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TATGARGRLTALAAAMAVTTATAGCATNGLASLPLPAPGLGSGGYSLNAVFSNALNLPMNAKVKLAGADV GQLESMVARNYTALTRLRIRDGVQLPRGSTAELRTATPLGDVFVALKPPPGDHDAPLLKNGDTIGLESTA AAATVESVLSSAAVLVNGGAVRNFTNIINGFGKATGDQGQAFGDMIRKSNELLGTLDARSDQISAALTQL STLADQLDAKNHTITDLMTAAGPATSALADNTGELSEVAQQVGDTSRLLARFPALGGTDTSGRSMIRDLN TIAGAANDVAVSPDTSWQSINRLIPALVKSTAGNSISVNVSVDKIMLGSLPDIGFPGDIGLHGPHHYNVN LLVGTLKYTLWRLQERVVGRGPNAPQVPVVPDPTVPGQIDVAPGPPPPQPGSPP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2384 | - | - | 100% (405) | mce related protein |
| M. avium 104 | MAV_0106 | - | e-138 | 62.56% (406) | mce related protein |
| M. avium 104 | MAV_2536 | - | 3e-25 | 27.03% (381) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 5e-22 | 28.03% (239) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0006 | - | 1e-144 | 64.50% (400) | hypothetical protein Mflv_0006 |
| M. tuberculosis H37Rv | Rv0593 | lprL | 5e-24 | 26.16% (409) | MCE-family lipoprotein LprL |
| M. leprae Br4923 | MLBr_02593 | lprK | 2e-25 | 25.31% (399) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4512c | - | 1e-145 | 65.00% (400) | putative Mce family protein |
| M. marinum M | MMAR_3868 | mce5E | 1e-172 | 75.63% (394) | Mce family protein, Mce5E |
| M. smegmatis MC2 155 | MSMEG_1147 | - | 1e-146 | 62.96% (405) | mce related protein |
| M. thermoresistible (build 8) | TH_4097 | - | 1e-134 | 61.62% (383) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_3800 | mce5E | 1e-170 | 75.13% (394) | Mce family protein, Mce5E |
| M. vanbaalenii PYR-1 | Mvan_0963 | - | 1e-146 | 66.07% (392) | hypothetical protein Mvan_0963 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3868|M.marinum_M --------------------MSGFG-----KAAAAIAMTTLLSSGCAANG
MUL_3800|M.ulcerans_Agy99 --------------------MSGFG-----KAAAAIAVTTLLSSGCAANG
MAV_2384|M.avium_104 --------------------MTATGARGRLTALAAAMAVTTATAGCATNG
MAB_4512c|M.abscessus_ATCC_199 --------------------MAARVAR-TVRAAVATLMTATVLSGCATNG
Mflv_0006|M.gilvum_PYR-GCK -----------------------MMTRRAATALAVAMTTCLSVTSCATEG
Mvan_0963|M.vanbaalenii_PYR-1 ------------------------MAIRAKGLMALLVTTSLSVSACATEG
MSMEG_1147|M.smegmatis_MC2_155 ------------------MMAASPKRLRKVRLVAAFAMT-VIVSGCATNG
TH_4097|M.thermoresistible__bu ---------------------MSVLRLR--RLVPALVTVGCLVSGCATNG
Mb0179|M.bovis_AF2122/97 ---MMSVLAR--------MRVMRHRAWQG----LVLLVLALLLSSCGWRG
MLBr_02593|M.leprae_Br4923 MRRAMSVVHT--------SRVR-HQTWRG----LVMLVAALLLSSCGWRG
Rv0593|M.tuberculosis_H37Rv MRCGVSAGSANGKPNRWTLRCGVSAGHRGSVFLLAVLLAPVVLTSCTWRG
:.* .*
MMAR_3868|M.marinum_M LDSLPLP-APTLGSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVA
MUL_3800|M.ulcerans_Agy99 LDSLPLP-APTLGSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVA
MAV_2384|M.avium_104 LASLPLP-APGLGSGGYSLNAVFSNALNLPMNAKVKLAGADVGQLESMVA
MAB_4512c|M.abscessus_ATCC_199 LGDLPLP-APGIGSGGYRLTALFSNVLNLPDSAKVKLAGADVGQVDEMHV
Mflv_0006|M.gilvum_PYR-GCK LSSLPLP-APGGGSGGYTLTAVFSNALNLPAMAKVKLAGADIGQLESMQA
Mvan_0963|M.vanbaalenii_PYR-1 LASLPLP-APSGGSGGYTLTAVFSNALNVPMMAKVKLAGADVGELESMQA
MSMEG_1147|M.smegmatis_MC2_155 LADLPLP-APGVGSGGYRITAIFSNALNLPANAKVKLAGADIGEMDSMVA
TH_4097|M.thermoresistible__bu LADLPLP-APGVGSGGYRLTAEFTNALNLPANAKVKLAGADVGEVESMVA
Mb0179|M.bovis_AF2122/97 ISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKL
MLBr_02593|M.leprae_Br4923 ISNVSIPGGPGSGKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINL
Rv0593|M.tuberculosis_H37Rv IANVPLPVGRGMGPDRMTIYVQMPDTLALNTNSRVRVADVWVGTVRDISL
: .:.:* . * . : . ..:.* : ::* :*.. :* : :
MMAR_3868|M.marinum_M RNYTAVTRLRITDDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAM
MUL_3800|M.ulcerans_Agy99 RNYTAVTRLRITDDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAM
MAV_2384|M.avium_104 RNYTALTRLRIRDGVQLPRGSTAELRTATPLGDVFVALKPPPGD-HDAPL
MAB_4512c|M.abscessus_ATCC_199 RNFTAVTTLRILDGVRLPKGSTAELRSATPLGDVFVSIRPPAGASADGPL
Mflv_0006|M.gilvum_PYR-GCK RDYTAVTTLRIREGVLLPVGSTAELRSATPLGDVFVSIKPPPSAGQGTPL
Mvan_0963|M.vanbaalenii_PYR-1 RDYTAVTTLRIREGVQLPKGSTAELRSATPLGDVFIAIKPPPSVQPGAAL
MSMEG_1147|M.smegmatis_MC2_155 RNYTAVTTLRIMEGVRLPEGSTAELRSATPLGDVFIAIKPPAPVEPGTPL
TH_4097|M.thermoresistible__bu RDYLAVTTLRIMDGVRLPRGSTAELRSATPLGDVFVAIKPPIDVPPDTPM
Mb0179|M.bovis_AF2122/97 KNWVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPDP--SPVP
MLBr_02593|M.leprae_Br4923 KNWVATLTLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPANP--SLEL
Rv0593|M.tuberculosis_H37Rv RNWIATLTLELEPTVRLPANATAKIGQTSLLGTQHVELAAPPIP--SPQP
::: * * : * ** .:**:: :: ** .: : .*
MMAR_3868|M.marinum_M LKDGDTIGLDSTTAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGD
MUL_3800|M.ulcerans_Agy99 LKDGDTIGLDSTTAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGD
MAV_2384|M.avium_104 LKNGDTIGLESTAAAATVESVLSSAAVLVNGGAVRNFTNIINGFGKATGD
MAB_4512c|M.abscessus_ATCC_199 LTDGDTIGLDSTTAAATVESVLSSAALASNGGAVRNLTNVVNGFGKATGD
Mflv_0006|M.gilvum_PYR-GCK LTDGDTIGLESTTAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGD
Mvan_0963|M.vanbaalenii_PYR-1 LRDGDTIGLESTTAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGD
MSMEG_1147|M.smegmatis_MC2_155 LKDGDTIDLDATAAAATVESVLSSAAILVNGGAVRNFTNLINGMGKATGD
TH_4097|M.thermoresistible__bu LRDGDTIGKDSTKAAATVESVLASAAILVNGGAVRNFTNIINGLGKATGD
Mb0179|M.bovis_AF2122/97 LKDGDTIPLKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTG
MLBr_02593|M.leprae_Br4923 LKNGDTIPLKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHG
Rv0593|M.tuberculosis_H37Rv LKSGDTIGLKNSSAYPTVERTLASVALILTGGGIVNLDVIQTEILNILDG
* .**** . : . .*.* .*:* : **.: *: : . .
