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MTVPNDDTWGPATSVGTTATMAAAARAIATRDGVINDPFAEPLVRAVGVNFLTRWAIGELVASDVDVEGS PWGLAQMPAAIAARTRYFDEFYADAAAAGIRQAVILASGLDTRAYRLDWPAGMTVFEIDQPAVVEFKTTA LARLAAEPKADLRTVAVDLRDDWSTALATAGLDSSKPTAWIAEGLFGYLAPEAQDRLLDAVTALSTPGSR LGSEAVPDTADMDPHAARQRMRAATAKWRDHGFELDVDVISFAGERHDVGAYLQALGWTTVATPMAELLA DQGLPAIARADDDRQTMNGVTYYTSTLGTGRQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4573 | - | - | 100% (313) | putative methyltransferase |
| M. avium 104 | MAV_2110 | - | e-106 | 62.62% (305) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_4236 | - | 2e-95 | 61.05% (285) | methyltransferase, putative, family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3816c | - | 9e-93 | 59.51% (284) | hypothetical protein Mb3816c |
| M. gilvum PYR-GCK | Mflv_5023 | - | 2e-90 | 58.66% (283) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv3787c | - | 9e-93 | 59.51% (284) | hypothetical protein Rv3787c |
| M. leprae Br4923 | MLBr_02640 | - | 7e-50 | 44.20% (276) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3787 | - | 6e-67 | 45.94% (320) | hypothetical protein MAB_3787 |
| M. marinum M | MMAR_3534 | - | 1e-105 | 63.61% (305) | O-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1888 | - | 2e-92 | 55.88% (306) | methyltransferase |
| M. thermoresistible (build 8) | TH_0301 | - | 4e-78 | 54.20% (286) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2766 | - | 1e-104 | 62.95% (305) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1346 | - | 4e-85 | 53.35% (313) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5023|M.gilvum_PYR-GCK MPRTENDTWDLASSVGATATMVAAARAVATRAEDPVIDDPYAEPLVRAVG
Mvan_1346|M.vanbaalenii_PYR-1 MARTDNDTWDLASSVGATATMVAAARAVATRAPRPVIDDPFAAPLVQAVG
TH_0301|M.thermoresistible__bu MX-------------GG-----------ASRDPKELINDPFAAPLVRAVG
MMAR_3534|M.marinum_M MPRTDNDSWDLATSVGATATMVAAARAIATNADNPLIADRFAEPLVRAVG
MUL_2766|M.ulcerans_Agy99 MPRTDNDSWDLATSVGATATMVAAARAIATNADNPLIADRFAEPLVRAVG
MAV_4573|M.avium_104 MTVPNDDTWGPATSVGTTATMAAAARAIATRDG--VINDPFAEPLVRAVG
Mb3816c|M.bovis_AF2122/97 MARTDDDSWDLATGVGATATLVAAGRARAARAAQPLIDDPFAEPLVRAVG
Rv3787c|M.tuberculosis_H37Rv MARTDDDSWDLATGVGATATLVAAGRARAARAAQPLIDDPFAEPLVRAVG
MSMEG_1888|M.smegmatis_MC2_155 MEST-HETWDLATSVGATATMVAAGRARATTTG--LIDDRFAEPLVRAVG
MAB_3787|M.abscessus_ATCC_1997 MARTDDDSWDLASSVGATATMVAAQRALASHVPNPLINDPYAEPLVRAVG
MLBr_02640|M.leprae_Br4923 -MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTG
* : :* * :* ** .*
Mflv_5023|M.gilvum_PYR-GCK IDFFAKLASGELTPEDLDVSGDESPVGMSRFADGMAARTRFFDDFFTDAC
