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HILVTDATGALGRLVAGQLIAAGHTVTGIAELPHPCLDGNVEFVCAPLRDRVLRELTDEADAVIHLAPID PTAPGNAAMDGLARVTDAAARAGSRLLFVSQAAGRPELYRPAEDLVASSWGPSVVVRIAPPVGRQLDWMV CRTVATVLRTKVSAQPMRVLHLDDLMRFLVTALDTDRTGVVDLASPDTVNLVTAWRMLRATDPRSRLHRV RSWSQLIPDLNVAAAQEDWLFEFGWHALDAVADTARGLVGRRLDTAGAINHGAQLALPVEVLPQRAGNGA HSAAPEGVEGEFDDRIDPRFPVFSATALTDALPGPLTPITLDVQLSGLRTASRVLGRVLALGGAVGEEWD SRAIAVFGHRPYVGVSVNMVAATQLPGWDQDAVARDALVGRPQVGDPLPFGEPALAGGALGSIAKAVAAG RSVALLRHLRANTRDYCAAAVAEQVDAAQLALLPQAALEVRLRLLRDRIHQGWILNALWLLDTGITAAAL VRSQAGQSVPGLGMITESGLVAAETAELAAMLAADPPLCALAADGNLASIRALAPKTAAAVDAAVARIGH RGPGDAELASQTFADDPAMLLSAAAAAAAAPAEPAAPATLAERLAANARGSKELAHDATMRFTHELRMTL RALGSLRVEADLIDAVDDVYYLTCNELVTMPGDARLRIKRRRTERERLQVQCPPEVIDGRWTPPQHCAEG SPAQRPAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2850 | - | - | 100% (709) | hypothetical protein MAV_2850 |
| M. avium 104 | MAV_2451 | - | 2e-65 | 30.40% (750) | hypothetical protein MAV_2451 |
| M. avium 104 | MAV_5056 | - | 3e-11 | 23.48% (477) | PEP-utilizing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1899 | - | 0.0 | 70.01% (697) | hypothetical protein Mb1899 |
| M. gilvum PYR-GCK | Mflv_0493 | - | 2e-15 | 26.03% (511) | pyruvate, water dikinase |
| M. tuberculosis H37Rv | Rv1868 | - | 0.0 | 70.01% (697) | hypothetical protein Rv1868 |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 4e-06 | 26.97% (152) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2747 | - | 0.0 | 69.15% (697) | hypothetical protein MMAR_2747 |
| M. smegmatis MC2 155 | MSMEG_1901 | - | 3e-05 | 26.64% (289) | DNA-binding HTH domain-containing protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3007 | - | 0.0 | 69.01% (697) | hypothetical protein MUL_3007 |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2747|M.marinum_M --------------------------------------------------
MUL_3007|M.ulcerans_Agy99 --------------------------------------------------
Mb1899|M.bovis_AF2122/97 --------------------------------------------------
Rv1868|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2850|M.avium_104 --------------------------------------------------
