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TIVDRLRYDGKRALVVGGATGMGAAAAKSAAELGAEVIVLDYAPVTYDVAKSIQVDLRDPASIDAALEQL DGPVHAVFSAAGIAEGTTDLMAINFLGHRYLIERLLERNQLPSGSAICFISSVAGMGWENDLDLLNEFLA TPDFATAQEWVKAHEPEGIIHYGFSKKVVNAYVATQGYPLLKKGIRINAICPGPTDTPLAQANADLWLTF AQDYRDETGSKVHTPEQMGDVMAFLNSAAAFGINGITLLVDYGHTMASLTGAYPPGKPIIDIIMGRVKL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1264 | - | - | 100% (280) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. avium 104 | MAV_5096 | - | 2e-36 | 36.15% (260) | 3-alpha-hydroxysteroid dehydrogenase |
| M. avium 104 | MAV_0882 | - | 1e-34 | 34.46% (267) | 3-alpha-hydroxysteroid dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 4e-12 | 26.74% (273) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2405 | - | 4e-31 | 36.05% (258) | 3-alpha-hydroxysteroid dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 4e-12 | 26.74% (273) | short chain dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3081 | - | 7e-10 | 26.53% (294) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4326 | - | 1e-138 | 83.57% (280) | short-chain type dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_4862 | - | 8e-28 | 31.40% (258) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3168 | - | 1e-103 | 70.16% (258) | PUTATIVE short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0136 | - | 1e-138 | 83.93% (280) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_2008 | - | 8e-30 | 33.08% (266) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4326|M.marinum_M -MTVVDRLRYDGKRALIVGGATGMGAAAAKSAAELGAEIIVMDYAPVG--
MUL_0136|M.ulcerans_Agy99 MMTVVDRLRYDGKRALIVGGATGMGAAAAKSAAELGAEVIVMDYAPVG--
MAV_1264|M.avium_104 -MTIVDRLRYDGKRALVVGGATGMGAAAAKSAAELGAEVIVLDYAPVT--
TH_3168|M.thermoresistible__bu -----------------------MGAAAARIVRDLGATVTVMDYAPVT--
Mflv_2405|M.gilvum_PYR-GCK -------MRYDGRHVVVTGCASGIGAQAARLLRDLGARVTGLDVRAPED-
MSMEG_4862|M.smegmatis_MC2_155 MAALDALVRYDGRHVVVTGCSSGIGAKVTDQLRCLGARVTGLDLRAPDS-
Mvan_2008|M.vanbaalenii_PYR-1 -------MQVEKRRIVVVGAGSGIGAAVAAHFHDNGDHVLAVDLRPND--
Mb2882c|M.bovis_AF2122/97 --MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAG-
Rv2857c|M.tuberculosis_H37Rv --MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAG-
MAB_3081|M.abscessus_ATCC_1997 ------MGKLDGKVAFITGAARGQGRAHAIKLASEGASIIAVDICAQIPS
* * : *
MMAR_4326|M.marinum_M ----YDAAQTLSVDLRDPASIDSAVERLGGPVHAVFSAAGVADGP----D
MUL_0136|M.ulcerans_Agy99 ----YDAAQTLSVDLRDPASIDSAVERLGGPVHAVFSAAGVADGP----D
MAV_1264|M.avium_104 ----YDVAKSIQVDLRDPASIDAALEQLDGPVHAVFSAAGIAEGTT---D
TH_3168|M.thermoresistible__bu ----YDTDRVIEMDLRDPGSIDHAVDELSGPVDAVFSAAGIADGP----D
Mflv_2405|M.gilvum_PYR-GCK ---VSALTDFISVDLADQDSVRAAAAAVDGAVDALFNVAGVSSGIGDPLL
MSMEG_4862|M.smegmatis_MC2_155 ---GAGPDAFREMDLADPDSVDAAAAAIDGPVHALFNVAGVSSGIGDPLL
Mvan_2008|M.vanbaalenii_PYR-1 ----TPAAAHAQCDLRDPQSIAGLLDDIGADWDVLAHVAGVP-GTAPADD
Mb2882c|M.bovis_AF2122/97 ---GAAADELSGLFVPTDVCDEDAVNGLFDGAAETYGRIDIAFNN-----
Rv2857c|M.tuberculosis_H37Rv ---GAAADELSGLFVPTDVCDEDAVNGLFDGAAETYGRIDIAFNN-----
MAB_3081|M.abscessus_ATCC_1997 VEYPMATTEDLDLTVKEVDALGRAISAHETDVRDREALQAAFDAG--VHD
: .
MMAR_4326|M.marinum_M LMKINFIGHRHLIDRLLANDQLPSGSAVCFISSVAGMGWENDLPRLTEFL
MUL_0136|M.ulcerans_Agy99 LMKINFIGHRHLIDRLLANDQLPSGSAVCFISSVAGMGWENDLPRLTEFL
MAV_1264|M.avium_104 LMAINFLGHRYLIERLLERNQLPSGSAICFISSVAGMGWENDLDLLNEFL
TH_3168|M.thermoresistible__bu LMRTNFIGHRHLLDRLFADGRLGRGSAICFISSVAGMGWENDLDRLLDFL
Mflv_2405|M.gilvum_PYR-GCK VLRINFLGMRQFTESLLD--RMPAGGAVTNVSSLAASAYRENAHVTAGLL
MSMEG_4862|M.smegmatis_MC2_155 VVRINFLGTRQFTEALVD--RIADGGSITSVSSLAASAYRENRAVTAGLV
Mvan_2008|M.vanbaalenii_PYR-1 VLTVNYLGMRKMVEGMLP--RMRRGGSVVAVASIAGIGWEQRLDELSELL
Mb2882c|M.bovis_AF2122/97 ------AGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLA
Rv2857c|M.tuberculosis_H37Rv ------AGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLA
MAB_3081|M.abscessus_ATCC_1997 LGPVDIVVANAGIATLTPECGDDGWRDVLDVNLTGVYHTIEVARPSMVQR
: : : . .
