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VQILVTDATGAVGRSVTRQLIAAGHTVSGIAQHPHDALDPRVDYVCASLRNPVLQELAGEADAVIHLAPV DTSAPGGVGITGLAHVANAAARAGARLLFVSQAAGRPELYRQAETLVSTGWAPSLVIRIAPPVGRQLDWM VCRTVATLLRSKVSARPIRVLHLDDLVRFLVLALNTDRNGVVDLATPDTTNVVTAWRLLRSVDPHLRTRR VRSWEQLIPEVDIAAVQEDWNFEFGWQATEAIVDTGRGLVGRRLHPAGATNGSGQLALPVEAPPRSVPSH GEPLGSAAPEGLEGEFDDRIDERFPVFSSASLAEALPGPLTPMTLDVQLSGLRAAGRAMGRVLALGGVVA DEWERRAIAVFGHRPYIGVSANIVAAAQLPGWDAQAVARRALGEQPQVTELLPFGRPQLAGGPLGSVAKV VVTARSLALLRHLRSDTHHYVAAADAEHLAAGQLASLPDAGLEVRIRLLRDRIHQGWILTVLWVIDTGVT AATLEHTRAGSAVSGGGMIMESGRIGAEIAPLAAVLRADPPLCALANDGNLASIRALSAPAAAAVDAVIA RIGHRGLGEAELANLTFADDPALLLKTAAEIAARPAGPAHPATLIQRLAAGTRSARELAHDTTIRFTHEL RMTLRELGSRRVAADVIDVVDDVFYLTCDELITTPADARLRIKRRRAERERLQAQRPPDVIDHAWVPVE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1868 | - | - | 100% (699) | hypothetical protein Rv1868 |
| M. tuberculosis H37Rv | Rv2047c | - | 4e-70 | 31.84% (738) | hypothetical protein Rv2047c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1899 | - | 0.0 | 100.00% (699) | hypothetical protein Mb1899 |
| M. gilvum PYR-GCK | Mflv_0493 | - | 7e-11 | 25.98% (435) | pyruvate, water dikinase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 5e-07 | 28.29% (152) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2747 | - | 0.0 | 79.77% (697) | hypothetical protein MMAR_2747 |
| M. avium 104 | MAV_2850 | - | 0.0 | 70.01% (697) | hypothetical protein MAV_2850 |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3007 | - | 0.0 | 78.91% (697) | hypothetical protein MUL_3007 |
| M. vanbaalenii PYR-1 | Mvan_1818 | - | 3e-06 | 22.24% (499) | pyruvate, water dikinase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1868|M.tuberculosis_H37Rv ----------MQILVTDATG--AVGRSVTRQLIAAGHTVSGIAQHPHDAL
Mb1899|M.bovis_AF2122/97 ----------MQILVTDATG--AVGRSVTRQLIAAGHTVSGIAQHPHDAL
MMAR_2747|M.marinum_M -------MSKVHVLVTDAAG--AIGRLVTRQLIAAGHTVSGISSHPHDYL
MUL_3007|M.ulcerans_Agy99 ----------MHVLVTDAAG--AIGRLVTRQLIAAGHTVSGISSHPHDYL
MAV_2850|M.avium_104 ----------MHILVTDATG--ALGRLVAGQLIAAGHTVTGIAELPHPCL
Mflv_0493|M.gilvum_PYR-GCK MFDASSRIVDLADVLDDSFGGKALGLAELTRLGLPVPPGFVIADASGTSL
Mvan_1818|M.vanbaalenii_PYR-1 ---MAPATIEFDDVTDDRFGGKAAGLAELRRIGLSVPVGFVIADASAHGA
MLBr_00204|M.leprae_Br4923 -----MYGEPVRALVTGAAG--FIGSTLVDRLLADGHTVVGLDNFATG--
. : . * * :: : . .
