For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SSGGENTRRAEPVEPRGTAVLDSAHLGDIEGAFGRIRVGETEHARTWKTRLLTLLAIVGPGIIVMVGDND AGGVATYAQAGQNYGYSLLWVLLLLVPVLIVNQEMVVRLGAVTGVGHARLINERFGRGWGWFSVGDLFLL NFLTIVTEFIGISLAAEYIGVSKYVVVPVSAVALVAIMASGSFRRWERAMFIFIAITLLQIPMLLMSHPQ WGRAAKSFVVPSISGGVSSDAVLLIIAIVGTTVAPWQLFFQQSNVVDKRITPRFMGYERADTVLGAFVVV IGAAALVMTGDWAARSTDTVGGFTDAGATAHLLGQHRQVLGSIFAIVLMDASIIGAAAVTLATSYAFGDV FGLKHSLHRGFADAKQFYLSYTAMVVVAAAIVLIPGAPLGLITTAVQALAGLLLPSASVFLLLLCNDREV LGPWVNRAWLNWVAGLIVGTLLLLSGILMATTLFPDLNVVAVAGYLTLALIILAAGAAPVLRWLARRQPA RPGPRLPARGVDRSTWRMPPLTLLEPVTWSPGTRLAMIALRGYLVVGALLLVVKAIQLSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2120 | - | - | 100% (551) | Mn2+/Fe2+ transporter |
| M. avium 104 | MAV_5197 | - | e-148 | 51.66% (573) | manganese/iron transporter |
| M. avium 104 | MAV_4571 | - | 8e-57 | 36.73% (373) | metal ion transporter, NRAMP family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0948c | mntH | 6e-15 | 25.00% (444) | putative manganese transport protein MntH |
| M. gilvum PYR-GCK | Mflv_1822 | - | 4e-14 | 24.21% (413) | Mn2+/Fe2+ transporter |
| M. tuberculosis H37Rv | Rv0924c | mntH | 7e-15 | 25.00% (444) | manganese transport protein MntH |
| M. leprae Br4923 | MLBr_02667 | - | 1e-149 | 52.01% (571) | putative membrane transport protein |
| M. abscessus ATCC 19977 | MAB_2716c | - | 0.0 | 76.30% (540) | manganese transport transmembrane protein |
| M. marinum M | MMAR_0315 | - | 1e-148 | 52.09% (574) | divalent cation-transport integral membrane protein |
| M. smegmatis MC2 155 | MSMEG_1780 | - | 1e-25 | 26.25% (419) | hypothetical protein MSMEG_1780 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4807 | - | 1e-149 | 52.44% (574) | divalent cation-transport integral membrane protein |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2120|M.avium_104 --------------------------------------------------
MAB_2716c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0315|M.marinum_M --------------------------------------------------
MUL_4807|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02667|M.leprae_Br4923 --------------------------------------------------
Mb0948c|M.bovis_AF2122/97 MTTTSDQNAAAPPRFDGLRALFINATLKRSPELSHTDGLIERSSGIMREH
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2120|M.avium_104 --------------------------------------------------
MAB_2716c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0315|M.marinum_M --------------------------------------------------
MUL_4807|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02667|M.leprae_Br4923 --------------------------------------------------
Mb0948c|M.bovis_AF2122/97 GVQVDTLRAVDHDIATGVWPDMTEHGWATDEWPALYRRVLDAHILVLCGP
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2120|M.avium_104 --------------------------------------------------
