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TGLYYDPWNREIDADPYPIYKMLRNEAPLYYNERHDFWGLSRYDDVDAALRDPLRLSSAKGDILDVVKAD PVMPPGVFINEDPPLHTIHRALVARAFTPKKMRTLEDKIRAFCVASLDMVADSDRFDFVEDLGAELPMRT IGMLLGIPDADQPSVREHARATLHNDTGGPMPIRKDHYFDGDMFSDYVEWRKQNPSDDLITELLSVDFED QSGTVRRLTTPELLIFLAVIAGAGVETTGRLFGWMGKVLADHPDQRKELAEDRSLIPAAVEELLRYEPPG PSVARYVTEDVEFHGQTVPSGSAMLLMLSSANRDERRFDHPDRFDIHRKPGRHLTFGRGVHFCLGAPLAR LEGRIGLEEVLNRWPEWEIDMDNARRSRTSTVRGWDSMPAIVT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1389 | - | - | 100% (394) | NikQ protein |
| M. avium 104 | MAV_0366 | - | e-126 | 53.44% (393) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_2984 | - | e-125 | 53.98% (389) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-66 | 37.44% (398) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_1257 | - | 0.0 | 74.87% (394) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 1e-66 | 37.44% (398) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-45 | 32.27% (406) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 2e-64 | 37.66% (401) | cytochrome P450 |
| M. marinum M | MMAR_4753 | cyp189A7 | 1e-135 | 56.67% (390) | cytochrome P450 189A7 Cyp189A7 |
| M. smegmatis MC2 155 | MSMEG_6622 | - | 1e-159 | 67.18% (390) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_2671 | - | 1e-164 | 68.46% (390) | PUTATIVE cytochrome P450 monooxygenase |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 1e-134 | 56.41% (390) | cytochrome P450 189A7 Cyp189A7 |
| M. vanbaalenii PYR-1 | Mvan_3187 | - | 1e-132 | 57.03% (391) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MAV_1389|M.avium_104 ---------------------------------MTGLYYDPWNREIDADP
Mflv_1257|M.gilvum_PYR-GCK ---------------------------------MSDLYYDPWHVDIDIDP
MSMEG_6622|M.smegmatis_MC2_155 ----------------------------MRVLD--ELSYDPYDVEIDVDP
TH_2671|M.thermoresistible__bu ----------------------------MRVLGGSRLYYDPYDIEIDRDP
MMAR_4753|M.marinum_M ----------------------------MTVTAASDVYFDPYDVELNADP
MUL_0324|M.ulcerans_Agy99 ----------------------------MTVTAASDVYFDPYDVELNADP
Mvan_3187|M.vanbaalenii_PYR-1 --------------------------------MADDLYYDPYDQGIVADP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: . **
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MAV_1389|M.avium_104 YPIYKMLRNEAPLYYNERHDFWGLSRYDDVDAALRDPLRLSSAKGDILDV
Mflv_1257|M.gilvum_PYR-GCK YPTYRRLRDEAPVYRNDEHGFWGLSRYADVDVALKDTTRLSSAKGDILEV
MSMEG_6622|M.smegmatis_MC2_155 YPTYRRLRDEAPVYFNGRFGFWALSRFADVEAALRDVDNLSNAKGDILEV
TH_2671|M.thermoresistible__bu YPTYRVLRDEVPLYYNDKFDFWALSRYADVEAALRDVENLSSAKGDILEV
MMAR_4753|M.marinum_M YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEI
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEF
Mvan_3187|M.vanbaalenii_PYR-1 YPTYARLRDEAPLYYNGRYDFWALSRHADVEKALQDWSTFSNSRSDILEL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
:* : * : *: : .* . * .: . *. :
Mb0789c|M.bovis_AF2122/97 SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ASFGPHAKL----VMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
MAV_1389|M.avium_104 VKADPVMP-----PGVFINEDPPLHTIHRALVARAFTPKKMRTLEDKIRA
