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MARTDDDTWDLATSVGATATMVAAGRARATRDGLIDDPFAEPLVRAVGVDFFTRWAAGELDAADVDVPGA AWGMQRMTDMITARTRYIDAFFAEAGAAGIRQVVILASGLDARAYRLPWPAGTTVFEIDQPRVLEFKAAT IAQLGAEPTAPVRAVAVDLRHDWPSALRQAGFDVGRPAAWAAEGLLGFLPPQAQDRLLDNVTALSADGSQ LVAEVFANTGASGDALNAAGEKWRRHGLDVALDDLGFPGERNDPASYLQQLGWQPVRTPLNQMLANNGLP LQSTEPGAPFAQNYYCTAVLNKAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4236 | - | - | 100% (304) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_2110 | - | e-100 | 60.32% (310) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_4573 | - | 2e-95 | 61.05% (285) | putative methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3816c | - | 1e-101 | 60.59% (307) | hypothetical protein Mb3816c |
| M. gilvum PYR-GCK | Mflv_5023 | - | 3e-87 | 54.72% (307) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv3787c | - | 1e-101 | 60.59% (307) | hypothetical protein Rv3787c |
| M. leprae Br4923 | MLBr_02640 | - | 7e-52 | 50.68% (221) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3787 | - | 1e-69 | 51.04% (288) | hypothetical protein MAB_3787 |
| M. marinum M | MMAR_3534 | - | 2e-96 | 58.12% (308) | O-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1888 | - | 1e-103 | 63.04% (303) | methyltransferase |
| M. thermoresistible (build 8) | TH_2706 | - | 1e-79 | 52.81% (303) | PUTATIVE putative methyltransferase |
| M. ulcerans Agy99 | MUL_2766 | - | 3e-96 | 57.79% (308) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1346 | - | 2e-85 | 56.59% (311) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5023|M.gilvum_PYR-GCK MPRTENDTWDLASSVGATATMVAAARAVATRAEDPVIDDPYAEPLVRAVG
Mvan_1346|M.vanbaalenii_PYR-1 MARTDNDTWDLASSVGATATMVAAARAVATRAPRPVIDDPFAAPLVQAVG
Mb3816c|M.bovis_AF2122/97 MARTDDDSWDLATGVGATATLVAAGRARAARAAQPLIDDPFAEPLVRAVG
Rv3787c|M.tuberculosis_H37Rv MARTDDDSWDLATGVGATATLVAAGRARAARAAQPLIDDPFAEPLVRAVG
MAV_4236|M.avium_104 MARTDDDTWDLATSVGATATMVAAGRARATRDG--LIDDPFAEPLVRAVG
MSMEG_1888|M.smegmatis_MC2_155 -MESTHETWDLATSVGATATMVAAGRARATTTG--LIDDRFAEPLVRAVG
MMAR_3534|M.marinum_M MPRTDNDSWDLATSVGATATMVAAARAIATNADNPLIADRFAEPLVRAVG
MUL_2766|M.ulcerans_Agy99 MPRTDNDSWDLATSVGATATMVAAARAIATNADNPLIADRFAEPLVRAVG
TH_2706|M.thermoresistible__bu MARSESDTWDLTSGVGVTATMVAAARALASREPEPLIDDPFAAPLVRAVG
MAB_3787|M.abscessus_ATCC_1997 MARTDDDSWDLASSVGATATMVAAQRALASHVPNPLINDPYAEPLVRAVG
MLBr_02640|M.leprae_Br4923 -MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTG
.: ::**: :.**.**.:*** ** : :* * :* ** .*
Mflv_5023|M.gilvum_PYR-GCK IDFFAKLASGELTPEDLDVSGDESPVGMSRFADGMAARTRFFDDFFTDAC
