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LNSLRLPGTAGGGPGSYTIQAQMPDVVTIQENTRVRVDDVNVGNVTKIELQDWHALVTMRIDGDVHLPAN STAKLGQTSLLGSMHIELAPPKGEPPVGRLTAGSVIPLSRASLYPTTEQTLASVSILLNGGGIGQLQEIT QAVAKAFAGREAETPWKSRRLLTLETRMQVCRRNSRPGSRRHVDTVPRRRPPRCGWSAPCARSWAPSRAQ CSGSLASSATEWNRCAPGSVRSTSTKAWLLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2065 | - | - | 100% (241) | LprM protein |
| M. avium 104 | MAV_2536 | - | 1e-57 | 68.63% (153) | virulence factor Mce family protein |
| M. avium 104 | MAV_3242 | - | 9e-51 | 100.00% (89) | actinomycin synthetase II |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 7e-38 | 52.00% (150) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0648 | - | 2e-57 | 69.28% (153) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 2e-57 | 70.20% (151) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 2e-37 | 48.67% (150) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 7e-42 | 49.70% (169) | MCE-family protein LprN |
| M. marinum M | MMAR_4055 | lprM_1 | 9e-56 | 68.21% (151) | MCE family lipoprotein LprM |
| M. smegmatis MC2 155 | MSMEG_0350 | - | 3e-56 | 64.71% (153) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3635 | - | 8e-56 | 68.21% (151) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | 6e-56 | 68.21% (151) | MCE family lipoprotein LprM |
| M. vanbaalenii PYR-1 | Mvan_0517 | - | 3e-57 | 69.28% (153) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4055|M.marinum_M ------MMWARWTTRIRIAAGIAALAVA-VSGCSGWRGLNSLPLPGVQGG
MUL_3922|M.ulcerans_Agy99 -------MRAGWTTRIRIAAGIAALAVA-VSGCSGWRGLNSLPLPGVQGG
MSMEG_0350|M.smegmatis_MC2_155 --------MTHMRRVVACAATVAALMIG-VTGCSNWRGLNSVSLPGTEGG
Mflv_0648|M.gilvum_PYR-GCK --------MTGKRFARAAAVIMIALTVAGLSGCG-FRGLNSFRLPGTQGQ
Mvan_0517|M.vanbaalenii_PYR-1 --------MTGKRFARAAAVIMIALTVAGLSGCG-FRGLNSFRLPGTQGQ
Rv1970|M.tuberculosis_H37Rv ---------------MRIGLTLVMIAAV-VASCG-WRGLNSLPLPGTQGN
TH_3635|M.thermoresistible__bu -----------MTYRWRIALVLVVALAG-VTGCADWRGVNTLSLPGTEGG
MAV_2065|M.avium_104 --------------------------------------MNSLRLPGTAGG
MAB_4149c|M.abscessus_ATCC_199 ------------MSRNVLRAAVMGVGVAVVVSGCQFNGLNSLNLPGTAGH
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
:... :** *
MMAR_4055|M.marinum_M GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
MUL_3922|M.ulcerans_Agy99 GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
MSMEG_0350|M.smegmatis_MC2_155 GPGAFDIQVQMPDITNLQPNSRVRVADVTVGTVTKVERQ-----GWHALL
Mflv_0648|M.gilvum_PYR-GCK GQGSYTIQAEMPDVETLQPNSRVRVGDVNVGTVTKIERR-----GWHALL
Mvan_0517|M.vanbaalenii_PYR-1 GQGSYTIQAEMPDVETLQPNSRVRVGDVNVGTVTKIERR-----GWHALL
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQ-----GWHALV
TH_3635|M.thermoresistible__bu GPGSFVVRAQMPDVNNLEPNARVRVDDVTVGAVTRIERQ-----GWHALV
MAV_2065|M.avium_104 GPGSYTIQAQMPDVVTIQENTRVRVDDVNVGNVTKIELQ-----DWHALV
MAB_4149c|M.abscessus_ATCC_199 GSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGV
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLK-----NWVATL
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLK-----NWVATL
* :: : .::** : *: * * ** ** : :. .* * :
MMAR_4055|M.marinum_M TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
MUL_3922|M.ulcerans_Agy99 TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
MSMEG_0350|M.smegmatis_MC2_155 TLRLNGDVNLPANCTATIGQTSLLGSLHVELAPPAAAPPQGRLHQGSLIP
Mflv_0648|M.gilvum_PYR-GCK TLALNGDVDLPANSTVSLGQTSLLGSLHIELAPPTDVRPAGKLRAGSLIP
