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MRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQLAGQACEEEL GGTLRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKE LSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDGNFSDQERARKRGITMGKQEFDGMSRI SGLLTPELRATIEAVLAKLAAPGACNPDDQTPVVDDTPDADAVRRDTRSQAQRHHDGLLAGLRGLLASGE LGQHRGLPVTVVVSTTLKELEAATGKGVTGGGSRVPMSDLIRMASNAHHYLALFDGAKPLALYHTKRLAS PAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLACGPDNRLVEKGWKTRKNAKGDT EWLPPAHLDHGQPRINRYHHPEKILCEPDDDEPH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1945 | - | - | 100% (454) | hypothetical protein Rv1945 |
| M. tuberculosis H37Rv | Rv1148c | - | 0.0 | 97.14% (454) | hypothetical protein Rv1148c |
| M. tuberculosis H37Rv | Rv1128c | - | e-161 | 62.19% (447) | hypothetical protein Rv1128c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1980 | - | 0.0 | 99.78% (454) | hypothetical protein Mb1980 |
| M. gilvum PYR-GCK | Mflv_4397 | - | 1e-103 | 46.02% (452) | hypothetical protein Mflv_4397 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-124 | 52.06% (436) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 1e-162 | 62.17% (452) | hypothetical protein MMAR_1523 |
| M. avium 104 | MAV_2352 | - | 1e-160 | 61.95% (452) | hypothetical protein MAV_2352 |
| M. smegmatis MC2 155 | MSMEG_2663 | - | 3e-83 | 39.96% (448) | hypothetical protein MSMEG_2663 |
| M. thermoresistible (build 8) | TH_3287 | - | 6e-77 | 38.60% (487) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-159 | 60.53% (451) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_3050 | - | 1e-104 | 46.00% (487) | hypothetical protein Mvan_3050 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1945|M.tuberculosis_H37Rv ---MRS---DTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLE
Mb1980|M.bovis_AF2122/97 ---MRS---DTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLE
MMAR_1523|M.marinum_M ---MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQRCE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAV_2352|M.avium_104 ---MHS---STREEIRADVDALRAAVSRVLGHSYDALTTPERLRLLEIFD
MAB_0394c|M.abscessus_ATCC_199 ---------------MSPIDDLLTTATAVVESSFDELNNPELLSALRQLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
Mvan_3050|M.vanbaalenii_PYR-1 -------MGCSREDVLGAFDALDAVVESILALDYDALSAAERVRLEARLE
Mflv_4397|M.gilvum_PYR-GCK ---------MSGGDLQTSIAALRAAFEEVAAADVDLLTRPDLVAALDELE
MSMEG_2663|M.smegmatis_MC2_155 --MIRTSVRYMAAEVGTALAALHAAMRDVLALPYTALSDADLLDVCAGIQ
. : : : :
Rv1945|M.tuberculosis_H37Rv VERRRQGAAEHALINQLAGQACEEELGGT-LRTALANRLHITPGEASRRI
Mb1980|M.bovis_AF2122/97 VERRRQGAAEHALINQLAGQACEEELGGT-LRTALANRLHITPGEASRRI
MMAR_1523|M.marinum_M VARRRLPSIEHPLINQLVEQAGEQELGGK-LAAVLAGRLRVSRGEASRRL
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGGR-LAAVVASRLRITRSEAGRRV
MAV_2352|M.avium_104 RETRRLRVPGHQLINQLAEQSDPTELGGR-LSFALAERLHITRSDASRRI
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVPA-VRDRLWARLRITPGEVKRRL
Mvan_3050|M.vanbaalenii_PYR-1 RNLRRIPTVEHELLASVIAETEPARLGEGSWKKVLTTALRISGAEAGRRL
Mflv_4397|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQVETSAREMGAKSWNQVLAVRWRISTGEAHRRL
MSMEG_2663|M.smegmatis_MC2_155 DVRNLAPAVEHRAIAALSEQTTPAAIGAKSWPLVLATRLGISSKEARRRC
: : : : :: . **
Rv1945|M.tuberculosis_H37Rv AEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKELSA
Mb1980|M.bovis_AF2122/97 AEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKELSA
MMAR_1523|M.marinum_M REAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQVPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAV_2352|M.avium_104 AEAADLGPRRALTGEPLPPLLPATAAAQRDGAIGTDHVAVIRQFFDQLPE
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
Mvan_3050|M.vanbaalenii_PYR-1 KRAKTLGPRRGLTGTPLPPLWESTAAAQAQGLLSEEHVAVIAAFHKRLPA
Mflv_4397|M.gilvum_PYR-GCK TEAALLAPRQSLTGTPLPPALPATAVAQSRGLINAEHVEVIRKAVKKLPG
MSMEG_2663|M.smegmatis_MC2_155 ADAAELGPRVSLTGEALAPKREHIAAAQADGALTPDHVTELFKFFTKCPD
* : * *:* : . * * * : *: : .