MLBr_00204|M.leprae_Br4923 --------------------------------------------------
Mflv_0493|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1901|M.smegmatis_MC2_155 MLCGRDRELSELGEHVAAAEHTARLVVLTGEPGIGKTALLRDLTQRHGAW
MMAR_2747|M.marinum_M ------------MSKVHVLVTDAAG----AIGRLVTRQLIAAGHTVSGIS
MUL_3007|M.ulcerans_Agy99 ---------------MHVLVTDAAG----AIGRLVTRQLIAAGHTVSGIS
Mb1899|M.bovis_AF2122/97 ---------------MQILVTDATG----AVGRSVTRQLIAAGHTVSGIA
Rv1868|M.tuberculosis_H37Rv ---------------MQILVTDATG----AVGRSVTRQLIAAGHTVSGIA
MAV_2850|M.avium_104 ---------------MHILVTDATG----ALGRLVAGQLIAAGHTVTGIA
MLBr_00204|M.leprae_Br4923 ----------MYGEPVRALVTGAAG----FIGSTLVDRLLADGHTVVGLD
Mflv_0493|M.gilvum_PYR-GCK -----MFDASSRIVDLADVLDDSFGGK--ALGLAELTRLGLPVPPGFVIA
MSMEG_1901|M.smegmatis_MC2_155 WALGASWETDLPGGVLAQLMQDDVPDDPLDGAAHLVDHVRAAGVRLLLVD
: :: . . :: :
MMAR_2747|M.marinum_M SHPHDYLDPNVDFVCASLRNPVLLELASEADAVIHLAPVEKGAPGAAGIT
MUL_3007|M.ulcerans_Agy99 SHPHDYLDPNVDFVCASLRNPVLLELASEADAVIHLAPVEKGAPGAAGIT
Mb1899|M.bovis_AF2122/97 QHPHDALDPRVDYVCASLRNPVLQELAGEADAVIHLAPVDTSAPGGVGIT
Rv1868|M.tuberculosis_H37Rv QHPHDALDPRVDYVCASLRNPVLQELAGEADAVIHLAPVDTSAPGGVGIT
MAV_2850|M.avium_104 ELPHPCLDGNVEFVCAPLRDRVLRELTDEADAVIHLAPIDPTAPGNAAMD
MLBr_00204|M.leprae_Br4923 NFATGHAAN-----------------------------------------
Mflv_0493|M.gilvum_PYR-GCK DASGTSLGDAVTERFSRMRAAGQTPVAVRSSAAGEDGAEHSFAGQYDTVL
MSMEG_1901|M.smegmatis_MC2_155 DAHHADVESLQALSTLVRHQRDLPVLVVLATQSVDALPIPLAADDVVELT
.
MMAR_2747|M.marinum_M GL---------------------AHVSNAAARAGARLLFVSQAAGSPELY
MUL_3007|M.ulcerans_Agy99 GL---------------------AHVSNAAARAGARLLFVSQAAGSPELY
Mb1899|M.bovis_AF2122/97 GL---------------------AHVANAAARAGARLLFVSQAAGRPELY
Rv1868|M.tuberculosis_H37Rv GL---------------------AHVANAAARAGARLLFVSQAAGRPELY
MAV_2850|M.avium_104 GL---------------------ARVTDAAARAGSRLLFVSQAAGRPELY
MLBr_00204|M.leprae_Br4923 ---------------------------------------LEHLASTPALA
Mflv_0493|M.gilvum_PYR-GCK GVGSV--------------DELTAAVEKCVRSAGSERAAAYQDGGAAARM
MSMEG_1901|M.smegmatis_MC2_155 GLPVAAVVELARLRGITIHPTLADRLTRHAGGNPRDVLALFDEVPASAWA
. .
