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M. marinum M MMAR_2593 (-)

annotation: divalent cation-transport integral membrane protein
coordinates: 3160614 - 3161909
length: 431

VTDRSDEQVRATTGPEASMRVPRGGWLRWGLLAVWGPGLVVMLADTDAGSLITAAESGAQWGYRMVLPQL
ILMPILYVVQEMTVRLGIVTGKGHGALIRERFGRGWAWLSAFTLFASAIGALLTEFVGVAGVGELFGISR
WVSIPIATVMLLALALTGSYRRVERIGLAVGAAEVAFLVAMVMARPQLDQLLAGLRSMPLGNSSYLLLVA
ANVGAVIMPWMIFYQQGAVVDKHLSVATIRQARLDTAVGAVLTQLIMIAVVVTVAATIGTHHGAASLQTV
GQIADALTPYLGRLGGTVLFGLGMLGAALVAAIVASLAGAWGLSEVFGWRHTLNQRPNRATAKFYTTYAL
AHIIGAVLVLGSVDLVNLAVDVEVMNALLLPIVLGLLLVLEAHTLPEEWRMRGVRKYITRTLCLFVIAFG
LYMVPQALGWL

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. marinum M MMAR_2593 - - 100% (431) divalent cation-transport integral membrane protein
M. marinum M MMAR_0315 - 5e-49 32.16% (398) divalent cation-transport integral membrane protein
M. marinum M MMAR_4584 mntH 1e-17 28.21% (319) divalent cation-transport integral membrane protein MntH

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0948c mntH 9e-17 26.65% (319) putative manganese transport protein MntH
M. gilvum PYR-GCK Mflv_1822 - 6e-15 26.60% (312) Mn2+/Fe2+ transporter
M. tuberculosis H37Rv Rv0924c mntH 9e-17 26.65% (319) manganese transport protein MntH
M. leprae Br4923 MLBr_02667 - 1e-49 32.79% (366) putative membrane transport protein
M. abscessus ATCC 19977 MAB_4716c - 8e-59 35.22% (372) membrane transport protein
M. avium 104 MAV_4571 - 0.0 84.86% (416) metal ion transporter, NRAMP family protein
M. smegmatis MC2 155 MSMEG_1780 - 9e-18 23.58% (352) hypothetical protein MSMEG_1780
M. thermoresistible (build 8) - - - - -
M. ulcerans Agy99 MUL_3167 - 0.0 99.77% (431) divalent cation-transport integral membrane protein
M. vanbaalenii PYR-1 - - - - -

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_2593|M.marinum_M               --------------------------------------------------
MUL_3167|M.ulcerans_Agy99           --------------------------------------------------
MAV_4571|M.avium_104                --------------------------------------------------
MLBr_02667|M.leprae_Br4923          --------------------------------------------------
MAB_4716c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0948c|M.bovis_AF2122/97           MTTTSDQNAAAPPRFDGLRALFINATLKRSPELSHTDGLIERSSGIMREH
Rv0924c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_2593|M.marinum_M               --------------------------------------------------
MUL_3167|M.ulcerans_Agy99           --------------------------------------------------
MAV_4571|M.avium_104                --------------------------------------------------
MLBr_02667|M.leprae_Br4923          --------------------------------------------------
MAB_4716c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0948c|M.bovis_AF2122/97           GVQVDTLRAVDHDIATGVWPDMTEHGWATDEWPALYRRVLDAHILVLCGP
Rv0924c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_2593|M.marinum_M               --------------------------------------------------
MUL_3167|M.ulcerans_Agy99           --------------------------------------------------
MAV_4571|M.avium_104                --------------------------------------------------
MLBr_02667|M.leprae_Br4923          --------------------------------------------------
MAB_4716c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0948c|M.bovis_AF2122/97           IWLGDNSSVMKRVIERLYACSSLLNEDGQYAYYGRAGGCLITGNEDGVKH
Rv0924c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_2593|M.marinum_M               --------------------------------------------------
MUL_3167|M.ulcerans_Agy99           --------------------------------------------------
MAV_4571|M.avium_104                --------------------------------------------------
MLBr_02667|M.leprae_Br4923          ---------------------------------------------MSLII
MAB_4716c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0948c|M.bovis_AF2122/97           CAMNVLYSLQHLGYTIPPQADAGWIGEAGPGPSYLDPGSGGPENDFTNRN
Rv0924c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_2593|M.marinum_M               --------------------------------------------------
MUL_3167|M.ulcerans_Agy99           --------------------------------------------------
MAV_4571|M.avium_104                --------------------------------------------------
MLBr_02667|M.leprae_Br4923          FEHEPVDNSENPMTYISTDAISAVAVPPTTGDAIMCVKNCATPRVTPDTS
MAB_4716c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0948c|M.bovis_AF2122/97           TTFMTFNLMHIAQMLRAPAASRPTAINAPSGTPAAGRTSPTPTTDSQRRS
Rv0924c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_2593|M.marinum_M               -MTDRSDEQVRATTG--PEASMRVPRGGWLRWG----LLAVWGPGLVVML
MUL_3167|M.ulcerans_Agy99           -MTDRSDEQVRATTG--PEASMRVHRGGWLRWG----LLAVWGPGLVVML
MAV_4571|M.avium_104                -MTETTTQPVADAVADRPSVSLRT-RGRWLRWG----LLSVWGPGLVVML
MLBr_02667|M.leprae_Br4923          GSSVLDSAHVGDIVGAFGRIGWDVTHASRSRWQQLRLMMVITGPGLIAMI
MAB_4716c|M.abscessus_ATCC_199      ----MDSAHVGDIVGALGTIGQHENIEGRSRWQRFRMLLAVLGPGLIVMV
Mb0948c|M.bovis_AF2122/97           RVARWLVAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAI
Rv0924c|M.tuberculosis_H37Rv        ------MAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAI
Mflv_1822|M.gilvum_PYR-GCK          --------------------------MTGDVRPQAKR-WLLLGPAFVAAI
MSMEG_1780|M.smegmatis_MC2_155      ----------------------------------MKKVFAVALGILTAIG
                                                                            :    : .  

MMAR_2593|M.marinum_M               ADTDAGSLITAAESGAQWGYRMVLPQLILMPILYVVQEMTVRLGIVTGKG
MUL_3167|M.ulcerans_Agy99           ADTDAGSLITAAESGAQWGYRMVLPQLILMPILYVVQEMTVRLGIVTGKG
MAV_4571|M.avium_104                ADTDAGSLITASQSGAQWGYRMVLPQLILMPVLYVVQEMTVRLGIVTGRG
MLBr_02667|M.leprae_Br4923          GDNDAGGVATYAQAGQKYGMNLLWTLVLLIPVLYVNQEMVLRLGAVTRVG
MAB_4716c|M.abscessus_ATCC_199      GDNDAGGVATYAQAGQNYGMALLWTLALLIPVLYVNQEMVVRLGAVAGVG
Mb0948c|M.bovis_AF2122/97           AYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRS
Rv0924c|M.tuberculosis_H37Rv        AYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRS
Mflv_1822|M.gilvum_PYR-GCK          AYVDPGNVAANVSAGAQFGFLLVWVIVAANLMACLVQYLSAKLGLVTGRS
MSMEG_1780|M.smegmatis_MC2_155      GFLDIGDLVTNAVVGSRFGLALVWVVVVGVVGICLFAQMAGRVAAVSGRA
                                    .  * *.: :    * .:*  ::           :   :  ::. *:  .

MMAR_2593|M.marinum_M               HGALIRERFGRGWAWLSAFTLFASAIGALLTEFVG-VAGVGELFGISRWV
MUL_3167|M.ulcerans_Agy99           HGALIRERFGRGWAWLSAFTLFASAIGALLTEFVG-VAGVGELFGISRWV
MAV_4571|M.avium_104                HGSLIRERFGRGWAWLSAFTLFASAIGALLTEFAG-VAGVGELFGVSRWV
MLBr_02667|M.leprae_Br4923          HARLIFERFGKFWGAFSVGDLLILNALTIVTEFIG-VSLALDFLGCPKTI
MAB_4716c|M.abscessus_ATCC_199      HARLIFSRFGRFWGAFSVGDLFVVNALTIVTEFIG-VAMALSYFGLPRWI
Mb0948c|M.bovis_AF2122/97           LPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPI
Rv0924c|M.tuberculosis_H37Rv        LPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPI
Mflv_1822|M.gilvum_PYR-GCK          LPEAVGSRMSRRTRLAYWVQAELVAMATDLAEVVGGAIALYLLFDLPLLV
MSMEG_1780|M.smegmatis_MC2_155      TFEIIRERLGPRTAAANLGASFFINLMTLTAEIGGIALALQLATDVGPMM
                                        : .*:.                 :  :*. * .       .    :

MMAR_2593|M.marinum_M               S---IPIATVMLLALALTGSYRRVERIG-LAVGAAEVAFLVAMVMARPQL
MUL_3167|M.ulcerans_Agy99           S---IPIATVMLLALALTGSYRRVERIG-LAVGAAEVAFLVAMVMARPQL
MAV_4571|M.avium_104                S---IPVATIALLALALTGSYRRVERIG-LAVGAAELAFLVAMVMARPDP
MLBr_02667|M.leprae_Br4923          A---IPVAAVLLFAMVAGGSFRRWEQVM-FMLISVNVAVIPLVLSVHPAL
MAB_4716c|M.abscessus_ATCC_199      S---VPLSAVLLFAVVAGGSFRRWERFL-FALIAINIVMIPMAILVHPSV
Mb0948c|M.bovis_AF2122/97           GGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIAIGFTASFFVVTPPP
Rv0924c|M.tuberculosis_H37Rv        GGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIAIGFTASFFVVTPPP
Mflv_1822|M.gilvum_PYR-GCK          GGIITGAVSLILLMVKDLRGQRVFERVITGLLMVIAIGFLTSLFAASPPV
MSMEG_1780|M.smegmatis_MC2_155      WIPVAAFAVWLVIWRVKFSVMENATGILGLCLIVFAVSVFALQPNWGDLA
                                               ::        .    .    :    : .           

MMAR_2593|M.marinum_M               DQLLAGLRSMPLG-----NSSYLLLVAANVGAVIMPWMIFYQQGAVVDKH
MUL_3167|M.ulcerans_Agy99           DQLLAGLRSMPLG-----NSSYLLLVAANVGAVIMPWMIFYQQGAVVDKH
MAV_4571|M.avium_104                GALAHGLTSMPLG-----DSSYLLLIAANVGAVIMPWMIFYQQGAVVDKH
MLBr_02667|M.leprae_Br4923          GPSLHGLLPSLPGKPDSPTSVVLLVIMAIVGTTVAPWQLFFQQSSVVDKR
MAB_4716c|M.abscessus_ATCC_199      SKTASGFVPSFPG---GLNAELLMLIVAIVGTTVAPWQLFFQQSNIVDKR
Mb0948c|M.bovis_AF2122/97           NAVLGGLAPRFQG------TESVLLAAAIMGATVMPHAVYLHSGLARDRH
Rv0924c|M.tuberculosis_H37Rv        NAVLGGLAPRFQG------TESVLLAAAIMGATVMPHAVYLHSGLARDRH
Mflv_1822|M.gilvum_PYR-GCK          GAAAEGLIPRFDG------AESVLLAAAMLGATVMPHAVYLHSGLARDRH
MSMEG_1780|M.smegmatis_MC2_155      GQAVQPAIPESES-----AATYWYYAIALFGAAMTPYEVFFFSSGAVEEH
                                    .       .   .      :       * .*:.: *  ::  ..   :.:

MMAR_2593|M.marinum_M               -------LSVATIRQARLDTAVGAVLTQLIMIAVVVTVAATIGTHHGAAS
MUL_3167|M.ulcerans_Agy99           -------LSVATIRQARLDTAVGAVLTQLIMIAVVVTVAATIGTHHGAAS
MAV_4571|M.avium_104                -------LSESTIRQARYDTAFGAVLTQLIMIAVVITMASTIGRHGDGAP
MLBr_02667|M.leprae_Br4923          -------ITPRWMRYGRADLVVGIVGVMAGAIALMSATAFGLAGTADSGN
MAB_4716c|M.abscessus_ATCC_199      -------LTPRWIRYERVDLAVGIVVVMIGAVCIMGAAAFGLAGTDAGGD
Mb0948c|M.bovis_AF2122/97           GHPDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTAS
Rv0924c|M.tuberculosis_H37Rv        GHPDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTAS
Mflv_1822|M.gilvum_PYR-GCK          GHPGPGEPRRALLRITRWDVGIAMLVAGAVNLSMLLVAATNLQGMADTDS
MSMEG_1780|M.smegmatis_MC2_155      -------WTTKDLGVSRMNVMVGFPLGGLLSIAIATCATLVLLP--QQVE
                                                :   * :  ..         .:    :  :        

MMAR_2593|M.marinum_M               LQTVGQIADALTPYLGRLGGTVLFGLGMLGAALVAAIVASLAGAWGLSEV
MUL_3167|M.ulcerans_Agy99           LQTVGQIADALTPYLGRLGGTVLFGLGMLGAALVAAIVASLAGAWGLSEV
MAV_4571|M.avium_104                LETVGQIAQSLTPYLGHVGGTVLFGLGMLGAALVAAIVASLAGAWGLAEV
MLBr_02667|M.leprae_Br4923          FTDAGAVASHLSDHVGHPIG-VLFAIILLDASLIGANVVGLATTYALGDA
MAB_4716c|M.abscessus_ATCC_199      FTDAGAVARLLHEHVSPTVG-ALFAILLLDASLIGANAVGLATTYALGDT
Mb0948c|M.bovis_AF2122/97           IEGA---YHAVHDTLGATIA-VLFAVGLLASGLASSSVGAYAGAMIMQGL
Rv0924c|M.tuberculosis_H37Rv        IEGA---YHAVHDTLGATIA-VLFAVGLLASGLASSSVGAYAGAMIMQGL
Mflv_1822|M.gilvum_PYR-GCK          IEGA---HAAVQNTLGDTVA-LLFAIGLLASGLASSSVGAYAGAMIMQGL
MSMEG_1780|M.smegmatis_MC2_155      VTSLSQVVMPVVEAGG-KLALAFAVIGIVAATFGAALETTLSSGYTLAQF
                                    .         :    .   .  :  : :: : : .:     :    :   

MMAR_2593|M.marinum_M               FGWRHTLNQRPNRATAKFYTTYALAHIIGAVLVLGSVDLVNLAVDVEVMN
MUL_3167|M.ulcerans_Agy99           FGWRHTLNQRPNRATAKFYTTYALAHIIGAVLVLGSVDLVNLAVDVEVMN
MAV_4571|M.avium_104                FGWKHTLNQRPNRATAKFYLTYSLAHIVGAVLVLASVDLVNLAVDVEIMN
MLBr_02667|M.leprae_Br4923          LGKPHSLHWKITEAPLFYGSYTALLGISAVVAFSPGHILGLITQGVQALA
MAB_4716c|M.abscessus_ATCC_199      FGKRHSLHWKPTEAPVFYLGYAMLLVVAAAVSFSPDPVLGVLTQGVQALA
Mb0948c|M.bovis_AF2122/97           LHWSVPMLVR-----------RLITLGPALAILTLGFDPTRTLVLSQVVL
Rv0924c|M.tuberculosis_H37Rv        LHWSVPMLVR-----------RLITLGPALAILTLGFDPTRTLVLSQVVL
Mflv_1822|M.gilvum_PYR-GCK          LRRSVPLLAR-----------RLITLLPALVILAVGIHPSRALVLSQVVL
MSMEG_1780|M.smegmatis_MC2_155      LGWPWGKFRRPAQAAR-FHVVMFVSIVVGAAVLFTGVDPVLVTEYSVVFS
                                    :        :             :    . . .  .            . 

