For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VKPRKPARGWLAVACCAVLTVSGCRFDGVNSLPLPGTVGTGSDAATFHVQIANVGTLEPNSPVMIDDVVV GAVRRMTLAGWHADVEVSVQPDVVVPANAVATVGQTSLLGSMHLALDPPVDSAPEGRLAPGATIPLSRST TYPSTEQTLSSLSLVVNGGGLMQIADIVHNFSAALDGRAVEIRDLLTRMNNVVGILDNQRDNIVATIAAM NRVAGTFAAQRSTLTEALDRIPPALEVLASQRPQITTAMNKLGAFSDIAHRLINDSQADLVRNLKNLEPT VKALADVGTDLVTALSYLPTYPYTQDFIDRGIRGDFMNQFIVFDFTIPRLKSGILLGTRWGQPGASLVPA PGDPWYSSYTLDPLKAPVTPKPTELAPFPPTVDGAGDAAPAAEGGN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2859 | - | - | 100% (396) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_4786 | - | e-140 | 62.63% (388) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0350 | - | 6e-74 | 41.62% (334) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3525c | lprN | 1e-58 | 37.78% (315) | MCE-family lipoprotein LprN |
| M. gilvum PYR-GCK | Mflv_4534 | - | 1e-165 | 74.09% (386) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 9e-69 | 41.56% (320) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 2e-49 | 31.90% (326) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 2e-68 | 42.27% (317) | MCE-family protein LprN |
| M. marinum M | MMAR_4706 | - | 1e-129 | 58.49% (383) | MCE family lipoprotein |
| M. avium 104 | MAV_2536 | - | 2e-74 | 42.68% (328) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2981 | - | 1e-177 | 78.41% (389) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | 3e-76 | 43.77% (329) | MCE family lipoprotein LprM |
| M. vanbaalenii PYR-1 | Mvan_2855 | - | 1e-171 | 73.74% (396) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2536|M.avium_104 -------MSQSPLRRRVMAALLAAVALATLSGCGFRGLNSFNLPGTKGGG
MUL_3922|M.ulcerans_Agy99 -------MRAGWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGGG
Rv1970|M.tuberculosis_H37Rv -------MRIG-LTLVMIAAVVAS--------CGWRGLNSLPLPGTQGNG
Mb3525c|M.bovis_AF2122/97 -----------MNRIWLRAIIL-TASSALLAGCQFGGLNSLPLPGTAGHG
MAB_4149c|M.abscessus_ATCC_199 -----------MSRNVLRAAVMGVGVAVVVSGCQFNGLNSLNLPGTAGHG
MSMEG_2859|M.smegmatis_MC2_155 ---------MKPRKPARGWLAVACCAVLTVSGCRFDGVNSLPLPGTVGTG
TH_2981|M.thermoresistible__bu ------------VTFLRSRIAVACCAVLTLSGCTFDGVSSLPLPGTVGTG
Mflv_4534|M.gilvum_PYR-GCK -------MTRPTVRRTRRWAAAACCVALTATGCSFDGLNSLPLPGTVGTG
Mvan_2855|M.vanbaalenii_PYR-1 -------MTSP-GKPVRRWAATACCVALTATGCSFDGLNSLPLPGTVGTG
MMAR_4706|M.marinum_M ------MTASTATPALRRLFVIGCCVMLAVTGCAFNGLNSLPLPGAVGRG
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVRHQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGSG
. : *:... :** * *
MAV_2536|M.avium_104 PGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVI-----DIELQGWNALVT
MUL_3922|M.ulcerans_Agy99 PGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVT-----KIERQGWHALVT
Rv1970|M.tuberculosis_H37Rv PGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVT-----KIERQGWHALVT
Mb3525c|M.bovis_AF2122/97 EGAYSVTVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAVK
MAB_4149c|M.abscessus_ATCC_199 SRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGVK
MSMEG_2859|M.smegmatis_MC2_155 SDAATFHVQIANVGTLEPNSPVMIDDVVVGAVR-----RMTLAGWHADVE
TH_2981|M.thermoresistible__bu SDAVTYQVQIANVGTLEPNSPVMVDDVVVGAVR-----RMTLDGWYADVE
Mflv_4534|M.gilvum_PYR-GCK SDAVTYRVQLANVGSLESNSPVMLDDVVVGAVG-----KMTFEDWHAAVD
Mvan_2855|M.vanbaalenii_PYR-1 SNALVYHLRIANVGTLESNSPVMLNDVVVGAVR-----KMTVNDFHADVD
MMAR_4706|M.marinum_M PGASVYHVEIANVGTLEANSPVMLNDVIVGSIS-----KMTVRGWHADVE
MLBr_02593|M.leprae_Br4923 KGAYTIYVQVPDTLAINGNSKVMVADVTVGSIR-----AINLKNWVATLT
: .:.:. : ** * : ** ** : .: * :
MAV_2536|M.avium_104 MTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLIPL
MUL_3922|M.ulcerans_Agy99 MKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIPL
Rv1970|M.tuberculosis_H37Rv MRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIAL
Mb3525c|M.bovis_AF2122/97 LDLDKNVLLPANAVAKVSQTSLLGSLHVELAPPTDRPPTGRLVDGSRITE
MAB_4149c|M.abscessus_ATCC_199 VSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIPL
MSMEG_2859|M.smegmatis_MC2_155 VSVQPDVVVPANAVATVGQTSLLGSMHLALDPPVDSAPEGRLAPGATIPL
TH_2981|M.thermoresistible__bu VTVRPGTVIPANAVATVGQTSLLGSMHLALDPPVGEPPTGALAPGATIPL
Mflv_4534|M.gilvum_PYR-GCK ISVRPDVVVPANAVATVGQTSLLGSMHVALDPPVGETPTGRLAPGANLPL
Mvan_2855|M.vanbaalenii_PYR-1 VSVKPDVVVPANAVATVGQTSLLGSMHVALDPPVGESPTGRLQPGASVPI
MMAR_4706|M.marinum_M ISVRRGAVIPDNAVASVGQTSLLGSMHLALNSPLGQVSDQRLQPGSTIPL
MLBr_02593|M.leprae_Br4923 LGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIPL
: : . :* *:.*.:. ****** *: * .* . * * :.
MAV_2536|M.avium_104 SSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRNLL
MUL_3922|M.ulcerans_Agy99 SSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSLI
Rv1970|M.tuberculosis_H37Rv SHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGLI
Mb3525c|M.bovis_AF2122/97 ANTDRFPTTEEVFSALGVVVNKGNVGALEEIIDETHQAVAGRQAQFVNLV
MAB_4149c|M.abscessus_ATCC_199 SRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQVL
MSMEG_2859|M.smegmatis_MC2_155 SRSTTYPSTEQTLSSLSLVVNGGGLMQIADIVHNFSAALDGRAVEIRDLL
TH_2981|M.thermoresistible__bu ERSSSFPSTEQTLASLSFVVNGGGLAQIADIVHNFTAALDGRAVHVRELL
Mflv_4534|M.gilvum_PYR-GCK NRTSTYPSTEQTLSSLSVVVNGGGLTQIGDIISNFSAALDGRQGQIRSLL
Mvan_2855|M.vanbaalenii_PYR-1 DRTSTYPSTEQTLSSLSVVVNGGGLTQIGDIIGNFNAALDGRQIQIRDLL
MMAR_4706|M.marinum_M SRSSTYPSTEQTLSSLSVILNAGGLGQIGDIIHNFTAALSGRTSDIRDLL
MLBr_02593|M.leprae_Br4923 KNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAFL
:*:**..::: ..::. *.: : : . ** .. .:
MAV_2536|M.avium_104 NQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQALT
MUL_3922|M.ulcerans_Agy99 EQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDALT
Rv1970|M.tuberculosis_H37Rv GQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDALA
Mb3525c|M.bovis_AF2122/97 PRLAELTAGLNRQVHDIIDALDGLNRVSAILARDKDNLGRALDTLPDAVR
MAB_4149c|M.abscessus_ATCC_199 PKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPALK
MSMEG_2859|M.smegmatis_MC2_155 TRMNNVVGILDNQRDNIVATIAAMNRVAGTFAAQRSTLTEALDRIPPALE
TH_2981|M.thermoresistible__bu TRMNNVVGLLDGQRDKILATIENLDRAAGTFAAQREELAAALDRIPPALE
Mflv_4534|M.gilvum_PYR-GCK TRMNDVVGILDDQRDNINATISALYRLSETFAGQREVLSAALKRIPEALA
Mvan_2855|M.vanbaalenii_PYR-1 TRMNDVVGILDNQRANIIDTIGALNRLAETFANQREVLTAALSRIPQALE
MMAR_4706|M.marinum_M VRLDRFVGTFDEQRDNLVASIQALNRLAGTLAGQRDVITQALQKIPPALD
MLBr_02593|M.leprae_Br4923 TKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLIK
:: . :: * .: : . .. : : : :
MAV_2536|M.avium_104 VLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSLAD
MUL_3922|M.ulcerans_Agy99 VLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLAN
Rv1970|M.tuberculosis_H37Rv VLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLAN
Mb3525c|M.bovis_AF2122/97 VLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDLKDLYSIVKALND
MAB_4149c|M.abscessus_ATCC_199 VLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALAE
MSMEG_2859|M.smegmatis_MC2_155 VLASQRPQITTAMNKLGAFSDIAHRLINDSQADLVRNLKNLEPTVKALAD
TH_2981|M.thermoresistible__bu VLAEQQPRISTALQSLGDFSDLANQLINESQEDLVRNLQNLEPTVRALAE
Mflv_4534|M.gilvum_PYR-GCK VLNQQRPRIVTAMRKLGDFSDTATQLIDESQEDIVGNLRNLEPAVRALAD
Mvan_2855|M.vanbaalenii_PYR-1 VLNRQRPRIVTAMQKLGDFSDTATQLINESQEDIVRNLQNLEPAVRALAD
MMAR_4706|M.marinum_M VLIRERPRITAALDKLGTFSDTATRLVNDAGSDLVQNLQNLGPTISALAD
MLBr_02593|M.leprae_Br4923 HFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELGR
: : : * : :: . : : : :*: * : *
MAV_2536|M.avium_104 AGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASFLT
MUL_3922|M.ulcerans_Agy99 AGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFFT
Rv1970|M.tuberculosis_H37Rv SGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLLT
Mb3525c|M.bovis_AF2122/97 DRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGETFFT
MAB_4149c|M.abscessus_ATCC_199 NRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLFT
MSMEG_2859|M.smegmatis_MC2_155 VGTDLVTALSYLPTYPYTQDFIDRGIRGDFMNQFIVFDFTIPRLKSGILL
TH_2981|M.thermoresistible__bu VGPDLVTALTYLPTYPYTQEFIDRGIRGDYMNQFIVFDFTIPRLKRGILL
Mflv_4534|M.gilvum_PYR-GCK VGPDLATALSYLPTYPYTQEFIDRGIRGDYMNQFIVFDFTIPRLKSGILL
Mvan_2855|M.vanbaalenii_PYR-1 VGPDLATALSYLPTYPYTQEFIDRGIRGDYMNQFIVFDFTISRLKSGIFL
MMAR_4706|M.marinum_M IGPDLDAAIAYAPTFPFTQGFIDRYIRGDYVNGYFIIDLTNAGLRKSILL
MLBr_02593|M.leprae_Br4923 GAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVLT
: :: * *: . . **:: * .*.* : .:
MAV_2536|M.avium_104 GTRFECNLTELELQWG---RTIGQLPSPCTGG----GPYNPGNPLVVPY-
MUL_3922|M.ulcerans_Agy99 GTRWEGDLTELELQWG---RTIGQMPS----------PYTVGNPLIVPY-
Rv1970|M.tuberculosis_H37Rv GTRWECHLTQLELQWG---RTIGQFPSPCTAG----YRGTPGNPLTIAY-
Mb3525c|M.bovis_AF2122/97 TAYFDPNMAHMDEILNPPDFLIGELANLSGQ---------AADPFKIPP-
MAB_4149c|M.abscessus_ATCC_199 TSFFDPNMQHFNDVVNPPEWLIGSMANLNGK---------ETSPFDLPA-
MSMEG_2859|M.smegmatis_MC2_155 GTRWGQPGASLVPAPGDPWYSSYTLDPLKAP-----VTPKPTELAPFPP-
TH_2981|M.thermoresistible__bu GTRWGQPGASLVPAPGDPWYSSYTRDPLKTP-----VTPAPPDLAPIPP-
Mflv_4534|M.gilvum_PYR-GCK GTRWGEPGASMVPAPGDPWYSMYTRDPLQAP-----ITPIPAEVATIPP-
Mvan_2855|M.vanbaalenii_PYR-1 GTRWGEPGASMVPAPGDPWYSSYTLDPLQAP-----VTPVPDEVATMPP-
MMAR_4706|M.marinum_M GTHWGRLGAEGVPAPGDPEYLQFKFGAPIPPGPPPADAPPPGDPAPGPPP
MLBr_02593|M.leprae_Br4923 GTGLSGALRALEQSFGRDPETMIPDVRYTTNP-----NDAPGGPLVERA-
: .
MAV_2536|M.avium_104 --------------HFDQGR--
MUL_3922|M.ulcerans_Agy99 --------------RWDQGP--
Rv1970|M.tuberculosis_H37Rv --------------RWDQGP--
Mb3525c|M.bovis_AF2122/97 -----------GTAS---GQ--
MAB_4149c|M.abscessus_ATCC_199 -----------PAAPQGGGR--
MSMEG_2859|M.smegmatis_MC2_155 ----TVDGAGDAAPAAEGGN--
TH_2981|M.thermoresistible__bu ----MTDDPADTG----GGN--
Mflv_4534|M.gilvum_PYR-GCK ----LVDLPPAPAGEPAGGGS-
Mvan_2855|M.vanbaalenii_PYR-1 ----LIEAPASATGQPVEAGGN
MMAR_4706|M.marinum_M DSAVPIPGATPAEAAPTDGGP-
MLBr_02593|M.leprae_Br4923 -----------------DRRC-