Mvan_1346|M.vanbaalenii_PYR-1 VDFFTRLATGELTTEELDTNDAESPVGMSRFADAMAARTRFFDDFFAEAM
TH_0301|M.thermoresistible__bu IDFFTRIADGELTVADLDP---QSAPRVQANIDEVAVRTRFFDDHFAAAT
MMAR_3534|M.marinum_M VDFFTRWVTGDLVVADVDD--TESGWQLAQMPDAMAVRTRFFDAFFQDAT
MUL_2766|M.ulcerans_Agy99 VDFFTRWVTGDLVVADVDD--TESGWQLAQMPDAMAVRARFFDAFFQDAT
MAV_4573|M.avium_104 VNFLTRWAIGELVASDVDV--EGSPWGLAQMPAAIAARTRYFDEFYADAA
Mb3816c|M.bovis_AF2122/97 VEFLTRWATGELDAADVDD--PDAAWGLQRMTTELVVRTRYFDQFFLDAA
Rv3787c|M.tuberculosis_H37Rv VEFLTRWATGELDAADVDD--PDAAWGLQRMTTELVVRTRYFDQFFLDAA
MSMEG_1888|M.smegmatis_MC2_155 IDFMTRWATGDLAAADVDI--PGATWGMQQMTDLLAARTRYFDAFFGDAA
MAB_3787|M.abscessus_ATCC_1997 IEYFTKLASGAFDPEQMAG-LVQLGITADGMANGMASRTWYYDTAFESST
MLBr_02640|M.leprae_Br4923 AGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAV
: . . .: . *: ::* : :
Mflv_5023|M.gilvum_PYR-GCK AAG---VRQAVILASGLDARGYRLTWPEGMTLFEIDQPEVIEFKRTTLAG
Mvan_1346|M.vanbaalenii_PYR-1 RAGPPPIRQGVILASGLDARAYRLSWPQDMVLFEIDQPEVLTFKAATLAD
TH_0301|M.thermoresistible__bu ARG---IRQAVILAAGLDARAYRLRWPDGTVVYEIDQPRVIEFKTRTLAR
MMAR_3534|M.marinum_M RAG---VRQAVILASGLDARAYRLDWPAGMTVFEIDQPEVIAFKTTTLAG
MUL_2766|M.ulcerans_Agy99 RAG---VRQAVILASGLDARAYRLDWPAGMTVFEIDQPEVIAFKTTTLAG
MAV_4573|M.avium_104 AAG---IRQAVILASGLDTRAYRLDWPAGMTVFEIDQPAVVEFKTTALAR
Mb3816c|M.bovis_AF2122/97 AAG---VRQAVILASGLDARGYRLPWPADTTVFEVDQPRVLEFKAQTLAG
Rv3787c|M.tuberculosis_H37Rv AAG---VRQAVILASGLDARGYRLPWPADTTVFEVDQPRVLEFKAQTLAG
MSMEG_1888|M.smegmatis_MC2_155 AAG---VRQAVILASGLDARGYRLDWPAGTVLFEIDMPDVLEFKGRALTD
MAB_3787|M.abscessus_ATCC_1997 AAG---VRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVITFKTDTLAE
MLBr_02640|M.leprae_Br4923 IDG---IRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAE
* :** ****:***:*.*** ** . .::*:* * *: :* :*:
Mflv_5023|M.gilvum_PYR-GCK LGATPSTHLATVAIDLREDWPTALRDAGFDPSVPTAWIAEGLLGYLPPDA
Mvan_1346|M.vanbaalenii_PYR-1 LGVRPSTKLATVAVDLRNDWPAALAEAGFDASAPTAWIAEGLLGYLPPDA
TH_0301|M.thermoresistible__bu LGAEPTAERRTVAADLRHDWPAALTAAGFDPAAPTVWIAEGLFGYLPPDA
MMAR_3534|M.marinum_M LGAVPRADLRTVAVDLRQDWPKALTDAGFDAGSPTAWIAEGLFGYLPPEA
MUL_2766|M.ulcerans_Agy99 LGAVPRADLRTVAVDLRQDWPKALTEAGFDAGRPTAWIAEGLFGYLPPEA
MAV_4573|M.avium_104 LAAEPKADLRTVAVDLRDDWSTALATAGLDSSKPTAWIAEGLFGYLAPEA
Mb3816c|M.bovis_AF2122/97 LGAQPTADLRMVPADLRHDWPDALRRGGFDAAEPAAWIAEGLFGYLPPDA
Rv3787c|M.tuberculosis_H37Rv LGAQPTADLRMVPADLRHDWPDALRRGGFDAAEPAAWIAEGLFGYLPPDA
MSMEG_1888|M.smegmatis_MC2_155 LRAEPTAEVRMVAVDLRDDWPAALRAKGFDPTRPTAWSAEGLLPFLPPEA
MAB_3787|M.abscessus_ATCC_1997 LGASPSAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGLLIYLPPEA
MLBr_02640|M.leprae_Br4923 HGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATA
. * :. *. ***.**. ** *:*. :.* ****: :*.. *
Mflv_5023|M.gilvum_PYR-GCK QDRLLDTIGELSASGSRLAVE-SVPSQQSADQDEMREKMKDST---DRWR
Mvan_1346|M.vanbaalenii_PYR-1 QDRLLDTIGELSAPGSRLAVE-SVPTHHEADQEELREKMKESS---DRWR
TH_0301|M.thermoresistible__bu QDRLLDQITDLSAVGSRLGVE-GVPAHADADEDEVRQRMRILA---ERWR
MMAR_3534|M.marinum_M QDRLLDNITALSAAGSRLACE-AIPNRPQQDAEKARELMRKAT---ARWR
MUL_2766|M.ulcerans_Agy99 QDRLLDNITALSATGSRLACE-AIPNRPQQDAEKARELMRKAT---ARWR
MAV_4573|M.avium_104 QDRLLDAVTALSTPGSRLGSE-AVPDTADMDPHAARQRMRAAT---AKWR
Mb3816c|M.bovis_AF2122/97 QNRLLDHVTDLSAPGSRLALE-AFLGSADRDSARVEEMIRTAT---RGWR
Rv3787c|M.tuberculosis_H37Rv QNRLLDHVTDLSAPGSRLALE-AFLGSADRDSARVEEMIRTAT---RGWR
MSMEG_1888|M.smegmatis_MC2_155 QDRLLDAITSLSASGSRLAAEVALLGSDSEDGALGADGARDLEPLLARWR
MAB_3787|M.abscessus_ATCC_1997 QDRLFASITELSAPGSRLVCE-QVPGLETADFSKARELTRQFA-------
MLBr_02640|M.leprae_Br4923 QDGLFTEIGGLSAVGSRIAVE-TSPLHGDEWREQMQLRFRRVS----DAL
*: *: : **: ***: * :
Mflv_5023|M.gilvum_PYR-GCK SHGFDLDFSELVFLGE-RANVPDYLRERGWAVTATPTNDLLTRYGLAPLD
Mvan_1346|M.vanbaalenii_PYR-1 SHGFDVDFSELVFLGE-RADVTDYLRDRGWTVDATPTNQLLTRYGLAPLD
TH_0301|M.thermoresistible__bu AHGLDLDFSELIYLGD-RADVAGYLADRGWRCTALTANELLVRTGLPPAE
MMAR_3534|M.marinum_M EHGFELEFGDLGYEGD-RADVALYLQDLGWQSVGTQMGQLLADNGAAPIP
MUL_2766|M.ulcerans_Agy99 EHGFELEFGDLGYEGD-RADVELYLQNLGWQSVGTQMSQLLADNGAAPIP
MAV_4573|M.avium_104 DHGFELDVDVISFAGE-RHDVGAYLQALGWTTVATPMAELLADQGLPAIA
Mb3816c|M.bovis_AF2122/97 EHGFHLDIWALNYAGP-RHEVSGYLDNHGWRSVGTTTAQLLAAHDLPAAP
Rv3787c|M.tuberculosis_H37Rv EHGFHLDIWALNYAGP-RHEVSGYLDNHGWRSVGTTTAQLLAAHDLPAAP
MSMEG_1888|M.smegmatis_MC2_155 EHGFDLDLGDLGNSGP-RNDVDDYLEARGWTSTRTPLAALLDAAGLEVPR
MAB_3787|M.abscessus_ATCC_1997 GETLDLDLESLVYTQE-RQMAADWLAEHGWTVITEENDELYARLNLDPPN
MLBr_02640|M.leprae_Br4923 GFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDG
::. : * . :* ** .
Mflv_5023|M.gilvum_PYR-GCK ----TDEGFAEVVYVNAAR-------
Mvan_1346|M.vanbaalenii_PYR-1 ----SDEGFAEVVYVSATR-------
TH_0301|M.thermoresistible__bu ----NDGRVTEVVYLSSEKSPGKRAG
MMAR_3534|M.marinum_M -HNDDSVTMADTIYYSSVLTA-----
MUL_2766|M.ulcerans_Agy99 -HNNDSVTMADTIYYSSVLTA-----
MAV_4573|M.avium_104 RADDDRQTMNGVTYYTSTLGTGRQR-
Mb3816c|M.bovis_AF2122/97 --ALPAGLADRPNYWTCVLG------
Rv3787c|M.tuberculosis_H37Rv --ALPAGLADRPNYWTCVLG------
MSMEG_1888|M.smegmatis_MC2_155 --PADGRKSLSDNYYSTAIKG-----
MAB_3787|M.abscessus_ATCC_1997 --PLLRSIFPNIVYVDATLG------
MLBr_02640|M.leprae_Br4923 -VPMADDKDAFAEFVTAHRL------
: