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MSGFGKAAAAIAVTTLLSSGCAANGLDSLPLPAPTLGSGGYTLTAVFADALNLPMNAKVKLAGADVGQVE SMVARNYTAVTRLRITDDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAMLKDGDTIGLDSTTAAA TVESVLSSAAILVNGGAIRNFTNMINGFGNATGDQGQAFGNLIRKSNRLLATLDSRSEQISTGLSELASL AEQLDAKNQAVTELMAAAEPAADALAANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIRDLNTIA GAANDIAVSPDTSWLALNRMIPPMVKSTARGALSVRASVDRLVLGSIPDIGFPGDVGLHGPHRYNWNQFI GSLKYTLWRLQERVVGRGPGSPQLPVMPDPEVPDEIQIAPPLSPQPPGPPP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3800 | mce5E | - | 100% (401) | Mce family protein, Mce5E |
| M. ulcerans Agy99 | MUL_4915 | mce6E | e-117 | 56.37% (369) | MCE family lipoprotein Mce6E |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | 2e-23 | 27.27% (286) | MCE family lipoprotein LprM |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 1e-21 | 30.23% (258) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0006 | - | 1e-147 | 66.08% (395) | hypothetical protein Mflv_0006 |
| M. tuberculosis H37Rv | Rv0173 | lprK | 1e-21 | 30.23% (258) | MCE-family lipoprotein LprK |
| M. leprae Br4923 | MLBr_02593 | lprK | 1e-23 | 25.81% (248) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4512c | - | 1e-143 | 64.72% (394) | putative Mce family protein |
| M. marinum M | MMAR_3868 | mce5E | 0.0 | 99.00% (401) | Mce family protein, Mce5E |
| M. avium 104 | MAV_2384 | - | 1e-170 | 75.13% (394) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1147 | - | 1e-147 | 63.91% (399) | mce related protein |
| M. thermoresistible (build 8) | TH_4097 | - | 1e-135 | 61.83% (393) | PUTATIVE mce related protein |
| M. vanbaalenii PYR-1 | Mvan_0963 | - | 1e-146 | 64.99% (397) | hypothetical protein Mvan_0963 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3800|M.ulcerans_Agy99 --------MSGFG-----KAAAAIAVTTLLSSGCAANGLDSLPLP-APTL
MMAR_3868|M.marinum_M --------MSGFG-----KAAAAIAMTTLLSSGCAANGLDSLPLP-APTL
MAV_2384|M.avium_104 --------MTATGARGRLTALAAAMAVTTATAGCATNGLASLPLP-APGL
MAB_4512c|M.abscessus_ATCC_199 --------MAARVAR-TVRAAVATLMTATVLSGCATNGLGDLPLP-APGI
Mflv_0006|M.gilvum_PYR-GCK -----------MMTRRAATALAVAMTTCLSVTSCATEGLSSLPLP-APGG
Mvan_0963|M.vanbaalenii_PYR-1 ------------MAIRAKGLMALLVTTSLSVSACATEGLASLPLP-APSG
MSMEG_1147|M.smegmatis_MC2_155 ------MMAASPKRLRKVRLVAAFAMT-VIVSGCATNGLADLPLP-APGV
TH_4097|M.thermoresistible__bu ---------MSVLRLR--RLVPALVTVGCLVSGCATNGLADLPLP-APGV
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
Rv0173|M.tuberculosis_H37Rv ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
:.*. .*: .:.:* .*
MUL_3800|M.ulcerans_Agy99 GSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVARNYTAVTRLRIT
MMAR_3868|M.marinum_M GSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVARNYTAVTRLRIT
MAV_2384|M.avium_104 GSGGYSLNAVFSNALNLPMNAKVKLAGADVGQLESMVARNYTALTRLRIR
MAB_4512c|M.abscessus_ATCC_199 GSGGYRLTALFSNVLNLPDSAKVKLAGADVGQVDEMHVRNFTAVTTLRIL
Mflv_0006|M.gilvum_PYR-GCK GSGGYTLTAVFSNALNLPAMAKVKLAGADIGQLESMQARDYTAVTTLRIR
Mvan_0963|M.vanbaalenii_PYR-1 GSGGYTLTAVFSNALNVPMMAKVKLAGADVGELESMQARDYTAVTTLRIR
MSMEG_1147|M.smegmatis_MC2_155 GSGGYRITAIFSNALNLPANAKVKLAGADIGEMDSMVARNYTAVTTLRIM
TH_4097|M.thermoresistible__bu GSGGYRLTAEFTNALNLPANAKVKLAGADVGEVESMVARDYLAVTTLRIM
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLK
Rv0173|M.tuberculosis_H37Rv GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLK
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLKNWVATLTLGLN
* *.* : . ..:.* : ::* :*.. :*.: : ::: * * :
MUL_3800|M.ulcerans_Agy99 DDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAMLKDGDTIGLDST
MMAR_3868|M.marinum_M DDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAMLKDGDTIGLDST
MAV_2384|M.avium_104 DGVQLPRGSTAELRTATPLGDVFVALKPPPGD-HDAPLLKNGDTIGLEST
MAB_4512c|M.abscessus_ATCC_199 DGVRLPKGSTAELRSATPLGDVFVSIRPPAGASADGPLLTDGDTIGLDST
Mflv_0006|M.gilvum_PYR-GCK EGVLLPVGSTAELRSATPLGDVFVSIKPPPSAGQGTPLLTDGDTIGLEST
Mvan_0963|M.vanbaalenii_PYR-1 EGVQLPKGSTAELRSATPLGDVFIAIKPPPSVQPGAALLRDGDTIGLEST
MSMEG_1147|M.smegmatis_MC2_155 EGVRLPEGSTAELRSATPLGDVFIAIKPPAPVEPGTPLLKDGDTIDLDAT
TH_4097|M.thermoresistible__bu DGVRLPRGSTAELRSATPLGDVFVAIKPPIDVPPDTPMLRDGDTIGKDST
Mb0179|M.bovis_AF2122/97 KDVTLPKNATAKIGQTSLLGSQHVELAAPPDP--SPVPLKDGDTIPLKRS
Rv0173|M.tuberculosis_H37Rv KDVTLPKNATAKIGQTSLLGSQHVELAAPPDP--SPVPLKDGDTIPLKRS
MLBr_02593|M.leprae_Br4923 KDVQLPKNTTAKIGQTSLLGSQHVELAAPANP--SLELLKNGDTIPLKNS
..* ** .:**:: :: **. .: : .* * :**** . :
MUL_3800|M.ulcerans_Agy99 TAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGDQGQAFGNLIRKS
MMAR_3868|M.marinum_M TAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGDQGQAFGNLIRKS
MAV_2384|M.avium_104 AAAATVESVLSSAAVLVNGGAVRNFTNIINGFGKATGDQGQAFGDMIRKS
MAB_4512c|M.abscessus_ATCC_199 TAAATVESVLSSAALASNGGAVRNLTNVVNGFGKATGDQGQAFGDLINDS
Mflv_0006|M.gilvum_PYR-GCK TAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGQAFGELIRKT
Mvan_0963|M.vanbaalenii_PYR-1 TAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGRAFGDLIRKT
MSMEG_1147|M.smegmatis_MC2_155 AAAATVESVLSSAAILVNGGAVRNFTNLINGMGKATGDQGQAFGNLIRKT
TH_4097|M.thermoresistible__bu KAAATVESVLASAAILVNGGAVRNFTNIINGLGKATGDEGQAFGNLVRKT
Mb0179|M.bovis_AF2122/97 SAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKL
Rv0173|M.tuberculosis_H37Rv SAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKL
MLBr_02593|M.leprae_Br4923 SVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAFLTKL
. .*.*..*:* : .**.: *: : : . ... : :: .