Rv1945|M.tuberculosis_H37Rv AVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDG-NFSDQERA
Mb1980|M.bovis_AF2122/97 AVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDG-NFSDQERA
MMAR_1523|M.marinum_M EVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDG-RYSDEDRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDEDRA
MAV_2352|M.avium_104 AVDVETCEHAERQLAAQATQFRPDQLSKLARRLMDCLNPDG-RYSDEDRA
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFSDIDRA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQDRA
Mvan_3050|M.vanbaalenii_PYR-1 WVDIETRAEADRQLAHAGSGLDPEGLDEAAGVLLAMINPDGAQPCDKERA
Mflv_4397|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGNGPKELRDAAELTLFLLDQDGPEPDDTERA
MSMEG_2663|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
* : * . . : .. ** * :
Rv1945|M.tuberculosis_H37Rv RKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAP----------
Mb1980|M.bovis_AF2122/97 RKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAP----------
MMAR_1523|M.marinum_M RRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAP----------
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAP----------
MAV_2352|M.avium_104 RARGLVLGNQQADGMSRLSGWLTPEARAGWEAVLAKLAAP----------
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAP----------
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVRPGRHLPHTTTDT
Mvan_3050|M.vanbaalenii_PYR-1 RKRGIRISKQHPDGTATISGTLTPEALAIWQAIFAKEAAPG----ANNPE
Mflv_4397|M.gilvum_PYR-GCK RKRGLTKGKQRPDGMIDLAGTLTPEAWAVLEVIFAKYAAP----------
MSMEG_2663|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAP----------
: *: . * ** : * : .: * : : .
Rv1945|M.tuberculosis_H37Rv ----------GACNPDDQTP-------VVDDTPDADAVRRDT--------
Mb1980|M.bovis_AF2122/97 ----------GACNPDDQTP-------LVDDTPDADAVRRDT--------
MMAR_1523|M.marinum_M ----------GMCNPDDESP-------VVQAPAGADAVSRDR--------
MUL_2371|M.ulcerans_Agy99 ----------GMCNPEDEAA-------VVDGPVSRDAADRDS--------
MAV_2352|M.avium_104 ----------GMCNPDDDAP-------VVDGPPPEAASQRDS--------
MAB_0394c|M.abscessus_ATCC_199 ----------GMCDPRDESP-------MTEGEPDSAAAERDT--------
TH_3287|M.thermoresistible__bu TGTTGTTETTGTAGTAGTAA-------TAADTAADGVGDIDTGGVDL---
Mvan_3050|M.vanbaalenii_PYR-1 SEHTEDSTSGGAADDASDAPGDHAGAASSAASGASDAAEHDPQPERCGSD
Mflv_4397|M.gilvum_PYR-GCK ----------GMCNPADPEP-------CTYGTPTQAQIDNDQ--------
MSMEG_2663|M.smegmatis_MC2_155 ----------GMCNPTDQTP-------CISGTPSQQQIDHDE--------
* .. . . *
Rv1945|M.tuberculosis_H37Rv -RSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKELEAAT--
Mb1980|M.bovis_AF2122/97 -RSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKELEAAT--
