For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VMSKVIQPPRAADVIVVGSGHNGLVAAAYLAKAGLDVLVVEASPTAGGMTSTNSFAPEAPEYTINEASIQ ASLFRTTTIDADLELSRKYGLRQTVIDPAHFQLAADGSSLGLWRDPRKTAAELEYFSKKDARALLELYEV IDAAVAIGLPMMQTNVVQPDIKAILKSARALVKNRKQLAALGRWMSSSQAEAVEESFEHDMIRAPLLTSL PFMPFDADLSGWSLIYLGVLSRYGVAMFHGGTGSLPKALIAVIKHYGGDVITSSPVEELIITGNRCTGVR VRGGTEIHARRAVLTACSPRTTLTRLLPRGVLEPKKQNAADHIPTRKRGIADAKVNVALSGRIDMSKHEK WRGDGIDLRLACNCYHTYEQALQAARSCVRGQVPDAIPGLAQVTNAFDPSMSPPGKDLWWFWTGLTPSYP EEGWDVARKKITDSIIKDAQEYYKGVEDLQVAVRPLVLPDIEERFWAIDGSVYHVDPTISRFGPNKPVAG FAGYRTPVEGLFLTGSGTHPVAGISGMPGQNAARTMLKQFRLEHTGGRVGALRARLRRDRNAAADPYSSG PNDPFPGAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5090 | - | - | 100% (569) | putative dehydrogenase |
| M. avium 104 | MAV_2787 | - | 9e-25 | 24.86% (547) | FAD dependent oxidoreductase, putative |
| M. avium 104 | MAV_0198 | - | 8e-20 | 23.38% (539) | FAD dependent oxidoreductase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3859c | - | 1e-21 | 22.75% (545) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1677 | - | 2e-24 | 25.33% (537) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3829c | - | 1e-21 | 22.75% (545) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0948c | - | 6e-12 | 23.99% (542) | hypothetical protein MAB_0948c |
| M. marinum M | MMAR_2813 | - | 1e-22 | 24.04% (545) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0664 | - | 9e-38 | 26.77% (564) | FAD dependent oxidoreductase |
| M. thermoresistible (build 8) | TH_2036 | - | 1e-14 | 25.10% (526) | POSSIBLE ALANINE RICH DEHYDROGENASE |
| M. ulcerans Agy99 | MUL_2934 | - | 2e-23 | 23.42% (555) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5076 | - | 4e-27 | 25.97% (539) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3859c|M.bovis_AF2122/97 --------MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGG--
Rv3829c|M.tuberculosis_H37Rv --------MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGG--
Mflv_1677|M.gilvum_PYR-GCK --------MTDFDAIVVGAGHNGLTAAALLQQAGLRTVCLDFKLYAGG--
Mvan_5076|M.vanbaalenii_PYR-1 --------MADFDAIVVGAGHNGLTAAALLQRAGLRTLCLDAKLYAGG--
MMAR_2813|M.marinum_M --------MTDYDAIVVGAGHNGLTAAAVLQRAGLRTLCMEANTYTGG--
MUL_2934|M.ulcerans_Agy99 --------MTDYDAIVVGAGHNGLTAAAVLQRAGLRTLCMEANTYAGG--
MSMEG_0664|M.smegmatis_MC2_155 -------MSNNYDALVIGGGHNGLVSAAYLARAGARTLVLESRSSLGG--
MAB_0948c|M.abscessus_ATCC_199 ---MGLSESDRYDTVIVGGGHNALTAAAYLARAGQRVMLLERLDVFGG--
MAV_5090|M.avium_104 MMSKVIQPPRAADVIVVGSGHNGLVAAAYLAKAGLDVLVVEASPTAGG--