MAB_2716c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0315|M.marinum_M --------------------------------------------------
MUL_4807|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02667|M.leprae_Br4923 --------------------------------------------------
Mb0948c|M.bovis_AF2122/97 IWLGDNSSVMKRVIERLYACSSLLNEDGQYAYYGRAGGCLITGNEDGVKH
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2120|M.avium_104 -------------------------------------------------M
MAB_2716c|M.abscessus_ATCC_199 -------------------------------------------------M
MMAR_0315|M.marinum_M --------------------------------------------------
MUL_4807|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02667|M.leprae_Br4923 ---------------------------------------------MSLII
Mb0948c|M.bovis_AF2122/97 CAMNVLYSLQHLGYTIPPQADAGWIGEAGPGPSYLDPGSGGPENDFTNRN
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2120|M.avium_104 S---------------SGGE-------------------NTRRAEPVEPR
MAB_2716c|M.abscessus_ATCC_199 SENGIVNGSVNGS--VNGAETA-----------------NGQLKVQVSQP
MMAR_0315|M.marinum_M ----------MLMTSISTSRR-------------------GAPNSAVHSA
MUL_4807|M.ulcerans_Agy99 ------------MTSISTSRR-------------------GAPNSAVHSA
MLBr_02667|M.leprae_Br4923 FEHEPVDNSENPMTYISTDAISAVAVPPTTGDAIMCVKNCATPRVTPDTS
Mb0948c|M.bovis_AF2122/97 TTFMTFNLMHIAQMLRAPAASRPTAINAPSGTPAAGRTSPTPTTDSQRRS
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2120|M.avium_104 GTAVLDSAHLGDIEGAFGRIRVGETEHARTWKTRLLTLLAIVGPGIIVMV
MAB_2716c|M.abscessus_ATCC_199 KSAVLDSAHLGDIEGAFGKISVSDPGQARTFRSRMATMAAILGPGIIVMV
MMAR_0315|M.marinum_M DAAVLDSAHTGDIVGAFGRIRRDGDGVASRRWQRLRTLMVISGPGLIVMV
MUL_4807|M.ulcerans_Agy99 DAAVLDSAHTGDIVGAFGRIRRDGDGVASRRWQRLRTLMVISGPGLIVMV
MLBr_02667|M.leprae_Br4923 GSSVLDSAHVGDIVGAFGRIGWDVTHASRSRWQQLRLMMVITGPGLIAMI
Mb0948c|M.bovis_AF2122/97 RVARWLVAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAI
Rv0924c|M.tuberculosis_H37Rv ------MAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAI
Mflv_1822|M.gilvum_PYR-GCK --------------------------MTGDVRPQAKR-WLLLGPAFVAAI
MSMEG_1780|M.smegmatis_MC2_155 ----------------------------------MKKVFAVALGILTAIG
: : .
MAV_2120|M.avium_104 GDNDAGGVATYAQAGQNYGYSLLWVLLLLVPVLIVNQEMVVRLGAVTGVG
MAB_2716c|M.abscessus_ATCC_199 GDNDAGGVATYAQAGQSYGYSLLWVLLLLIPVLIVNQEMVVRLGAVTGVG
MMAR_0315|M.marinum_M GDNDAGGVATYAQAGQNYGMTLLWTLALLIPVLYVNQEMVLRLGAVVRVG
MUL_4807|M.ulcerans_Agy99 GDNDAGGVATYAQAGQNYGMTLLWTLALLIPVLYVNQEMVLRLGAVVRVG
MLBr_02667|M.leprae_Br4923 GDNDAGGVATYAQAGQKYGMNLLWTLVLLIPVLYVNQEMVLRLGAVTRVG
Mb0948c|M.bovis_AF2122/97 AYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRS
Rv0924c|M.tuberculosis_H37Rv AYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRS
Mflv_1822|M.gilvum_PYR-GCK AYVDPGNVAANVSAGAQFGFLLVWVIVAANLMACLVQYLSAKLGLVTGRS
MSMEG_1780|M.smegmatis_MC2_155 GFLDIGDLVTNAVVGSRFGLALVWVVVVGVVGICLFAQMAGRVAAVSGRA
. * *.:.: . * :* *:*.: : : ::. * .
