For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RRAAIVAPRRTPVGTFGGSLRPLRAEDLAAHVIRAVVAQSAIDPPVIDDVVFAQSYANSEAPCIGRWAAL HAGLPISVPGQQIDRRCGGGLQAVITAAMMVQTGAADVVLAGGVESMSNIEHYTTTARWGSRSGNQILYD RLDRGREMSQPTWRFGPISGMIETAENLAADYGIDRAAADAFAARSHQRAAAAQRSGAFDSEIVAVEAPQ RRGDPVVVDRDEGVRPDCTPESLARLRPITSNGTVTAGNSSQQNDAAAACLVVAEDRLGNLGLEPIGYLE SWAVVGCEPSRMGIGPVRAVEKLFYKTGVGFDDLALIEINEAFAVQVLAVLSGWGIKLDDVDDRLNVNGS GISLGHPIGATGVRILTTMLHELHRRGGGLALETMCIGGGQGLAALFRGAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5081 | - | - | 100% (402) | acetyl-CoA acetyltransferase |
| M. avium 104 | MAV_1573 | - | e-104 | 49.26% (406) | acetyl-CoA acetyltransferase |
| M. avium 104 | MAV_1276 | - | 5e-67 | 38.60% (399) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1103c | fadA3 | 1e-58 | 35.71% (420) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_1347 | - | 1e-110 | 54.89% (399) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 1e-58 | 35.71% (420) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 3e-60 | 34.75% (400) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_1463 | - | 2e-66 | 37.19% (398) | acetyl-CoA acetyltransferase FadA |
| M. marinum M | MMAR_4032 | - | 1e-100 | 48.88% (403) | beta-ketoacyl CoA thiolase |
| M. smegmatis MC2 155 | MSMEG_1896 | - | 1e-112 | 55.47% (402) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_0255 | - | 2e-67 | 40.60% (399) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_0971 | fadA6_3 | 7e-66 | 37.59% (399) | acetyl-CoA acetyltransferase FadA6_3 |
| M. vanbaalenii PYR-1 | Mvan_1976 | - | 1e-102 | 49.25% (402) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1347|M.gilvum_PYR-GCK -------MDVVICNPVRTPVG-RMGGALSPLTAADLATVTLRALIDRT-G
MSMEG_1896|M.smegmatis_MC2_155 MASDSSASQVVICNPLRTPVG-RMGGVLAALTAADLATSTLRELATRT-G
MMAR_4032|M.marinum_M --MSAAMRQAVICEPVRTPIG-RYGGMFKSHSAVDLGVVALRGLLDRT-G
Mvan_1976|M.vanbaalenii_PYR-1 -----MMRDAVVCEPVRTPIG-RYNGMFKSLTAVELGVAALQGLLART-G
MAV_5081|M.avium_104 ------MRRAAIVAPRRTPVG-TFGGSLRPLRAEDLAAHVIRAVVAQS-A
TH_0255|M.thermoresistible__bu ------MRETVIVEAVRTAVG-KRNGALADVHAADLSAVVLSELVERA-G
MUL_0971|M.ulcerans_Agy99 ------MAEAVIVEAVRSPVG-KRNGALSGVHPADLSAQVLNGLADKA-G
Mb1103c|M.bovis_AF2122/97 ------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPA
Rv1074c|M.tuberculosis_H37Rv ------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPA
MLBr_01158|M.leprae_Br4923 ------MTTSVIVTGARTPIG-KLMGSLKDFSASDLGAITIAAALKKA-N
MAB_1463|M.abscessus_ATCC_1997 ---MAATNRSVIVAGARTPVG-RFQGSLKDFSGAQLGGIAIAGALAKA-G
.: *:.:* * : :*. : :
Mflv_1347|M.gilvum_PYR-GCK LGEGDVDDVILGNGYANGE-APALGRVAALDAGLGTAVPGLQIDRRCGSG
MSMEG_1896|M.smegmatis_MC2_155 LGEGDIDDVVLGHGYPSGE-APAIGRIAALDAGLGTAVPGLQLDRRCGSG
MMAR_4032|M.marinum_M LAPAAVGDVILGHCYPSSE-APAIGRVVALDAGLPVTVPGMQVDRRCGSG
Mvan_1976|M.vanbaalenii_PYR-1 VAPGAVEDVVVGHCYPSME-APAIGRVIALDAGLPVTVPGMQIDRRCGSG
MAV_5081|M.avium_104 IDPPVIDDVVFAQSYANSE-APCIGRWAALHAGLPISVPGQQIDRRCGGG
TH_0255|M.thermoresistible__bu IDPELIDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSS
MUL_0971|M.ulcerans_Agy99 IDPEIVDDVIWGCVMQAGEQALDIARTSLLTAGWPETVPGVTVDRQCGSS
Mb1103c|M.bovis_AF2122/97 LNPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPGTTVNRYCSSS
Rv1074c|M.tuberculosis_H37Rv LNPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPGTTVNRYCSSS
MLBr_01158|M.leprae_Br4923 VAPSIVQYVIIGQVLTAGA-GQMPARQAAVAAGIGWDVPALTINKMCLSG
MAB_1463|M.abscessus_ATCC_1997 VAPSAVDYVIMGQVLTAGA-GQMPARQAAVAGGIGMDVPALTINKVCLSG
: : :: . . .* : * :*. ::: * ..