MMAR_3868|M.marinum_M QGQAFGNLIRKSNRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTEL
MUL_3800|M.ulcerans_Agy99 QGQAFGNLIRKSNRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTEL
MAV_2384|M.avium_104 QGQAFGDMIRKSNELLGTLDARSDQISAALTQLSTLADQLDAKNHTITDL
MAB_4512c|M.abscessus_ATCC_199 QGQAFGDLINDSNRLLGALNSRSVQISEALTQTSQLADQLDAKNQVVTDI
Mflv_0006|M.gilvum_PYR-GCK QGQAFGELIRKTNHTLGTLNGRSEEIKTALTETSQLAAQLEAKNQSLAEV
Mvan_0963|M.vanbaalenii_PYR-1 QGRAFGDLIRKTNSTLGTMNARSGEISTAITETSRLAAQMEAKNAALGEV
MSMEG_1147|M.smegmatis_MC2_155 QGQAFGNLIRKTNNTLATLTARSEEISTAMTETSRLAQQISAKNQALSDV
TH_4097|M.thermoresistible__bu EGQAFGNLVRKTNATLAKLNARSAEISTAMTETSRLASEIAAKNQVLSEV
Mb0179|M.bovis_AF2122/97 RADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRV
MLBr_02593|M.leprae_Br4923 RADQIHAFLTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQI
Rv0593|M.tuberculosis_H37Rv HAGQIREFLERLATFTAELNNQRGDLTRAIDSTNQLLTIIANRNDTLDRV
.. : :: : : ::. .: . * : :. : :
MMAR_3868|M.marinum_M MAAAEPAADALAANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIR
MUL_3800|M.ulcerans_Agy99 MAAAEPAADALAANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIR
MAV_2384|M.avium_104 MTAAGPATSALADNTGELSEVAQQVGDTSRLLARFPALGGTDTSGRSMIR
MAB_4512c|M.abscessus_ATCC_199 VTAAGPATETLASNTAQLSELLLMMGDTTRQLQKFPSIAGTDTSGRSIIA
Mflv_0006|M.gilvum_PYR-GCK MDAAAPATSTLAAQTNGIADLVLTVGATTEQLRKFPSIAGTDTSGRSVIA
Mvan_0963|M.vanbaalenii_PYR-1 MDAAGPAADTLAAHTDEIADLVQQVGATAELLRRFPSIAGSDTSGRSVIA
MSMEG_1147|M.smegmatis_MC2_155 MAQARPATDTLAAHTTQIADLVTQIGDVSDQLRKFPSIAGADTSGRSVIA
TH_4097|M.thermoresistible__bu MAEARPATDTLAGHATEIADLVERFGGISDQAHRFPSIAGTDTSGRSVIA
Mb0179|M.bovis_AF2122/97 LTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAARGD-----LHQ
MLBr_02593|M.leprae_Br4923 LTDIPPLIKHFADTKNLLINAVGSVGQLSQAVDQYLSEARGP-----LHT
Rv0593|M.tuberculosis_H37Rv LTDVPPLIEHFADTGQLFADATESLGRFSEVANRALAATRPN-----LHQ
: * . :* : : .* : : : :
MMAR_3868|M.marinum_M DLNTIAGAANDIAVSPDTSWLALNRMIPPMVKSTAGGALSVRASVDRLVL
MUL_3800|M.ulcerans_Agy99 DLNTIAGAANDIAVSPDTSWLALNRMIPPMVKSTARGALSVRASVDRLVL
MAV_2384|M.avium_104 DLNTIAGAANDVAVSPDTSWQSINRLIPALVKSTAGNSISVNVSVDKIML
MAB_4512c|M.abscessus_ATCC_199 DANTIAKAWNDVAVDPDTSLAAFNRIFPTAIKATAGNSLSLHASLDQLVL
Mflv_0006|M.gilvum_PYR-GCK DASRIAGAWNDVVLAPGADLYSLNRLMPPFIKSTTSNAIAVRASIDRLVL
