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VGVFLSSEQARQRIGAALDAIDAAHDVLRRTSSDLVGTGFRIDVAERLETQDRTNRGLMYRFFGEIADPP DEAGSLPVARSMLWARLRVSPGELRRRFALAARIRPRRSLTGPPLDPELPALAAAVASGAVGEDHIRAVC AAVDALPCAVPRSAASDAERTLVRHAAKLDAAVITKLGRRIADYLNPDGEFSDVDRARRRGLHLGPQGVD GMSRLSGLLDPETRAYFEAVASAVRPGRHQPEGGGDPRARDERTPSQRCHDALKLGLEVAIASGGLGVHR GHPVTVIASTTLAELDQAARAVADPSIPMPAPALTGGGSRLPMPDLIRMATKAIHYLAVFDEHTGRPLYL GRQKRVATADQRLICYARDRGCTRPNCLEPGYHCEVHHAPDWADGGRTDADKLFFACGPDHGAVSRGEWR TSVGDDGRLAWTDGNGPPQTNRAHHPDELLRGDPDPPEND
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4055 | - | - | 100% (460) | hypothetical protein MAV_4055 |
| M. avium 104 | MAV_3664 | - | 4e-85 | 41.79% (469) | hypothetical protein MAV_3664 |
| M. avium 104 | MAV_2352 | - | 4e-85 | 42.23% (457) | hypothetical protein MAV_2352 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1980 | - | 1e-83 | 40.91% (462) | hypothetical protein Mb1980 |
| M. gilvum PYR-GCK | Mflv_4014 | - | 5e-72 | 41.53% (378) | hypothetical protein Mflv_4014 |
| M. tuberculosis H37Rv | Rv1945 | - | 1e-83 | 40.91% (462) | hypothetical protein Rv1945 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 2e-89 | 47.23% (379) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_3121 | - | 8e-90 | 42.92% (459) | hypothetical protein MMAR_3121 |
| M. smegmatis MC2 155 | MSMEG_2663 | - | 2e-62 | 36.09% (460) | hypothetical protein MSMEG_2663 |
| M. thermoresistible (build 8) | TH_3287 | - | 1e-156 | 54.99% (491) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 7e-92 | 43.36% (459) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_3050 | - | 6e-74 | 35.59% (503) | hypothetical protein Mvan_3050 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4055|M.avium_104 MG-VFLSSEQARQRIGAALDAIDAA-----HDVLRRTSSDLVGTGFRIDV
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAA-----YAEMRALCLDEVGTGFRLEL
Mb1980|M.bovis_AF2122/97 ---MRSD---TREEISAALDAYHAS-----LSRVLDLKCDALTTPELLAC
Rv1945|M.tuberculosis_H37Rv ---MRSD---TREEISAALDAYHAS-----LSRVLDLKCDALTTPELLAC
MMAR_3121|M.marinum_M ---MHSNGCSDRESVVATLDRLDRA-----VDALVEVSFEALTTPERLRV
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRA-----VDALVEVSFEALTTPERLRV
MAB_0394c|M.abscessus_ATCC_199 ---------------MSPIDDLLTT-----ATAVVESSFDELNNPELLSA
Mflv_4014|M.gilvum_PYR-GCK ----MAGLSVGRTSVRCMDGVAEAVGVIGEQLAVLAKAAEDLSHRELIGL
Mvan_3050|M.vanbaalenii_PYR-1 -------MGCSREDVLGAFDALDAV-----VESILALDYDALSAAERVRL
MSMEG_2663|M.smegmatis_MC2_155 --MIRTSVRYMAAEVGTALAALHAA-----MRDVLALPYTALSDADLLDV
: : :
MAV_4055|M.avium_104 AERLETQDRTNRGLMYRFFGEIADPPDEAGSLPV-ARSMLWARLRVSPGE
TH_3287|M.thermoresistible__bu AERLETQCRINRGLMYRVFAQLADPPDEPAMVPA-VRDRLWARLRITPGE
Mb1980|M.bovis_AF2122/97 LQRLEVERRRQGAAEHALINQLAGQACEEELGGT-LRTALANRLHITPGE
Rv1945|M.tuberculosis_H37Rv LQRLEVERRRQGAAEHALINQLAGQACEEELGGT-LRTALANRLHITPGE
MMAR_3121|M.marinum_M LERLEVVARRLPVAQYALLNQLDEQAGEAELGGR-LAAVVASRLRITRSE
MUL_2371|M.ulcerans_Agy99 LERLEVVARRLPAAQYALVNQLDEQPGEAELGGR-LAAVVASRLRITRSE
