For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
AAVSGAAALLSGRGAVVSGGSRGIGRAVAELLAGLGAGVVVNGRDPQAVRETVAAITAAGGRATAVVGAA DDERIARSLVDECIGAFGRLDALINCAGIAEPAGSSILNITADEFDHLIGAHLGTAFHTCRAAAPVMVEQ RHGSIVNTSSVAFLGDYGGTGYPAGKGAVNALTMAIAAELKAYGVRANVVCPGARTRLSTGADYERHIED LHRRGLLDDMTRRASLDSAPPVFVAPVYGYLVSDLARDVTGQILVAAGGFVGSFDRQTPRLLGYRDHHRA GPWSIEEVHTMIGAAATP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2962 | - | - | 100% (299) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. avium 104 | MAV_5205 | - | 6e-31 | 35.80% (257) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. avium 104 | MAV_0612 | - | 6e-28 | 36.19% (268) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3578c | - | 2e-27 | 34.42% (276) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1591 | - | 5e-89 | 62.85% (253) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3548c | - | 1e-27 | 34.42% (276) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 4e-21 | 33.49% (215) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1210c | - | 1e-101 | 65.47% (278) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_2633 | - | 1e-118 | 70.98% (286) | short-chain type dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_5869 | - | 1e-95 | 62.82% (277) | putative short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_1252 | - | 6e-90 | 62.99% (254) | putative short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_3108 | - | 1e-115 | 69.58% (286) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_5166 | - | 1e-101 | 63.67% (278) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3578c|M.bovis_AF2122/97 --------------------------------------------------
Rv3548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2633|M.marinum_M --------------------------------------------------
MUL_3108|M.ulcerans_Agy99 --------------------------------------------------
MAV_2962|M.avium_104 --------------------------------------------------
MAB_1210c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1591|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5166|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5869|M.smegmatis_MC2_155 --------------------------------------------------
TH_1252|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mb3578c|M.bovis_AF2122/97 --------------------------------------------------
Rv3548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2633|M.marinum_M --------------------------------------------------
MUL_3108|M.ulcerans_Agy99 --------------------------------------------------
MAV_2962|M.avium_104 --------------------------------------------------
MAB_1210c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1591|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5166|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5869|M.smegmatis_MC2_155 --------------------------------------------------
TH_1252|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mb3578c|M.bovis_AF2122/97 --------------------------------------------------
Rv3548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2633|M.marinum_M --------------------------------------------------
MUL_3108|M.ulcerans_Agy99 --------------------------------------------------
MAV_2962|M.avium_104 --------------------------------------------------
MAB_1210c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1591|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5166|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5869|M.smegmatis_MC2_155 --------------------------------------------------
TH_1252|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mb3578c|M.bovis_AF2122/97 --------------------------------------------------
Rv3548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2633|M.marinum_M --------------------------------------------------
MUL_3108|M.ulcerans_Agy99 --------------------------------------------------
MAV_2962|M.avium_104 --------------------------------------------------
MAB_1210c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1591|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5166|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5869|M.smegmatis_MC2_155 --------------------------------------------------
TH_1252|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mb3578c|M.bovis_AF2122/97 --------------------------------------------------
Rv3548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2633|M.marinum_M --------------------------------------------------
MUL_3108|M.ulcerans_Agy99 --------------------------------------------------
MAV_2962|M.avium_104 --------------------------------------------------
MAB_1210c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1591|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5166|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5869|M.smegmatis_MC2_155 --------------------------------------------------
TH_1252|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mb3578c|M.bovis_AF2122/97 --------------------------------------------------
Rv3548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2633|M.marinum_M --------------------------------------------------
MUL_3108|M.ulcerans_Agy99 --------------------------------------------------
MAV_2962|M.avium_104 --------------------------------------------------
MAB_1210c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1591|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5166|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5869|M.smegmatis_MC2_155 --------------------------------------------------
TH_1252|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mb3578c|M.bovis_AF2122/97 ----------------------MGLVDGRVVIVTGAGGGIGRAHALAFAA
Rv3548c|M.tuberculosis_H37Rv ----------------------MGLVDGRVVIVTGAGGGIGRAHALAFAA
MMAR_2633|M.marinum_M ---------------MTDRD----LLAGRGVVVVGGSRGIGRAVAELLAR
MUL_3108|M.ulcerans_Agy99 ---------------MTDRD----LLAGRGVVVVGGSRGIGRAVAELLAR
MAV_2962|M.avium_104 ---------------MAAVSGAAALLSGRGAVVSGGSRGIGRAVAELLAG
MAB_1210c|M.abscessus_ATCC_199 ---------------------------MPNCVVVGGSRGIGRAVALLLGE
Mflv_1591|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5166|M.vanbaalenii_PYR-1 -------------------------------MVVGGTRGVGLAVAELLAA
MSMEG_5869|M.smegmatis_MC2_155 -------------------------------MVVGGSRGIGLAVAGLLAA
TH_1252|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
Mb3578c|M.bovis_AF2122/97 EGARVVVNDIGVGLDGSPASGGSAAQDVVDEILAAGGQAVADGSDISDWD
Rv3548c|M.tuberculosis_H37Rv EGARVVVNDIGVGLDGSPASGGSAAQDVVDEILAAGGQAVADGSDISDWD
MMAR_2633|M.marinum_M LGAGVVISGR----------EPDAVRDATEAVISAGGRAAGIAGAADHED
MUL_3108|M.ulcerans_Agy99 LGAGVVISGR----------EPDAVRDATEAVISAGGRAAGIAGAADHED
MAV_2962|M.avium_104 LGAGVVVNGR----------DPQAVRETVAAITAAGGRATAVVGAADDER
MAB_1210c|M.abscessus_ATCC_199 LGTNVVVNGR----------HADVVDDTVGAITSSGGTAVGFVGAPDNER
Mflv_1591|M.gilvum_PYR-GCK -----MVNGR----------DPDAAHEAAQRIPG----ALAHPGSPADPA
Mvan_5166|M.vanbaalenii_PYR-1 LGAGVVVNGR----------DEVAAGQAAERIPR----AIGFSGSPSDPD
MSMEG_5869|M.smegmatis_MC2_155 QGAGVVVNGR----------DADAAEAAAKRIS-----GVAHAGSPADPA
TH_1252|M.thermoresistible__bu ----VVVNGR----------DPEVVTEAAQRIS-----GVGHAGSPADPA
MLBr_00862|M.leprae_Br4923 RGAEVVVSDI----------DEAAAKNTAAQIVASGGVAYAYALDVSDAA
::.. .. .. : . . .