MMAR_2593|M.marinum_M               ALLLP-IVLGLLLVLEAHTLPEEWRMRGVRKYITRTLCLFVIAFGLYMVP
MUL_3167|M.ulcerans_Agy99           ALLLP-IVLGLLLVLEAHTLPEEWRMRGVRKYITRTLCLFVIAFGLYMVP
MAV_4571|M.avium_104                ALLLP-IVLGLLLALEARALPEQWRMRGLHKHVTRALCLVTIGFGLYMVP
MLBr_02667|M.leprae_Br4923          GVLLPSATVFLVLLCNDRPVLGPWVNTARQNVFAWMIVWSLVVLSLMLTV
MAB_4716c|M.abscessus_ATCC_199      GVLLPSATVFLVLLCNDKAVLGPWVNSTRQNIVAGVIVWVLVLLSLSLTA
Mb0948c|M.bovis_AF2122/97           SFGIPFAVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLNVMLIY
Rv0924c|M.tuberculosis_H37Rv        SFGIPFAVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLNVMLIY
Mflv_1822|M.gilvum_PYR-GCK          SFGIPFALIPLVRLTADRALMGADVNHRVTTAAGWVVAGLISLLNVVLIY
MSMEG_1780|M.smegmatis_MC2_155      AIALPLTYLPILIVANDPEYMGENTNGKVTNMFGTIYLVIILAASLAAIP
                                    .. :*   : ::                  .             .:    

MMAR_2593|M.marinum_M               QALGWL--------------------------------------------
MUL_3167|M.ulcerans_Agy99           QALGWL--------------------------------------------
MAV_4571|M.avium_104                QALGWA--------------------------------------------
MLBr_02667|M.leprae_Br4923          VTLFPNLSTAAMVGGLGAGTALGVVGAAAVIVAGWLAERRGAGGIAQQPS
MAB_4716c|M.abscessus_ATCC_199      ATFFPDLTTTQLKVFFVVGAGVGLLGGLFVSLAKSRAEHAAASAVAAELG
Mb0948c|M.bovis_AF2122/97           LTVTG---------------------------------------------
Rv0924c|M.tuberculosis_H37Rv        LTVTG---------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK          LTLWG---------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155      LMIVTGAGQ-----------------------------------------
                                      .                                               

MMAR_2593|M.marinum_M               --------------------------------------------------
MUL_3167|M.ulcerans_Agy99           --------------------------------------------------
MAV_4571|M.avium_104                --------------------------------------------------
MLBr_02667|M.leprae_Br4923          CSGSEQAQFDALARLTRAERRALCDERRANWTMPVLANLDRPVMSPVRRI
MAB_4716c|M.abscessus_ATCC_199      GLDPDQVQDLDSMPRDRVLRRDIQWQERESWRTPALETLERPAWSPLRTA
Mb0948c|M.bovis_AF2122/97           --------------------------------------------------
Rv0924c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_2593|M.marinum_M               --------------------------
MUL_3167|M.ulcerans_Agy99           --------------------------
MAV_4571|M.avium_104                --------------------------
MLBr_02667|M.leprae_Br4923          GLLMLRGYLVLACVLVVVKVVQVGVG
MAB_4716c|M.abscessus_ATCC_199      GMIALRGYLVVAVLLVGVKVAQTIIG
Mb0948c|M.bovis_AF2122/97           --------------------------
Rv0924c|M.tuberculosis_H37Rv        --------------------------
Mflv_1822|M.gilvum_PYR-GCK          --------------------------
MSMEG_1780|M.smegmatis_MC2_155      --------------------------

species	id	gene	e-value	identity (len)	annotation
M. marinum M	MMAR_2593	-	-	100% (431)	divalent cation-transport integral membrane protein
M. marinum M	MMAR_0315	-	5e-49	32.16% (398)	divalent cation-transport integral membrane protein
M. marinum M	MMAR_4584	mntH	1e-17	28.21% (319)	divalent cation-transport integral membrane protein MntH