MAB_0394c|M.abscessus_ATCC_199 LRQLEIAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTAT
Mflv_4014|M.gilvum_PYR-GCK LSELTTVLRSAPAVEHAVLARLLDETEPHHLGEASWKKVLTTSLRMSSAE
Mvan_3050|M.vanbaalenii_PYR-1 EARLERNLRRIPTVEHELLASVIAETEPARLGEGSWKKVLTTALRISGAE
MSMEG_2663|M.smegmatis_MC2_155 CAGIQDVRNLAPAVEHRAIAALSEQTTPAAIGAKSWPLVLATRLGISSKE
: . : : : * ::
MAV_4055|M.avium_104 LRRRFALAARIRPRRSLTGPPLDPELPALAAAVASGAVGEDHIRAVCAAV
TH_3287|M.thermoresistible__bu VKRRLRVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVM
Mb1980|M.bovis_AF2122/97 ASRRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFF
Rv1945|M.tuberculosis_H37Rv ASRRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFF
MMAR_3121|M.marinum_M AGRRVAEAADVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFF
MUL_2371|M.ulcerans_Agy99 AGRRVAEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFF
MAB_0394c|M.abscessus_ATCC_199 ARRRLADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFF
Mflv_4014|M.gilvum_PYR-GCK AGRRLQRAKNLGPRRAMTGEPLAPVWESTAAAQAQGHLGEEHVEIIAKFH
Mvan_3050|M.vanbaalenii_PYR-1 AGRRLKRAKTLGPRRGLTGTPLPPLWESTAAAQAQGLLSEEHVAVIAAFH
MSMEG_2663|M.smegmatis_MC2_155 ARRRCADAAELGPRVSLTGEALAPKREHIAAAQADGALTPDHVTELFKFF
** * : * ::* .: . * * .* : *: :
MAV_4055|M.avium_104 DALPCAVPRSAASDAERTLVRHAAKLDAAVITKLGRRIADYLNPDG-EFS
TH_3287|M.thermoresistible__bu AALPSAVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYD
Mb1980|M.bovis_AF2122/97 KELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDG-NFS
Rv1945|M.tuberculosis_H37Rv KELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDG-NFS
MMAR_3121|M.marinum_M RRLPAGVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHS
MUL_2371|M.ulcerans_Agy99 RQLPAGVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHS
MAB_0394c|M.abscessus_ATCC_199 DVLPDAVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFS
Mflv_4014|M.gilvum_PYR-GCK KKLPSWVDVDTRAAADAQLAHTGSGLGPEELAQVADRLLMMIDQDGPEPS
Mvan_3050|M.vanbaalenii_PYR-1 KRLPAWVDIETRAEADRQLAHAGSGLDPEGLDEAAGVLLAMINPDGAQPC
MSMEG_2663|M.smegmatis_MC2_155 TKCPDWVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPT
. * : * . . : .. **
MAV_4055|M.avium_104 DVDRARRRGLHLGPQGVDGMSRLSGLLDPETRAYFEAVASAVR-PGRHQP
TH_3287|M.thermoresistible__bu DQDRARRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLP
Mb1980|M.bovis_AF2122/97 DQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNP
Rv1945|M.tuberculosis_H37Rv DQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNP
MMAR_3121|M.marinum_M DEDRARRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNP
MUL_2371|M.ulcerans_Agy99 DEDRARRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNP
MAB_0394c|M.abscessus_ATCC_199 DIDRARRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDP
Mflv_4014|M.gilvum_PYR-GCK EKEKATRFWVKLGTQQRDGGRTISGYVDAETSAYWEAVLAKEAAPGANMA
Mvan_3050|M.vanbaalenii_PYR-1 DKERARKRGIRISKQHPDGTATISGTLTPEALAIWQAIFAKEAAPGANNP
MSMEG_2663|M.smegmatis_MC2_155 DNPPTKPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNP
: : : :. * ** : * : .: * :.: ** .
