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TTTDPDDLTARARIRHAALREFGEKGYEGATIRSIAAAAGVSSGLLRHHFGSKQELRQACDDYLVKTMRD LNAQVQDNAKRGDVHYVSARIRLGQYQDYITRALVEGGAGELFDALVSMTEEWLASADEHRAEPADVDAK SRATLITAMALAIPLLRQHISRGLGVDISTEQGDLRVAAILVDIYSNPLLTPEQAKSARDDLAGRLSAAA GPPGRPGRAAAAGRRPAPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4046 | - | - | 100% (230) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1363 | - | 2e-15 | 57.81% (64) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_2705 | - | 1e-11 | 35.20% (125) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1251c | - | 1e-16 | 34.97% (143) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_2198 | - | 3e-17 | 32.47% (194) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1219c | - | 1e-16 | 34.97% (143) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1518 | - | 9e-90 | 77.29% (207) | hypothetical protein MAB_1518 |
| M. marinum M | MMAR_2316 | - | 4e-18 | 31.22% (205) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5074 | - | 7e-15 | 32.64% (144) | transcriptional regulatory protein |
| M. thermoresistible (build 8) | TH_0547 | - | 1e-15 | 33.33% (144) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. ulcerans Agy99 | MUL_1500 | - | 9e-17 | 32.66% (199) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4498 | - | 3e-17 | 32.46% (191) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1251c|M.bovis_AF2122/97 --MR-SADLTAHARIREAAIEQFGRHGFG-VGLRAIAEAAGVSAALVIHH
Rv1219c|M.tuberculosis_H37Rv --MR-SADLTAHARIREAAIEQFGRHGFG-VGLRAIAEAAGVSAALVIHH
MSMEG_5074|M.smegmatis_MC2_155 -----MDDRTAMARIRDTAIEQFGQHGFN-VGLRSIAEAAGVSAALVIHH
TH_0547|M.thermoresistible__bu --MRSADDRTAAARIRDAAIDQFGRHGFD-VSVRAIAEAAGVSPALVIHH
Mflv_2198|M.gilvum_PYR-GCK --MRSVDDLTAAARIRDAAVELFGAEGFA-VSVRTIAAAAGVSPGLVIHH
Mvan_4498|M.vanbaalenii_PYR-1 --MRSADDLTAAARIRDAAIDLFGRDGFA-VGVRSIASAAGVSPGLVIHH
MMAR_2316|M.marinum_M ---MCSADLTAKARIRNAAVARFARDGFQKVNLRAIATSAGVSEALIFHH
MAV_4046|M.avium_104 MTTTDPDDLTARARIRHAALREFGEKGYEGATIRSIAAAAGVSSGLLRHH
MAB_1518|M.abscessus_ATCC_1997 METVDPDDLTARARIRDAALREFGDKGYDGATIRGIAARAGVSSGLLRHH
MUL_1500|M.ulcerans_Agy99 -MHLATDDRTARARIRDEALRLFAERGPDAVTMRDIATAAGVSPALLIRH
* ** ****. *: *. * . :* ** **** .*: :*
Mb1251c|M.bovis_AF2122/97 FGSKEGLRKACDDFVAEEIRSSKAAALKSNDPTTWL-AQMAEIES-----
Rv1219c|M.tuberculosis_H37Rv FGSKEGLRKACDDFVAEEIRSSKAAALKSNDPTTWL-AQMAEIES-----
MSMEG_5074|M.smegmatis_MC2_155 FGSKEGLRKACDDHVAEVILELKTESMHASDPATWL-AYVAEIES-----
TH_0547|M.thermoresistible__bu FGSKDNLRKACDDHIAEEIRSGKSAAIRSNDPATWF-AQIAELES-----
Mflv_2198|M.gilvum_PYR-GCK FGSKDQLHKACDAYVAETVRAAKSESIQTSDPATWL-AQMAEIEE-----
Mvan_4498|M.vanbaalenii_PYR-1 FGSKDGLRKACDDFVAETVRASKSEAIQSSDPATWL-AQIAEIEE-----
MMAR_2316|M.marinum_M FGSKDGLRAACDEYVLNVLVGRARTAGRPTAMADLLGVYLSNPEE-----
MAV_4046|M.avium_104 FGSKQELRQACDDYLVKTMRDLNAQVQDNAKRGDVHYVSARIRLG-----
MAB_1518|M.abscessus_ATCC_1997 FGSKQELRDACDEYLVKTMRDINEQVQANVERGDVHYVSARIPVG-----
MUL_1500|M.ulcerans_Agy99 YGSKDGLIEAVDNHVIAIFEVLLTEATRETEAVGLGQAAVGGLLDGLATH
:***: * * * .: . .
Mb1251c|M.bovis_AF2122/97 ---YAPLMAYLVRSMQSGGELAKMLWQKMIDNAEEYLDEGVRAGTVKPSR
Rv1219c|M.tuberculosis_H37Rv ---YAPLMAYLVRSMQSGGELAKMLWQKMIDNAEEYLDEGVRAGTVKPSR
MSMEG_5074|M.smegmatis_MC2_155 ---YAPLMAYLVRSMQSGSELAKKFWRRMVDNAEQYLEEGVRTGMLKPSR
TH_0547|M.thermoresistible__bu ---YAPIMAYLVRSMQSGSDLAKMLWQKMIDDTRWYLDEGERAGTVKPSR
Mflv_2198|M.gilvum_PYR-GCK ---YAPLMAYLVRSLQAGGELGKMLWRTMTNDVEQYLEDGVRAGTVKPSA
Mvan_4498|M.vanbaalenii_PYR-1 ---YAPLMAYLVRTLQTGGELAKMLWQNMIDNAEQYIEEGVRAGTVKPSA
MMAR_2316|M.marinum_M ---YRLQVQYMARAIEDDAPAAGTFVDTMVEESEAIFRAGAADGSMRPSS
MAV_4046|M.avium_104 -----QYQDYITRALVEGGAG--ELFDALVSMTEEWLASADEHRAEPADV
MAB_1518|M.abscessus_ATCC_1997 -----QYQAYITRALVEGSAG--QLFDEMVAMTEGWLAVADQNRAYPAAV
MUL_1500|M.ulcerans_Agy99 LPPDSAVPAYLSRMLISGGTAGPGLFARLFRLSQDTLNAMAAAGTASPGA
*: * : .. : : . : .
Mb1251c|M.bovis_AF2122/97 DPRARARFLAITGGGGFLLYLQMHENPTDLRAALRDYAHDMVLPSLEVYT
Rv1219c|M.tuberculosis_H37Rv DPRARARFLAITGGGGFLLYLQMHENPTDLRAALRDYAHDMVLPSLEVYT
MSMEG_5074|M.smegmatis_MC2_155 DPRARARFLAICGGGGFLLYLQMHDNPTDLRAVLRDYGEDMMLPALEIYS
TH_0547|M.thermoresistible__bu DPKARARFLAISGGGSFLLYLQLHDNPTDLAAVLRDYSRDMMLPALEIYT
Mflv_2198|M.gilvum_PYR-GCK DPRARAFFLSMASGGGFLLYLQLHES-TDIRVVLRDYSEAMVLPALELYT
Mvan_4498|M.vanbaalenii_PYR-1 DPRGRARFLAMAGGGGFLLYLQMHDNPTDLRAVLRDYSEEMVLPALELYT
MMAR_2316|M.marinum_M DPRALAVLNLLVALG-LLTMAPPMARALGHEHFGPEVLQRMAVPALELYT
MAV_4046|M.avium_104 DAKSRATLITAMALAIPLLRQHISRG-LGVDISTEQGDLRVAAILVDIYS
MAB_1518|M.abscessus_ATCC_1997 DVKSRAAVITAMALAVPLLQQHVSRG-LGVDIDSPEGDLKMAATLVDVYA
MUL_1500|M.ulcerans_Agy99 DPAVRAAFLLVNDLAVLTLRPRLIEV-LGVDPLTDAGMRRWAGEVFAVYR
* * . . . . :*
Mb1251c|M.bovis_AF2122/97 EGLLADRAMYEAFLAEAQQGEAHVG------------------
Rv1219c|M.tuberculosis_H37Rv EGLLADRAMYEAFLAEAQQGEAHVG------------------
MSMEG_5074|M.smegmatis_MC2_155 HGLMADTTMYETFLHQREAGVPFTGTSEEAT------------
TH_0547|M.thermoresistible__bu HGLMADSTMFDAFVARETQQLSDQGGAHDDDVAAV--------
Mflv_2198|M.gilvum_PYR-GCK HGLLTDSTMYDAFVAERAHDHSSPSTG-ARDA-----------
Mvan_4498|M.vanbaalenii_PYR-1 NGLMTDSTMYDAFVARRAQGIPFTSTEGAHDD-----------
MMAR_2316|M.marinum_M RGLYTDDTLAKAAQDAWVARRAPQQEG----------------
MAV_4046|M.avium_104 NPLLTPEQAKSARDDLAGRLSAAAGPPGRPGRAAAAGRRPAPR
MAB_1518|M.abscessus_ATCC_1997 NPLLTPEQAKSAQEDLARRMR----------------------
MUL_1500|M.ulcerans_Agy99 DGLVSD-------------------------------------
* :