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MSEGQYGTFHLPRLDFATLPMSVDRGLGWKTLRDAGPVVFMNGHYYLTRREDVLAALRNPKVFSSTVLQP PGHPLPVLPLAFDPPQHTRYRKILQPYFSPHALGKSRPVLERHAAEMIAALADRGECEVMADFAHLYPFQ VFMDLYGLPLQDRDRLLDWKNAVVGEKPFVTESDVEKSEQLLAYLADAIAQRRQHPGTDMLSQVMTGEGN FTDIELLGMSHLLILAGLDTVTAAIGFSLFELARRPQLRKELRDNPKQTRVFIEEIVRLEPSAPVAPRIT TEYVEVGGMTLPPGTSVRLCMAAVNRDDSDSMSTNELNMDGKVHRHWGFGGGPHRCLGSHLARIELTVVV AEWLTQIPDFELPDGYEPVINYPSKSFALKELPLHWG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2931 | - | - | 100% (387) | P450 heme-thiolate protein |
| M. avium 104 | MAV_2548 | - | e-128 | 57.18% (383) | putative cytochrome P450 143 |
| M. avium 104 | MAV_1953 | - | 1e-81 | 41.44% (374) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1813c | cyp143 | 1e-167 | 73.39% (387) | cytochrome P450 143 |
| M. gilvum PYR-GCK | Mflv_1764 | - | 1e-117 | 53.32% (377) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1785c | cyp143 | 1e-167 | 73.39% (387) | cytochrome P450 143 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-32 | 27.93% (333) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 6e-32 | 28.65% (363) | cytochrome P450 |
| M. marinum M | MMAR_2666 | cyp143A4 | 0.0 | 78.44% (385) | cytochrome P450 143A4 Cyp143A4 |
| M. smegmatis MC2 155 | MSMEG_3551 | - | 4e-38 | 30.14% (365) | linalool 8-monooxygenase |
| M. thermoresistible (build 8) | TH_3303 | - | 5e-42 | 31.32% (348) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_3091 | cyp143A4 | 0.0 | 78.70% (385) | cytochrome P450 143A4 Cyp143A4 |
| M. vanbaalenii PYR-1 | Mvan_4983 | - | 1e-116 | 53.03% (379) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2666|M.marinum_M ---MSTPGEGSASSFYLPRLEYSTLPLAAD----RAVGWNTLRDAGP---
MUL_3091|M.ulcerans_Agy99 ---MSTPGEGSASSFYLPRLEYSTLPLSAD----RAVGWNTLRDAGP---
MAV_2931|M.avium_104 ---MS---EGQYGTFHLPRLDFATLPMSVD----RGLGWKTLRDAGP---
Mb1813c|M.bovis_AF2122/97 ---MTTPGEDHAGSFYLPRLEYSTLPMAVD----RGVGWKTLRDAGP---
Rv1785c|M.tuberculosis_H37Rv ---MTTPGEDHAGSFYLPRLEYSTLPMAVD----RGVGWKTLRDAGP---
Mflv_1764|M.gilvum_PYR-GCK -------MTATAAPLGLPQVLYGDLPMSRD----RGHGWATLRDLGP---
Mvan_4983|M.vanbaalenii_PYR-1 -------MSA------LPHVLYGDLPMAAD----RGAGWATLREFGP---
MSMEG_3551|M.smegmatis_MC2_155 MGIAPRVNGAAPPDVPLSEINLGSWDFWALDDDIRDGAFATLRREAP---
MAB_1406c|M.abscessus_ATCC_199 -------MSVDVSHTVAPRYVPGTADNWTN----PWPMYAALRDHDP---
TH_3303|M.thermoresistible__bu --------MTTFDTRPTVDFDHHSPEYAQN----SAAINAELRAKCP---
MLBr_02088|M.leprae_Br4923 ---MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTR
** *
MMAR_2666|M.marinum_M ----VVFM------------NGHYYLTRREDVLAALRNPKIFSSR-----
MUL_3091|M.ulcerans_Agy99 ----VVFM------------NGHYYLTRREDVLAALRNPKIFSSR-----
MAV_2931|M.avium_104 ----VVFM------------NGHYYLTRREDVLAALRNPKVFSST-----
Mb1813c|M.bovis_AF2122/97 ----VVFM------------NGWYYLTRREDVLAALRNPKVFSSRK----
Rv1785c|M.tuberculosis_H37Rv ----VVFM------------NGWYYLTRREDVLAALRNPKVFSSRK----
Mflv_1764|M.gilvum_PYR-GCK ----VLYG------------DGWFYLTRREDVLAALRNPEVFSSRI----
Mvan_4983|M.vanbaalenii_PYR-1 ----VAYG------------DGWYYLTRRDDVLAALRNPEVFSSRI----
MSMEG_3551|M.smegmatis_MC2_155 ----ISFHPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELFSSAS----
MAB_1406c|M.abscessus_ATCC_199 ----VHHVVPEYTPD-----QDYYVLTRHADVYEAARDWETFSSAR----
TH_3303|M.thermoresistible__bu ----VAHTDAH---------GGFWVISRYDDVVAAAKNDEVFASGYTVNG
MLBr_02088|M.leprae_Br4923 ADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKAT-
. :: * * :. :.