TH_2036|M.thermoresistible__bu -----------MDVTVVGSGPNGLAAAVTCARAGLSVQVLEAQPTAGGGA
*. ::*.* *.*.:*. :** . :: **
Mb3859c|M.bovis_AF2122/97 MASTVELFDG---YRFDIAGSVQFPT-SSAVSSELGLDSLPTVDLEVMS-
Rv3829c|M.tuberculosis_H37Rv MASTVELFDG---YRFEIAGSVQFPT-SSAVSSELGLDSLPTVDLEVMS-
Mflv_1677|M.gilvum_PYR-GCK MASTVELFDG---FRFEIAGSVQVPT-SAVVSDALELGDLPTVDLDVMS-
Mvan_5076|M.vanbaalenii_PYR-1 MASTVELFDG---FRFEIAGSVQVPT-SAVVSDALGLAELPTVDLDVMS-
MMAR_2813|M.marinum_M MAATVELIDG---FHFEIAGSVQFPT-ASQISKELGLDTLPTVAPEVMS-
MUL_2934|M.ulcerans_Agy99 MAATVELIDG---FHFEIAGSVQFPT-ASQISKELGLDTLPTVAPEVMS-
MSMEG_0664|M.smegmatis_MC2_155 AATTEAPWDDAPHLRVTRLSYVMSLM-PPTIVRDLALERHGYKVHPMGP-
MAB_0948c|M.abscessus_ATCC_199 AAISAPAFEG-VEARLSRYSYLVSLM-PRQIIDDLGLDVR-LARRKYAS-
MAV_5090|M.avium_104 MTSTNSFAPEAPEYTINEASIQASLFRTTTIDADLELSRKYGLRQTVIDP
TH_2036|M.thermoresistible__bu RTTADPEFEG---IVHDVCSAVHPMALASPFMAEFDLPAR-GVRLQVPAI
: : . . . : *
Mb3859c|M.bovis_AF2122/97 -VALRGVGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRA
Rv3829c|M.tuberculosis_H37Rv -VALRGVGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRA
Mflv_1677|M.gilvum_PYR-GCK -VQLRGVGDDPLVYYTDPMKLLTHLNDVHGAEAVNGMAGLMAWCQAPTRA
Mvan_5076|M.vanbaalenii_PYR-1 -VQLRGIGDDPLVYYTDPMKLLTHLNEVHGAEAVNGMAGLMAWCQAPTRA
MMAR_2813|M.marinum_M -TNIGESSEEAMIFYRDPLQLISHLGEKHGSAAVTGMAELIGWSQGPARA
MUL_2934|M.ulcerans_Agy99 -TNIGESDEEAMIFYRDPLQLISHLGEKHGSAAVTGMAELIGWSQGPARA
MSMEG_0664|M.smegmatis_MC2_155 -YYQAFPEGGSLTIYEDDPARTYEQLSRFSKKDADAWPKWNAWLEGIADV
MAB_0948c|M.abscessus_ATCC_199 -YTPDPMNGGQRGFLAGP----------------NDFAEFGALCDSVTRP
MAV_5090|M.avium_104 AHFQLAADGSSLGLWRDPRKTAAELEYFSKKDARALLELYEVIDAAVAIG
TH_2036|M.thermoresistible__bu SYANPLLDRPAAVAYRDLDRTCAELVN--GHSWRRLFGPLTARDDGVLDL
. .
Mb3859c|M.bovis_AF2122/97 LGRFEAGTLP----KSFDEMYACATNEFERSAIDDMLFGSVTDVLDR---
Rv3829c|M.tuberculosis_H37Rv LGRFEAGTLP----KSFDEMYACATNEFERSAIDDMLFGSVTDVLDR---
Mflv_1677|M.gilvum_PYR-GCK LGRFEAAQPP----KTLDEMFACATNEFERQAISDILFGSVTDVLDR---
Mvan_5076|M.vanbaalenii_PYR-1 VGRFDAAQRP----KSLDEMFACATNEFERQAISDMLFGSVTDVLDR---
MMAR_2813|M.marinum_M LGRFEVRTPP----RTLDEMYACATNQAERRAIHEMLFGSAMDVIDR---
MUL_2934|M.ulcerans_Agy99 LGRFEVRTPP----RTLDEMYACATNQAERRAIHEMLFGSAMDVIDR---
MSMEG_0664|M.smegmatis_MC2_155 MGPLLTQVPPNIGSHRPADLLDLAKLAWGQRGITSRAVADITRLLTMSIA
MAB_0948c|M.abscessus_ATCC_199 MWDSMLQPLR----------RRGAVRTGAWEQLIETPIGEVIRAATP---
MAV_5090|M.avium_104 LPMMQTNVVQPDIKAILKSARALVKNRKQLAALGRWMSSSQAEAVEES--
TH_2036|M.thermoresistible__bu VMGDKRSIPS--------DPIAALQLGMRMLAQGSAAWGSLSGSDAR---
: ..