MAV_2120|M.avium_104 HARLINERFGRGWGWFSVGDLFLLNFLTIVTEFIGISLAAEYIG----VS
MAB_2716c|M.abscessus_ATCC_199 HARLINERFGRGWGWFSVGDLFILNFLTLVTEFIGVALASEYLG----VS
MMAR_0315|M.marinum_M HARLIFERFGKFWGAFSVGDLLILNALTIVTEFIGVSMALGFLG----CP
MUL_4807|M.ulcerans_Agy99 HARLIFERFGKFWGAFSVGDLLILNALTIVTEFIGVSMALGFLG----CP
MLBr_02667|M.leprae_Br4923 HARLIFERFGKFWGAFSVGDLLILNALTIVTEFIGVSLALDFLG----CP
Mb0948c|M.bovis_AF2122/97 LPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPI
Rv0924c|M.tuberculosis_H37Rv LPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPI
Mflv_1822|M.gilvum_PYR-GCK LPEAVGSRMSRRTRLAYWVQAELVAMATDLAEVVGGAIALYLLFDLPLLV
MSMEG_1780|M.smegmatis_MC2_155 TFEIIRERLGPRTAAANLGASFFINLMTLTAEIGGIALALQLATD---VG
. : .*:. :: * :*. * ::*
MAV_2120|M.avium_104 KYVVVPVSAVALVAIMASGSFRRWERAMFIFIAITLLQIPMLLMSHPQWG
MAB_2716c|M.abscessus_ATCC_199 KYYTVPLAAIALILIMATGSFRRWERAMFVFIAITLLQIPMFLLAEPQWG
MMAR_0315|M.marinum_M KAVAIPAAAVLLFAVVAGGSFRRWEQMMFLLIAVNVVIIPMALLVHPTFS
MUL_4807|M.ulcerans_Agy99 KAVAIPAAAVLLFAVVAGGSFRRWEQMMFLLIAVNVVIIPMALLVHPTFS
MLBr_02667|M.leprae_Br4923 KTIAIPVAAVLLFAMVAGGSFRRWEQVMFMLISVNVAVIPLVLSVHPALG
Mb0948c|M.bovis_AF2122/97 GGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIAIGFTASFFVVTPPP
Rv0924c|M.tuberculosis_H37Rv GGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIAIGFTASFFVVTPPP
Mflv_1822|M.gilvum_PYR-GCK GGIITGAVSLILLMVKDLRGQRVFERVITGLLMVIAIGFLTSLFAASPPV
MSMEG_1780|M.smegmatis_MC2_155 PMMWIPVAAFAVWLVIWRVKFSVMENATGILGLCLIVFAVSVFALQPNWG
:. : : *. : : .
MAV_2120|M.avium_104 RAAKSFVVPSISGGVSS---DAVLLIIAIVGTTVAPWQLFFQQSNVVDKR
MAB_2716c|M.abscessus_ATCC_199 RAAHDFVVPGIDGGVSS---GAVLLIIAMVGTTVAPWQLFFQQSNIVDKR
MMAR_0315|M.marinum_M GTVGG-LVPRFPGGLDS---TVLLLIVAIVGTTIAPWQLFFQQSNVVDKR
MUL_4807|M.ulcerans_Agy99 GTVGG-LVPRFPGGLDS---TVLLLIVAIVGTTIAPWQLFFQQSNVVDKR
MLBr_02667|M.leprae_Br4923 PSLHG-LLPSLPGKPDSPTSVVLLVIMAIVGTTVAPWQLFFQQSSVVDKR
Mb0948c|M.bovis_AF2122/97 NAVLGGLAPRFQGTES------VLLAAAIMGATVMPHAVYLHSGLARDRH
Rv0924c|M.tuberculosis_H37Rv NAVLGGLAPRFQGTES------VLLAAAIMGATVMPHAVYLHSGLARDRH
Mflv_1822|M.gilvum_PYR-GCK GAAAEGLIPRFDGAES------VLLAAAMLGATVMPHAVYLHSGLARDRH
MSMEG_1780|M.smegmatis_MC2_155 DLAGQAVQPAIPESESAAT--YWYYAIALFGAAMTPYEVFFFSSGAVEEH
: * : . *:.*::: * ::: .. :.:
MAV_2120|M.avium_104 ITP-------RFMGYERADTVLGAFVVVIGAAALVMTGDWAARST-----
MAB_2716c|M.abscessus_ATCC_199 ITP-------RFIGYERADTVIGSLVVVIGAAALLMTADYAARATGNSGP
MMAR_0315|M.marinum_M ITA-------RWIPYARADLVLGIVVVIVGATALMAVTAFGLAGT-----
MUL_4807|M.ulcerans_Agy99 ITA-------RWIPYARADLVLGIVVVIVGATALMAVTAFGLAGT-----
MLBr_02667|M.leprae_Br4923 ITP-------RWMRYGRADLVVGIVGVMAGAIALMSATAFGLAGT-----