MAV_4055|M.avium_104 E-----------------------------------------GGGDPRAR
TH_3287|M.thermoresistible__bu HTTTDTTGTTGTTETTGT------AGTAGTAATAADTAADGVGDIDTGGV
Mb1980|M.bovis_AF2122/97 DDQT--------------------------------PLVDDTPDADAVRR
Rv1945|M.tuberculosis_H37Rv DDQT--------------------------------PVVDDTPDADAVRR
MMAR_3121|M.marinum_M EDEA--------------------------------AVVDGPVSPDAADR
MUL_2371|M.ulcerans_Agy99 EDEA--------------------------------AVVDGPVSRDAADR
MAB_0394c|M.abscessus_ATCC_199 RDES--------------------------------PMTEGEPDSAAAER
Mflv_4014|M.gilvum_PYR-GCK EQ-------------------------------------------EKAG-
Mvan_3050|M.vanbaalenii_PYR-1 ESEHTEDSTSGGAADDASDAPGDHAGAASSAASGASDAAEHDPQPERCGS
MSMEG_2663|M.smegmatis_MC2_155 TDQTPCISG--------------------------------TPSQQQIDH
MAV_4055|M.avium_104 DERTPSQRCHDALKLGLEVAIASGGLGVHRGHPVTVIASTTLAELDQAAR
TH_3287|M.thermoresistible__bu DLRSAAQRRHDGLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAAH
Mb1980|M.bovis_AF2122/97 DTRSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKELEAAT-
Rv1945|M.tuberculosis_H37Rv DTRSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKELEAAT-
MMAR_3121|M.marinum_M DSRSVGQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-
MUL_2371|M.ulcerans_Agy99 DSRSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-
MAB_0394c|M.abscessus_ATCC_199 DTRTSAQRNHDGLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA-
Mflv_4014|M.gilvum_PYR-GCK DTRTQGQRNHDGLKAVLRRTLESGQLGSHNGLPVTVIVSTTLQELEKGA-
Mvan_3050|M.vanbaalenii_PYR-1 DTRTQAQRNHDAFLAVGRRLLESGELGTHNGLPVTVIVSTTLQELEKGA-
MSMEG_2663|M.smegmatis_MC2_155 DERGAPERRHDAMLTAMRLLLAHKDLGQINGLPATLLITTTLQELEKAA-
* * :* **.: . : ** .* *.::: *** **: .:
MAV_4055|M.avium_104 AVADPSIPMPAPALTGGGSRLPMPDLIRMATKAIHYLAVFDEHTGRPLYL
TH_3287|M.thermoresistible__bu AVADPRVSMPGPARTGGTGVLPMRELIRMAADAIHYLAVFDDHTERPLYL
Mb1980|M.bovis_AF2122/97 ----------GKGVTGGGSRVPMSDLIRMASNAHHYLALF--DGAKPLAL
Rv1945|M.tuberculosis_H37Rv ----------GKGVTGGGSRVPMSDLIRMASNAHHYLALF--DGAKPLAL
MMAR_3121|M.marinum_M ----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVF--DRGEAIGL
MUL_2371|M.ulcerans_Agy99 ----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVF--DRGEAIGL
MAB_0394c|M.abscessus_ATCC_199 ----------GRAISGSGNLVPIPDLIRMATHAFHYLTIFG-DDGRPLHL
Mflv_4014|M.gilvum_PYR-GCK ----------GVAVTGGGSLLPIPELIRLAADAHHYLYVYDGHTGQSLYL
Mvan_3050|M.vanbaalenii_PYR-1 ----------GVAVTGGGSLLPMPDLIRLAARAHHYLYVYDQHSGKSLYL
MSMEG_2663|M.smegmatis_MC2_155 ----------GVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGVPLYL
. . :.. :.: ::**:* * *** :: . .: *
MAV_4055|M.avium_104 GRQKRVATADQRLICYARDRGCTRPNCLEPGYHCEVHHAP-DWADGGRTD
TH_3287|M.thermoresistible__bu GRQKRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQP-AWEDGGLTD
Mb1980|M.bovis_AF2122/97 YHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVT-PWTTTHRTD
Rv1945|M.tuberculosis_H37Rv YHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVT-PWTTTHRTD
MMAR_3121|M.marinum_M YHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAISGRTD
MUL_2371|M.ulcerans_Agy99 YHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAISGRTD
MAB_0394c|M.abscessus_ATCC_199 GRSKRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHVD-DWRDDGPTD
Mflv_4014|M.gilvum_PYR-GCK GRAKRLANAAQRIVMHARDRGCTRPGCTVPGYWCQAHHASADWKDDGHTD
Mvan_3050|M.vanbaalenii_PYR-1 GRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHASADFVDGGLTN
MSMEG_2663|M.smegmatis_MC2_155 GRARRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLTD
: :* *.. **: *:* **: *.* .* .:.** : *:
MAV_4055|M.avium_104 ADKLFFACGPDHGAVSRGE--WRTSVG-DDGRLAWTD----GNGPPQTNR
TH_3287|M.thermoresistible__bu ADHLFFACGPHHSGLTEGR--WQATIT-PTGRLAWTN----DHHPPTVNH
Mb1980|M.bovis_AF2122/97 INDLTLACGPDNRLVEKG---WKTRKN-AKGDTEWLPPAHLDHGQPRINR
Rv1945|M.tuberculosis_H37Rv INDLTLACGPDNRLVEKG---WKTRKN-AKGDTEWLPPAHLDHGQPRINR
MMAR_3121|M.marinum_M INQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNT
MUL_2371|M.ulcerans_Agy99 INQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNS
MAB_0394c|M.abscessus_ATCC_199 IDNLTFACGPHHRLLQQG---WTTRKRRSDGITEWIPPPHLDTGQSRTND
Mflv_4014|M.gilvum_PYR-GCK IDDLTFACGPENRMIENTG--WTTAKN-SRNQTEWIPPPDLETGQHRVNG
Mvan_3050|M.vanbaalenii_PYR-1 IDDLTLACPCDHRMLDNTG--WRTRKN-GKNQTEWLPPPDLDTGQHRVNG
MSMEG_2663|M.smegmatis_MC2_155 ADALALACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPQLLDRGQHRTNT
: * :** .: : . * : . * *
MAV_4055|M.avium_104 AHHPDELLRGDPDPPEND--------------------------------
TH_3287|M.thermoresistible__bu AHHPEELLRAHTDPPEDPG-------------------------------
Mb1980|M.bovis_AF2122/97 YHHPEKILCE--PDDDEPH-------------------------------
Rv1945|M.tuberculosis_H37Rv YHHPEKILCE--PDDDEPH-------------------------------
MMAR_3121|M.marinum_M YHHPEKLLRDSADDDDEGHGAA----------------------------
MUL_2371|M.ulcerans_Agy99 YHHPEKLLRDSADDDDEGHGAA----------------------------
MAB_0394c|M.abscessus_ATCC_199 HHHPERFIRRF---------------------------------------
Mflv_4014|M.gilvum_PYR-GCK YHHPERHLLPHEEGEDSSTSRDCDDP------------------------
Mvan_3050|M.vanbaalenii_PYR-1 HHHPERYLLPEDD-----LPEDDQGP------------------------
MSMEG_2663|M.smegmatis_MC2_155 YHHPETLLADIKSGFTDDTADSRSQTSKTTGSETHAKQAADTEPDTAIAR
***: :
MAV_4055|M.avium_104 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mb1980|M.bovis_AF2122/97 --------------------------------------------------
Rv1945|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3121|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4014|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3050|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2663|M.smegmatis_MC2_155 GNDLSDRPAIPPELLGQNHQQPNTNHHPDTERGDARNSGATGHNQDHSRK
MAV_4055|M.avium_104 -----------------------------
TH_3287|M.thermoresistible__bu -----------------------------
Mb1980|M.bovis_AF2122/97 -----------------------------
Rv1945|M.tuberculosis_H37Rv -----------------------------
MMAR_3121|M.marinum_M -----------------------------
MUL_2371|M.ulcerans_Agy99 -----------------------------
MAB_0394c|M.abscessus_ATCC_199 -----------------------------
Mflv_4014|M.gilvum_PYR-GCK -----------------------------
Mvan_3050|M.vanbaalenii_PYR-1 -----------------------------
MSMEG_2663|M.smegmatis_MC2_155 NGDRNSGDASKGNNGNADGDDGESDCHPA