MMAR_1523|M.marinum_M -RSVGQRHHDGLNAAVRALLASGDLGQHNGLPASIIVTTTLGELQRAC--
MUL_2371|M.ulcerans_Agy99 -RSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA--
MAV_2352|M.avium_104 -RSAAQRNHDGLNAALRALLAGGKLGQHNGLPASIIVTTTLRDLESAA--
MAB_0394c|M.abscessus_ATCC_199 -RTSAQRNHDGLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA--
TH_3287|M.thermoresistible__bu -RSAAQRRHDGLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAAHA
Mvan_3050|M.vanbaalenii_PYR-1 TRTQAQRNHDAFLAVGRRLLESGELGTHNGLPVTVIVSTTLQELEKGA--
Mflv_4397|M.gilvum_PYR-GCK -RSLAQRQHDALVAVGRIALMSGELGQLNGLPVSIIIRTTLQDLESRA--
MSMEG_2663|M.smegmatis_MC2_155 -RGAPERRHDAMLTAMRLLLAHKDLGQINGLPATLLITTTLQELEKAA--
* :*.**.: : : ** .* *.:::: *** :*:
Rv1945|M.tuberculosis_H37Rv ---------GKGVTGGGSRVPMSDLIRMASNAHHYLALF--DGAKPLALY
Mb1980|M.bovis_AF2122/97 ---------GKGVTGGGSRVPMSDLIRMASNAHHYLALF--DGAKPLALY
MMAR_1523|M.marinum_M ---------GRGLTGGGTVLPISDVIRLARHAHHYLAVF--DRGKAVGLY
MUL_2371|M.ulcerans_Agy99 ---------GRGLTGGGTLLPMSDVIRLARHAHHYLAVF--DRGEAIGLY
MAV_2352|M.avium_104 ---------GKGLTGGGTLLPMSEVIRLARHAHHYLAVF--DNGKPLALY
MAB_0394c|M.abscessus_ATCC_199 ---------GRAISGSGNLVPIPDLIRMATHAFHYLTIFG-DDGRPLHLG
TH_3287|M.thermoresistible__bu VADPRVSMPGPARTGGTGVLPMRELIRMAADAIHYLAVFDDHTERPLYLG
Mvan_3050|M.vanbaalenii_PYR-1 ---------GVAVTGGGSLLPMPDLIRLAARAHHYLYVYDQHSGKSLYLG
Mflv_4397|M.gilvum_PYR-GCK ---------GVGTTGGGTVVPIKDVIRMAGHANHYLAVFDRATGSALDLF
MSMEG_2663|M.smegmatis_MC2_155 ---------GVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGVPLYLG
* . :.. :.: ::**:* * *** :: .: *
Rv1945|M.tuberculosis_H37Rv HTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTP-WTTTHRTDI
Mb1980|M.bovis_AF2122/97 HTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTP-WTTTHRTDI
MMAR_1523|M.marinum_M HAKRLATAGQRLVLYAKDRGCTRPGCDVPGYQCEVHHVAA-WATSGRTDI
MUL_2371|M.ulcerans_Agy99 HAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVAA-WAISGRTDI
MAV_2352|M.avium_104 HTKRLASPGQRIVLYAKDRGCSHPGCDVSGYYCEVHHVTG-YAKCGRTDI
MAB_0394c|M.abscessus_ATCC_199 RSKRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHVDD-WRDDGPTDI
TH_3287|M.thermoresistible__bu RQKRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQPA-WEDGGLTDA
Mvan_3050|M.vanbaalenii_PYR-1 RAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHASADFVDGGLTNI
Mflv_4397|M.gilvum_PYR-GCK RTRRVASPAQRVMLIARDGGCTKPCCTVGAYGCQVHHAETDYAHGGNTNI
MSMEG_2663|M.smegmatis_MC2_155 RARRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLTDA
: :* *.. **: *:* **: * * .* .:.** : *:
Rv1945|M.tuberculosis_H37Rv NDLTLACGPDNR-LVEKG--WKTRKN-AKGDTEWLPPAHLDHGQPRINRY