Rv1868|M.tuberculosis_H37Rv DPRVDYVCASLRNP------VLQELAGEADAVIHLAPVDTSAPGGVGITG
Mb1899|M.bovis_AF2122/97 DPRVDYVCASLRNP------VLQELAGEADAVIHLAPVDTSAPGGVGITG
MMAR_2747|M.marinum_M DPNVDFVCASLRNP------VLLELASEADAVIHLAPVEKGAPGAAGITG
MUL_3007|M.ulcerans_Agy99 DPNVDFVCASLRNP------VLLELASEADAVIHLAPVEKGAPGAAGITG
MAV_2850|M.avium_104 DGNVEFVCAPLRDR------VLRELTDEADAVIHLAPIDPTAPGNAAMDG
Mflv_0493|M.gilvum_PYR-GCK GDAVTERFSRMRAAGQTPVAVRSSAAGEDGAEHSFAGQYDTVLGVGSVDE
Mvan_1818|M.vanbaalenii_PYR-1 LDAAVDRFCQMAAEGVTPVAVRSSAVGEDGEDQSFAGQYDTVLGVASVDD
MLBr_00204|M.leprae_Br4923 -------------------------------------------HAANLEH
:
Rv1868|M.tuberculosis_H37Rv LAHVANAAAR-AGARLLFVSQAAGRPELYRQAETLVSTGWAPSLVIRIAP
Mb1899|M.bovis_AF2122/97 LAHVANAAAR-AGARLLFVSQAAGRPELYRQAETLVSTGWAPSLVIRIAP
MMAR_2747|M.marinum_M LAHVSNAAAR-AGARLLFVSQAAGSPELYQQAETLVSTGWAPSLVIRIAP
MUL_3007|M.ulcerans_Agy99 LAHVSNAAAR-AGARLLFVSQAAGSPELYQQAETLVSTGWAPSSVIRIAP
MAV_2850|M.avium_104 LARVTDAAAR-AGSRLLFVSQAAGRPELYRPAEDLVASSWGPSVVVRIAP
Mflv_0493|M.gilvum_PYR-GCK LTAAVEKCVRSAGSERAAAYQDGGAAARMHLVVQQMVDARAAGVVFTADP
Mvan_1818|M.vanbaalenii_PYR-1 FTAAVRRCAGSVASQRASSYS-GHSPATMHVVVQQMVDARAAGVVFTADP
MLBr_00204|M.leprae_Br4923 LASTPALAFV--------------EADIVTADLQTILDEHRPEVVFHLAA
:: . . . : . *. .
Rv1868|M.tuberculosis_H37Rv PVGR---------------------QLDWMVCRTVATLLRSKVSARPIRV
Mb1899|M.bovis_AF2122/97 PVGR---------------------QLDWMVCRTVATLLRSKVSARPIRV
MMAR_2747|M.marinum_M PVGR---------------------QLDWMVCRTVATLMRSKVSARPMRV
MUL_3007|M.ulcerans_Agy99 PVGR---------------------QLDWTVCRTVTTLMRSKVSARPMRV
MAV_2850|M.avium_104 PVGR---------------------QLDWMVCRTVATVLRTKVSAQPMRV
Mflv_0493|M.gilvum_PYR-GCK TSGRRDLLVIDAVRGLGESLVDGSTASDHFVLTHAGDTVTTEASSQPALA
Mvan_1818|M.vanbaalenii_PYR-1 ATGRRDLMVIDAIAGLGEALVDGSASPDHVVLNADGSTAVREVGTAPVLS
MLBr_00204|M.leprae_Br4923 QIDVR----------------------------------HSVVDPQFDAS
. ...
Rv1868|M.tuberculosis_H37Rv LHLDDLVRFLVLALNTDRNGVVDLATPDTTNVVTAWRLLR-----SVDPH
Mb1899|M.bovis_AF2122/97 LHLDDLVRFLVLALNTDRNGVVDLATPDTTNVVTAWRLLR-----SVDPH
MMAR_2747|M.marinum_M LHLDDLVRFLVLALDTDRNGVVDLATPDTTNVVTAWRLLG-----SVDPR
MUL_3007|M.ulcerans_Agy99 LHLDDLVRFLVLALDTDRNGVVDLATPDTTNVVTAWRLLG-----SIDPR
MAV_2850|M.avium_104 LHLDDLMRFLVTALDTDRTGVVDLASPDTVNLVTAWRMLR-----ATDPR
Mflv_0493|M.gilvum_PYR-GCK DDEIDRIRTGALLAAAHWGRPLDLEWAIDRDGLLWWLQARPITTLPGDPN
Mvan_1818|M.vanbaalenii_PYR-1 SDDVAEIRSGALRAARHWGRPLDLEWAIDGTGKLWWLQARPITTLPGDLN
MLBr_00204|M.leprae_Br4923 VNVIGTVRLAEAARHTGVRKIVHTSSGGS---------------------
. :* :.
