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KRILQLGAAMVAAVMVTCVAGCEWRGLNSLPLPGTAGGGSGAYTVTAQLPDVSNIEPNSRVRVGDVTVGN VVKIERQGWHALATIKLDGDIELPANTHAAVGQTSLFGTLHVELFSPIDAAPVGRLREGSLIPLSNTRSY PTTEQTLASLSFLLNGGGIGQMQDITAAFSTALNGREDDLRGFNEQVGMFMESLNMQRDDIIAATESLNR LVSRFGERQETLDAALRTIPKALTVLKDQRENMVEALVEFGRLSALTTETLEKSEENLVREVSDLGPVFA ALAAAGPSLTRSASLLTTIWPKENLTKWFRGDYGNLTMVLDLTLNRLDAGLLTGTRWEGDLTALELQWGR TIGQLPSPYTAGNPLLAPYHHEQGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4395 | - | - | 100% (376) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0926 | - | e-134 | 62.23% (376) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3978 | - | e-129 | 59.04% (376) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 4e-65 | 38.52% (366) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0648 | - | 1e-125 | 57.33% (375) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 1e-120 | 59.31% (376) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 4e-63 | 37.75% (347) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 3e-62 | 40.42% (334) | MCE-family protein LprN |
| M. marinum M | MMAR_4055 | lprM_1 | 1e-130 | 61.25% (369) | MCE family lipoprotein LprM |
| M. avium 104 | MAV_2536 | - | 1e-128 | 60.00% (375) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0350 | - | 1e-130 | 60.70% (369) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4336 | - | 1e-129 | 58.82% (374) | PUTATIVE MCE-family lipoprotein LprM_1 |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | 1e-131 | 61.52% (369) | MCE family lipoprotein LprM |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0648|M.gilvum_PYR-GCK ---------MTGKRFARAAAVIMIALTVAGLSGCGFRGLNSFRLPGTQGQ
TH_4336|M.thermoresistible__bu ------------MRSATVSALALVVLSAALLAGCGWQGLNSVPLPGTQGR
MMAR_4055|M.marinum_M -------MMWARWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGG
MUL_3922|M.ulcerans_Agy99 --------MRAGWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGG
MSMEG_0350|M.smegmatis_MC2_155 ---------MTHMRRVVACAATVAALMIGVTGCSNWRGLNSVSLPGTEGG
Rv1970|M.tuberculosis_H37Rv -----------------MRIGLTLVMIAAVVASCGWRGLNSLPLPGTQGN
MAV_2536|M.avium_104 --------MSQSPLRRRVMAALLAAVALATLSGCGFRGLNSFNLPGTKGG
Mvan_4395|M.vanbaalenii_PYR-1 -----------MKRILQLGAAMVAAVMVTCVAGCEWRGLNSLPLPGTAGG
MAB_4149c|M.abscessus_ATCC_199 ------------MSRNVLRAAVMGVGVAVVVSGCQFNGLNSLNLPGTAGH
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
. . :.*:... :** *
Mflv_0648|M.gilvum_PYR-GCK GQGSYTIQAEMPDVETLQPNSRVRVGDVNVGTVTKIERR-----GWHALL
TH_4336|M.thermoresistible__bu GADAFTIQAQLPDVNNLQQNSRVRVGDVDVGTVAKIERQ-----GWHALV
MMAR_4055|M.marinum_M GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
MUL_3922|M.ulcerans_Agy99 GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
MSMEG_0350|M.smegmatis_MC2_155 GPGAFDIQVQMPDITNLQPNSRVRVADVTVGTVTKVERQ-----GWHALL
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQ-----GWHALV
MAV_2536|M.avium_104 GPGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVIDIELQ-----GWNALV
Mvan_4395|M.vanbaalenii_PYR-1 GSGAYTVTAQLPDVSNIEPNSRVRVGDVTVGNVVKIERQ-----GWHALA
MAB_4149c|M.abscessus_ATCC_199 GSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGV
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLK-----NWVATL
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLK-----NWVATL
* :: : .::** : ** * * ** ** : :. .* *
Mflv_0648|M.gilvum_PYR-GCK TLALNGDVDLPANSTVSLGQTSLLGSLHIELAPPTDVRPAGKLRAGSLIP
TH_4336|M.thermoresistible__bu TIRLNGDVDLPANSTVTVGQTSLLGSLHVELAPPVDEPPQGSLRDGAFIP
MMAR_4055|M.marinum_M TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
MUL_3922|M.ulcerans_Agy99 TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
MSMEG_0350|M.smegmatis_MC2_155 TLRLNGDVNLPANCTATIGQTSLLGSLHVELAPPAAAPPQGRLHQGSLIP
Rv1970|M.tuberculosis_H37Rv TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIA
MAV_2536|M.avium_104 TMTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLIP
Mvan_4395|M.vanbaalenii_PYR-1 TIKLDGDIELPANTHAAVGQTSLFGTLHVELFSPIDAAPVGRLREGSLIP
MAB_4149c|M.abscessus_ATCC_199 KVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIP
Mb0179|M.bovis_AF2122/97 TLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPD-PSPVPLKDGDTIP
MLBr_02593|M.leprae_Br4923 TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIP
.: :. :: ** * . :. ***:*: *:** .* * * *.