MMAR_2747|M.marinum_M QQAETLVSTGWAPSLVIRIAPPVGRQ----------------------LD
MUL_3007|M.ulcerans_Agy99 QQAETLVSTGWAPSSVIRIAPPVGRQ----------------------LD
Mb1899|M.bovis_AF2122/97 RQAETLVSTGWAPSLVIRIAPPVGRQ----------------------LD
Rv1868|M.tuberculosis_H37Rv RQAETLVSTGWAPSLVIRIAPPVGRQ----------------------LD
MAV_2850|M.avium_104 RPAEDLVASSWGPSVVVRIAPPVGRQ----------------------LD
MLBr_00204|M.leprae_Br4923 FVEADIVT------------------------------------------
Mflv_0493|M.gilvum_PYR-GCK HLVVQQMVDARAAGVVFTADPTSGRRDLLVIDAVRGL-GESLVDGSTASD
MSMEG_1901|M.smegmatis_MC2_155 RLDSSLPAPRHVVERVATQLDSCGPAGRALVQALAVLGAAGGGDATDATD
MMAR_2747|M.marinum_M WMVCRTVATLMRSKVSARPMRVLHLDDLVRFLVLALDTDRNGVVDLATPD
MUL_3007|M.ulcerans_Agy99 WTVCRTVTTLMRSKVSARPMRVLHLDDLVRFLVLALDTDRNGVVDLATPD
Mb1899|M.bovis_AF2122/97 WMVCRTVATLLRSKVSARPIRVLHLDDLVRFLVLALNTDRNGVVDLATPD
Rv1868|M.tuberculosis_H37Rv WMVCRTVATLLRSKVSARPIRVLHLDDLVRFLVLALNTDRNGVVDLATPD
MAV_2850|M.avium_104 WMVCRTVATVLRTKVSAQPMRVLHLDDLMRFLVTALDTDRTGVVDLASPD
MLBr_00204|M.leprae_Br4923 -------ADLQTILDEHRPEVVFHLAAQI--------DVRHSVVDPQFDA
Mflv_0493|M.gilvum_PYR-GCK HFVLTHAGDTVTTEASSQPALADDEIDRIRTGALLAAAHWGRPLDLEWAI
MSMEG_1901|M.smegmatis_MC2_155 TVTLAEAADLAGLSGPSEPLAALDEAVDAGLVTHVVHFEPRLTDGLTGPA
.* . . .
MMAR_2747|M.marinum_M TTNVVTAWRLLG-----SVDPRLRPHRVQGWSQLIPEMDIAAAQEDWNFQ
MUL_3007|M.ulcerans_Agy99 TTNVVTAWRLLG-----SIDPRLRPHRVQGWSQLIPEMDIAAAQEDWNFQ
Mb1899|M.bovis_AF2122/97 TTNVVTAWRLLR-----SVDPHLRTRRVRSWEQLIPEVDIAAVQEDWNFE
Rv1868|M.tuberculosis_H37Rv TTNVVTAWRLLR-----SVDPHLRTRRVRSWEQLIPEVDIAAVQEDWNFE
MAV_2850|M.avium_104 TVNLVTAWRMLR-----ATDPRSRLHRVRSWSQLIPDLNVAAAQEDWLFE
MLBr_00204|M.leprae_Br4923 SVNVIGTVRLAE-----AAR------------------------------
Mflv_0493|M.gilvum_PYR-GCK DRDGLLWWLQARPITTLPGDPNEMDTPVTGPTHVYTRCNIGEMMPGAFCP
MSMEG_1901|M.smegmatis_MC2_155 VLTLLGARATAEAHRRAAEVITDPRRRLRHRVAAAAAPDEALAGEVDALA
: .
MMAR_2747|M.marinum_M YGWQATDAIVDTGRGLVGRRLDPAGATIGSAQLALPVEPTPRLTPADGTA
MUL_3007|M.ulcerans_Agy99 YGWQATDAIVDTGRGLVGRRLDPAGATIGSAQLALPVEPTPRLTPADGTA
Mb1899|M.bovis_AF2122/97 FGWQATEAIVDTGRGLVGRRLHPAGATNGSGQLALPVEAPPRSVPSHGEP
Rv1868|M.tuberculosis_H37Rv FGWQATEAIVDTGRGLVGRRLHPAGATNGSGQLALPVEAPPRSVPSHGEP
MAV_2850|M.avium_104 FGWHALDAVADTARGLVGRRLDTAGAINHGAQLALPVEVLP---QRAGNG
MLBr_00204|M.leprae_Br4923 --HTGVRKIVHTS-------------------------------------
Mflv_0493|M.gilvum_PYR-GCK LTASVSGHAIDYAMQMVQVAGGVQERYEDRARQVGYFFGHMFLNMTEGTA
MSMEG_1901|M.smegmatis_MC2_155 RASGADGAWALAATLFHDASRLTSDPLLRDERLTRSVDALVAAGDCGAAA
.