Rv1868|M.tuberculosis_H37Rv LRTRRVRSWEQLIPEVDIAAVQEDWNFEFGWQATEAIVDTGRGLVGRRLH
Mb1899|M.bovis_AF2122/97 LRTRRVRSWEQLIPEVDIAAVQEDWNFEFGWQATEAIVDTGRGLVGRRLH
MMAR_2747|M.marinum_M LRPHRVQGWSQLIPEMDIAAAQEDWNFQYGWQATDAIVDTGRGLVGRRLD
MUL_3007|M.ulcerans_Agy99 LRPHRVQGWSQLIPEMDIAAAQEDWNFQYGWQATDAIVDTGRGLVGRRLD
MAV_2850|M.avium_104 SRLHRVRSWSQLIPDLNVAAAQEDWLFEFGWHALDAVADTARGLVGRRLD
Mflv_0493|M.gilvum_PYR-GCK EMDTPVTGPTHVYTRCNIGEMMPGAFCPLTASVSGHAIDYAMQMVQVAGG
Mvan_1818|M.vanbaalenii_PYR-1 EMDSPVAGSDHVYTRCNIGEMMPGAFCPLTASVSGYAIDYAMQMTQVVAR
MLBr_00204|M.leprae_Br4923 -----IYGTPSQYPTPETVPTDPTSPYAAGKVAGEIYLNTFRHLCGLDCS
: . . : . : :
Rv1868|M.tuberculosis_H37Rv PAGATNGSGQLALPVEAPPRSVPSHGEPLGSAAPEG--------LEGEFD
Mb1899|M.bovis_AF2122/97 PAGATNGSGQLALPVEAPPRSVPSHGEPLGSAAPEG--------LEGEFD
MMAR_2747|M.marinum_M PAGATIGSAQLALPVEPTPRLTPADGTALDSAAPDG--------LEGEFD
MUL_3007|M.ulcerans_Agy99 PAGATIGSAQLALPVEPTPRLTPADGTALDSAAPDG--------LEGEFD
MAV_2850|M.avium_104 TAGAINHGAQLALPVEVLP---QRAGNGAHSAAPEG--------VEGEFD
Mflv_0493|M.gilvum_PYR-GCK VQERYEDRARQVGYFFGHMFLNMTEGTALSSGILGNSLEQFSLSVCGRVI
Mvan_1818|M.vanbaalenii_PYR-1 AQPRYEKPWLQVGYFYGHMFLNLTEGTALSSGILGNSREQFSMSICGRVV
MLBr_00204|M.leprae_Br4923 HIAPAN-----------------VYGPRQDPYGEAG--------VVAIFV
* . . : . .
Rv1868|M.tuberculosis_H37Rv DRIDERFPVFSSASLAEALPGPLTPMTLDVQLSGLRAAGRAMGRVLALGG
Mb1899|M.bovis_AF2122/97 DRIDERFPVFSSASLAEALPGPLTPMTLDVQLSGLRAAGRAMGRVLALGG
MMAR_2747|M.marinum_M DRIDPRFPVFSAASLAEALPGPLTPMTLDVQMSGLRAAGRAMGQVLALGD
MUL_3007|M.ulcerans_Agy99 DRIDPRFPVFSAASLAEALPGPLTPMTLDVQMSGLRAAGRAMGQVLALGD
MAV_2850|M.avium_104 DRIDPRFPVFSATALTDALPGPLTPITLDVQLSGLRTASRVLGRVLALGG
Mflv_0493|M.gilvum_PYR-GCK DELEPGPPKPFVRKLINTVRLSTFALSSAPAIRRLPQTIAAFPPITSRDP
Mvan_1818|M.vanbaalenii_PYR-1 DELEAKPPRPFARKLVNTVRLTSHALSAGPAIRRLADQIAGWPIPSHEDA
MLBr_00204|M.leprae_Br4923 QALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGGQ--------
: : * .: :
Rv1868|M.tuberculosis_H37Rv VVADEWERRAIAVFGHRPYIGVSANIVAAAQLPGWDAQAVARRALGEQPQ
Mb1899|M.bovis_AF2122/97 VVADEWERRAIAVFGHRPYIGVSANIVAAAQLPGWDAQAVARRALGEQPQ
MMAR_2747|M.marinum_M VVAEEWGSRAIAVFGHRPYVGVSANLVAATQLPGWNERAVTQQALGGNTQ