Mflv_1347|M.gilvum_PYR-GCK LQAVLYAAGQVATGAARTVIAGGAESMSNVEHYALGLR------------
MSMEG_1896|M.smegmatis_MC2_155 LQAVLYAAGQVATGAAGVVVAGGAESMSNVEHYALGLR------------
MMAR_4032|M.marinum_M LQAVIQACQQVSSGDSDLVVAGGCESMSNVTFYSTDMR------------
Mvan_1976|M.vanbaalenii_PYR-1 LQAVIQAAMQVASGNNDLVVAGGAESMSNVVFHSTDMR------------
MAV_5081|M.avium_104 LQAVITAAMMVQTGAADVVLAGGVESMSNIEHYTTTAR------------
TH_0255|M.thermoresistible__bu QQALDFAVHAVMSGQQDVVVAGGVEVMSRVPLG-----------------
MUL_0971|M.ulcerans_Agy99 QQSVHFAAAGVVAGHYDVVVAGGVESMSRTPMG-----------------
Mb1103c|M.bovis_AF2122/97 LQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQ
Rv1074c|M.tuberculosis_H37Rv LQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQ
MLBr_01158|M.leprae_Br4923 LDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSR------------
MAB_1463|M.abscessus_ATCC_1997 VDAIALADQLIRAGEFEVVVAGGQESMTNAPHLLPKSR------------
:: * : :* .::.* * ::.
Mflv_1347|M.gilvum_PYR-GCK ---TGVRQGGIALQDRLDRARETAGGTS--HPVAGGMIETAENLRREYGI
MSMEG_1896|M.smegmatis_MC2_155 ---TGVRQGGVALHDRLDRARETAGGTS--HPIAGGMIETAENLRREYGI
MMAR_4032|M.marinum_M ---WGGARGGIRVHDGLARGRVTAGGRH--YPVPGGMLETAENLRRQYGI
Mvan_1976|M.vanbaalenii_PYR-1 ---WGGARGGITVHDALARGRTTAGGKN--YPVPGGMLETAENLRRDYGI
MAV_5081|M.avium_104 ---WGSRSGNQILYDRLDRGREMSQPTWRFGPISG-MIETAENLAADYGI
TH_0255|M.thermoresistible__bu ----AARATG-MPYGPKVLERYDNFGFN--------QGISAELIAERWNL
MUL_0971|M.ulcerans_Agy99 ----SSLANGGRPYSQTFLERYDGRIPN--------QGLGAEMIAEQWGL
Mb1103c|M.bovis_AF2122/97 ERSAAAAAGADEWHDPRTDQKLPDIYIA--------MGQTAENVAIMTGI
Rv1074c|M.tuberculosis_H37Rv ERSAAAAAGADEWHDPRTDQKLPDIYIA--------MGQTAENVAIMTGI
MLBr_01158|M.leprae_Br4923 ---SGYKYGDVTIVDHLAYDGLHDVFTN------QPMGALTEQRNDVEKF
MAB_1463|M.abscessus_ATCC_1997 ---AGFKYGDVTLIDHMAFDGLHDAFTD------QAMGLLTEQRNASDKF
. . :* :