MMAR_2747|M.marinum_M LDSAAPD--------GLEGEFDDRIDPRFPVFSAASLAEALPGPLTPMTL
MUL_3007|M.ulcerans_Agy99 LDSAAPD--------GLEGEFDDRIDPRFPVFSAASLAEALPGPLTPMTL
Mb1899|M.bovis_AF2122/97 LGSAAPE--------GLEGEFDDRIDERFPVFSSASLAEALPGPLTPMTL
Rv1868|M.tuberculosis_H37Rv LGSAAPE--------GLEGEFDDRIDERFPVFSSASLAEALPGPLTPMTL
MAV_2850|M.avium_104 AHSAAPE--------GVEGEFDDRIDPRFPVFSATALTDALPGPLTPITL
MLBr_00204|M.leprae_Br4923 --------------------------------SGGSIYGTPSQYPTPETV
Mflv_0493|M.gilvum_PYR-GCK LSSGILGNSLEQFSLSVCGRVIDELEPGPPKPFVRKLINTVRLSTFALSS
MSMEG_1901|M.smegmatis_MC2_155 QLIPVVESLR---ETPLRNAVLAYLAILRGRATEAEVRLRRAWDIVNAER
:
MMAR_2747|M.marinum_M DVQMSGLRAAGRAMGQVLALGDVVAEEWGSRAIAVFGHRPYVGVSANLVA
MUL_3007|M.ulcerans_Agy99 DVQMSGLRAAGRAMGQVLALGDVVAEEWGSRAIAVFGHRPYVGVSANLVA
Mb1899|M.bovis_AF2122/97 DVQLSGLRAAGRAMGRVLALGGVVADEWERRAIAVFGHRPYIGVSANIVA
Rv1868|M.tuberculosis_H37Rv DVQLSGLRAAGRAMGRVLALGGVVADEWERRAIAVFGHRPYIGVSANIVA
MAV_2850|M.avium_104 DVQLSGLRTASRVLGRVLALGGAVGEEWDSRAIAVFGHRPYVGVSVNMVA
MLBr_00204|M.leprae_Br4923 PTDPTSPYAAGKVAGEIYLN----------------TFRHLCGLDCSHIA
Mflv_0493|M.gilvum_PYR-GCK APAIRRLPQTIAAFPPITSRDPAVVLRHLEAGVDIYREVTLIHVRSSSRS
MSMEG_1901|M.smegmatis_MC2_155 DPETAALIAQRYVLHSLVRGRGTELVRWADTALRLADRESPTAVESAAVR
. : :
MMAR_2747|M.marinum_M ATQLPGW-NERAVTQQALGGNTQVTELLPFGRPQLTGGPLRSAAKVLVTA
MUL_3007|M.ulcerans_Agy99 ATQLPGW-NERAVTQQALGGNTQVTGLLPFGRPQLTGGPLRSAAKVLVTA
Mb1899|M.bovis_AF2122/97 AAQLPGW-DAQAVARRALGEQPQVTELLPFGRPQLAGGPLGSVAKVVVTA
Rv1868|M.tuberculosis_H37Rv AAQLPGW-DAQAVARRALGEQPQVTELLPFGRPQLAGGPLGSVAKVVVTA
MAV_2850|M.avium_104 ATQLPGW-DQDAVARDALVGRPQVGDPLPFGEPALAGGALGSIAKAVAAG
MLBr_00204|M.leprae_Br4923 PANVYGP-RQD-----------------PYG----EAGVVAIFVQALLSD
Mflv_0493|M.gilvum_PYR-GCK AVAANVL-ESHLVRRAAKRGASDTAGSAEAIRLMTGAGVESALMVEELTA
MSMEG_1901|M.smegmatis_MC2_155 GLGLAAAGRAEQATAAYDELAERITHGAQAQRVTLGRGWLQLIRDDVDGA
*
MMAR_2747|M.marinum_M RS---LSLLRHIRADTQAYVTAAADEHVGAEQLSTLPDASLEVRIRLLRD
MUL_3007|M.ulcerans_Agy99 RS---LSLLRHIRADTQAYVTAAADEHVGAEQLSTLPDASLEVRIRLLRD
Mb1899|M.bovis_AF2122/97 RS---LALLRHLRSDTHHYVAAADAEHLAAGQLASLPDAGLEVRIRLLRD
Rv1868|M.tuberculosis_H37Rv RS---LALLRHLRSDTHHYVAAADAEHLAAGQLASLPDAGLEVRIRLLRD