Mb3578c|M.bovis_AF2122/97 QAANLIQAAVETYGGVDVLVNNAGIVR--DRMIANTSEEEFDAVIAVHLK
Rv3548c|M.tuberculosis_H37Rv QAANLIQAAVETYGGVDVLVNNAGIVR--DRMIANTSEEEFDAVIAVHLK
MMAR_2633|M.marinum_M TANALVDRCMTSFGRLDALINCAGIAEPPGSSILNISPAQFDGLLRAHLG
MUL_3108|M.ulcerans_Agy99 TANALVDRCMTSFGRLDALINCAGIAEPPGSSILNISPAQSDGLLRAHLG
MAV_2962|M.avium_104 IARSLVDECIGAFGRLDALINCAGIAEPAGSSILNITADEFDHLIGAHLG
MAB_1210c|M.abscessus_ATCC_199 TATDLIDTCRTQYGGIDALINCAGIPEPTGSSILTITSGDFHRLIDAHLG
Mflv_1591|M.gilvum_PYR-GCK VADALIDICVREFGRIDILINCAGTAEPRGSSILNVTSAQFRELLDAHLG
Mvan_5166|M.vanbaalenii_PYR-1 VADALIDTCVREFGRIDILVNCAGTAEPVGSSILNVTPAQFQELIDAHLG
MSMEG_5869|M.smegmatis_MC2_155 VADALVDTCVTEFGRIDILVNCAGTAEPHGSSILDITSAQFRELLDAHLG
TH_1252|M.thermoresistible__bu VADALVDTCVQNFGSIDILINCAGTAEPPGSSILNISSGQFRELLDAHLG
MLBr_00862|M.leprae_Br4923 AVEAFAEQVSAKHGVPDIVVNNAGIGQ--AGRFLDTPPEEFDRVLAVNLG
. : : .* * ::* ** . : . : :: .:*
Mb3578c|M.bovis_AF2122/97 GHFATMRHAASHWRGLSKAGKAPKDIDARIINTSSGAGLQGSVGQGNYSA
Rv3548c|M.tuberculosis_H37Rv GHFATMRHAASHWRGLSKAGKAPKDIDARIINTSSGAGLQGSVGQGNYSA
MMAR_2633|M.marinum_M TVFHTCRVAAPVLAAQGHG---------SIINTGS-VAFLGDYGGSGYPA
MUL_3108|M.ulcerans_Agy99 TVFHACRVAAPVLAAQGHG---------SIINTGS-VAFLGDYGGSGYPA
MAV_2962|M.avium_104 TAFHTCRAAAPVMVEQRHG---------SIVNTSS-VAFLGDYGGTGYPA
MAB_1210c|M.abscessus_ATCC_199 TVFHTCRVVAPLMVQQRHG---------AIINTGS-TASLGIYGGTGYPA
Mflv_1591|M.gilvum_PYR-GCK TTFETCRAAAPVMVAQGGG---------AIVNTGS-FAFLGDYGGTGYPA
Mvan_5166|M.vanbaalenii_PYR-1 TAFQTCRAAAPLMARQGSG---------AIVNTSS-FAFLGDYGGTGYAA
MSMEG_5869|M.smegmatis_MC2_155 TVFETCRAAAPKMVAHGGG---------AIVNTGS-FAYLGDYGGTGYPA
TH_1252|M.thermoresistible__bu TVFETCRAAAPRMVAQGGG---------AIVNTSS-FAFLGDYGGTGYPA
MLBr_00862|M.leprae_Br4923 GVVNCCRAFGQRLVERGTGG--------HIVNVSSMAAYAPLQSLSAYCT
. * . . *:*..* . . * :
Mb3578c|M.bovis_AF2122/97 AKAGIAALTLVGAAEMRRYGVTVNAIAPAARTRMT-----ETVFAEVMAK
Rv3548c|M.tuberculosis_H37Rv AKAGIAALTLVGAAEMRRYGVTVNAIAPAARTRMT-----ETVFAEMMAK
MMAR_2633|M.marinum_M GKAAVNGLTLAISAELKARGVRANVICPGARTRLSSGPDYEAHINELHRR
MUL_3108|M.ulcerans_Agy99 GKAAVNGLTLAISAELKARGVRANVICPGARTRLSSGPNYEAHINELHRR
MAV_2962|M.avium_104 GKGAVNALTMAIAAELKAYGVRANVVCPGARTRLSTGADYERHIEDLHRR