Mflv_0648|M.gilvum_PYR-GCK LTSAGAYPSTEQTLASVSLLLNGGGVGQVQDITTALTSALGGREADFRSL
TH_4336|M.thermoresistible__bu LDSGGAYPSTEQTLAAVSLLLNGGGLGQVQDITRALSTAFGGREDELRSL
MMAR_4055|M.marinum_M LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
MUL_3922|M.ulcerans_Agy99 LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
MSMEG_0350|M.smegmatis_MC2_155 LADSTTHPTTEQTLAAVSMLLNGGGLGQMQDITKALSTALRGREADLRNL
Rv1970|M.tuberculosis_H37Rv LSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGL
MAV_2536|M.avium_104 LSSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRNL
Mvan_4395|M.vanbaalenii_PYR-1 LSNTRSYPTTEQTLASLSFLLNGGGIGQMQDITAAFSTALNGREDDLRGF
MAB_4149c|M.abscessus_ATCC_199 LSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQV
Mb0179|M.bovis_AF2122/97 LKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAF
MLBr_02593|M.leprae_Br4923 LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
* .*:**..*:: : ::. *.: : : . ** :: .
Mflv_0648|M.gilvum_PYR-GCK LTQLDTFTANVNGQIGDIIAATQSLNDLVAQFAAQKPIIDKALETIPDAL
TH_4336|M.thermoresistible__bu MSRLETFTSRINDQTDDVIAATEALNRLVAQFSSQRPVVDKALDTIPAAL
MMAR_4055|M.marinum_M IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
MUL_3922|M.ulcerans_Agy99 IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
MSMEG_0350|M.smegmatis_MC2_155 IGQLETFVAKTNDQTGDIIEATEKLNRLTGKFAAQQPVVDKAVRTIPDAL
Rv1970|M.tuberculosis_H37Rv IGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDAL
MAV_2536|M.avium_104 LNQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQAL
Mvan_4395|M.vanbaalenii_PYR-1 NEQVGMFMESLNMQRDDIIAATESLNRLVSRFGERQETLDAALRTIPKAL
MAB_4149c|M.abscessus_ATCC_199 LPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPAL
Mb0179|M.bovis_AF2122/97 LGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLI
MLBr_02593|M.leprae_Br4923 LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
:: : * .*: * : : : .. : .. : : :
Mflv_0648|M.gilvum_PYR-GCK AVINAERDQLVEAVDQLGKFSALAADTVNQSQESLIQILNDMGPVLESLA
TH_4336|M.thermoresistible__bu AVLNSEREELIEAVEELGTFNELAADTIDQTRDAVVEELRDMGPVLESLA
MMAR_4055|M.marinum_M AVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
MUL_3922|M.ulcerans_Agy99 TVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
MSMEG_0350|M.smegmatis_MC2_155 EVLKDQRDNLTAALDQLGRFSALAADSTRQTKDSLVREFRNIGPVLESLA
Rv1970|M.tuberculosis_H37Rv AVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLA
MAV_2536|M.avium_104 TVLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSLA
Mvan_4395|M.vanbaalenii_PYR-1 TVLKDQRENMVEALVEFGRLSALTTETLEKSEENLVREVSDLGPVFAALA