Mflv_1347|M.gilvum_PYR-GCK EREEQDELALRSHRRAVAAHENGSFVDEMVPVTVPGARGGADTVVDRDEH
MSMEG_1896|M.smegmatis_MC2_155 SRAEQDELAVRSHQRAVAAHDAGRFADELVPVTVPGKRGRPGTVVDRDEH
MMAR_4032|M.marinum_M SRLEQDELAVTSHQRAVAAQKDGIFAEETIAVPVRTRQG--EELIDTDEH
Mvan_1976|M.vanbaalenii_PYR-1 SRQEQDELAVLSHRRAVTAQKDGLLAETIIPVTVTSRSG--DQVIDTDEH
MAV_5081|M.avium_104 DRAAADAFAARSHQRAAAAQRSGAFDSEIVAVEAPQRRGD-PVVVDRDEG
TH_0255|M.thermoresistible__bu SRTRLDEYSAQSHERAAAAQSSGAFKDQIVPVFTDD------AVVTEDEG
MUL_0971|M.ulcerans_Agy99 SRTMLDEFSLMSHEKAAAAQDSGAFDDQIVGIKDQDG-----NPVLKDEG
Mb1103c|M.bovis_AF2122/97 SREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDG-----TTVSTDDG
Rv1074c|M.tuberculosis_H37Rv SREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDG-----TTVSTDDG
MLBr_01158|M.leprae_Br4923 TRQEQDEFAARSHQKAAAAWKDGVFADEVVPVSIPQSKGD-SLQFTEDEG
MAB_1463|M.abscessus_ATCC_1997 TREEQDEFAARSHQNAARGWKDGAFADEVVPVRIPQRKGD-PIEFAEDEG
* * . *:..* . * : : . *:
Mflv_1347|M.gilvum_PYR-GCK PRTDLTADKLAALRPIRSRVDAGSTVTAGNASGQNDGAAMCVVTTRAEAE
MSMEG_1896|M.smegmatis_MC2_155 PRADIDVETLSALRPIRGKVDAEATVTAGNASGQNDGAAMCVVTTREEAE
MMAR_4032|M.marinum_M PRADTSVEALSGLKPILHQDDPEATVTAGNASGQNDAASVCVVTTPEKAD
Mvan_1976|M.vanbaalenii_PYR-1 PRADTSLESLAKLKPVLGKSDPDATVTAGNSSGQNDAASMCLVTTPQKAA
MAV_5081|M.avium_104 VRPDCTPESLARLRPITSN----GTVTAGNSSQQNDAAAACLVVAEDRLG
TH_0255|M.thermoresistible__bu IRRGTTVEKLATLKPAFTE---NGVIHAGNSSQISDGAAALLVMTAETAV
MUL_0971|M.ulcerans_Agy99 IRRGTPMEKMAALKPAFKE---DGVIHAGNSSQISDGSAALLFMSAEKAK
Mb1103c|M.bovis_AF2122/97 PRPGTTYEKVSELKPAFRP---NGTVTAGNACPLNDGAAAVVITSDTKAK
Rv1074c|M.tuberculosis_H37Rv PRPGTTYEKVSELKPAFRP---NGTVTAGNACPLNDGAAAVVITSDTKAK
MLBr_01158|M.leprae_Br4923 IRANTSAESLAGLKPAFRC---GGTITPGSASQISDGAATVVVMNKEKAQ
MAB_1463|M.abscessus_ATCC_1997 IRADTTAASLAGLRPAFSK---DGTITAGSSSPISDGACAVVVMSKERAE
* . :: *:* ..: .*.:. .*.:. :.