Mflv_1257|M.gilvum_PYR-GCK VMADPVMP-----PGIFINEDPPLHTIHRAIVARAFTPKKMRAIEDKIRA
MSMEG_6622|M.smegmatis_MC2_155 VKAEPKMP-----LGVFINEDPPLHTVHRLLVSRAFTPRKMRAIEDQIRT
TH_2671|M.thermoresistible__bu VKAEPVMP-----LGVFIHEDPPLHTVHRLLVSRAFTPRKMAAIEDQVRA
MMAR_4753|M.marinum_M IKANIDIP-----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
MUL_0324|M.ulcerans_Agy99 IKANIDIP-----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
Mvan_3187|M.vanbaalenii_PYR-1 IKSDFDMP-----KGVMMFEDPPEHTMLRGLMSRVFTPRRMAEIEDQIRR
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
:: * * * * :::: *:*: : :* .:
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIREL
MAV_1389|M.avium_104 FCVASLDMVADSDR---FDFVEDLGAELPMRTIGMLLGIPDADQPSVREH
Mflv_1257|M.gilvum_PYR-GCK FCVACLDPLVGGDR---FDFVEDLGAELPMRTIGMLAGIPNSEQPAVREH
MSMEG_6622|M.smegmatis_MC2_155 FCAACLDPLTSGDR---FDFTLDLGAEMPMRVIGMLIGIPEELQRSVRKV
TH_2671|M.thermoresistible__bu FCAACLDPLNAGDR---FDFTRDLGAEMPMRVIGMLVGMPDSLQREVRSV
MMAR_4753|M.marinum_M FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
MUL_0324|M.ulcerans_Agy99 FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
Mvan_3187|M.vanbaalenii_PYR-1 YCVNCLDPLVGSDG---FDVIAELAAMMPMRVIGMLLGIPESEQVSVRDA
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
** **. : . :.: .* * *:*
Mb0789c|M.bovis_AF2122/97 ADAVLH------REDG-VADVPPPAMAASIELMRYYADLIAEFRR-RPAN
Rv0766c|M.tuberculosis_H37Rv ADAVLH------REDG-VADVPPPAMAASIELMRYYADLIAEFRR-RPAN
MAB_1216c|M.abscessus_ATCC_199 ADGVMH------REDG-LADVPPEAIQASFDLMTYYIEMVRERRR-RPTE
MAV_1389|M.avium_104 ARATLH------NDTGGPMPIR-KDHYFDGDMFSDYVEWRKQ----NPSD
Mflv_1257|M.gilvum_PYR-GCK ANEVLR------NEAGKPMAID-KDRYFTGEMFGEYIEWREN----NPSD
MSMEG_6622|M.smegmatis_MC2_155 AGQRLR------NKPGEPLPVN-KDNYFNGNMFRDYVEWRAQ----NPSD
TH_2671|M.thermoresistible__bu AGRRLR------NQPGRPLPVS-RDNYFNGDMFRDYVAWRER----HPSD
MMAR_4753|M.marinum_M ATAQLR------TEAGKPMKAS-ADGMVSGDFFAHYIDWRAE----HPSS
MUL_0324|M.ulcerans_Agy99 ATAQLR------TEAGKPMKAS-ADGMVSGDFFAHYIDWRAE----HPSS
Mvan_3187|M.vanbaalenii_PYR-1 NDANLR------TRPGAPMKVADPDRIADGRIYSDYVEWRAA----NPSD
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEAT-EERLRAGVWLRDYLEQLVKCRRGTPGE
:: * * * .
Mb0789c|M.bovis_AF2122/97 NLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVY
Rv0766c|M.tuberculosis_H37Rv NLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVY
MAB_1216c|M.abscessus_ATCC_199 DLTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVY
MAV_1389|M.avium_104 DLITELLSVDFEDQSGTVRRLTTPELLIFLAVIAGAGVETTGRLFGWMGK
Mflv_1257|M.gilvum_PYR-GCK DLITELLNVEFEDETGTVRKLTKQELTVFLAVVAGAGVETTGRLFGWMGK
MSMEG_6622|M.smegmatis_MC2_155 DLVTELLNVEFEDVTGTTRKLSSEELLVFLGVIANAGTETVGRLFGWLGK
TH_2671|M.thermoresistible__bu DLVTELLNVEFEDVSGTVRRLRTEELLVFLGVIANAGTETVGRLFGWLGK
MMAR_4753|M.marinum_M DIMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGK
MUL_0324|M.ulcerans_Agy99 DIMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGK
Mvan_3187|M.vanbaalenii_PYR-1 DLMTALLNVEFTDEAGVHRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAK
MLBr_02088|M.leprae_Br4923 DLISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVL
:: : *: : . :* *: :: ** **. .*:.