MMAR_4326|M.marinum_M ATPD----YGAAQDWVSAHE-AEGIIHYGFSKKAINAYVATRA-YPLLKR
MUL_0136|M.ulcerans_Agy99 ATPD----YGAAQDWVSAHE-AEGIIHYGFSKKAINAYVATRA-YPLLKR
MAV_1264|M.avium_104 ATPD----FATAQEWVKAHE-PEGIIHYGFSKKVVNAYVATQG-YPLLKK
TH_3168|M.thermoresistible__bu STTD----YRSADAWVKEHE-GDGFIHYGFSKQVVNAYVATWA-FELLKQ
Mflv_2405|M.gilvum_PYR-GCK ATRS----VDEGLRWCADHPEALADGGYRQSKEAIILYGMQRV-TDLGAR
MSMEG_4862|M.smegmatis_MC2_155 STGS----VDEGLRWCAENPDALADGGYRLSKEAIILYGMSKA-VELGAR
Mvan_2008|M.vanbaalenii_PYR-1 AATD----PEAVAAWQSRQDPSYP--VYTTSKQAVILYAKRLAGTALSRY
Mb2882c|M.bovis_AF2122/97 GKGS----IVNTASFVAVMGSATSQISYTASKGGVLAMSRELG-VQFARQ
Rv2857c|M.tuberculosis_H37Rv GKGS----IVNTASFVAVMGSATSQISYTASKGGVLAMSRELG-VQFARQ
MAB_3081|M.abscessus_ATCC_1997 GAGGSIVLTSSVAGLTGMVMDNPGGLAYTAAKHGLVGLMRSYA-NMLAPH
. . * :* : :
MMAR_4326|M.marinum_M GIRINAICPGPTDT-----PLAQANADLWL-TFAQDYRDETGSKVHTPEQ
MUL_0136|M.ulcerans_Agy99 GIRINAICPGPTDT-----PLAQANADLWL-TFAQDYRDETGSKVHTPEQ
MAV_1264|M.avium_104 GIRINAICPGPTDT-----PLAQANADLWL-TFAQDYRDETGSKVHTPEQ
TH_3168|M.thermoresistible__bu GVRINAICPGPTDT-----PLARANADLWL-TFAQDYRDATGVGVHQPEQ
Mflv_2405|M.gilvum_PYR-GCK GIRVNCTAPGVTET-----PILDQLRSAYG-QQYLDSFTAPLGRVSTPEE
MSMEG_4862|M.smegmatis_MC2_155 GIRVNCTGPGVTDT-----PILDQLRSAYG-QQYLDSFTTPLGRNSEPDE
Mvan_2008|M.vanbaalenii_PYR-1 GVRVNTVSPGPVET-----PILADFEQTMG-KEILDMLRDTYGRHGTVDD
Mb2882c|M.bovis_AF2122/97 GIRVNALCPGPVNT-----PLLQELFAKNPERAARRMVHVPLGRFAEPDE
Rv2857c|M.tuberculosis_H37Rv GIRVNALCPGPVNT-----PLLQELFAKNPERAARRMVHVPLGRFAEPDE
MAB_3081|M.abscessus_ATCC_1997 NIRVNTIHPSGVATPMLINPVTEKLFADGSPEGMSDTGNALPVVLMEPED
.:*:* *. . * *: ::
MMAR_4326|M.marinum_M MGDVMVFLNSAAAFGISGITLLVDYGHTMSSLTGAYPPGKPIIDLIMGRV
MUL_0136|M.ulcerans_Agy99 MGDVMVFLNSAAAFGISGITLLVDYGHTMSSLTGAYPPGKPIIDLIMGRV
MAV_1264|M.avium_104 MGDVMAFLNSAAAFGINGITLLVDYGHTMASLTGAYPPGKPIIDIIMGRV
TH_3168|M.thermoresistible__bu MGSAMAFLNSPAASGISGITLLVDSGHAMSSLTNAFPPGKPIMDLITGRA
Mflv_2405|M.gilvum_PYR-GCK QAAVLVFLGSRAAGYISGQVLWTDGGILGRRIASQMFDEPLTQGN-----
MSMEG_4862|M.smegmatis_MC2_155 QAALLVFLGSAAASYVTGQVIWADGGIIAQRETALIESTRATQES-----
Mvan_2008|M.vanbaalenii_PYR-1 IVPVIAFLASDAAQWINGQDVHVDSGFVTSMTAGTPIAL-----------
Mb2882c|M.bovis_AF2122/97 IAAAVAFLASDDASFITASTFLVDGGISSAYVTPL---------------
Rv2857c|M.tuberculosis_H37Rv IAAAVAFLASDDASFITASTFLVDGGISSAYVTPL---------------
MAB_3081|M.abscessus_ATCC_1997 MANTVAWLVSEDARYITGVALPVDAGFTNRR-------------------
:.:* * * :.. . .* *
MMAR_4326|M.marinum_M PMP
MUL_0136|M.ulcerans_Agy99 PMP
MAV_1264|M.avium_104 KL-
TH_3168|M.thermoresistible__bu KL-
Mflv_2405|M.gilvum_PYR-GCK ---
MSMEG_4862|M.smegmatis_MC2_155 ---
Mvan_2008|M.vanbaalenii_PYR-1 ---
Mb2882c|M.bovis_AF2122/97 ---
Rv2857c|M.tuberculosis_H37Rv ---
MAB_3081|M.abscessus_ATCC_1997 ---