Mvan_0963|M.vanbaalenii_PYR-1 DANQIAGAWNDVVLAPGADLYSLNKLMPPFIKSTTSNAIAVNASIDRLVL
MSMEG_1147|M.smegmatis_MC2_155 DANTVAGAWNDVALAPDATLYALNRLLPPFIKSMSSGAISLDASVDRLIL
TH_4097|M.thermoresistible__bu DANTIANAWNDVALAPGATLYALNRLMPPFIKTMSGGSVALDASVDRLVW
Mb0179|M.bovis_AF2122/97 DLQALQCPLKELRRAAPYLVGALKLILTQPFDVD---------TVPQLVR
MLBr_02593|M.leprae_Br4923 DLQALACPLRELGRGAPYFIGAMKLILTQPYDVD---------TVPKIMR
Rv0593|M.tuberculosis_H37Rv TLQSLQRPLRQLERASPYVVGALKLGLTAPFNID---------EVPNVIR
. : . .:: . ::: :. . : .::
MMAR_3868|M.marinum_M GSIPDIGFPGDIGLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGPGSPQL
MUL_3800|M.ulcerans_Agy99 GSIPDIGFPGDVGLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGPGSPQL
MAV_2384|M.avium_104 GSLPDIGFPGDIGLHGPHHYNVNLLVGTLKYTLWRLQERVVGRGPNAPQV
MAB_4512c|M.abscessus_ATCC_199 GSIPDVGSYADVGLHGPKRYNWAQLAGSVKYTLWRLQERVVGKGAFGQEA
Mflv_0006|M.gilvum_PYR-GCK GSIPDIGFAGDPGLHGPKRYNWHQLVGSLRYTLLRLQERVVGKGPGVPQM
Mvan_0963|M.vanbaalenii_PYR-1 GSIPDIGFAGDSGLHGPKRYNWHQLVGSLQYTLYRLQERIVGKGPGVPQV
MSMEG_1147|M.smegmatis_MC2_155 GSTPDIGFAGDQGLHGPKRHDWHQLVGTLKYTLLRLQERVVGQGPGVPQV
TH_4097|M.thermoresistible__bu GHHPDIGFAGDPGLHGPKWSDWHQLVGTLQYTLFRLQERVVGKGPDVPQL
Mb0179|M.bovis_AF2122/97 GDYMNLSLTLDLTYS---AIDNAFLTGTGFSGALRALEQSFGRDPE-TMI
MLBr_02593|M.leprae_Br4923 GDYQNVSLTLDVTYS---AMDNAVLTGTGLSGALRALEQSFGRDPE-TMI
Rv0593|M.tuberculosis_H37Rv GDYVNVSATFDVTLS---ALDNALLSGTGISGMLRALEQAWGRDPD-TMI
* ::. * : : *: * *: *:..
MMAR_3868|M.marinum_M PVMPDPEVPGEIQIAPPLSPQPPGPPP---------------------
MUL_3800|M.ulcerans_Agy99 PVMPDPEVPDEIQIAPPLSPQPPGPPP---------------------
MAV_2384|M.avium_104 PVVPDPTVPGQIDVAPGPPPPQPGSPP---------------------
MAB_4512c|M.abscessus_ATCC_199 PVGPSPTEPGVIEPVP--PAPGPGR-----------------------
Mflv_0006|M.gilvum_PYR-GCK PVIPSPTEPGQWAPAPPPGPVPPGPAP-----------AVAPPAPGVP
Mvan_0963|M.vanbaalenii_PYR-1 PVMPHPTEPGLIVPVPAPAP-PPG--------------APAPEAPR--
MSMEG_1147|M.smegmatis_MC2_155 PVIPSPTEPGEIIVEPGAAAPPEDAPAPEPAPAAQAPAPLPAEAPR--
TH_4097|M.thermoresistible__bu PVIPSPTEPGEIIPAPGPAAG-----------------AAPEEAPR--
Mb0179|M.bovis_AF2122/97 PDIRYTPNPNDAPGGPLVERGNRQC-----------------------
MLBr_02593|M.leprae_Br4923 PDVRYTTNPNDAPGGPLVERADRRC-----------------------
Rv0593|M.tuberculosis_H37Rv PDVRYTPNPNDAPGGPLVERAE--------------------------
* . *. *