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NALPQPGKSYSDGYELAIEFANVLNLPERAKVVQDGTTVGVVTRIELKSNHVDVISRIDRDVAVPSNVHA TLQQSTVLGDTYVALERPQQGADAAAAPAGENGRIPLAQTTSPPQLEDTIANMANFVGSGSVQRIQNTII GINNVTPSRNAELHKISSRVVADLKDLSNNIDVVDTWLNGVSGTGQVMHQNLPIYRYWFSPDGMLGFDRG TQTASYIGTVLPSIGSIYSGGFWLVPTLESLANATGAVQHTKWDFEREAPAWRKLFYEDFLPVDKNPAIN ITSIKGPDGREMIGNVQDVLRILGATP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5048 | - | - | 100% (308) | putative Mce family protein |
| M. avium 104 | MAV_2065 | - | 9e-14 | 29.27% (164) | LprM protein |
| M. avium 104 | MAV_2384 | - | 2e-13 | 25.24% (313) | mce related protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3525c | lprN | 3e-11 | 26.00% (200) | MCE-family lipoprotein LprN |
| M. gilvum PYR-GCK | Mflv_4534 | - | 5e-16 | 28.95% (190) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 7e-12 | 25.27% (186) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 6e-11 | 22.73% (198) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4034 | - | 2e-26 | 35.57% (194) | putative Mce family protein |
| M. marinum M | MMAR_3868 | mce5E | 9e-17 | 34.09% (176) | Mce family protein, Mce5E |
| M. smegmatis MC2 155 | MSMEG_2859 | - | 2e-18 | 31.05% (190) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2981 | - | 4e-13 | 27.61% (163) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3800 | mce5E | 6e-17 | 34.09% (176) | Mce family protein, Mce5E |
| M. vanbaalenii PYR-1 | Mvan_4395 | - | 1e-14 | 27.53% (178) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1970|M.tuberculosis_H37Rv ----------MR--IGLTLVMIAAV----VASCGWRGLNSLPLPGTQGNG
Mvan_4395|M.vanbaalenii_PYR-1 ----------MKRILQLGAAMVAAVMVTCVAGCEWRGLNSLPLPGTAGGG
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVRHQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGSG
MSMEG_2859|M.smegmatis_MC2_155 ---------MKPRKPARGWLAVACCAVLTVSGCRFDGVNSLPLPGTVGTG
TH_2981|M.thermoresistible__bu ------------VTFLRSRIAVACCAVLTLSGCTFDGVSSLPLPGTVGTG
Mflv_4534|M.gilvum_PYR-GCK -------MTRPTVRRTRRWAAAACCVALTATGCSFDGLNSLPLPGTVGTG
Mb3525c|M.bovis_AF2122/97 ------------MNRIWLRAIILTASSALLAGCQFGGLNSLPLPGTAGHG
MMAR_3868|M.marinum_M ------------MSGFGKAAAAIAMTTLLSSGCAANGLDSLPLP-APTLG
MUL_3800|M.ulcerans_Agy99 ------------MSGFGKAAAAIAVTTLLSSGCAANGLDSLPLP-APTLG
MAB_4034|M.abscessus_ATCC_1997 -------------MIRSILIILFAAAFAVVPACSSEALDPTKMPMPGAYL
MAV_5048|M.avium_104 -------------------------------------MNALPQPGKSYSD
:. *
Rv1970|M.tuberculosis_H37Rv -PGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQ-----GWHALV
Mvan_4395|M.vanbaalenii_PYR-1 -SGAYTVTAQLPDVSNIEPNSRVRVGDVTVGNVVKIERQ-----GWHALA
MLBr_02593|M.leprae_Br4923 -KGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLK-----NWVATL
MSMEG_2859|M.smegmatis_MC2_155 -SDAATFHVQIANVGTLEPNSPVMIDDVVVGAVRRMTLA-----GWHADV
TH_2981|M.thermoresistible__bu -SDAVTYQVQIANVGTLEPNSPVMVDDVVVGAVRRMTLD-----GWYADV
Mflv_4534|M.gilvum_PYR-GCK -SDAVTYRVQLANVGSLESNSPVMLDDVVVGAVGKMTFE-----DWHAAV
Mb3525c|M.bovis_AF2122/97 -EGAYSVTVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAV
MMAR_3868|M.marinum_M -SGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVAR-----NYTAVT
MUL_3800|M.ulcerans_Agy99 -SGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVAR-----NYTAVT
MAB_4034|M.abscessus_ATCC_1997 PKNTYRLKIEFSSVLNLPGRAKVDSGGVQVGLLDRVELK-----GTTPVA
MAV_5048|M.avium_104 ---GYELAIEFANVLNLPERAKVVQDGTTVGVVTRIELK-----SNHVDV
.... : .: * .. ** : : .