Mb1980|M.bovis_AF2122/97 NDLTLACGPDNR-LVEKG--WKTRKN-AKGDTEWLPPAHLDHGQPRINRY
MMAR_1523|M.marinum_M DQLTLACGPDHK-LLEQG--WRTRKN-AHGDTEWLPPPHLDHGQPRTNTY
MUL_2371|M.ulcerans_Agy99 NQLTLACGPDHK-LLEQG--WRTRKN-AHGDTEWLPPPHLDHGQPRTNSY
MAV_2352|M.avium_104 DQLTFACGGHHP-LAEQG--WITRKN-GRGETEWIPPPHLERGQPRVNSF
MAB_0394c|M.abscessus_ATCC_199 DNLTFACGPHHR-LLQQG--WTTRKRRSDGITEWIPPPHLDTGQSRTNDH
TH_3287|M.thermoresistible__bu DHLFFACGPHHSGLTEGR--WQATIT-PTGRLAWTN----DHHPPTVNHA
Mvan_3050|M.vanbaalenii_PYR-1 DDLTLACPCDHRMLDNTG--WRTRKN-GKNQTEWLPPPDLDTGQHRVNGH
Mflv_4397|M.gilvum_PYR-GCK DELGLACGPDNRSVTEGG--WTTRIN-DRCEVEWIPPPGLDTGQARVNTY
MSMEG_2663|M.smegmatis_MC2_155 DALALACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPQLLDRGQHRTNTY
: * :** .: : : * : * : *
Rv1945|M.tuberculosis_H37Rv HHPEKILCEP-----DDDEPH-----------------------------
Mb1980|M.bovis_AF2122/97 HHPEKILCEP-----DDDEPH-----------------------------
MMAR_1523|M.marinum_M HHPEKLLRDS-----AADEG---------EEGG-----------------
MUL_2371|M.ulcerans_Agy99 HHPEKLLRDS-----ADDDD---------EGHGAA---------------
MAV_2352|M.avium_104 HHPEDMLCDT-----EDQQDQQDQQDQADEEDGAA---------------
MAB_0394c|M.abscessus_ATCC_199 HHPERFIRRF----------------------------------------
TH_3287|M.thermoresistible__bu HHPEELLRAH-----TDPPEDPG---------------------------
Mvan_3050|M.vanbaalenii_PYR-1 HHPERYLLPE-----DDLPEDDQGP-------------------------
Mflv_4397|M.gilvum_PYR-GCK HRPERLLAPP------DDPEPPNQT-RTTATEPVEDQAID----------
MSMEG_2663|M.smegmatis_MC2_155 HHPETLLADIKSGFTDDTADSRSQTSKTTGSETHAKQAADTEPDTAIARG
*:** :
Rv1945|M.tuberculosis_H37Rv --------------------------------------------------
Mb1980|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1523|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAV_2352|M.avium_104 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mvan_3050|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4397|M.gilvum_PYR-GCK -------------------DPETDAPPPLD-----DPGEPG---------
MSMEG_2663|M.smegmatis_MC2_155 NDLSDRPAIPPELLGQNHQQPNTNHHPDTERGDARNSGATGHNQDHSRKN
Rv1945|M.tuberculosis_H37Rv ----------------------------
Mb1980|M.bovis_AF2122/97 ----------------------------
MMAR_1523|M.marinum_M ----------------------------
MUL_2371|M.ulcerans_Agy99 ----------------------------
MAV_2352|M.avium_104 ----------------------------
MAB_0394c|M.abscessus_ATCC_199 ----------------------------
TH_3287|M.thermoresistible__bu ----------------------------
Mvan_3050|M.vanbaalenii_PYR-1 ----------------------------
Mflv_4397|M.gilvum_PYR-GCK -----GPAPPDNRAA-------------
MSMEG_2663|M.smegmatis_MC2_155 GDRNSGDASKGNNGNADGDDGESDCHPA