Mb3859c|M.bovis_AF2122/97 -HFPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFGLG--VPEGDF
Rv3829c|M.tuberculosis_H37Rv -HFPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFGLG--VPEGDF
Mflv_1677|M.gilvum_PYR-GCK -YLPDREKHGALRGMLAFLAVNTTYRGPATPGSAAALAFGLA--VPDENA
Mvan_5076|M.vanbaalenii_PYR-1 -YLPDREKHGALRGMLAFLAVNTTYRGPATPGSAAALAFGLA--VPDENA
MMAR_2813|M.marinum_M -FLPDKEKHAVMRGMLAFLAVNSTYRGPFTPGSAACLAFALA--VPDDST
MUL_2934|M.ulcerans_Agy99 -FLPDKEKHAVMRGILAFLAVNSTYRGPFTPGSAACLAFALA--VPDDST
MSMEG_0664|M.smegmatis_MC2_155 DLLDDWFESPQIKGALAVNGVIGTWAGPYEPGTAYVMAHHSIGDVGDGQL
MAB_0948c|M.abscessus_ATCC_199 --------DDVRRGVLLTDALIGTFASADDLSLQQNICFLYH------QM
MAV_5090|M.avium_104 ------FEHDMIRAPLLTSLPFMPFDADLSGWSLIYLGVLSR--------
TH_2036|M.thermoresistible__bu ---------ALFSG--VAGHAISRMPSLISAGAGLLLATLAH-------T
. . :
Mb3859c|M.bovis_AF2122/97 VRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRG
Rv3829c|M.tuberculosis_H37Rv VRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRG
Mflv_1677|M.gilvum_PYR-GCK TLIKKFRGGMGAVTEHLLQMFTAAGGELRLRTKVDEILVDG----GRVTG
Mvan_5076|M.vanbaalenii_PYR-1 TLIKKFRGGMGAVTEHLLQMFSAAGGELRLRSKVDEIIVED----GRVAG
MMAR_2813|M.marinum_M AMMTKLRGGIGALTDHLRELFASAGGEIRFRSKVVEIVVDR----GAVSG
MUL_2934|M.ulcerans_Agy99 AMMTKLRGGIGALTDHLRERFASAGGEIRFRSKVVEIVVDR----GAVSG
MSMEG_0664|M.smegmatis_MC2_155 GSWGFPEGGMGAVSAAIACSARSFGAEIRTNARVSRLLVRN----GRVEG
MAB_0948c|M.abscessus_ATCC_199 NPWDVPIGGMGAVTGSLEASARRHGAELLSGAEVLSISPDA-----EVRY
MAV_5090|M.avium_104 YGVAMFHGGTGSLPKALIAVIKHYGGDVITSSPVEELIITG----NRCTG
TH_2036|M.thermoresistible__bu VGWPIPIGGSQRITDALIADLTAHGGELRVGEPVTRPPEGV-----VIYD
** :. : *.:: *
Mb3859c|M.bovis_AF2122/97 VRTAAGDTLTSP-IVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRG-
Rv3829c|M.tuberculosis_H37Rv VRTAAGDTLTSP-IVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRG-
Mflv_1677|M.gilvum_PYR-GCK VRLEDGATLSAP-VVVSNLAPDLTVNQLVDGSAIPADIRERFARIDHRG-
Mvan_5076|M.vanbaalenii_PYR-1 VRLEDGSTLAAP-MVVSAVAPDLTVNTLVDGGAVPPDVRERFSRIDHRG-