Mb0789c|M.bovis_AF2122/97 WAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVA-HDLTLYDT
Rv0766c|M.tuberculosis_H37Rv WAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVA-HDLTLYDT
MAB_1216c|M.abscessus_ATCC_199 WGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVA-EDITVYDT
MAV_1389|M.avium_104 VLADHPDQRKELAEDRSLIPAAVEELLRYEPPGPSVARYVT-EDVEFHGQ
Mflv_1257|M.gilvum_PYR-GCK VLAEHPDQRKELTSTPALIPSAIEELLRFEPPGPHVARYVATDDVTFHGV
MSMEG_6622|M.smegmatis_MC2_155 LLGEHPDQRRALVADPSLIPGAVEEVLRYEPPVHNIARYVS-ADVDYHGQ
TH_2671|M.thermoresistible__bu LLGEHPDQRRELARDPALIPGAVEEVLRYESPVHNIARYVA-NDVEYHGQ
MMAR_4753|M.marinum_M VLAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVT-RDLRYYGE
MUL_0324|M.ulcerans_Agy99 VLAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVT-RDLRYYGQ
Mvan_3187|M.vanbaalenii_PYR-1 VLAEHPQQRREIVEDRSLLGRAVDETLRFEPTGPHVARYLA-RDFEYDGT
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAA-KDMTIGQT
:* * : ::* **::.. :.* : *.
Mb0789c|M.bovis_AF2122/97 TIPEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCL
Rv0766c|M.tuberculosis_H37Rv TIPEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCL
MAB_1216c|M.abscessus_ATCC_199 KIPAGDILLLLPGSANRDDRVFD-DADQYRIGREIGAKLVSFGSGAHFCL
MAV_1389|M.avium_104 TVPSGSAMLLMLSSANRDERRFD-HPDRFDIHRKPGRHLT-FGRGVHFCL
Mflv_1257|M.gilvum_PYR-GCK VIPAGSPLLLMLASANRDERQFD-DPDRFDIHRKQGGHLT-FGRGAHFCV
MSMEG_6622|M.smegmatis_MC2_155 TIPAGSALLLMTGAANRDERRFD-DPDRFDIRRSP-NHLS-FGRGAHFCL
TH_2671|M.thermoresistible__bu TVPAGSALLLMAGAANRDERRFE-DPDRFDIHRSSGSHLA-FGRGTHFCL
MMAR_4753|M.marinum_M SVPEGSIMMMLIGAANRDHRQFPPDGDVFDIRREPHQHLT-FSVGTHYCL
MUL_0324|M.ulcerans_Agy99 SVPEGSIMMMLIGAANRDHRQFRPDGDVFNIRREPHQHLT-FSVGTHYCL
Mvan_3187|M.vanbaalenii_PYR-1 TVPAGSAILLLFGAANRDERRYR-NPDTFDIHRDNISHLT-FGKGLHYCL
MLBr_02088|M.leprae_Br4923 TLTEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSSRHLA-FAVGSHFCL
:. *. :::: .:**** : * : * :* *. * *:*:
Mb0789c|M.bovis_AF2122/97 GAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQA
Rv0766c|M.tuberculosis_H37Rv GAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQA
MAB_1216c|M.abscessus_ATCC_199 GAHLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQL
MAV_1389|M.avium_104 GAPLARLEGRIGLEEVLNRWPEWEIDMDNARRSRTSTVRGWDSMPAIVT-
Mflv_1257|M.gilvum_PYR-GCK GAPLARLEGRVALEEVLKRWPEWDIDMSGARRSRTSTVRGWDSMPAVIR-
MSMEG_6622|M.smegmatis_MC2_155 GASLARVEGRVALEEILKRWPDWTVDMGNAVRAPTATVRGWDSMPAIVG-
TH_2671|M.thermoresistible__bu GASLARLEGRVALEEILKRWPDWTIDADNAVRAPTATVRGWDSMPAVLG-
MMAR_4753|M.marinum_M GSALARLEGRIALEEILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD-
MUL_0324|M.ulcerans_Agy99 GSALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD-
Mvan_3187|M.vanbaalenii_PYR-1 GANLARLEGRVALDELLNRWPEWNIDYDTARLAPTSTVRGWEHLRMLVG-
MLBr_02088|M.leprae_Br4923 GAALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV--
*: ***:*. : * : * : . :** : .
Mb0789c|M.bovis_AF2122/97 R---
Rv0766c|M.tuberculosis_H37Rv R---
MAB_1216c|M.abscessus_ATCC_199 REGR
MAV_1389|M.avium_104 ----
Mflv_1257|M.gilvum_PYR-GCK ----
MSMEG_6622|M.smegmatis_MC2_155 ----
TH_2671|M.thermoresistible__bu ----
MMAR_4753|M.marinum_M ----
MUL_0324|M.ulcerans_Agy99 ----
Mvan_3187|M.vanbaalenii_PYR-1 ----
MLBr_02088|M.leprae_Br4923 ----