Mb0948c|M.bovis_AF2122/97 GHPDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGR-----
Rv0924c|M.tuberculosis_H37Rv GHPDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGR-----
Mflv_1822|M.gilvum_PYR-GCK GHPGPGEPRRALLRITRWDVGIAMLVAGAVNLSMLLVAATNLQGM-----
MSMEG_1780|M.smegmatis_MC2_155 WTT-------KDLGVSRMNVMVGFPLGGLLSIAIATCATLVLLPQ-----
. : * : :. ::
MAV_2120|M.avium_104 DTVGGFTDAGATAHLLG-QHRQVLGSIFAIVLMDASIIGAAAVTLATSYA
MAB_2716c|M.abscessus_ATCC_199 DKWGDSGDAGLIAEWLG-QVQPLLGKIFAIVLLDASIIGAAAVTLATSYA
MMAR_0315|M.marinum_M SDVGHFSDAGAVATSLTNHFGSTVGILFAVVLLDASLIGANAIGLATTYA
MUL_4807|M.ulcerans_Agy99 SDVGYFSDAGAVATSLTNHFGSTVGILFAVVLLDASLIGANAIGLATTYA
MLBr_02667|M.leprae_Br4923 ADSGNFTDAGAVASHLSDHVGHPIGVLFAIILLDASLIGANVVGLATTYA
Mb0948c|M.bovis_AF2122/97 ---GDTASIEGAYHAVHDTLGATIAVLFAVGLLASGLASSSVG------A
Rv0924c|M.tuberculosis_H37Rv ---GDTASIEGAYHAVHDTLGATIAVLFAVGLLASGLASSSVG------A
Mflv_1822|M.gilvum_PYR-GCK ---ADTDSIEGAHAAVQNTLGDTVALLFAIGLLASGLASSSVG------A
MSMEG_1780|M.smegmatis_MC2_155 --QVEVTSLSQVVMPVVEAGGKLALAFAVIGIVAATFGAALETTLSSGYT
. : : .: :: : : .: :
MAV_2120|M.avium_104 FGDVFGLKHSLHRGFADAKQFYLSYTAMVVVAAAIVLIPGAPLGLITTAV
MAB_2716c|M.abscessus_ATCC_199 FGDTFGLKHSLHRSFKDAKPFYLSYTVMVGVGAAIVLIPNAPLGLMTTAV
MMAR_0315|M.marinum_M VGDAMGKRHSLHWKISEAPLFYGGYAALLAISAAVAFSPDYVLGLVTQGV
MUL_4807|M.ulcerans_Agy99 VGDAMGKRHSLHWKISEAPLFYGGYAALLAISAAVAFSPDYLLGLVTQGV
MLBr_02667|M.leprae_Br4923 LGDALGKPHSLHWKITEAPLFYGSYTALLGISAVVAFSPGHILGLITQGV
Mb0948c|M.bovis_AF2122/97 YAGAMIMQGLLHW---SVPMLVRRLITLGPALAILTLGFDPTRTLVLS--
Rv0924c|M.tuberculosis_H37Rv YAGAMIMQGLLHW---SVPMLVRRLITLGPALAILTLGFDPTRTLVLS--
Mflv_1822|M.gilvum_PYR-GCK YAGAMIMQGLLRR---SVPLLARRLITLLPALVILAVGIHPSRALVLS--
MSMEG_1780|M.smegmatis_MC2_155 LAQFLGWPWGKFRRPAQAARFHVVMFVSIVVGAAVLFT-GVDPVLVTEYS
. : .. : . . : . *:
MAV_2120|M.avium_104 QALAGLLLPSASVFLLLLCNDREVLGPWVNRAWLNWVAGLIVGTLLLLSG
MAB_2716c|M.abscessus_ATCC_199 QALAGLLLPSASVFLLLLCNDKAVLGPWVNKPWLNIVAGLIVGVLLFLSG
MMAR_0315|M.marinum_M QALAGILLPSATVFLVLLCNDHAVLGPWVNTLRQNIIAWTTVWCLVLLSL
MUL_4807|M.ulcerans_Agy99 QALAGILLPSATVFLVLLCNDHAVLGPWVNTLRQNIIAWTTVWCLVLLSL
MLBr_02667|M.leprae_Br4923 QALAGVLLPSATVFLVLLCNDRPVLGPWVNTARQNVFAWMIVWSLVVLSL
Mb0948c|M.bovis_AF2122/97 QVVLSFGIPFAVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLNV
Rv0924c|M.tuberculosis_H37Rv QVVLSFGIPFAVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLNV
Mflv_1822|M.gilvum_PYR-GCK QVVLSFGIPFALIPLVRLTADRALMGADVNHRVTTAAGWVVAGLISLLNV
MSMEG_1780|M.smegmatis_MC2_155 VVFSAIALPLTYLPILIVANDPEYMGENTNGKVTNMFGTIYLVIILAASL
.. .. :* : : :: : . :* .* . . : .