MMAR_2813|M.marinum_M VRLPDGSVISTP-VVVSNLAPDVTLAKLVGPEHVGADLLARLAGRDHRA-
MUL_2934|M.ulcerans_Agy99 VRLPDGSVIGTP-VVVSNLAPDVTLAKLVGPEHVPADLLARLAGRDHRA-
MSMEG_0664|M.smegmatis_MC2_155 AVLDNGDEIHAP-VVVTTLHPKTAFLDHIPRTELPQDFVGDIEHWKSRS-
MAB_0948c|M.abscessus_ATCC_199 RSDGGEHTVAGD-RVLSGVSP-----------TVLAGLLGETPPAGQPG-
MAV_5090|M.avium_104 VRVRGGTEIHARRAVLTACSPRTTLTRLLPRGVLEPKKQNAADHIPTRKR
TH_2036|M.thermoresistible__bu TAPTALLDIYGD--------------------ALPARYARALRRYRFGP-
: :
Mb3859c|M.bovis_AF2122/97 --SYLQMHFALAQPPAFAAPYQALND-PSMQASMGIFCTPEQVQQQWEDC
Rv3829c|M.tuberculosis_H37Rv --SYLQMHFALAQPPAFAAPYQALND-PSMQASMGIFCTPEQVQQQWEDC
Mflv_1677|M.gilvum_PYR-GCK --SYVQMHFALDGPPTFAEPYEVLND-PEYQSAIGIFTTPEELQQQWEDS
Mvan_5076|M.vanbaalenii_PYR-1 --SYLQMHFALDGAPTFAEPYEMLND-PGYQSAIGIFTTPEELQQQWEDS
MMAR_2813|M.marinum_M --SFVQIHFALDALPEFAPPYELLNE-PGMQQSVGIFGTPEEQQQQWETC
MUL_2934|M.ulcerans_Agy99 --SFVQIHFALDALPEFAPPYELLNE-PGMQQSVGIFGTPEEQQQQWETC
MSMEG_0664|M.smegmatis_MC2_155 --GVVKINLALAELPNFTADPSSGIA-EHHTGSVEMAPTMEFIEAAFQDA
MAB_0948c|M.abscessus_ATCC_199 --AQVKVNLLLRRLPRLRDE-NVTPE-QAFGGTFHVNETYTQLEYAYQQA
MAV_5090|M.avium_104 GIADAKVNVALSGRIDMSKHEKWRGDGIDLRLACNCYHTYEQALQAARSC
TH_2036|M.thermoresistible__bu --GVAKVDFVLSDEIPWQDPRLANAP------TLHLGGSREQMAHAEREI
. ::.. * : : .
Mb3859c|M.bovis_AF2122/97 RRGIVPADP-----TVVLQIPSLHDPS-LAPAGKQAASAFAMWFPIEG-G
Rv3829c|M.tuberculosis_H37Rv RRGIVPADP-----TVVLQIPSLHDPS-LAPAGKQAASAFAMWFPIEG-G
Mflv_1677|M.gilvum_PYR-GCK RRGVVPADP-----AIALQIPSANDPT-LAPPGKHAVSAFSLWFPLS---
Mvan_5076|M.vanbaalenii_PYR-1 RRGVVPADP-----AIALQIPSANDPG-LAPPGKHAVSAFALWFPLS---
MMAR_2813|M.marinum_M RRGIVPENP-----SMGMQIPSVHDSG-LAPPGKHAASAYAYAFPVE---
MUL_2934|M.ulcerans_Agy99 RRGIVPENP-----SMGMQIPSVHDSG-LAPPGKHAASAYAYAFPVE---
MSMEG_0664|M.smegmatis_MC2_155 RNGKPALLP-----FSDGVIPTTLDTT-LNPDGTHIMSLFTQWVPAE---
MAB_0948c|M.abscessus_ATCC_199 SHGRIPDPLPCEIYCHSLADPSILSPE-LRASGAHTLTVFGLHTPHGLGA
MAV_5090|M.avium_104 VRGQVPDAIP-----GLAQVTNAFDPS-MSPPGKDLWWFWTGLTPSYP--
TH_2036|M.thermoresistible__bu FADRHAEWP-----MTLASLPHLVDPGRVDGQGRRPLWSYVHVPAHSP--
. . . .. : * : .