Rv1970|M.tuberculosis_H37Rv TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGE--ARQGKLRDGSL
Mvan_4395|M.vanbaalenii_PYR-1 TIKLDGDIELPANTHAAVGQTSLFGTLHVELFSPIDA--APVGRLREGSL
MLBr_02593|M.leprae_Br4923 TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN---PSLELLKNGDT
MSMEG_2859|M.smegmatis_MC2_155 EVSVQPDVVVPANAVATVGQTSLLGSMHLALDPPVDS--APEGRLAPGAT
TH_2981|M.thermoresistible__bu EVTVRPGTVIPANAVATVGQTSLLGSMHLALDPPVGE--PPTGALAPGAT
Mflv_4534|M.gilvum_PYR-GCK DISVRPDVVVPANAVATVGQTSLLGSMHVALDPPVGE--TPTGRLAPGAN
Mb3525c|M.bovis_AF2122/97 KLDLDKNVLLPANAVAKVSQTSLLGSLHVELAPPTDR--PPTGRLVDGSR
MMAR_3868|M.marinum_M RLRITDDVRLPRGSTAELRTATPLGDVFVALRPPAGAG-TEAAMLKDGDT
MUL_3800|M.ulcerans_Agy99 RLRITDDVRLPRGSTAELRTATPLGDVFVALRPPAGAG-TEAAMLKDGDT
MAB_4034|M.abscessus_ATCC_1997 YVEIDGDAKFPENVRAELRQATVLGDIYIAMISPKDP---ATTHLKDGDT
MAV_5048|M.avium_104 ISRIDRDVAVPSNVHATLQQSTVLGDTYVALERPQQGADAAAAPAGENGR
: . .* . * : :: :* .: : * .
Rv1970|M.tuberculosis_H37Rv IALSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLR
Mvan_4395|M.vanbaalenii_PYR-1 IPLSNTRSYPTTEQTLASLSFLLNGGGIGQMQDITAAFSTALNGREDDLR
MLBr_02593|M.leprae_Br4923 IPLKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIH
MSMEG_2859|M.smegmatis_MC2_155 IPLSRSTTYPSTEQTLSSLSLVVNGGGLMQIADIVHNFSAALDGRAVEIR
TH_2981|M.thermoresistible__bu IPLERSSSFPSTEQTLASLSFVVNGGGLAQIADIVHNFTAALDGRAVHVR
Mflv_4534|M.gilvum_PYR-GCK LPLNRTSTYPSTEQTLSSLSVVVNGGGLTQIGDIISNFSAALDGRQGQIR
Mb3525c|M.bovis_AF2122/97 ITEANTDRFPTTEEVFSALGVVVNKGNVGALEEIIDETHQAVAGRQAQFV
MMAR_3868|M.marinum_M IGLDSTTAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGDQGQAFG
MUL_3800|M.ulcerans_Agy99 IGLDSTTAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGDQGQAFG
MAB_4034|M.abscessus_ATCC_1997 ITLANTVPAANVEDLMRSMSNLIGGGSLNTMQTTVANMNSAFP-PPEELD
MAV_5048|M.avium_104 IPLAQTTSPPQLEDTIANMANFVGSGSVQRIQNTIIGINNVTPSRNAELH
: . *. : . .: * : . .
Rv1970|M.tuberculosis_H37Rv GLIGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPD
Mvan_4395|M.vanbaalenii_PYR-1 GFNEQVGMFMESLNMQRDDIIAATESLNRLVSRFGERQETLDAALRTIPK
MLBr_02593|M.leprae_Br4923 AFLTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPP
MSMEG_2859|M.smegmatis_MC2_155 DLLTRMNNVVGILDNQRDNIVATIAAMNRVAGTFAAQRSTLTEALDRIPP
TH_2981|M.thermoresistible__bu ELLTRMNNVVGLLDGQRDKILATIENLDRAAGTFAAQREELAAALDRIPP
Mflv_4534|M.gilvum_PYR-GCK SLLTRMNDVVGILDDQRDNINATISALYRLSETFAGQREVLSAALKRIPE
Mb3525c|M.bovis_AF2122/97 NLVPRLAELTAGLNRQVHDIIDALDGLNRVSAILARDKDNLGRALDTLPD
MMAR_3868|M.marinum_M NLIRKSNRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTELMAAAEP
MUL_3800|M.ulcerans_Agy99 NLIRKSNRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTELMAAAEP
MAB_4034|M.abscessus_ATCC_1997 RIHRALAGVIHDLSSNQDTLNKILTNMQTVSESFRANKGTYLRLLSEGPT
MAV_5048|M.avium_104 KISSRVVADLKDLSNNIDVVDTWLNGVSGTGQVMHQNLPIYRYWFS--PD
: *. . : . :
Rv1970|M.tuberculosis_H37Rv ALAVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLES
Mvan_4395|M.vanbaalenii_PYR-1 ALTVLKDQRENMVEALVEFGRLSALTTETLEKSEENLVREVSDLGPVFAA
MLBr_02593|M.leprae_Br4923 LIKHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRE
MSMEG_2859|M.smegmatis_MC2_155 ALEVLASQRPQITTAMNKLGAFSDIAHRLINDSQADLVRNLKNLEPTVKA
TH_2981|M.thermoresistible__bu ALEVLAEQQPRISTALQSLGDFSDLANQLINESQEDLVRNLQNLEPTVRA
Mflv_4534|M.gilvum_PYR-GCK ALAVLNQQRPRIVTAMRKLGDFSDTATQLIDESQEDIVGNLRNLEPAVRA
Mb3525c|M.bovis_AF2122/97 AVRVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDLKDLYSIVKA
MMAR_3868|M.marinum_M AADALAANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIRDLNTIA
MUL_3800|M.ulcerans_Agy99 AADALAANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIRDLNTIA
MAB_4034|M.abscessus_ATCC_1997 KLPSLAKVVLSLSDLIINASEFGRQIGQILDYP--NLMQILSYLTPFVHS
MAV_5048|M.avium_104 GMLGFDRGTQTASYIGTVLPSIGSIYS-----GGFWLVPTLESLANATGA
:
Rv1970|M.tuberculosis_H37Rv LANSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQG
Mvan_4395|M.vanbaalenii_PYR-1 LAAAGPSLTRSASLLTTI-WPKENLTKWFRGDYGNLTMVLDLTLNRLDAG
MLBr_02593|M.leprae_Br4923 LGRGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNA
MSMEG_2859|M.smegmatis_MC2_155 LADVGTDLVTALSYLPTYPYTQDFIDRGIRGDFMNQFIVFDFTIPRLKSG
TH_2981|M.thermoresistible__bu LAEVGPDLVTALTYLPTYPYTQEFIDRGIRGDYMNQFIVFDFTIPRLKRG
Mflv_4534|M.gilvum_PYR-GCK LADVGPDLATALSYLPTYPYTQEFIDRGIRGDYMNQFIVFDFTIPRLKSG
Mb3525c|M.bovis_AF2122/97 LNDDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGET
MMAR_3868|M.marinum_M GAANDIAVSPDTSWLALNRMIPPMVKSTAGGALSVRASVDRLVLGSIPDI
MUL_3800|M.ulcerans_Agy99 GAANDIAVSPDTSWLALNRMIPPMVKSTARGALSVRASVDRLVLGSIPDI
MAB_4034|M.abscessus_ATCC_1997 ASTADTTIP-VLGDKMVRTIRDRIIPFFKDG--GPKYTVTDIQNPDGTLG
MAV_5048|M.avium_104 VQHTKWDFEREAPAWRKLFYEDFLP--------VDKNPAINITSIKGPDG
. .
Rv1970|M.tuberculosis_H37Rv LLTGTR---------WECHLTQLELQWGRTIGQFP--SPCTAGYRGTPGN
Mvan_4395|M.vanbaalenii_PYR-1 LLTGTR---------WEGDLTALELQWGRTIGQLP--SPYTAG------N
MLBr_02593|M.leprae_Br4923 VLTGTG---------LSGALRALEQSFGRDPETMIPDVRYTTNPNDAPGG
MSMEG_2859|M.smegmatis_MC2_155 ILLGTR---------WGQPGASLVPAPGDPWYSSYTLDPLKAPVTPKPTE
TH_2981|M.thermoresistible__bu ILLGTR---------WGQPGASLVPAPGDPWYSSYTRDPLKTPVTPAPPD
Mflv_4534|M.gilvum_PYR-GCK ILLGTR---------WGEPGASMVPAPGDPWYSMYTRDPLQAPITPIPAE
Mb3525c|M.bovis_AF2122/97 FFTTAY---------FDPNMAHMDEILNPPDFLIG----ELANLSGQAAD
MMAR_3868|M.marinum_M GFPGDIGLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGPGSPQLPVMPDP
MUL_3800|M.ulcerans_Agy99 GFPGDVGLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGPGSPQLPVMPDP
MAB_4034|M.abscessus_ATCC_1997 VSPGER----------ADSVIRNMQTMGLVR-------------------
MAV_5048|M.avium_104 REMIGN-------------VQDVLRILGATP-------------------
Rv1970|M.tuberculosis_H37Rv PLTIAYRWDQGP-----------
Mvan_4395|M.vanbaalenii_PYR-1 PLLAPYHHEQGR-----------
MLBr_02593|M.leprae_Br4923 PLVERADRRC-------------
MSMEG_2859|M.smegmatis_MC2_155 LAPFPPTVDGAGDAAPAAEGGN-
TH_2981|M.thermoresistible__bu LAPIPPMTDDPADTG----GGN-
Mflv_4534|M.gilvum_PYR-GCK VATIPPLVDLPPAPAGEPAGGGS
Mb3525c|M.bovis_AF2122/97 PFKIPPGTASGQ-----------
MMAR_3868|M.marinum_M EVPGEIQIAPPLSPQPPGPPP--
MUL_3800|M.ulcerans_Agy99 EVPDEIQIAPPLSPQPPGPPP--
MAB_4034|M.abscessus_ATCC_1997 -----------------------
MAV_5048|M.avium_104 -----------------------