Mflv_1347|M.gilvum_PYR-GCK KRSLEPLLTLRSWSVTGCAPETMGIGPVSAAAAALERADLTLDEIDLIEV
MSMEG_1896|M.smegmatis_MC2_155 KRGLTPMLALKSWAVTGCAPEKMGIGPVAASDAALQRAGITLDEVDLIEL
MMAR_4032|M.marinum_M EYGLRPLVRLVSWGLAGVAPDVMGIGPVPATEAALAKAALRLADIDLIEL
Mvan_1976|M.vanbaalenii_PYR-1 ELGLRPLVRLVSWGVAGVAPNVMGIGPVPATEVALGNAGLALSDVDLIEL
MAV_5081|M.avium_104 NLGLEPIGYLESWAVVGCEPSRMGIGPVRAVEKLFYKTGVGFDDLALIEI
TH_0255|M.thermoresistible__bu TLGLTPIVRYRAGAVTGADPVLMLTGPIPATEKVLRKTGLNIDDIGVFEV
MUL_0971|M.ulcerans_Agy99 SLGMKPIAKVHTAVLAGADPVIMLTAPIPATQKVLKRSGLSIGDIGAYEV
Mb1103c|M.bovis_AF2122/97 ELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEI
Rv1074c|M.tuberculosis_H37Rv ELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEI
MLBr_01158|M.leprae_Br4923 QLGLTWLVEIGAHGVVAGPDSTLQSQPANAIKKAVDREGISVEQLDVVEI
MAB_1463|M.abscessus_ATCC_1997 REGLEWLAEIGAHGVVAGPDSSLQLQPANAIRKACEREGISPEQLDLVEI
.: : : : . : * * . : :: *:
Mflv_1347|M.gilvum_PYR-GCK NEAFAAQVLAVLAEWKIDPLD--DRLNPNGSGISLGHPIGATGARILATA
MSMEG_1896|M.smegmatis_MC2_155 NEAFAAQVLAVLAEWKVDPLD--ERLNPNGSGISLGHPIGATGARILATA
MMAR_4032|M.marinum_M NEAFAAQALAVMREWNFGAADR-DRTNVHGSGISLGHPVGATGARMLATL
Mvan_1976|M.vanbaalenii_PYR-1 NEAFAAQALACMREWKFTQADL-ERTNVHGSGISLGHPVGATGGRMLATL
MAV_5081|M.avium_104 NEAFAVQVLAVLSGWGIKLDDVDDRLNVNGSGISLGHPIGATGVRILTTM
TH_0255|M.thermoresistible__bu NEAFAPVPLAWQAETGADPAK----LNPLGGAIALGHPLGASGAVLMTRM
MUL_0971|M.ulcerans_Agy99 NEAFAPVPLAWLCDIGADENR----LNPNGGAIALGHPLGGSGARVMTTL
Mb1103c|M.bovis_AF2122/97 NEAFAVQVLGSARELGIDEDK----LNISGGAIALGHPFGMTGARITTTL
Rv1074c|M.tuberculosis_H37Rv NEAFAVQVLGSARELGIDEDK----LNISGGAIALGHPFGMTGARITTTL
MLBr_01158|M.leprae_Br4923 NEAFAAVALASARELGIAPEL----VNVNGGAIAVGHPLGMSGARITLHV
MAB_1463|M.abscessus_ATCC_1997 NEAFALVGLASIKDLGIDPEK----VNVNGGAIAIGHPIGMSGARITLHL
***** *. * *..*::***.* :* :
Mflv_1347|M.gilvum_PYR-GCK AYEARRRDARYVLEAMCIGGGQGLAAVFEVTR-
MSMEG_1896|M.smegmatis_MC2_155 AHEALRRDARYVLETMCIGGGQGLAAVFEAVR-
MMAR_4032|M.marinum_M ARELTRRQARYGLETMCIGGGQGLAAIFERVG-
Mvan_1976|M.vanbaalenii_PYR-1 ARELNRRDGRFGLETMCIGGGQGLAAVFERVTP
MAV_5081|M.avium_104 LHELHRRGGGLALETMCIGGGQGLAALFRGAA-
TH_0255|M.thermoresistible__bu VHHMRANGIRYGLQTMCEGGGTANATVVELLA-
MUL_0971|M.ulcerans_Agy99 LYHMRDNGIRYGLQTMCEGGGQANATVLELL--
Mb1103c|M.bovis_AF2122/97 LNNLQTYDKTFGLETMCVGGGQGMAMVIERLA-
Rv1074c|M.tuberculosis_H37Rv LNNLQTYDKTFGLETMCVGGGQGMAMVIERLA-
MLBr_01158|M.leprae_Br4923 ALELARRGSGYGVAALCGAGGQGDALILRAV--
MAB_1463|M.abscessus_ATCC_1997 AQELKRRGGGIGVAALCGGGGQGDALIVRV---
. : ::* .** . * :..