Mb3859c|M.bovis_AF2122/97 SKYGGYGRAKVEMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMFGAP
Rv3829c|M.tuberculosis_H37Rv SKYGGYGRAKVEMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMFGAP
Mflv_1677|M.gilvum_PYR-GCK EEISGYGALKTEMGRRVIDKITRLATDFEKLILRHTTFTPKHMGTMFNAP
Mvan_5076|M.vanbaalenii_PYR-1 EERASYGEMKAEMGQRVIDKITRLAPDFESLMLRHTTFTPKHMGTMFGAP
MMAR_2813|M.marinum_M VGRDQHGHLKRLMAQRVIDKITRFAPNFKDIVIRYITFAPYHMQTMFGAP
MUL_2934|M.ulcerans_Agy99 VDRDQHGHLKRIMARRVIDKITRFAPNFKDIVIRYITFAPYHMQTMFGAP
MSMEG_0664|M.smegmatis_MC2_155 WAAEPHTEELDAYADRLIELYDQVAPGFKASITHRDIVGPYDMEHEYGLI
MAB_0948c|M.abscessus_ATCC_199 SAEQLQQAVLASLSSVLAEPITDVVATDTHGRPCIETKTTIDLESALGMT
MAV_5090|M.avium_104 --EEGWDVARKKITDSIIKDAQEYYKGVEDLQVAVRPLVLPDIEERFWAI
TH_2036|M.thermoresistible__bu ----------VDQTESVIKIFERFAPGFRDIVVAARCVPAARLADDNANY
: . :
Mb3859c|M.bovis_AF2122/97 GGDYCHALLHSDQIGPNRPGPKGFIGQPIPIAG--LYLGSAGCHGGPGIT
Rv3829c|M.tuberculosis_H37Rv GGDYCHALLHSDQIGPNRPGPKGFIGQPIPIAG--LYLGSAGCHGGPGIT
Mflv_1677|M.gilvum_PYR-GCK GGDYCHGLIHPEQMGPNRPGPKGYVDQPIPIAG--LYLAGAGCHGGPGIT
Mvan_5076|M.vanbaalenii_PYR-1 GGDYCHGLIHPEQMGPNRPGPKGYADQPIPVDG--LYLASAGCHGGPGIT
MMAR_2813|M.marinum_M SGDFCHGLLHPDLMGPNRPGPKGFLDFPIPIDG--LYLGGAGCHGGPGIT
MUL_2934|M.ulcerans_Agy99 SGDFCHGLLHPDLMGPNRPGPGGFLDFPIPIDG--LYLGGAGCHGGPGIT
MSMEG_0664|M.smegmatis_MC2_155 GGNIFHGELSLEQLFHMRPAP-GYADYRTPIAG--LYNGSSATHAGGGVC
MAB_0948c|M.abscessus_ATCC_199 AGNIFHGGLQWPFAEDDDPLETAAQRWGVATNHDRILLCGSGSRRGGGVS
MAV_5090|M.avium_104 DGSVYHVDPTISRFGPNKPVA-GFAGYRTPVEG--LFLTGSGTHPVAGIS
TH_2036|M.thermoresistible__bu VGGDIAVGGNDTWRALAGPTP-RLNPWSTPIPR--AYQCSSATPPGPGVH
*. * . .:. *:
Mb3859c|M.bovis_AF2122/97 FIPGYNAARQALADRRAANCCVLSGR------------------------
Rv3829c|M.tuberculosis_H37Rv FIPGYNAARQALADRRAANCCVLSGR------------------------
Mflv_1677|M.gilvum_PYR-GCK FIPGYNAAQQVLAEH-----------------------------------
Mvan_5076|M.vanbaalenii_PYR-1 FIPGYNAAQQVLADRT----------------------------------
MMAR_2813|M.marinum_M FIPGYNAAYQVLEDVATRQTSG----------------------------
MUL_2934|M.ulcerans_Agy99 FIPGYNAAYQVLEDVATRQTSG----------------------------
MSMEG_0664|M.smegmatis_MC2_155 GIPGWQAARAVLADKKRARRSEALRKRLPAALGGRS--------------
MAB_0948c|M.abscessus_ATCC_199 GLGGYHAARAVLETH-----------------------------------
MAV_5090|M.avium_104 GMPGQNAARTMLKQFRLEHTGGRVGALRARLRRDRNAAADPYSSGPNDPF
TH_2036|M.thermoresistible__bu GLAGYYAARTVLRREFGXXXGTATSSRTPTTYSARRSEFGASYRRRFFAL
: * ** *
Mb3859c|M.bovis_AF2122/97 ------------------------------
Rv3829c|M.tuberculosis_H37Rv ------------------------------
Mflv_1677|M.gilvum_PYR-GCK ------------------------------
Mvan_5076|M.vanbaalenii_PYR-1 ------------------------------
MMAR_2813|M.marinum_M ------------------------------
MUL_2934|M.ulcerans_Agy99 ------------------------------
MSMEG_0664|M.smegmatis_MC2_155 ------------------------------
MAB_0948c|M.abscessus_ATCC_199 ------------------------------
MAV_5090|M.avium_104 PGAR--------------------------
TH_2036|M.thermoresistible__bu ASFLRRGLLIAPTNSLVCNIEGRDRRELDR