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VRGIAATPLRAVAEAADVSIGLVQHHFRTKAALTAAVDQYVLQVLDEALKPTMLPEPPEDGLNEAGHRLT TLMAERPDVVMYLGRALAEGGALGSVIFDGLLRICATQGEQFVAQGNTQLDLDPDWAAINILVLRVGAII LHPYIELHLGKPFFTEQQLRRWDASVTSLIRHGMFLEDTQHPYGDANAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3130 | - | - | 100% (189) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_2705 | - | 8e-11 | 26.09% (138) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_4046 | - | 3e-08 | 26.88% (160) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1251c | - | 5e-08 | 25.71% (140) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_2369 | - | 7e-43 | 50.87% (173) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1219c | - | 6e-08 | 25.71% (140) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1861c | - | 4e-16 | 32.61% (138) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2297 | - | 1e-13 | 32.58% (178) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5074 | - | 2e-06 | 27.14% (140) | transcriptional regulatory protein |
| M. thermoresistible (build 8) | TH_0547 | - | 3e-05 | 24.29% (140) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. ulcerans Agy99 | MUL_1500 | - | 1e-12 | 31.46% (178) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4277 | - | 2e-38 | 46.82% (173) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1251c|M.bovis_AF2122/97 ------MR-SADLTAHARIREAAIEQFGRHG-FGVGLRAIAEAAGVSAAL
Rv1219c|M.tuberculosis_H37Rv ------MR-SADLTAHARIREAAIEQFGRHG-FGVGLRAIAEAAGVSAAL
MSMEG_5074|M.smegmatis_MC2_155 ---------MDDRTAMARIRDTAIEQFGQHG-FNVGLRSIAEAAGVSAAL
TH_0547|M.thermoresistible__bu ------MRSADDRTAAARIRDAAIDQFGRHG-FDVSVRAIAEAAGVSPAL
MMAR_2297|M.marinum_M -----MHLASDDRTARARIRDEALRLFAERGPDAVTMRDIATAAGVSPAL
MUL_1500|M.ulcerans_Agy99 -----MHLATDDRTARARIRDEALRLFAERGPDAVTMRDIATAAGVSPAL
Mflv_2369|M.gilvum_PYR-GCK MS---GRIGSEGPRNIERIRAAALHSFGEHGAAATTLRGVAAAAGVSLGL
Mvan_4277|M.vanbaalenii_PYR-1 MVSDVGRTGAEEPRNIERIRAAALRSLAANGAAATTMRGVAAAAGVSLGL
MAV_3130|M.avium_104 ----------------------------MRGIAATPLRAVAEAADVSIGL
MAB_1861c|M.abscessus_ATCC_199 --MANPRASDEDLTAKARIRNTALDLYAQYGEERISLRAVASEAGVTLGL
* :* :* *.*: .*
Mb1251c|M.bovis_AF2122/97 VIHHFGSKEGLRKACDDFVAEEIRSSKAAALKSNDPT---------TWLA
Rv1219c|M.tuberculosis_H37Rv VIHHFGSKEGLRKACDDFVAEEIRSSKAAALKSNDPT---------TWLA
MSMEG_5074|M.smegmatis_MC2_155 VIHHFGSKEGLRKACDDHVAEVILELKTESMHASDPA---------TWLA
TH_0547|M.thermoresistible__bu VIHHFGSKDNLRKACDDHIAEEIRSGKSAAIRSNDPA---------TWFA
MMAR_2297|M.marinum_M LIRHYGSKDGLVEAVDNHVIAIFEVLLTEATRETEAVGLSQAAVGGLLDG
MUL_1500|M.ulcerans_Agy99 LIRHYGSKDGLIEAVDNHVIAIFEVLLTEATRETEAVGLGQAAVGGLLDG
Mflv_2369|M.gilvum_PYR-GCK VQHHFATKAGLIEAVDDYVMKLVVTTMS-RPLPEPPVD----SVAEIGNR
Mvan_4277|M.vanbaalenii_PYR-1 VQHHFATKAGLINDVDEYVLRLITTTMS-RPLADPPVD----SVVEIGDR
MAV_3130|M.avium_104 VQHHFRTKAALTAAVDQYVLQVLDEALKPTMLPEPPED----GLNEAGHR
MAB_1861c|M.abscessus_ATCC_199 VQHHFKTKAGLREAVDQLVVDYFVEALRSVDAEKDPRK----LVAARDAA
: :*: :* * *: : . .
Mb1251c|M.bovis_AF2122/97 QMAEIESYAPLMAYLVRSMQSGGELAKMLWQKMIDNAEEYLDEGVRAGTV
Rv1219c|M.tuberculosis_H37Rv QMAEIESYAPLMAYLVRSMQSGGELAKMLWQKMIDNAEEYLDEGVRAGTV
MSMEG_5074|M.smegmatis_MC2_155 YVAEIESYAPLMAYLVRSMQSGSELAKKFWRRMVDNAEQYLEEGVRTGML
TH_0547|M.thermoresistible__bu QIAELESYAPIMAYLVRSMQSGSDLAKMLWQKMIDDTRWYLDEGERAGTV
MMAR_2297|M.marinum_M LAAHLPPDSAVPAYLSRMLITGGTAGPGLFARLFRLSQDTLNAMVAAGTA
MUL_1500|M.ulcerans_Agy99 LATHLPPDSAVPAYLSRMLISGGTAGPGLFARLFRLSQDTLNAMAAAGTA
Mflv_2369|M.gilvum_PYR-GCK ITRMFAEEPDVVAYLGRALADGSPIGTRIFDTLLASGIARWQQRIDRGEV
Mvan_4277|M.vanbaalenii_PYR-1 VTTLFSEHPDVATYLGRALVDGSPAGVRIFDTLFAVGVARWQQRLDRGEL
MAV_3130|M.avium_104 LTTLMAERPDVVMYLGRALAEGGALGSVIFDGLLRICATQGEQFVAQGNT
MAB_1861c|M.abscessus_ATCC_199 VTSMLKANPPIVNYVRRAVLEPSDEQMHLLDALIGLTRDEVAMLRDEGMA
: . : *: * : . : :. *
Mb1251c|M.bovis_AF2122/97 KPSRDPRARARFLAITGGGGFLLYLQMHENPTDLRAALRDYAHDMVLPSL
Rv1219c|M.tuberculosis_H37Rv KPSRDPRARARFLAITGGGGFLLYLQMHENPTDLRAALRDYAHDMVLPSL
MSMEG_5074|M.smegmatis_MC2_155 KPSRDPRARARFLAICGGGGFLLYLQMHDNPTDLRAVLRDYGEDMMLPAL
TH_0547|M.thermoresistible__bu KPSRDPKARARFLAISGGGSFLLYLQLHDNPTDLAAVLRDYSRDMMLPAL
MMAR_2297|M.marinum_M SPGADPAVRAAFLLVNDLAVLTLRPRLIEVLG-VDPLTDAGMRRWAGEVF
MUL_1500|M.ulcerans_Agy99 SPGADPAVRAAFLLVNDLAVLTLRPRLIEVLG-VDPLTDAGMRRWAGEVF
Mflv_2369|M.gilvum_PYR-GCK RPDIDITWAAINGLVLALGAISLRHHLDRHLS-EPFTTPRQLDRWQRAVD
Mvan_4277|M.vanbaalenii_PYR-1 RPDVDITWAAINGLVLALGAISLRSHLDRHLA-EPLISPGQLARWQKAVD
MAV_3130|M.avium_104 QLDLDPDWAAINILVLRVGAIILHPYIELHLG-KPFFTEQQLRRWDASVT
MAB_1861c|M.abscessus_ATCC_199 PTDRTASTQVVSVLVRQMGALLLQPLIDAAWD------RVQSGDAPKPTL
. . : . : * :
Mb1251c|M.bovis_AF2122/97 EVYTEGLLADRAMYEAFLAEAQQGEAHVG----------
Rv1219c|M.tuberculosis_H37Rv EVYTEGLLADRAMYEAFLAEAQQGEAHVG----------
MSMEG_5074|M.smegmatis_MC2_155 EIYSHGLMADTTMYETFLHQREAGVPFTGTSEEAT----
TH_0547|M.thermoresistible__bu EIYTHGLMADSTMFDAFVARETQQLSDQGGAHDDDVAAV
MMAR_2297|M.marinum_M AVYRDGLVSD-----------------------------
MUL_1500|M.ulcerans_Agy99 AVYRDGLVSD-----------------------------
Mflv_2369|M.gilvum_PYR-GCK TLLREGLFRRE----------------------------
Mvan_4277|M.vanbaalenii_PYR-1 ALLREGLFRRPVSE-------------------------
MAV_3130|M.avium_104 SLIRHGMFLEDTQHPYGDANAR-----------------
MAB_1861c|M.abscessus_ATCC_199 SIKVLD---------------------------------
: .