MUL_3800|M.ulcerans_Agy99 NRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTELMAAAEPAADALA
MMAR_3868|M.marinum_M NRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTELMAAAEPAADALA
MAV_2384|M.avium_104 NELLGTLDARSDQISAALTQLSTLADQLDAKNHTITDLMTAAGPATSALA
MAB_4512c|M.abscessus_ATCC_199 NRLLGALNSRSVQISEALTQTSQLADQLDAKNQVVTDIVTAAGPATETLA
Mflv_0006|M.gilvum_PYR-GCK NHTLGTLNGRSEEIKTALTETSQLAAQLEAKNQSLAEVMDAAAPATSTLA
Mvan_0963|M.vanbaalenii_PYR-1 NSTLGTMNARSGEISTAITETSRLAAQMEAKNAALGEVMDAAGPAADTLA
MSMEG_1147|M.smegmatis_MC2_155 NNTLATLTARSEEISTAMTETSRLAQQISAKNQALSDVMAQARPATDTLA
TH_4097|M.thermoresistible__bu NATLAKLNARSAEISTAMTETSRLASEIAAKNQVLSEVMAEARPATDTLA
Mb0179|M.bovis_AF2122/97 DTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLIKHFA
Rv0173|M.tuberculosis_H37Rv DTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLIKHFA
MLBr_02593|M.leprae_Br4923 DTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLIKHFA
: : : :*. .: . * : .:. : :: * . :*
MUL_3800|M.ulcerans_Agy99 ANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIRDLNTIAGAANDI
MMAR_3868|M.marinum_M ANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIRDLNTIAGAANDI
MAV_2384|M.avium_104 DNTGELSEVAQQVGDTSRLLARFPALGGTDTSGRSMIRDLNTIAGAANDV
MAB_4512c|M.abscessus_ATCC_199 SNTAQLSELLLMMGDTTRQLQKFPSIAGTDTSGRSIIADANTIAKAWNDV
Mflv_0006|M.gilvum_PYR-GCK AQTNGIADLVLTVGATTEQLRKFPSIAGTDTSGRSVIADASRIAGAWNDV
Mvan_0963|M.vanbaalenii_PYR-1 AHTDEIADLVQQVGATAELLRRFPSIAGSDTSGRSVIADANQIAGAWNDV
MSMEG_1147|M.smegmatis_MC2_155 AHTTQIADLVTQIGDVSDQLRKFPSIAGADTSGRSVIADANTVAGAWNDV
TH_4097|M.thermoresistible__bu GHATEIADLVERFGGISDQAHRFPSIAGTDTSGRSVIADANTIANAWNDV
Mb0179|M.bovis_AF2122/97 DKQELLINASDAVGRLSQSADQYLSAARG-----DLHQDLQALQCPLKEL
Rv0173|M.tuberculosis_H37Rv DKQELLINASDAVGRLSQSADQYLSAARG-----DLHQDLQALQCPLKEL
MLBr_02593|M.leprae_Br4923 DTKNLLINAVGSVGQLSQAVDQYLSEARG-----PLHTDLQALACPLREL
: : .* : :: : . : * . : . .::
MUL_3800|M.ulcerans_Agy99 AVSPDTSWLALNRMIPPMVKSTARGALSVRASVDRLVLGSIPDIGFPGDV
MMAR_3868|M.marinum_M AVSPDTSWLALNRMIPPMVKSTAGGALSVRASVDRLVLGSIPDIGFPGDI
MAV_2384|M.avium_104 AVSPDTSWQSINRLIPALVKSTAGNSISVNVSVDKIMLGSLPDIGFPGDI
MAB_4512c|M.abscessus_ATCC_199 AVDPDTSLAAFNRIFPTAIKATAGNSLSLHASLDQLVLGSIPDVGSYADV