MAV_2120|M.avium_104 ILMATTLFPDLNVVAVAGYLTLALII----LAAGAAPVLRWLARR-----
MAB_2716c|M.abscessus_ATCC_199 ILMATTLFPDLDVVEVARDLAVGVTI----LAVLIGTGLWWVSSR-----
MMAR_0315|M.marinum_M ALTVTTFFPRLSTAAIEIGLVAGAAIGMMGGAAVLITGRRRSDRRDAEAI
MUL_4807|M.ulcerans_Agy99 ALTVTTFFPRLSTAAIEIGLVAGAAIGMMGGAAVLITGRRRSDRRDAEAI
MLBr_02667|M.leprae_Br4923 MLTVVTLFPNLSTAAMVGGLGAGTALGVVGAAAVIVAG-WLAERRGAGGI
Mb0948c|M.bovis_AF2122/97 MLIYLTVTG-----------------------------------------
Rv0924c|M.tuberculosis_H37Rv MLIYLTVTG-----------------------------------------
Mflv_1822|M.gilvum_PYR-GCK VLIYLTLWG-----------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 AAIPLMIVTGAGQ-------------------------------------
.
MAV_2120|M.avium_104 ----------------QPARPGPRLPAR---GVDRSTWRMPPLTLLEPVT
MAB_2716c|M.abscessus_ATCC_199 ----------------QRADPAVLAMTKVLDGVDARTWRMPPLALLEPVR
MMAR_0315|M.marinum_M SQSLGGGLDPGEVDEINDAKLLSRAERRAIRQQDRAQWCTPNLTDLARPA
MUL_4807|M.ulcerans_Agy99 SQSLGGGLDPGEVDEINDAKLLSRAERRAIRQQDRAQWCTPNLTDLARPA
MLBr_02667|M.leprae_Br4923 AQQPS--CSGSEQAQFDALARLTRAERRALCDERRANWTMPVLANLDRPV
Mb0948c|M.bovis_AF2122/97 --------------------------------------------------
Rv0924c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1822|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1780|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2120|M.avium_104 WSPGTRLAMIALRGYLVVGALLLVVKAIQLSR--
MAB_2716c|M.abscessus_ATCC_199 WSPGTKLGMLALRGYLVVGAILLVVKAIQLAHGN
MMAR_0315|M.marinum_M MSQAHRVGLFTLRAYLVVAVVLVVVKVVQAGIG-
MUL_4807|M.ulcerans_Agy99 MSPAHRLGLFTLRAYLVVAVVLVVVKVVQAGIG-
MLBr_02667|M.leprae_Br4923 MSPVRRIGLLMLRGYLVLACVLVVVKVVQVGVG-
Mb0948c|M.bovis_AF2122/97 ----------------------------------
Rv0924c|M.tuberculosis_H37Rv ----------------------------------
Mflv_1822|M.gilvum_PYR-GCK ----------------------------------
MSMEG_1780|M.smegmatis_MC2_155 ----------------------------------