Mvan_1346|M.vanbaalenii_PYR-1 VDFFTRLATGELTTEELDTNDAESPVGMSRFADAMAARTRFFDDFFAEAM
Mb3816c|M.bovis_AF2122/97 VEFLTRWATGELDAADVDDPD--AAWGLQRMTTELVVRTRYFDQFFLDAA
Rv3787c|M.tuberculosis_H37Rv VEFLTRWATGELDAADVDDPD--AAWGLQRMTTELVVRTRYFDQFFLDAA
MAV_4236|M.avium_104 VDFFTRWAAGELDAADVDVPG--AAWGMQRMTDMITARTRYIDAFFAEAG
MSMEG_1888|M.smegmatis_MC2_155 IDFMTRWATGDLAAADVDIPG--ATWGMQQMTDLLAARTRYFDAFFGDAA
MMAR_3534|M.marinum_M VDFFTRWVTGDLVVADVDDTE--SGWQLAQMPDAMAVRTRFFDAFFQDAT
MUL_2766|M.ulcerans_Agy99 VDFFTRWVTGDLVVADVDDTE--SGWQLAQMPDAMAVRARFFDAFFQDAT
TH_2706|M.thermoresistible__bu VEFFTRLVDGDLELP-ADTAE--ERAAAQVLTEVMAVRTRFFDDFFTDAT
MAB_3787|M.abscessus_ATCC_1997 IEYFTKLASGAFDPEQMAGLVQ-LGITADGMANGMASRTWYYDTAFESST
MLBr_02640|M.leprae_Br4923 AGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAV
: . . : . *: : * * .:
Mflv_5023|M.gilvum_PYR-GCK AAG---VRQAVILASGLDARGYRLTWPEGMTLFEIDQPEVIEFKRTTLAG
Mvan_1346|M.vanbaalenii_PYR-1 RAGPPPIRQGVILASGLDARAYRLSWPQDMVLFEIDQPEVLTFKAATLAD
Mb3816c|M.bovis_AF2122/97 AAG---VRQAVILASGLDARGYRLPWPADTTVFEVDQPRVLEFKAQTLAG
Rv3787c|M.tuberculosis_H37Rv AAG---VRQAVILASGLDARGYRLPWPADTTVFEVDQPRVLEFKAQTLAG
MAV_4236|M.avium_104 AAG---IRQVVILASGLDARAYRLPWPAGTTVFEIDQPRVLEFKAATIAQ
MSMEG_1888|M.smegmatis_MC2_155 AAG---VRQAVILASGLDARGYRLDWPAGTVLFEIDMPDVLEFKGRALTD
MMAR_3534|M.marinum_M RAG---VRQAVILASGLDARAYRLDWPAGMTVFEIDQPEVIAFKTTTLAG
MUL_2766|M.ulcerans_Agy99 RAG---VRQAVILASGLDARAYRLDWPAGMTVFEIDQPEVIAFKTTTLAG
TH_2706|M.thermoresistible__bu RVG---ARQAVILASGLDARAYRLTWPDGTVVYEIDQPEVIAFKTRTLAE
MAB_3787|M.abscessus_ATCC_1997 AAG---VRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVITFKTDTLAE
MLBr_02640|M.leprae_Br4923 IDG---IRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAE
* ** ********:*.*** ** . .::*:* * *: :* :::
Mflv_5023|M.gilvum_PYR-GCK LGATPSTHLATVAIDLREDWPTALRDAGFDPSVPTAWIAEGLLGYLPPDA
Mvan_1346|M.vanbaalenii_PYR-1 LGVRPSTKLATVAVDLRNDWPAALAEAGFDASAPTAWIAEGLLGYLPPDA
Mb3816c|M.bovis_AF2122/97 LGAQPTADLRMVPADLRHDWPDALRRGGFDAAEPAAWIAEGLFGYLPPDA
Rv3787c|M.tuberculosis_H37Rv LGAQPTADLRMVPADLRHDWPDALRRGGFDAAEPAAWIAEGLFGYLPPDA
MAV_4236|M.avium_104 LGAEPTAPVRAVAVDLRHDWPSALRQAGFDVGRPAAWAAEGLLGFLPPQA
MSMEG_1888|M.smegmatis_MC2_155 LRAEPTAEVRMVAVDLRDDWPAALRAKGFDPTRPTAWSAEGLLPFLPPEA
MMAR_3534|M.marinum_M LGAVPRADLRTVAVDLRQDWPKALTDAGFDAGSPTAWIAEGLFGYLPPEA
MUL_2766|M.ulcerans_Agy99 LGAVPRADLRTVAVDLRQDWPKALTEAGFDAGRPTAWIAEGLFGYLPPEA
TH_2706|M.thermoresistible__bu LGAPPTAPHRPVAVDLRDDWPAALTAAGFDPTVATAWSAEGLLRYLPPDA
MAB_3787|M.abscessus_ATCC_1997 LGASPSAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGLLIYLPPEA
MLBr_02640|M.leprae_Br4923 HGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATA
. * : *. ***.*** ** *** :.* ****: :**. *
Mflv_5023|M.gilvum_PYR-GCK QDRLLDTIGELSASGSRLAVESVPS-QQSADQDEMREKMK---DSTDRWR
Mvan_1346|M.vanbaalenii_PYR-1 QDRLLDTIGELSAPGSRLAVESVPT-HHEADQEELREKMK---ESSDRWR
Mb3816c|M.bovis_AF2122/97 QNRLLDHVTDLSAPGSRLALEAFLG-SADRDSARVEEMIR---TATRGWR
Rv3787c|M.tuberculosis_H37Rv QNRLLDHVTDLSAPGSRLALEAFLG-SADRDSARVEEMIR---TATRGWR
MAV_4236|M.avium_104 QDRLLDNVTALSADGSQLVAEVFANTGASGD-ALNAAG--------EKWR
MSMEG_1888|M.smegmatis_MC2_155 QDRLLDAITSLSASGSRLAAEVALLGSDSEDGALGADGARDLEPLLARWR
MMAR_3534|M.marinum_M QDRLLDNITALSAAGSRLACEAIPN-RPQQDAEKARELMR---KATARWR
MUL_2766|M.ulcerans_Agy99 QDRLLDNITALSATGSRLACEAIPN-RPQQDAEKARELMR---KATARWR
TH_2706|M.thermoresistible__bu QDRLFDHITDLSAPGSRLATEDHPG-PGAGLGEKADELGR-------RWR
MAB_3787|M.abscessus_ATCC_1997 QDRLFASITELSAPGSRLVCEQVPG-LETADFSKARELTR-------QFA
MLBr_02640|M.leprae_Br4923 QDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRR-----VSDAL
*: *: : *** **::. *
Mflv_5023|M.gilvum_PYR-GCK SHGFDLDFSELVFLGE-RANVPDYLRERGWAVTATPTNDLLTRYGLAPLD
Mvan_1346|M.vanbaalenii_PYR-1 SHGFDVDFSELVFLGE-RADVTDYLRDRGWTVDATPTNQLLTRYGLAPLD
Mb3816c|M.bovis_AF2122/97 EHGFHLDIWALNYAGP-RHEVSGYLDNHGWRSVGTTTAQLLAAHDLPAAP
Rv3787c|M.tuberculosis_H37Rv EHGFHLDIWALNYAGP-RHEVSGYLDNHGWRSVGTTTAQLLAAHDLPAAP
MAV_4236|M.avium_104 RHGLDVALDDLGFPGE-RNDPASYLQQLGWQPVRTPLNQMLANNGLPLQS
MSMEG_1888|M.smegmatis_MC2_155 EHGFDLDLGDLGNSGP-RNDVDDYLEARGWTSTRTPLAALLDAAGLEVPR
MMAR_3534|M.marinum_M EHGFELEFGDLGYEGD-RADVALYLQDLGWQSVGTQMGQLLADNGAAPIP
MUL_2766|M.ulcerans_Agy99 EHGFELEFGDLGYEGD-RADVELYLQNLGWQSVGTQMSQLLADNGAAPIP
TH_2706|M.thermoresistible__bu EHGFEVQLSELFHPGE-RTPVVDYLRGRGWDARARPRAEVFAGYGREFP-
MAB_3787|M.abscessus_ATCC_1997 GETLDLDLESLVYTQE-RQMAADWLAEHGWTVITEENDELYARLNLDPPN
MLBr_02640|M.leprae_Br4923 GFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDG
: . * * :* ** .
Mflv_5023|M.gilvum_PYR-GCK TDEG---FAEVVYVNAAR--------
Mvan_1346|M.vanbaalenii_PYR-1 SDEG---FAEVVYVSATR--------
Mb3816c|M.bovis_AF2122/97 ALPAGLADRPNYWTCVLG--------
Rv3787c|M.tuberculosis_H37Rv ALPAGLADRPNYWTCVLG--------
MAV_4236|M.avium_104 TEPG-APFAQNYYCTAVLNKAG----
MSMEG_1888|M.smegmatis_MC2_155 PADGRKSLSDNYYSTAIKG-------
MMAR_3534|M.marinum_M HNDDSVTMADTIYYSSVLTA------
MUL_2766|M.ulcerans_Agy99 HNNDSVTMADTIYYSSVLTA------
TH_2706|M.thermoresistible__bu DSAALAAMRDSSAVTAVRPVVRAGMR
MAB_3787|M.abscessus_ATCC_1997 PLLR-SIFPNIVYVDATLG-------
MLBr_02640|M.leprae_Br4923 VPMADDKDAFAEFVTAHRL-------