Mflv_0006|M.gilvum_PYR-GCK VLAPGADLYSLNRLMPPFIKSTTSNAIAVRASIDRLVLGSIPDIGFAGDP
Mvan_0963|M.vanbaalenii_PYR-1 VLAPGADLYSLNKLMPPFIKSTTSNAIAVNASIDRLVLGSIPDIGFAGDS
MSMEG_1147|M.smegmatis_MC2_155 ALAPDATLYALNRLLPPFIKSMSSGAISLDASVDRLILGSTPDIGFAGDQ
TH_4097|M.thermoresistible__bu ALAPGATLYALNRLMPPFIKTMSGGSVALDASVDRLVWGHHPDIGFAGDP
Mb0179|M.bovis_AF2122/97 RRAAPYLVGALKLILTQPFDVDT---------VPQLVRGDYMNLSLTLDL
Rv0173|M.tuberculosis_H37Rv RRAAPYLVGALKLILTQPFDVDT---------VPQLVRGDYMNLSLTLDL
MLBr_02593|M.leprae_Br4923 GRGAPYFIGAMKLILTQPYDVDT---------VPKIMRGDYQNVSLTLDV
. ::: ::. . : : ::: * ::. *
MUL_3800|M.ulcerans_Agy99 GLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGPGSPQLPVMPDPEVPDEI
MMAR_3868|M.marinum_M GLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGPGSPQLPVMPDPEVPGEI
MAV_2384|M.avium_104 GLHGPHHYNVNLLVGTLKYTLWRLQERVVGRGPNAPQVPVVPDPTVPGQI
MAB_4512c|M.abscessus_ATCC_199 GLHGPKRYNWAQLAGSVKYTLWRLQERVVGKGAFGQEAPVGPSPTEPGVI
Mflv_0006|M.gilvum_PYR-GCK GLHGPKRYNWHQLVGSLRYTLLRLQERVVGKGPGVPQMPVIPSPTEPGQW
Mvan_0963|M.vanbaalenii_PYR-1 GLHGPKRYNWHQLVGSLQYTLYRLQERIVGKGPGVPQVPVMPHPTEPGLI
MSMEG_1147|M.smegmatis_MC2_155 GLHGPKRHDWHQLVGTLKYTLLRLQERVVGQGPGVPQVPVIPSPTEPGEI
TH_4097|M.thermoresistible__bu GLHGPKWSDWHQLVGTLQYTLFRLQERVVGKGPDVPQLPVIPSPTEPGEI
Mb0179|M.bovis_AF2122/97 TYS---AIDNAFLTGTGFSGALRALEQSFGRDPE-TMIPDIRYTPNPNDA
Rv0173|M.tuberculosis_H37Rv TYS---AIDNAFLTGTGFSGALRALEQSFGRDPE-TMIPDIRYTPNPNDA
MLBr_02593|M.leprae_Br4923 TYS---AMDNAVLTGTGLSGALRALEQSFGRDPE-TMIPDVRYTTNPNDA
: : *: * *: .*:.. * . *.
MUL_3800|M.ulcerans_Agy99 QIAPPLSPQPPGPPP---------------------
MMAR_3868|M.marinum_M QIAPPLSPQPPGPPP---------------------
MAV_2384|M.avium_104 DVAPGPPPPQPGSPP---------------------
MAB_4512c|M.abscessus_ATCC_199 EPVP--PAPGPGR-----------------------
Mflv_0006|M.gilvum_PYR-GCK APAPPPGPVPPGPAP-----------AVAPPAPGVP
Mvan_0963|M.vanbaalenii_PYR-1 VPVPAPAP-PPG--------------APAPEAPR--
MSMEG_1147|M.smegmatis_MC2_155 IVEPGAAAPPEDAPAPEPAPAAQAPAPLPAEAPR--
TH_4097|M.thermoresistible__bu IPAPGPAAG-----------------AAPEEAPR--
Mb0179|M.bovis_AF2122/97 PGGPLVERGNRQC-----------------------
Rv0173|M.tuberculosis_H37Rv PGGPLVERGNRQC-----------------------
MLBr_02593|M.leprae_Br4923 PGGPLVERADRRC-----------------------
*