MAV_2850|M.avium_104 RS---VALLRHLRANTRDYCAAAVAEQVDAAQLALLPQAALEVRLRLLRD
MLBr_00204|M.leprae_Br4923 RP---TKVFGDG-THTRDYVFVDD--------------------------
Mflv_0493|M.gilvum_PYR-GCK VV---SMLRRDGDAAARFLAAPAGEAVTRLRAAETPSGAALRTFLDRHGH
MSMEG_1901|M.smegmatis_MC2_155 RSNLESAIATANLGGSSRITLWAMAWLARAHFVSGDWDAALATVVSGRDL
: :
MMAR_2747|M.marinum_M RIHQGWIL-TALWVIDTGVTAATLEHTRAGTSVSGVGVIMESGRIAAEIA
MUL_3007|M.ulcerans_Agy99 RIHQGWIL-TALWVIDTGVTAATLEHTRAGTSVSGVGVIMESGRIAAETA
Mb1899|M.bovis_AF2122/97 RIHQGWIL-TVLWVIDTGVTAATLEHTRAGSAVSGGGMIMESGRIGAEIA
Rv1868|M.tuberculosis_H37Rv RIHQGWIL-TVLWVIDTGVTAATLEHTRAGSAVSGGGMIMESGRIGAEIA
MAV_2850|M.avium_104 RIHQGWIL-NALWLLDTGITAAALVRSQAGQSVPGLGMITESGLVAAETA
MLBr_00204|M.leprae_Br4923 --------------------------------------------------
Mflv_0493|M.gilvum_PYR-GCK RGYRELCMRDPSWADDPDGLGAMMQVMLRGAAPENPAATAPSDPAQSRTL
MSMEG_1901|M.smegmatis_MC2_155 AASSGITITTPLLEWIAAQISALRGDWETAHAAVQAADRVTQDYEMMRIP
MMAR_2747|M.marinum_M ALTEILRADAPLCALARDGNVDSIRALSASAAAALDATVARLAHR-----
MUL_3007|M.ulcerans_Agy99 ALTEILRADAPLCALARDGNVDSIRALSASAAAALDATVARLAHR-----
Mb1899|M.bovis_AF2122/97 PLAAVLRADPPLCALANDGNLASIRALSAPAAAAVDAVIARIGHR-----
Rv1868|M.tuberculosis_H37Rv PLAAVLRADPPLCALANDGNLASIRALSAPAAAAVDAVIARIGHR-----
MAV_2850|M.avium_104 ELAAMLAADPPLCALAADGNLASIRALAPKTAAAVDAAVARIGHR-----
MLBr_00204|M.leprae_Br4923 ---------------------------------VVDAFIKASGDA-----
Mflv_0493|M.gilvum_PYR-GCK RVLARLAQAGARGREETKSRMALMAHLLKRGYRHLGEVLHEAGRLPDADL
MSMEG_1901|M.smegmatis_MC2_155 TILARAQVAEAEADYPKVRR--VLEPLAALAARAPGTVLTEPGYWPWPDV
. : .
MMAR_2747|M.marinum_M ---------------------------------------GCGEAELANPS
MUL_3007|M.ulcerans_Agy99 ---------------------------------------GCGEAELANPS
Mb1899|M.bovis_AF2122/97 ---------------------------------------GLGEAELANLT
Rv1868|M.tuberculosis_H37Rv ---------------------------------------GLGEAELANLT
MAV_2850|M.avium_104 ---------------------------------------GPGDAELASQT
MLBr_00204|M.leprae_Br4923 ---------------------------------------GGGQRFNIGTG
Mflv_0493|M.gilvum_PYR-GCK VF-------------------------FFDRRELPLVVSGDDVTELVHRA
MSMEG_1901|M.smegmatis_MC2_155 LANALVIDGALDEADEFLRPHEEVARERGHRSAMARLGYARGRLLGARGE
. .