Mvan_0517|M.vanbaalenii_PYR-1 TLALNGDVDLPANSTVSLGQTSLLGSLHIELAPPTDVRPAGKLRAGSLIP
Rv1970|M.tuberculosis_H37Rv TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIA
TH_3635|M.thermoresistible__bu TMRLDGSVRLPANATAKLGQTSILGSQHIELAPPEHTAPEGVLRDGSVIA
MAV_2065|M.avium_104 TMRIDGDVHLPANSTAKLGQTSLLGSMHIELAPPKGEPPVGRLTAGSVIP
MAB_4149c|M.abscessus_ATCC_199 KVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIP
Mb0179|M.bovis_AF2122/97 TLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPD-PSPVPLKDGDTIP
MLBr_02593|M.leprae_Br4923 TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIP
.: :. .* ** * ...:. **:*** *:***.* * * *.
MMAR_4055|M.marinum_M LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
MUL_3922|M.ulcerans_Agy99 LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
MSMEG_0350|M.smegmatis_MC2_155 LADSTTHPTTEQTLAAVSMLLNGGGLGQMQDITKALSTALRGREADLRNL
Mflv_0648|M.gilvum_PYR-GCK LTSAGAYPSTEQTLASVSLLLNGGGVGQVQDITTALTSALGGREADFRSL
Mvan_0517|M.vanbaalenii_PYR-1 LTSAGAYPSTEQTLASVSLLLNGGGVGQVQDITTALTSALGGREADFRSL
Rv1970|M.tuberculosis_H37Rv LSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGL
TH_3635|M.thermoresistible__bu LENAGMYPTTEQTLASLSAVLNGGGIGQIYDITEALSLAFAGREDDLRNL
MAV_2065|M.avium_104 LSRASLYPTTEQTLASVSILLNGGGIGQLQEITQAVAKAFAGRE------
MAB_4149c|M.abscessus_ATCC_199 LSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQV
Mb0179|M.bovis_AF2122/97 LKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAF
MLBr_02593|M.leprae_Br4923 LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
* .*:**:.*:: : ::. *.: : : . **
MMAR_4055|M.marinum_M IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
MUL_3922|M.ulcerans_Agy99 IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
MSMEG_0350|M.smegmatis_MC2_155 IGQLETFVAKTNDQTGDIIEATEKLNRLTGKFAAQQPVVDKAVRTIPDAL
Mflv_0648|M.gilvum_PYR-GCK LTQLDTFTANVNGQIGDIIAATQSLNDLVAQFAAQKPIIDKALETIPDAL
Mvan_0517|M.vanbaalenii_PYR-1 LTQLDTFTANVNGQIGDIIAATDSLNNLVAQFAAQKPIIDKALETIPDAL
Rv1970|M.tuberculosis_H37Rv IGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDAL
TH_3635|M.thermoresistible__bu VDQLDLFATQLNDQSGDIIAAAESLNDLIGRFAAQEPVLDRALTTIPDAL
MAV_2065|M.avium_104 ---------------------------------AETPWKSRRLLTLETRM
MAB_4149c|M.abscessus_ATCC_199 LPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPAL
Mb0179|M.bovis_AF2122/97 LGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLI
MLBr_02593|M.leprae_Br4923 LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
. .: : : :
MMAR_4055|M.marinum_M AVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
MUL_3922|M.ulcerans_Agy99 TVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
MSMEG_0350|M.smegmatis_MC2_155 EVLKDQRDNLTAALDQLGRFSALAADSTRQTKDSLVREFRNIGPVLESLA
Mflv_0648|M.gilvum_PYR-GCK AVINAERDQLVEAVDQLGKFSALAADTVNQSQESLIQILNDMGPVLESLA
Mvan_0517|M.vanbaalenii_PYR-1 AVINAERDQLVEAVDQLGKFSALAADTVNQSQESLIQILNDMGPVLESLA
Rv1970|M.tuberculosis_H37Rv AVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLA
TH_3635|M.thermoresistible__bu AVLTEQRDSLVDSVDRLGRLGTLVTETVTETRHDLVRILEHSGPVLARLA
MAV_2065|M.avium_104 QVCRRN--------SRPG--SRRHVDTVPRRRP---PRCGWSAPCARSWA
MAB_4149c|M.abscessus_ATCC_199 KVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALA
Mb0179|M.bovis_AF2122/97 KHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKELR
MLBr_02593|M.leprae_Br4923 KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELG
. .
