQLADNIVVIDRGRIIAEGSPLHLKQQAGR
Mvan_4796|M.vanbaalenii_PYR-1 GLVA-QGTTLLLTTQYLEEADQLADNIVVIDRGHIIAEGSPLELKQQAGR
MAB_1689|M.abscessus_ATCC_1997 LLRS-EGRTVVLTTHDMDEAVSLADEVGIVKSGRLVASGSTQEFTRSHG-
TH_2424|M.thermoresistible__bu RLHEEVHVTTVLVTHDQSEALDVADRIAVLNNGRIEQVGSPAEVYDSPAN
: : :*.*: ** :.*.: ::. * : *:. .. .
MAV_5181|M.avium_104 ---------------------------RVSQHA---TLEDVFRHYAASDL
MSMEG_6509|M.smegmatis_MC2_155 ---------------------------QASDDAGETTLEDVFRHYAGSDL
Mb2961|M.bovis_AF2122/97 TFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRML
Rv2936|M.tuberculosis_H37Rv TFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRML
MLBr_02352|M.leprae_Br4923 TFCEIVPRDLKDLGTVVAALGSLLPERSRAMLTPTSDRITMPAPDGTQTL
MMAR_1771|M.marinum_M TFCEIVPRHLKDLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTL
MUL_2014|M.ulcerans_Agy99 TFCEIVPRHLKDLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTL
Mflv_1936|M.gilvum_PYR-GCK ASLVVTVADAADLESARGLLA---RTGAEVYVDAGARRLTATA-DGLDDM
Mvan_4796|M.vanbaalenii_PYR-1 ASLVVTVGDAADLEGARTLLG---QTGAEVFVDAGARRLTASA-DGLDDM
MAB_1689|M.abscessus_ATCC_1997 ----YAVEVSADSVIPEEAAGRLAEAGYALRRTDSGTLSGTLDSASAADL
TH_2424|M.thermoresistible__bu EFVMSFLGAVSSLNGTLVRPHDIWVGRHPELPTSDSTLQATGVVRARIDR
.
MAV_5181|M.avium_104 GGDDAAHPRPSGSIRQVRS--------------SRKVARRVG--------
MSMEG_6509|M.smegmatis_MC2_155 EG--GADPRRSG-LGEVRS--------------TRRTARRVS--------
Mb2961|M.bovis_AF2122/97 VEAARRIDEARIELADIAL--------------RRPSLDDVFLAMTTDPT
Rv2936|M.tuberculosis_H37Rv VEAARRIDEARIELADIAL--------------RRPSLDHVFLAMTTDPT
MLBr_02352|M.leprae_Br4923 IEAARRIDEVSVELADIAL--------------RRPSLDDVFLSMTTDPS
MMAR_1771|M.marinum_M IEAARRIDEANIELADIAL--------------RRPSLDDVFLSMTTDPS
MUL_2014|M.ulcerans_Agy99 IEAARKIDEANIELADIAL--------------RRPSLDDVFLSMTTDPS
Mflv_1936|M.gilvum_PYR-GCK VKVAGWLRDSGITVDDIGL--------------SRPSLDDVFLMLTGHRT
Mvan_4796|M.vanbaalenii_PYR-1 IRVAEWLRDSGIAVDDIGL--------------SRPSLDDVFLTLTGHRT
MAB_1689|M.abscessus_ATCC_1997 GALSAELDRVGLGAASIEV--------------RSTSLRDAFLEVTQ---
TH_2424|M.thermoresistible__bu VVMLGFEVRLELTSATNNAPFTAQITRGDAEALGLRSGDTVYVRATRVPA
.
MAV_5181|M.avium_104 --------------
MSMEG_6509|M.smegmatis_MC2_155 --------------
Mb2961|M.bovis_AF2122/97 ES--LTHLVSGSAR
Rv2936|M.tuberculosis_H37Rv ES--LTHLVSGSAR
MLBr_02352|M.leprae_Br4923 ES--LSHLAAGAMR
MMAR_1771|M.marinum_M EAHALSHVASGAML
MUL_2014|M.ulcerans_Agy99 EAHVLSHVASGAML
Mflv_1936|M.gilvum_PYR-GCK DD----TEEVGA--
Mvan_4796|M.vanbaalenii_PYR-1 ED----SEEIGA--
MAB_1689|M.abscessus_ATCC_1997 --------------
TH_2424|M.thermoresistible__bu LPTGDVDERVAAR-