MAB_1210c|M.abscessus_ATCC_199 GKAAVNGLTLAIAAELKRSGVRANVICPGARTRLSEGPEYTAHLHDLHTR
Mflv_1591|M.gilvum_PYR-GCK GKGAVNSLTLAIAAELAEHGVRANVVCPGAKTRLSTGPEYESHITELNRR
Mvan_5166|M.vanbaalenii_PYR-1 GKGAVNSLTLAIAAELKEHGIRANVVCPGAKTRLSTGSDYESHIAELNRR
MSMEG_5869|M.smegmatis_MC2_155 GKGGVNALTMAIAAELREHKVRANVVCPGAKTRLSTGPEYERHIAELNRR
TH_1252|M.thermoresistible__bu GKGGVNGLTLAIAAELKEHSVRANVVCPGARTRLSTGPEYEAHIAELHRR
MLBr_00862|M.leprae_Br4923 SKAATYMFSDCLRAELDAVGVGLTTICPGV---------IDTNIIQSTRI
.*.. :: **: : ..:.*.. : :
Mb3578c|M.bovis_AF2122/97 -------PQEGFDAMAPENVSPLVVWLGSAESRDVTGKVFEVEGGIIRVA
Rv3548c|M.tuberculosis_H37Rv -------PQEGFDAMAPENVSPLVVWLGSAESRDVTGKVFEVEGGIIRVA
MMAR_2633|M.marinum_M GLLDEMTRQASLDAPPADFVAPLYAYLASDLASGITGQIFVASGGFVGTF
MUL_3108|M.ulcerans_Agy99 GLLDEMTRQASLDAPPADFVAPLYAYLASDLASGITGQIFVASGGSVGTF
MAV_2962|M.avium_104 GLLDDMTRRASLDSAPPVFVAPVYGYLVSDLARDVTGQILVAAGGFVGSF
MAB_1210c|M.abscessus_ATCC_199 GLLDDMTLQASLVPAPPACVAPLYAYLAGDLSARVTGQIFLAAGGFIGRF
Mflv_1591|M.gilvum_PYR-GCK GLLDDVSFQGALDAAPPEYVAPTYAYLASDLATQVTGQIFIAAGGFVGRF
Mvan_5166|M.vanbaalenii_PYR-1 GMLDDVSYQGALDAAPPEYAAPTYAYLVSDLANHITGQIFIAAGGFVGRF
MSMEG_5869|M.smegmatis_MC2_155 GLLDDVSAQGALDAAAPEYAAATYAYLVSDAARDVTGRIFIAAGGFVGEF
TH_1252|M.thermoresistible__bu GLLDEVSMQGALDAAPPEYVAPTYAYLVSDLAKDITGRIFIAAGGFLGEF
MLBr_00862|M.leprae_Br4923 DTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKP--IRPV
: : . : : . : :
Mb3578c|M.bovis_AF2122/97 EGWAHGPQVDKGVKWDPAELGPVVSDLLAKSRPPVPVYGA
Rv3548c|M.tuberculosis_H37Rv EGWAHGPQVDKGVKWDPAELGPVVSDLLAKSRPPVPVYGA
MMAR_2633|M.marinum_M DRPTPRVLGWRDHRADPPWPVEDLHTMINARLLDTD----
MUL_3108|M.ulcerans_Agy99 DRPTPRVLGWRDHRADPPWPVEDLHTMINARLLDTD----
MAV_2962|M.avium_104 DRQTPRLLGYRDHHRAGPWSIEEVHTMIGAAATP------
MAB_1210c|M.abscessus_ATCC_199 KRQTPVPLGYRDHALDAPWSMEEIDDLMGRR---------
Mflv_1591|M.gilvum_PYR-GCK ERQTPSLVAYRGHDDEPPWTVEEIAAQVR-----------
Mvan_5166|M.vanbaalenii_PYR-1 DRQTPALVAYRGHHDEPPWTVEEIAAQVG-----------
MSMEG_5869|M.smegmatis_MC2_155 ARPTPGFLGFRDHHTSPPWTADELHQMISGG---------
TH_1252|M.thermoresistible__bu ARPTPDFLGFRDANDSPPFSVEEIHDMINR----------
MLBr_00862|M.leprae_Br4923 APEAYALYGISRVLPQVLRSTARIRVI-------------
: :