MMAR_2666|M.marinum_M ----ILQPPGNPLPVVP-------LAFDPPEHTRYRKALQPYFSPHALGK
MUL_3091|M.ulcerans_Agy99 ----ILQPPGNPLPVVP-------LAFDPPEHTRYRKALQPYFSPHALGK
MAV_2931|M.avium_104 ----VLQPPGHPLPVLP-------LAFDPPQHTRYRKILQPYFSPHALGK
Mb1813c|M.bovis_AF2122/97 ----ALQPPGNPLPVVP-------LAFDPPEHTRYRRILQPYFSPAALSK
Rv1785c|M.tuberculosis_H37Rv ----ALQPPGNPLPVVP-------LAFDPPEHTRYRRILQPYFSPAALSK
Mflv_1764|M.gilvum_PYR-GCK ----AYDDMISPVPLVP-------LGFDPPEHTRYRHILHPFFSPQTLAA
Mvan_4983|M.vanbaalenii_PYR-1 ----AYDDMISPVPLVP-------LGFDPPEHTRYRRILHPFFSPQALGV
MSMEG_3551|M.smegmatis_MC2_155 ----GIVIGDQTPELAEYFGS--MIAMDDPRHTRLRNIVRSAFTPRVLAV
MAB_1406c|M.abscessus_ATCC_199 ----GLTVTYGDLEKTGMGDNPPMVMQDPPTHTEFRKLVSRGFTPRQVTA
TH_3303|M.thermoresistible__bu VSPLGVTIPPSPVPMCP-------IEMDPPEYLPYRKLLNPFFSPGESKK
MLBr_02088|M.leprae_Br4923 LAQQAIAAGAEPRPFYASS----FMFLDPPDHTRLRKLVSKAFAPKVVQA
: * * : *. : *:*
MMAR_2666|M.marinum_M SRPVLERHAAEMIAGFAGR---GECDAMAEFARLYPFQVFLDLYGLPLQD
MUL_3091|M.ulcerans_Agy99 SRPVLERHAAEMIAGFAGR---GECDAMAEFARLYPFQVFLDLYGLPLQD
MAV_2931|M.avium_104 SRPVLERHAAEMIAALADR---GECEVMADFAHLYPFQVFMDLYGLPLQD
Mb1813c|M.bovis_AF2122/97 ALPSLRRHTVAMIDAIAGR---GECEAMADLANLFPFQLFLVLYGLPLED
Rv1785c|M.tuberculosis_H37Rv ALPSLRRHTVAMIDAIAGR---GECEAMADLANLFPFQLFLVLYGLPLED
Mflv_1764|M.gilvum_PYR-GCK LLPSLQAQVADIVEEIARR---DRCEVMAELATPYPSQVFLTLFGLPLQD
Mvan_4983|M.vanbaalenii_PYR-1 LLPSLQAQAADIVETIAQR---DACEVMAELATPYPSQVFLTLFGLPLQD
MSMEG_3551|M.smegmatis_MC2_155 IEDSVRDRARRLVAGMVDRNPDGHAELVTELAGPLPLQIICDMMGIPESD
MAB_1406c|M.abscessus_ATCC_199 VEPKVREFVVQRLERLKER---GEGDIVVELFKPLPSMVVAHYLGVPEED
TH_3303|M.thermoresistible__bu WEPRIAHWVDVCLDQVIEK---GSFDLVDDLANPVPSLFTCEFLGLPIEK
MLBr_02088|M.leprae_Br4923 LEGDIAALVDSLLDKGAAA---GQFDVIADLAFPLAVAVICRLLGVPYED
: . : . : : :: . . *:* ..
MMAR_2666|M.marinum_M RDRVIAWKDAIIG--------DKLYLTR-EELEVGQLELLEYLNNAIQQR
MUL_3091|M.ulcerans_Agy99 RDRVIAWKDAIIG--------DKLYLTR-EELEVGQLELLEYLNNAIQQR
MAV_2931|M.avium_104 RDRLLDWKNAVVG--------EKPFVTE-SDVEK-SEQLLAYLADAIAQR
Mb1813c|M.bovis_AF2122/97 RDRLIGWKDAVIAMS------DRPHPTE-ADVAA-ARELLEYLTAMVAER
Rv1785c|M.tuberculosis_H37Rv RDRLIGWKDAVIAMS------DRPHPTE-ADVAA-ARELLEYLTAMVAER
Mflv_1764|M.gilvum_PYR-GCK RERLIAWKDAIIAFS------LTTDPSS-VDLKP-AVELYTYLSEAVAAQ
Mvan_4983|M.vanbaalenii_PYR-1 RERLIAWKDAIIAFS------LTNDPTS-VDLTP-AVELYGYLTEAVARQ
MSMEG_3551|M.smegmatis_MC2_155 HQQIFHWTNVILGFG------DPDLTTDFDEFVTVAMDIGAYATALADQR
MAB_1406c|M.abscessus_ATCC_199 RTQFDAWTDGIVAAAS---GGAIDIEAMQGEVAQTIGELMMYFTGLIERR
TH_3303|M.thermoresistible__bu WNDFASVQHEIIYTP----------PEEQEDILRRYMELCGEVFQLITER
MLBr_02088|M.leprae_Br4923 APEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCR
. :: : : :
MMAR_2666|M.marinum_M RQNPG-SDMLSQVMTGPGE-----FTDLELLGMSHLLILAGLDTVTAAIG
MUL_3091|M.ulcerans_Agy99 RQNPG-SDMLSQVMTGPGE-----FTDLELLGMSHLLILAGLDTVTAAIG
MAV_2931|M.avium_104 RQHPG-TDMLSQVMTGEGN-----FTDIELLGMSHLLILAGLDTVTAAIG
Mb1813c|M.bovis_AF2122/97 RRNPG-PDVLSQVQIGEDP-----LSEIEVLGLSHLLILAGLDTVTAAVG
Rv1785c|M.tuberculosis_H37Rv RRNPG-PDVLSQVQIGEDP-----LSEIEVLGLSHLLILAGLDTVTAAVG
Mflv_1764|M.gilvum_PYR-GCK RDDPR-EGVLSHLLHGDDP-----LTDNEAVGLSLVFVLAGLDTVTSAIG
Mvan_4983|M.vanbaalenii_PYR-1 REKPR-EGILSHLLHGDEQ-----LTDNEAVGLSLVFVLAGLDTVTSTIG
MSMEG_3551|M.smegmatis_MC2_155 RSAPA-DDLTTSLVQAEVDGE--RLTSAEVASFFILLVVAGNETTRNAIS
MAB_1406c|M.abscessus_ATCC_199 RAEPE-DDTVSHLVAAGVGADGDISGTLQILGFAFTMVTGGNDTTTGMLG
TH_3303|M.thermoresistible__bu RQNPTGEGLIDFLVTAEIDGE--PIPDDKVFSMVNLVIAGGFDTTTAVTV
MLBr_02088|M.leprae_Br4923 RGTPG-EDLISRLIELDESGD--QLTEEEIIATCGLLLVAGHETTVNLIA
* * . : : . .: .* :*.
MMAR_2666|M.marinum_M FSLLELARRPQLRTQLRDNPKEIR-VFIEEIVRLEPSAPVAPRITTDFVN
MUL_3091|M.ulcerans_Agy99 FSLLELARRPQLRTQLRDNPKEIR-VFIEEIVRLEPSAPVAPRITTDFVN
MAV_2931|M.avium_104 FSLFELARRPQLRKELRDNPKQTR-VFIEEIVRLEPSAPVAPRITTEYVE
Mb1813c|M.bovis_AF2122/97 FSLLELARRPQLRAMLRDNPKQIR-VFIEEIVRLEPSAPVAPRVTTEPVT
Rv1785c|M.tuberculosis_H37Rv FSLLELARRPQLRAMLRDNPKQIR-VFIEEIVRLEPSAPVAPRVTTEPVT
Mflv_1764|M.gilvum_PYR-GCK ATMLELARRPELRGALREDPEGIA-VFVEEMIRLEPAAPIVGRVTTRPVT
Mvan_4983|M.vanbaalenii_PYR-1 ATMLELARRPELRAALLGDPDGIA-GFVEEMIRLEPAAPVVGRVTTREVT
MSMEG_3551|M.smegmatis_MC2_155 HGVLALTRYPEQRRLWWSRFDELAPTAVEEIVRWASPVSYMRRTVTRDTE
MAB_1406c|M.abscessus_ATCC_199 GAIQLLHQNPAQRQKLIDDPSLIP-GAVEEFLRLTSPVQGLARTATRDVI
TH_3303|M.thermoresistible__bu SSLVYLAEHPEDRQRLIDNPDLLP-RAIEEFLRAFTPQQALARTVTKPVT
MLBr_02088|M.leprae_Br4923 NAVLAMLRNPSQWKALSSNPQRAP-LVVEETLRYDPAIHLIGRVAAKDMT
: : . * . :** :* .. * .:
MMAR_2666|M.marinum_M VGGMTLPPGSQVRLCMAAVNRDGSDA-MSTNELVMDGKVHRHWGFGGG-P
MUL_3091|M.ulcerans_Agy99 VGGMTLPPGSQVRLCMAAVNRDGSDA-MSTNELVMDGKVHRHWGFGGG-P
MAV_2931|M.avium_104 VGGMTLPPGTSVRLCMAAVNRDDSDS-MSTNELNMDGKVHRHWGFGGG-P
Mb1813c|M.bovis_AF2122/97 VGGMTLPAGSPVRLCMAAVNRDGSDA-MSTDELVMDGKVHRHWGFGGG-P
Rv1785c|M.tuberculosis_H37Rv VGGMTLPAGSPVRLCMAAVNRDGSDA-MSTDELVMDGKVHRHWGFGGG-P
Mflv_1764|M.gilvum_PYR-GCK VAGVTLPAGSEVRLCLGAINRDGTDE-HSGDDLVLDGKLHKHWGFGGG-P
Mvan_4983|M.vanbaalenii_PYR-1 VAGVTLPKGAEVRLCLGAINRDGADE-HSGDDFVLDGKLHKHWGFGGG-P
MSMEG_3551|M.smegmatis_MC2_155 LAGTALPAGSKVTLWYGSANRDETKF-DNPWMFDVQRHPNPHVGFGGGGA
MAB_1406c|M.abscessus_ATCC_199 IGDTTIPAGRRALLLYGSANRDEREYGNDAAELDVLRKPRNILTFSHG-N
TH_3303|M.thermoresistible__bu VAGVELQPGERVLLSWASANQDETAF-ERPEEIILDRFPNRHTTFGIG-I
MLBr_02088|M.leprae_Br4923 IGQTTLTEGDTMVLLLAAANRDPAVY-SRPDEFDPDRPSSRHLAFAVG-S
:. : * * .: *:* : *. *
MMAR_2666|M.marinum_M HRCLGSHLARIELTVIVAEWLKQLPDFELAPDYSPEIAFPSKTFALKSLP
MUL_3091|M.ulcerans_Agy99 HRCLGSHLARIELTVIVAEWLKQLPDFELAPDYSPEIAFPSKTFALKSLP
MAV_2931|M.avium_104 HRCLGSHLARIELTVVVAEWLTQIPDFELPDGYEPVINYPSKSFALKELP
Mb1813c|M.bovis_AF2122/97 HRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLP
Rv1785c|M.tuberculosis_H37Rv HRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLP
Mflv_1764|M.gilvum_PYR-GCK HRCLGSHLARMELKLVVSEWLSRIPDFDLEPGYVPEITWPSATCTLTGLP
Mvan_4983|M.vanbaalenii_PYR-1 HRCLGSHLARMELRLVVTEWLSRIPDFELAPGYVPEITWPSATCTLPTLP
MSMEG_3551|M.smegmatis_MC2_155 HFCLGANLARREITVLFSELHRHLPDIVATE--EPDRLQSAFIHGIKRLP
MAB_1406c|M.abscessus_ATCC_199 HHCLGAAAARMQSRIALEELLTRIPDFEVDLDGVTWADG-SYVRRPLTVP
TH_3303|M.thermoresistible__bu HRCLGSHVARIELETMIRRVLDRMPDYHVDLAAARRYPSIGIINGWINAP
MLBr_02088|M.leprae_Br4923 HFCLGAALARLEATVTLSAISARFPQVQLAG--ELVYKPNVAMRGMSALP
* ***: ** : . ::*: *
MMAR_2666|M.marinum_M LRWA-------------
MUL_3091|M.ulcerans_Agy99 LRWA-------------
MAV_2931|M.avium_104 LHWG-------------
Mb1813c|M.bovis_AF2122/97 LRWS-------------
Rv1785c|M.tuberculosis_H37Rv LRWS-------------
Mflv_1764|M.gilvum_PYR-GCK LRILR------------
Mvan_4983|M.vanbaalenii_PYR-1 LILTRKTP---------
MSMEG_3551|M.smegmatis_MC2_155 VAWR-------------
MAB_1406c|M.abscessus_ATCC_199 IRVR-------------
TH_3303|M.thermoresistible__bu ATFTPGQRLRDEKLPGA
MLBr_02088|M.leprae_Br4923 VQV--------------