MMAR_4055|M.marinum_M NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
MUL_3922|M.ulcerans_Agy99 NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
MSMEG_0350|M.smegmatis_MC2_155 NAGPNMTRALSILTTYPFPNETLEKWLRGDYGNMTAIVDLTLSRIDAGFF
Mflv_0648|M.gilvum_PYR-GCK NAGPALTRSLNLFTTIPFVKDNLTKWWRGDYANITTIVDLTLSRIDAGLF
Mvan_0517|M.vanbaalenii_PYR-1 NAGPALTRSLNLFTTIPFVKDNLTKWWRGDYANITTIVDLTLSRIDAGLF
Rv1970|M.tuberculosis_H37Rv NSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLL
TH_3635|M.thermoresistible__bu DAGPAMTRGLSGIVTYPFPFETIELWQRGDYANLTAVFDLTLSRLDAGFF
MAV_2065|M.avium_104 PSRAQCSGSLASSAT---------EWNRCAPGSVR-------STSTKAWL
MAB_4149c|M.abscessus_ATCC_199 ENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLF
Mb0179|M.bovis_AF2122/97 RAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFL
MLBr_02593|M.leprae_Br4923 RGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVL
.: * * .: :
MMAR_4055|M.marinum_M TGTRWEGDLTELELQWGRTIGQMPSPYTVG------NPLIVPYRWDQGP-
MUL_3922|M.ulcerans_Agy99 TGTRWEGDLTELELQWGRTIGQMPSPYTVG------NPLIVPYRWDQGP-
MSMEG_0350|M.smegmatis_MC2_155 TGTRWEGDLTELEMQWGRTIGQLPSPYTAV------NPLVAPYRWDQGR-
Mflv_0648|M.gilvum_PYR-GCK TGTRFEGHLTELELQWGRTIGQLPSPYTAR------NPLIVPYRLDQGP-
Mvan_0517|M.vanbaalenii_PYR-1 TGTRFEGHLTELELQWGRTIGQLPSPYTAR------NPLIVPYRLDQGP-
Rv1970|M.tuberculosis_H37Rv TGTRWECHLTQLELQWGRTIGQFPSPCTAGYRGTPGNPLTIAYRWDQGP-
TH_3635|M.thermoresistible__bu TGTRWECHLTWLEMQWGRTIGQFPSPCTAGGPGTPGNPLTIPYRWDQGP-
MAV_2065|M.avium_104 LG------------------------------------------------
MAB_4149c|M.abscessus_ATCC_199 TTSFFDPNMQHFNDVVNPPEWLIGSMANLNGKETSPFDLPAPAAPQGGGR
Mb0179|M.bovis_AF2122/97 TGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC-
MLBr_02593|M.leprae_Br4923 TGTGLSGALRALEQSFGRDPETMIPDVRYTTNPNDAPGGPLVERADRRC-