MMAR_2747|M.marinum_M FGDDPALLLTAAAKAAAAPATPAAAPTLSQRLAASARGSRELAHDTTIRF
MUL_3007|M.ulcerans_Agy99 FGDDPALLLTAAAKAAAAPATPAAAPTLSQRLAASARGSRELAHDTTIRF
Mb1899|M.bovis_AF2122/97 FADDPALLLKTAAEIAARPAGPAHPATLIQRLAAGTRSARELAHDTTIRF
Rv1868|M.tuberculosis_H37Rv FADDPALLLKTAAEIAARPAGPAHPATLIQRLAAGTRSARELAHDTTIRF
MAV_2850|M.avium_104 FADDPAMLLSAAAAAAAAPAEPAAPATLAERLAANARGSKELAHDATMRF
MLBr_00204|M.leprae_Br4923 IETSDRQLHTAVSAAVGGPDDPEFHP---PRLGDLKRSCLDIGLATTV--
Mflv_0493|M.gilvum_PYR-GCK RQRREALPFQAALEFGDVSVGRPTPIVRAAVSGDGVVAGRPAGHGSVEGV
MSMEG_1901|M.smegmatis_MC2_155 LSAARARFEESLALLDGLPLRYDRARVNFAYGQTLRRAGKRRDADAVIAT
: . . :.
MMAR_2747|M.marinum_M THDLRMTLRELASRRVTADLMDTIDDVYYLTADELVTMP---ADARLRIK
MUL_3007|M.ulcerans_Agy99 THDLRMTLRELASRRVTADLMDTIDDVYYLTADELVTMP---ADARLRIK
Mb1899|M.bovis_AF2122/97 THELRMTLRELGSRRVAADVIDVVDDVFYLTCDELITTP---ADARLRIK
Rv1868|M.tuberculosis_H37Rv THELRMTLRELGSRRVAADVIDVVDDVFYLTCDELITTP---ADARLRIK
MAV_2850|M.avium_104 THELRMTLRALGSLRVEADLIDAVDDVYYLTCNELVTMP---GDARLRIK
MLBr_00204|M.leprae_Br4923 -----------------------------LGWSPQVQLD---DGVRRTVE
Mflv_0493|M.gilvum_PYR-GCK VRVARSVVEARDLQPGEILVAPVTDVGWTPYFAVIAALV---TDIGSSVS
MSMEG_1901|M.smegmatis_MC2_155 ARDLYLSLGAHTYVARCDRELKAGGLHQLRGSRDSVELTPQEDAVTALVA
:
MMAR_2747|M.marinum_M RRRTERERLQAQHPPEVIDGNWNPAL-------------------
MUL_3007|M.ulcerans_Agy99 RRRTERERLQAQHPPEVIDGNWNPAL-------------------
Mb1899|M.bovis_AF2122/97 RRRAERERLQAQRPPDVIDHAWVPVE-------------------
Rv1868|M.tuberculosis_H37Rv RRRAERERLQAQRPPDVIDHAWVPVE-------------------
MAV_2850|M.avium_104 RRRTERERLQVQCPPEVIDGRWTPPQHCAEGSPAQRPAG------
MLBr_00204|M.leprae_Br4923 YFRAAQRS-------------------------------------
Mflv_0493|M.gilvum_PYR-GCK HGAVVAREYGLPCVVNTLVGTQVLRTGDRVRVDGDRGLVTVLDSP
MSMEG_1901|M.smegmatis_MC2_155 QGLSNREVAAELYVSPKTVQYHLTRVYAKLGVRSRAELAALRR--
.