MAB_4149c|M.abscessus_ATCC_199 KVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALA
Mb0179|M.bovis_AF2122/97 KHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKELR
MLBr_02593|M.leprae_Br4923 KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELG
: : : * .. : . : : . : . *
Mflv_0648|M.gilvum_PYR-GCK NAGPALTRSLNLFTTIPFVKDNLTKWWRGDYANITTIVDLTLSRIDAGLF
TH_4336|M.thermoresistible__bu NAGPALTRSLSLFTTFPFPKETLTKWMRGDYANITVVADLTLSRMDSALF
MMAR_4055|M.marinum_M NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
MUL_3922|M.ulcerans_Agy99 NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
MSMEG_0350|M.smegmatis_MC2_155 NAGPNMTRALSILTTYPFPNETLEKWLRGDYGNMTAIVDLTLSRIDAGFF
Rv1970|M.tuberculosis_H37Rv NSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLL
MAV_2536|M.avium_104 DAGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASFL
Mvan_4395|M.vanbaalenii_PYR-1 AAGPSLTRSASLLTTI-WPKENLTKWFRGDYGNLTMVLDLTLNRLDAGLL
MAB_4149c|M.abscessus_ATCC_199 ENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLF
Mb0179|M.bovis_AF2122/97 RAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFL
MLBr_02593|M.leprae_Br4923 RGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVL
: : :: * : . . : **:* *: *:* :. .:
Mflv_0648|M.gilvum_PYR-GCK TGTRFEGHLTELELQWG---RTIGQLPSPYTA------RNPLIVPYRLD-
TH_4336|M.thermoresistible__bu TGTRWEGDLTELEMQWG---RTIGQLPSPYTA------ANPLLAPYRWN-
MMAR_4055|M.marinum_M TGTRWEGDLTELELQWG---RTIGQMPSPYTV------GNPLIVPYRWD-
MUL_3922|M.ulcerans_Agy99 TGTRWEGDLTELELQWG---RTIGQMPSPYTV------GNPLIVPYRWD-
MSMEG_0350|M.smegmatis_MC2_155 TGTRWEGDLTELEMQWG---RTIGQLPSPYTA------VNPLVAPYRWD-
Rv1970|M.tuberculosis_H37Rv TGTRWECHLTQLELQWG---RTIGQFPSPCTAGYRGTPGNPLTIAYRWD-
MAV_2536|M.avium_104 TGTRFECNLTELELQWG---RTIGQLPSPCTGGGPYNPGNPLVVPYHFD-
Mvan_4395|M.vanbaalenii_PYR-1 TGTRWEGDLTALELQWG---RTIGQLPSPYTA------GNPLLAPYHHE-
MAB_4149c|M.abscessus_ATCC_199 TTSFFDPNMQHFNDVVNPPEWLIGSMANLNGK-----ETSPFDLPAPAAP
Mb0179|M.bovis_AF2122/97 TGTGFSGALRALEQSFG--RDPETMIPDIRYT------PNPNDAPGGPLV
MLBr_02593|M.leprae_Br4923 TGTGLSGALRALEQSFG--RDPETMIPDVRYT------TNPNDAPGGPLV
* : . : :: . :.. .* .
Mflv_0648|M.gilvum_PYR-GCK QGP----
TH_4336|M.thermoresistible__bu QGP----
MMAR_4055|M.marinum_M QGP----
MUL_3922|M.ulcerans_Agy99 QGP----
MSMEG_0350|M.smegmatis_MC2_155 QGR----
Rv1970|M.tuberculosis_H37Rv QGP----
MAV_2536|M.avium_104 QGR----
Mvan_4395|M.vanbaalenii_PYR-1 QGR----
MAB_4149c|M.abscessus_ATCC_199 QGGGR--
Mb0179|M.bovis_AF2122/97 ERGNRQC
MLBr_02593|M.leprae_Br4923 ERADRRC
: