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TETTTQPVADAVADRPSVSLRTRGRWLRWGLLSVWGPGLVVMLADTDAGSLITASQSGAQWGYRMVLPQL ILMPVLYVVQEMTVRLGIVTGRGHGSLIRERFGRGWAWLSAFTLFASAIGALLTEFAGVAGVGELFGVSR WVSIPVATIALLALALTGSYRRVERIGLAVGAAELAFLVAMVMARPDPGALAHGLTSMPLGDSSYLLLIA ANVGAVIMPWMIFYQQGAVVDKHLSESTIRQARYDTAFGAVLTQLIMIAVVITMASTIGRHGDGAPLETV GQIAQSLTPYLGHVGGTVLFGLGMLGAALVAAIVASLAGAWGLAEVFGWKHTLNQRPNRATAKFYLTYSL AHIVGAVLVLASVDLVNLAVDVEIMNALLLPIVLGLLLALEARALPEQWRMRGLHKHVTRALCLVTIGFG LYMVPQALGWA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4571 | - | - | 100% (432) | metal ion transporter, NRAMP family protein |
| M. avium 104 | MAV_2120 | - | 6e-57 | 36.73% (373) | Mn2+/Fe2+ transporter |
| M. avium 104 | MAV_5197 | - | 2e-48 | 32.27% (406) | manganese/iron transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0948c | mntH | 4e-19 | 26.96% (319) | putative manganese transport protein MntH |
| M. gilvum PYR-GCK | Mflv_1822 | - | 3e-17 | 27.62% (315) | Mn2+/Fe2+ transporter |
| M. tuberculosis H37Rv | Rv0924c | mntH | 4e-19 | 26.96% (319) | manganese transport protein MntH |
| M. leprae Br4923 | MLBr_02667 | - | 9e-51 | 33.42% (380) | putative membrane transport protein |
| M. abscessus ATCC 19977 | MAB_2716c | - | 3e-57 | 36.02% (372) | manganese transport transmembrane protein |
| M. marinum M | MMAR_2593 | - | 0.0 | 84.86% (416) | divalent cation-transport integral membrane protein |
| M. smegmatis MC2 155 | MSMEG_1780 | - | 5e-19 | 23.70% (346) | hypothetical protein MSMEG_1780 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3167 | - | 0.0 | 84.86% (416) | divalent cation-transport integral membrane protein |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2593|M.marinum_M --------------------------------------------------
MUL_3167|M.ulcerans_Agy99 --------------------------------------------------
MAV_4571|M.avium_104 --------------------------------------------------
MLBr_02667|M.leprae_Br4923 --------------------------------------------------
MAB_2716c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0948c|M.bovis_AF2122/97 MTTTSDQNAAAPPRFDGLRALFINATLKRSPELSHTDGLIERSSGIMREH
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2593|M.marinum_M --------------------------------------------------
MUL_3167|M.ulcerans_Agy99 --------------------------------------------------
MAV_4571|M.avium_104 --------------------------------------------------
MLBr_02667|M.leprae_Br4923 --------------------------------------------------
MAB_2716c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0948c|M.bovis_AF2122/97 GVQVDTLRAVDHDIATGVWPDMTEHGWATDEWPALYRRVLDAHILVLCGP
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2593|M.marinum_M --------------------------------------------------
MUL_3167|M.ulcerans_Agy99 --------------------------------------------------
MAV_4571|M.avium_104 --------------------------------------------------
MLBr_02667|M.leprae_Br4923 --------------------------------------------------
MAB_2716c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0948c|M.bovis_AF2122/97 IWLGDNSSVMKRVIERLYACSSLLNEDGQYAYYGRAGGCLITGNEDGVKH
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2593|M.marinum_M --------------------------------------------------
MUL_3167|M.ulcerans_Agy99 --------------------------------------------------
MAV_4571|M.avium_104 --------------------------------------------------
MLBr_02667|M.leprae_Br4923 ---------------------------------------------MSLII
MAB_2716c|M.abscessus_ATCC_199 -------------------------------------------------M
Mb0948c|M.bovis_AF2122/97 CAMNVLYSLQHLGYTIPPQADAGWIGEAGPGPSYLDPGSGGPENDFTNRN
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2593|M.marinum_M --------------------------------------------------
MUL_3167|M.ulcerans_Agy99 --------------------------------------------------
MAV_4571|M.avium_104 --------------------------------------------------
MLBr_02667|M.leprae_Br4923 FEHEPVDNSENPMTYISTDAISAVAVPPTTGDAIMCVKNCATPRVTPDTS
MAB_2716c|M.abscessus_ATCC_199 SENGIVNGSVN-------------------GSVNGAETANGQLKVQVSQP
Mb0948c|M.bovis_AF2122/97 TTFMTFNLMHIAQMLRAPAASRPTAINAPSGTPAAGRTSPTPTTDSQRRS
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2593|M.marinum_M -MTDRSDEQVRATTG--PEASMRVPRGGWLRWG----LLAVWGPGLVVML
MUL_3167|M.ulcerans_Agy99 -MTDRSDEQVRATTG--PEASMRVHRGGWLRWG----LLAVWGPGLVVML
MAV_4571|M.avium_104 -MTETTTQPVADAVADRPSVSLRT-RGRWLRWG----LLSVWGPGLVVML
MLBr_02667|M.leprae_Br4923 GSSVLDSAHVGDIVGAFGRIGWDVTHASRSRWQQLRLMMVITGPGLIAMI
MAB_2716c|M.abscessus_ATCC_199 KSAVLDSAHLGDIEGAFGKISVSDPGQARTFRSRMATMAAILGPGIIVMV
Mb0948c|M.bovis_AF2122/97 RVARWLVAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAI
Rv0924c|M.tuberculosis_H37Rv ------MAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAI
Mflv_1822|M.gilvum_PYR-GCK --------------------------MTGDVRPQAKR-WLLLGPAFVAAI
MSMEG_1780|M.smegmatis_MC2_155 ----------------------------------MKKVFAVALGILTAIG
: : .
MMAR_2593|M.marinum_M ADTDAGSLITAAESGAQWGYRMVLPQLILMPILYVVQEMTVRLGIVTGKG
MUL_3167|M.ulcerans_Agy99 ADTDAGSLITAAESGAQWGYRMVLPQLILMPILYVVQEMTVRLGIVTGKG
MAV_4571|M.avium_104 ADTDAGSLITASQSGAQWGYRMVLPQLILMPVLYVVQEMTVRLGIVTGRG
MLBr_02667|M.leprae_Br4923 GDNDAGGVATYAQAGQKYGMNLLWTLVLLIPVLYVNQEMVLRLGAVTRVG
MAB_2716c|M.abscessus_ATCC_199 GDNDAGGVATYAQAGQSYGYSLLWVLLLLIPVLIVNQEMVVRLGAVTGVG
Mb0948c|M.bovis_AF2122/97 AYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRS
Rv0924c|M.tuberculosis_H37Rv AYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRS
Mflv_1822|M.gilvum_PYR-GCK AYVDPGNVAANVSAGAQFGFLLVWVIVAANLMACLVQYLSAKLGLVTGRS
MSMEG_1780|M.smegmatis_MC2_155 GFLDIGDLVTNAVVGSRFGLALVWVVVVGVVGICLFAQMAGRVAAVSGRA
. * *.: : * :* :: : : : ::. *: .
MMAR_2593|M.marinum_M HGALIRERFGRGWAWLSAFTLFASAIGALLTEFVGVAGVGELFG-----I
MUL_3167|M.ulcerans_Agy99 HGALIRERFGRGWAWLSAFTLFASAIGALLTEFVGVAGVGELFG-----I
MAV_4571|M.avium_104 HGSLIRERFGRGWAWLSAFTLFASAIGALLTEFAGVAGVGELFG-----V
MLBr_02667|M.leprae_Br4923 HARLIFERFGKFWGAFSVGDLLILNALTIVTEFIGVSLALDFLG-----C
MAB_2716c|M.abscessus_ATCC_199 HARLINERFGRGWGWFSVGDLFILNFLTLVTEFIGVALASEYLG-----V
Mb0948c|M.bovis_AF2122/97 LPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPI
Rv0924c|M.tuberculosis_H37Rv LPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPI
Mflv_1822|M.gilvum_PYR-GCK LPEAVGSRMSRRTRLAYWVQAELVAMATDLAEVVGGAIALYLLFDLPLLV
MSMEG_1780|M.smegmatis_MC2_155 TFEIIRERLGPRTAAANLGASFFINLMTLTAEIGGIALALQLAT----DV
: .*:. : :*. * : .
MMAR_2593|M.marinum_M SRWVSIPIATVMLLALALTGSYRRVERIGLAVGAAEVAFLVAMVMARPQL
MUL_3167|M.ulcerans_Agy99 SRWVSIPIATVMLLALALTGSYRRVERIGLAVGAAEVAFLVAMVMARPQL
MAV_4571|M.avium_104 SRWVSIPVATIALLALALTGSYRRVERIGLAVGAAELAFLVAMVMARPDP
MLBr_02667|M.leprae_Br4923 PKTIAIPVAAVLLFAMVAGGSFRRWEQVMFMLISVNVAVIPLVLSVHPAL
MAB_2716c|M.abscessus_ATCC_199 SKYYTVPLAAIALILIMATGSFRRWERAMFVFIAITLLQIPMFLLAEPQW
Mb0948c|M.bovis_AF2122/97 GGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIAIGFTASFFVVTPPP
Rv0924c|M.tuberculosis_H37Rv GGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIAIGFTASFFVVTPPP
Mflv_1822|M.gilvum_PYR-GCK GGIITGAVSLILLMVKDLRGQRVFERVITGLLMVIAIGFLTSLFAASPPV
MSMEG_1780|M.smegmatis_MC2_155 GPMMWIPVAAFAVWLVIWRVKFSVMENATGILGLCLIVFAVSVFALQPNW
:: . : . . . : .. *
MMAR_2593|M.marinum_M DQLLAGLRSMPLGN-----SSYLLLVAANVGAVIMPWMIFYQQGAVVDKH
MUL_3167|M.ulcerans_Agy99 DQLLAGLRSMPLGN-----SSYLLLVAANVGAVIMPWMIFYQQGAVVDKH
MAV_4571|M.avium_104 GALAHGLTSMPLGD-----SSYLLLIAANVGAVIMPWMIFYQQGAVVDKH
MLBr_02667|M.leprae_Br4923 GPSLHGLLPSLPGKPDSPTSVVLLVIMAIVGTTVAPWQLFFQQSSVVDKR
MAB_2716c|M.abscessus_ATCC_199 GRAAHDFV--VPGIDGGVSSGAVLLIIAMVGTTVAPWQLFFQQSNIVDKR
Mb0948c|M.bovis_AF2122/97 NAVLGGLAPRFQGT------ESVLLAAAIMGATVMPHAVYLHSGLARDRH
Rv0924c|M.tuberculosis_H37Rv NAVLGGLAPRFQGT------ESVLLAAAIMGATVMPHAVYLHSGLARDRH
Mflv_1822|M.gilvum_PYR-GCK GAAAEGLIPRFDGA------ESVLLAAAMLGATVMPHAVYLHSGLARDRH
MSMEG_1780|M.smegmatis_MC2_155 GDLAGQAVQPAIPESES-AATYWYYAIALFGAAMTPYEVFFFSSGAVEEH
. * .*:.: * :: .. :.:
MMAR_2593|M.marinum_M -------LSVATIRQARLDTAVGAVLTQLIMIAVVVTVAATIGTHHGAAS
MUL_3167|M.ulcerans_Agy99 -------LSVATIRQARLDTAVGAVLTQLIMIAVVVTVAATIGTHHGAAS
MAV_4571|M.avium_104 -------LSESTIRQARYDTAFGAVLTQLIMIAVVITMASTIGRHGDGAP
MLBr_02667|M.leprae_Br4923 -------ITPRWMRYGRADLVVGIVGVMAGAIALMSATAFGLAGTADSG-
MAB_2716c|M.abscessus_ATCC_199 -------ITPRFIGYERADTVIGSLVVVIGAAALLMTADYAARATGNSGP
Mb0948c|M.bovis_AF2122/97 GHPDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTAS
Rv0924c|M.tuberculosis_H37Rv GHPDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTAS
Mflv_1822|M.gilvum_PYR-GCK GHPGPGEPRRALLRITRWDVGIAMLVAGAVNLSMLLVAATNLQGMADTDS
MSMEG_1780|M.smegmatis_MC2_155 -------WTTKDLGVSRMNVMVGFPLGGLLSIAIATCATLVLLPQQVEVT
: * : .. ::
MMAR_2593|M.marinum_M -----LQTVGQIADALTPYLGRLGGTVLFGLGMLGAALVAAIVASLAGAW
MUL_3167|M.ulcerans_Agy99 -----LQTVGQIADALTPYLGRLGGTVLFGLGMLGAALVAAIVASLAGAW
MAV_4571|M.avium_104 -----LETVGQIAQSLTPYLGHVGGTVLFGLGMLGAALVAAIVASLAGAW
MLBr_02667|M.leprae_Br4923 ----NFTDAGAVASHLSDHVGHPIG-VLFAIILLDASLIGANVVGLATTY
MAB_2716c|M.abscessus_ATCC_199 DKWGDSGDAGLIAEWLG-QVQPLLG-KIFAIVLLDASIIGAAAVTLATSY
Mb0948c|M.bovis_AF2122/97 --------IEGAYHAVHDTLGATIA-VLFAVGLLASGLASSSVGAYAGAM
Rv0924c|M.tuberculosis_H37Rv --------IEGAYHAVHDTLGATIA-VLFAVGLLASGLASSSVGAYAGAM
Mflv_1822|M.gilvum_PYR-GCK --------IEGAHAAVQNTLGDTVA-LLFAIGLLASGLASSSVGAYAGAM
MSMEG_1780|M.smegmatis_MC2_155 --------SLSQVVMPVVEAGGKLALAFAVIGIVAATFGAALETTLSSGY
. : : :: : : .: :
MMAR_2593|M.marinum_M GLSEVFGWRHTLNQRPNRATAKFYTTYALAHIIGAVLVLGSVDLVNLAVD
MUL_3167|M.ulcerans_Agy99 GLSEVFGWRHTLNQRPNRATAKFYTTYALAHIIGAVLVLGSVDLVNLAVD
MAV_4571|M.avium_104 GLAEVFGWKHTLNQRPNRATAKFYLTYSLAHIVGAVLVLASVDLVNLAVD
MLBr_02667|M.leprae_Br4923 ALGDALGKPHSLHWKITEAPLFYGSYTALLGISAVVAFSPGHILGLITQG
MAB_2716c|M.abscessus_ATCC_199 AFGDTFGLKHSLHRSFKDAKPFYLSYTVMVGVGAAIVLIPNAPLGLMTTA
Mb0948c|M.bovis_AF2122/97 IMQGLLHWSVPMLVR-----------RLITLGPALAILTLGFDPTRTLVL
Rv0924c|M.tuberculosis_H37Rv IMQGLLHWSVPMLVR-----------RLITLGPALAILTLGFDPTRTLVL
Mflv_1822|M.gilvum_PYR-GCK IMQGLLRRSVPLLAR-----------RLITLLPALVILAVGIHPSRALVL
MSMEG_1780|M.smegmatis_MC2_155 TLAQFLGWPWGKFRRPAQAAR-FHVVMFVSIVVGAAVLFTGVDPVLVTEY
: : : . . .
MMAR_2593|M.marinum_M VEVMNALLLP-IVLGLLLVLEAHTLPEEWRMRGVRKYITRTLCLFVIAFG
MUL_3167|M.ulcerans_Agy99 VEVMNALLLP-IVLGLLLVLEAHTLPEEWRMRGVRKYITRTLCLFVIAFG
MAV_4571|M.avium_104 VEIMNALLLP-IVLGLLLALEARALPEQWRMRGLHKHVTRALCLVTIGFG
MLBr_02667|M.leprae_Br4923 VQALAGVLLPSATVFLVLLCNDRPVLGPWVNTARQNVFAWMIVWSLVVLS
MAB_2716c|M.abscessus_ATCC_199 VQALAGLLLPSASVFLLLLCNDKAVLGPWVNKPWLNIVAGLIVGVLLFLS
Mb0948c|M.bovis_AF2122/97 SQVVLSFGIPFAVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLN
Rv0924c|M.tuberculosis_H37Rv SQVVLSFGIPFAVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLN
Mflv_1822|M.gilvum_PYR-GCK SQVVLSFGIPFALIPLVRLTADRALMGADVNHRVTTAAGWVVAGLISLLN
MSMEG_1780|M.smegmatis_MC2_155 SVVFSAIALPLTYLPILIVANDPEYMGENTNGKVTNMFGTIYLVIILAAS
. .. :* : :: . .
MMAR_2593|M.marinum_M LYMVPQALGWL---------------------------------------
MUL_3167|M.ulcerans_Agy99 LYMVPQALGWL---------------------------------------
MAV_4571|M.avium_104 LYMVPQALGWA---------------------------------------
MLBr_02667|M.leprae_Br4923 LMLTVVTLFPNLSTAAMVGGLGAGTALGVVGAAAVIVAGWLAERRGAGGI
MAB_2716c|M.abscessus_ATCC_199 GILMATTLFPDLDVVEVARDLAVG-----VTILAVLIG---------TGL
Mb0948c|M.bovis_AF2122/97 VMLIYLTVTG----------------------------------------
Rv0924c|M.tuberculosis_H37Rv VMLIYLTVTG----------------------------------------
Mflv_1822|M.gilvum_PYR-GCK VVLIYLTLWG----------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 LAAIPLMIVTGAGQ------------------------------------
:
MMAR_2593|M.marinum_M --------------------------------------------------
MUL_3167|M.ulcerans_Agy99 --------------------------------------------------
MAV_4571|M.avium_104 --------------------------------------------------
MLBr_02667|M.leprae_Br4923 AQQPSCSGSEQAQFDALARLTRAERRALCDERRANWTMPVLANLDRPVMS
MAB_2716c|M.abscessus_ATCC_199 WWVSSRQRADPAVLAMTKVLDGVDAR--------TWRMPPLALLEPVRWS
Mb0948c|M.bovis_AF2122/97 --------------------------------------------------
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2593|M.marinum_M --------------------------------
MUL_3167|M.ulcerans_Agy99 --------------------------------
MAV_4571|M.avium_104 --------------------------------
MLBr_02667|M.leprae_Br4923 PVRRIGLLMLRGYLVLACVLVVVKVVQVGVG-
MAB_2716c|M.abscessus_ATCC_199 PGTKLGMLALRGYLVVGAILLVVKAIQLAHGN
Mb0948c|M.bovis_AF2122/97 --------------------------------
Rv0924c|M.tuberculosis_H37Rv --------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------