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M. avium 104 MAV_0366 (-)

annotation: cytochrome P450 superfamily protein
coordinates: 359623 - 360825
length: 400

MTVANDTAVYYDPYDIGIITDPYPTYARLREEAPIYYNERYDFWALSRHSDVERALANWQVFSNRRSDIL
ELIQSKFDMPGGVMMFQDPPEHTVLRGLMSRVFTPRRMAALEDQIRQYCIRCLDPLVGSSSFDIIAELAS
MMPMRVIGMLLGIPESEQVSVRDANDANLRTKPGAPLRVADADSIADGRIYADYVEWRSKNPSDDLMTTL
LNVEFDDEDGVRRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKVLAEHPDQRREVYRDRSLLTRTVDET
LRFEPTGPHVARWMAADFECYGTTVPAGSAMLLLFGAANRDPRRYTDPDTFNIHRDNISHITFGKGVHYC
LGANLARLEGRVALDELLNRWPEWDIDYDTAQLASTSTVRGWERLRIVVP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_0366--100% (400)cytochrome P450 superfamily protein
M. avium 104MAV_2984-e-13053.62% (401) cytochrome P450
M. avium 104MAV_2138-e-12853.13% (399) cytochrome P450 superfamily protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0789ccyp1237e-6938.24% (408) cytochrome P450 123
M. gilvum PYR-GCKMflv_1266-1e-12654.96% (393) cytochrome P450
M. tuberculosis H37RvRv0766ccyp1237e-6938.24% (408) cytochrome P450 123
M. leprae Br4923MLBr_02088-4e-3932.35% (374) putative cytochrome p450
M. abscessus ATCC 19977MAB_1216c-1e-6637.96% (411) cytochrome P450
M. marinum MMMAR_0928cyp189A60.082.58% (396) cytochrome P450 189A6 Cyp189A6
M. smegmatis MC2 155MSMEG_3693-0.085.13% (390) cytochrome P450 monooxygenase
M. thermoresistible (build 8)TH_4114-0.084.56% (395) PUTATIVE cytochrome P450
M. ulcerans Agy99MUL_0324cyp189A71e-13154.64% (399) cytochrome P450 189A7 Cyp189A7
M. vanbaalenii PYR-1Mvan_3187-0.083.12% (397) cytochrome P450

CLUSTAL 2.0.9 multiple sequence alignment


Mb0789c|M.bovis_AF2122/97           --------------------MTVRVGDPE-------LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv        --------------------MTVRVGDPE-------LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199      --------------------MTVAETSAVP------LVFDPYDYDFHEDP
MAV_0366|M.avium_104                --------------------MTVANDT--------AVYYDPYDIGIITDP
TH_4114|M.thermoresistible__bu      ---------------------MATVET--------DVYYDPYDVDIVADP
MSMEG_3693|M.smegmatis_MC2_155      ---------------------MTVDDSGVVVTGVAGPYYDPYDVGIVADP
Mvan_3187|M.vanbaalenii_PYR-1       ----------------------MADD----------LYYDPYDQGIVADP
MMAR_0928|M.marinum_M               --------------MATHIEAAQAHDT--------DVYYDPYDVNITANP
MUL_0324|M.ulcerans_Agy99           --------------------MTVTAAS--------DVYFDPYDVELNADP
Mflv_1266|M.gilvum_PYR-GCK          ------------------------MSG---------LYYDPYNVEIDVLP
MLBr_02088|M.leprae_Br4923          MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
                                                                              :      *

Mb0789c|M.bovis_AF2122/97           YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv        YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199      YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MAV_0366|M.avium_104                YPTYARLREEAPIYYNERYDFWALSRHSDVERALANWQVFSNRRSDILEL
TH_4114|M.thermoresistible__bu      YPVYARLRDEAPIYYNERYDFWALSRYADVEKALLNWETFSNSRSDILEL
MSMEG_3693|M.smegmatis_MC2_155      YPVYARLRDEAPLYHNERYGFWALSRHADVESALANWETFSNSRSDILEL
Mvan_3187|M.vanbaalenii_PYR-1       YPTYARLRDEAPLYYNGRYDFWALSRHADVEKALQDWSTFSNSRSDILEL
MMAR_0928|M.marinum_M               YPTYARLREQAPLYYNQRYDFWAISRHADVEKALADWQTFSNSRSDILEL
MUL_0324|M.ulcerans_Agy99           YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEF
Mflv_1266|M.gilvum_PYR-GCK          YPVYKRLRDEAPLYYNEKFDFWALSRFAEVDSALKDVDNLSNAKGDILEV
MLBr_02088|M.leprae_Br4923          FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
                                    :* :  * : .*:       : ..* . :   .: .    *.     :  

Mb0789c|M.bovis_AF2122/97           SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv        SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199      ASFGPHAKL----VMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
MAV_0366|M.avium_104                IQ-SKFDMP----GGVMMFQDPPEHTVLRGLMSRVFTPRRMAALEDQIRQ
TH_4114|M.thermoresistible__bu      VQ-SDFDMP----PGVMMFQDPPMHTMLRGLMSRVFTPRRMAALEEQIRA
MSMEG_3693|M.smegmatis_MC2_155      VK-SDFDMP----PGVMMFTDPPMHTMLRGLMSRVFTPRRMAEIEDQIRR
Mvan_3187|M.vanbaalenii_PYR-1       IK-SDFDMP----KGVMMFEDPPEHTMLRGLMSRVFTPRRMAEIEDQIRR
MMAR_0928|M.marinum_M               IK-SKYDMP----PGVMMFEDPPVHTMLRGVMSRVFTPRRMAQLEDQIRR
MUL_0324|M.ulcerans_Agy99           IK-ANIDIP----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
Mflv_1266|M.gilvum_PYR-GCK          VK-AEPVMP----DGVFINEDPPVHTVHRLLVSRAFTPRKMKAIEEQVRA
MLBr_02088|M.leprae_Br4923          QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
                                                    ::  * * *   * ::*: *:*: :  :* .:  

Mb0789c|M.bovis_AF2122/97           LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
Rv0766c|M.tuberculosis_H37Rv        LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
MAB_1216c|M.abscessus_ATCC_199      LARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIREL
MAV_0366|M.avium_104                YCIRCLDPLVGSSS---FDIIAELASMMPMRVIGMLLGIPESEQVSVRDA
TH_4114|M.thermoresistible__bu      YCVRCLDPLVGAEG---FDIIAELAAMMPMRVIGMLLGIPESDQISVRDA
MSMEG_3693|M.smegmatis_MC2_155      YCVRCLDPLVGSDR---FDIIAELASTMPMRVIGMLLGIPESEQIGVRDA
Mvan_3187|M.vanbaalenii_PYR-1       YCVNCLDPLVGSDG---FDVIAELAAMMPMRVIGMLLGIPESEQVSVRDA
MMAR_0928|M.marinum_M               FCVRCLDPLVGRDS---FDIIAELASMMPMRVIGMLLGIPESDQIGVRDA
MUL_0324|M.ulcerans_Agy99           FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
Mflv_1266|M.gilvum_PYR-GCK          FCQACLDPLQGGDR---FDFTLDLGAEMPMRVIGMLVGMPDSLQRSVRKA
MLBr_02088|M.leprae_Br4923          LVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
                                         **          **.  : .  :.: **  *:*:*          

Mb0789c|M.bovis_AF2122/97           ADAVLHRED-------GVADVPPPAMAASIELMRYYADLIAEFRRRPANN
Rv0766c|M.tuberculosis_H37Rv        ADAVLHRED-------GVADVPPPAMAASIELMRYYADLIAEFRRRPANN
MAB_1216c|M.abscessus_ATCC_199      ADGVMHRED-------GLADVPPEAIQASFDLMTYYIEMVRERRRRPTED
MAV_0366|M.avium_104                NDANLRTKP-------GAP--LRVADADSIADGRIYADYVEWRSKNPSDD
TH_4114|M.thermoresistible__bu      NDANLRTKP-------GAP--MKVADPGRIADGSIYAEYIDWRARNPSDD
MSMEG_3693|M.smegmatis_MC2_155      NDANLRTKP-------GAP--MKVAQADKIADGRIYADYVEWRSKNPSDD
Mvan_3187|M.vanbaalenii_PYR-1       NDANLRTRP-------GAP--MKVADPDRIADGRIYSDYVEWRAANPSDD
MMAR_0928|M.marinum_M               NDANLRTQP-------GTP--MKVARPDKIADGSIYADYIDWRAKNPSDD
MUL_0324|M.ulcerans_Agy99           ATAQLRTEA-------GKP--MKAS-ADGMVSGDFFAHYIDWRAEHPSSD
Mflv_1266|M.gilvum_PYR-GCK          AGARLRNKP-------GEP--LPVK-KDNYFNGNMFRDYVAWRKDNPSDD
MLBr_02088|M.leprae_Br4923          SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
                                        ::            .                  . :      * .:

Mb0789c|M.bovis_AF2122/97           LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
Rv0766c|M.tuberculosis_H37Rv        LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
MAB_1216c|M.abscessus_ATCC_199      LTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVYW
MAV_0366|M.avium_104                LMTTLLNVEFDDEDGVRRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
TH_4114|M.thermoresistible__bu      LMTALLNVEFTDEHGVVRKLTRREVLHYTQVVAGAGNETTGRLIGWLAKV
MSMEG_3693|M.smegmatis_MC2_155      LMTALLGVEFTDEHGVTRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
Mvan_3187|M.vanbaalenii_PYR-1       LMTALLNVEFTDEAGVHRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
MMAR_0928|M.marinum_M               LMTALLNVEFDDEHAVRRKLTRTEVLHYTQVVAGAGNETTGRLIGWLAKV
MUL_0324|M.ulcerans_Agy99           IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
Mflv_1266|M.gilvum_PYR-GCK          LVTELLNVEFEDVDGSRRKLRDEELLVFLGVIANAGSETVGRLFGWLGKV
MLBr_02088|M.leprae_Br4923          LISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVLA
                                    : : *:  :  .      :*   *::    ::  ** **. .*:.     

Mb0789c|M.bovis_AF2122/97           AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
Rv0766c|M.tuberculosis_H37Rv        AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
MAB_1216c|M.abscessus_ATCC_199      GHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKI
MAV_0366|M.avium_104                LAEHPDQRREVYRDRSLLTRTVDETLRFEPTGPHVARWMAADFECYGTTV
TH_4114|M.thermoresistible__bu      LAEHPDQRRDVYEDRSLLGRVIEETLRFEPTGPHVARWMARDFECYGTTV
MSMEG_3693|M.smegmatis_MC2_155      LAEHPDQRRQIEQDRSLLTRAVDETLRFEPTGPHVARWVARDFEAYGQTV
Mvan_3187|M.vanbaalenii_PYR-1       LAEHPQQRREIVEDRSLLGRAVDETLRFEPTGPHVARYLARDFEYDGTTV
MMAR_0928|M.marinum_M               LAEHPDQRRQVHQDRSLLTRTVDETLRFEPTGPHVARFTLRDYHCYDTTV
MUL_0324|M.ulcerans_Agy99           LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQSV
Mflv_1266|M.gilvum_PYR-GCK          LADHPDARRELAADPSLIPGAIEEILRMEPPVHNIARYVAKDVTYHGQTV
MLBr_02088|M.leprae_Br4923          MLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
                                       :*     :  : .     ::* ** :..   :.*    *      .:

Mb0789c|M.bovis_AF2122/97           PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
Rv0766c|M.tuberculosis_H37Rv        PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
MAB_1216c|M.abscessus_ATCC_199      PAGDILLLLPGSANRDDRVFD-DADQYRIGREIGAKLVSFGSGAHFCLGA
MAV_0366|M.avium_104                PAGSAMLLLFGAANRDPRRYT-DPDTFNIHRDNISHIT-FGKGVHYCLGA
TH_4114|M.thermoresistible__bu      PAGSAMLLLFGAANRDPRRYD-DPDTFNIHRERGSHLT-FGKGLHFCLGA
MSMEG_3693|M.smegmatis_MC2_155      PAGSAMLLLFGAANRDPRRYT-DPDVFDIHRDNISHLT-FGKGLHYCLGA
Mvan_3187|M.vanbaalenii_PYR-1       PAGSAILLLFGAANRDERRYR-NPDTFDIHRDNISHLT-FGKGLHYCLGA
MMAR_0928|M.marinum_M               PAGSAILMLFGAANRDPRRYH-DPDTFDIRRDNISHLT-FGKGVHYCLGA
MUL_0324|M.ulcerans_Agy99           PEGSIMMMLIGAANRDHRQFRPDGDVFNIRREPHQHLT-FSVGTHYCLGS
Mflv_1266|M.gilvum_PYR-GCK          PAGSALLLMAGAANRDERRFD-NPDVFDIRRSP-NHLT-FGRGAHFCLGT
MLBr_02088|M.leprae_Br4923          TEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSSRHLA-FAVGSHFCLGA
                                    . *. :::: .:****   :    * :   *    ::. *. * *:***:

Mb0789c|M.bovis_AF2122/97           HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv        HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
MAB_1216c|M.abscessus_ATCC_199      HLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLRE
MAV_0366|M.avium_104                NLARLEGRVALDELLNRWPEWDIDYDTAQLASTSTVRGWERLRIVVP---
TH_4114|M.thermoresistible__bu      NLARLEGRVALDELLNRWPEWDIDYDTAQLAPTSTVRGWERLRIVFP---
MSMEG_3693|M.smegmatis_MC2_155      NLARLEGRVALDELLNRFPEWDIDYSTARLAPTSTVRGWERLDVLVG---
Mvan_3187|M.vanbaalenii_PYR-1       NLARLEGRVALDELLNRWPEWNIDYDTARLAPTSTVRGWEHLRMLVG---
MMAR_0928|M.marinum_M               NLARLEGRVALDELLNRWPQWDIDYDSLQLAPTSTVRGWERLRVLVS---
MUL_0324|M.ulcerans_Agy99           ALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD---
Mflv_1266|M.gilvum_PYR-GCK          SLARLEGRIALEEILKRWPDWTFDEDNAHRAPTATVRGWDSMPAIVG---
MLBr_02088|M.leprae_Br4923          ALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV----
                                     ***:*. ::*  :  *     .         .  :**   :   .    

Mb0789c|M.bovis_AF2122/97           --
Rv0766c|M.tuberculosis_H37Rv        --
MAB_1216c|M.abscessus_ATCC_199      GR
MAV_0366|M.avium_104                --
TH_4114|M.thermoresistible__bu      --
MSMEG_3693|M.smegmatis_MC2_155      --
Mvan_3187|M.vanbaalenii_PYR-1       --
MMAR_0928|M.marinum_M               --
MUL_0324|M.ulcerans_Agy99           --
Mflv_1266|M.gilvum_PYR-GCK          --
MLBr_02088|M.leprae_Br4923          --