MUL_3007|M.ulcerans_Agy99 VVAEEWGSRAIAVFGHRPYVGVSANLVAATQLPGWNERAVTQQALGGNTQ
MAV_2850|M.avium_104 AVGEEWDSRAIAVFGHRPYVGVSVNMVAATQLPGWDQDAVARDALVGRPQ
Mflv_0493|M.gilvum_PYR-GCK AVVLRHLEAGVDIYREVTLIHVRSSSRSAVAANVLESHLVRRAAKRGASD
Mvan_1818|M.vanbaalenii_PYR-1 RLVLQQLESGVQLYCDVTLTHVRSSSRAAVAANILESTLVRQAVKNGRSE
MLBr_00204|M.leprae_Br4923 ----------------------RFNIGTGIETSDRQLHTAVSAAVGGPDD
. :. : . . :
Rv1868|M.tuberculosis_H37Rv -VTELLPFGRPQLAGGPLGSVAKVVVTARSLALLRHLRSDTHHYVAAADA
Mb1899|M.bovis_AF2122/97 -VTELLPFGRPQLAGGPLGSVAKVVVTARSLALLRHLRSDTHHYVAAADA
MMAR_2747|M.marinum_M -VTELLPFGRPQLTGGPLRSAAKVLVTARSLSLLRHIRADTQAYVTAAAD
MUL_3007|M.ulcerans_Agy99 -VTGLLPFGRPQLTGGPLRSAAKVLVTARSLSLLRHIRADTQAYVTAAAD
MAV_2850|M.avium_104 -VGDPLPFGEPALAGGALGSIAKAVAAGRSVALLRHLRANTRDYCAAAVA
Mflv_0493|M.gilvum_PYR-GCK -TAGSAEAIRLMTGAG-VESALMVEELTAVVSMLRRDGDAAARFLAAPAG
Mvan_1818|M.vanbaalenii_PYR-1 -EEGQAEAARLMAGASDVESAMMLDQLQSVVRAIAADSGVATRFLAAAPD
MLBr_00204|M.leprae_Br4923 PEFHPPRLGDLKRSCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS
: : . : :*
Rv1868|M.tuberculosis_H37Rv EHLAAGQLASLP--DAGLEVRIRLLRDRIHQGWILTVLWVIDTGVTAATL
Mb1899|M.bovis_AF2122/97 EHLAAGQLASLP--DAGLEVRIRLLRDRIHQGWILTVLWVIDTGVTAATL
MMAR_2747|M.marinum_M EHVGAEQLSTLP--DASLEVRIRLLRDRIHQGWILTALWVIDTGVTAATL
MUL_3007|M.ulcerans_Agy99 EHVGAEQLSTLP--DASLEVRIRLLRDRIHQGWILTALWVIDTGVTAATL
MAV_2850|M.avium_104 EQVDAAQLALLP--QAALEVRLRLLRDRIHQGWILNALWLLDTGITAAAL
Mflv_0493|M.gilvum_PYR-GCK EAVTRLRAAETPSGAALRTFLDRHGHRGYRELCMRDPSWADDPDGLGAMM
Mvan_1818|M.vanbaalenii_PYR-1 VAVVELQRADNASGEALRQFLLRHGHRGYRELCMRDPSWAQDAGGLGAMM
MLBr_00204|M.leprae_Br4923 --------------------------------------------------
Rv1868|M.tuberculosis_H37Rv EHTRAGSAVSGGGMIMES-----------GRIGAEIAPLAAVLRADPPLC
Mb1899|M.bovis_AF2122/97 EHTRAGSAVSGGGMIMES-----------GRIGAEIAPLAAVLRADPPLC
MMAR_2747|M.marinum_M EHTRAGTSVSGVGVIMES-----------GRIAAEIAALTEILRADAPLC
MUL_3007|M.ulcerans_Agy99 EHTRAGTSVSGVGVIMES-----------GRIAAETAALTEILRADAPLC
MAV_2850|M.avium_104 VRSQAGQSVPGLGMITES-----------GLVAAETAELAAMLAADPPLC
Mflv_0493|M.gilvum_PYR-GCK QVMLRGAAPENPAATAPSDPAQSRTLRVLARLAQAGARGREETKSRMALM
Mvan_1818|M.vanbaalenii_PYR-1 QVMVRAASSDRQPAHSPTEAPTSPAIRFLARLAQGGARGREETKSKMALM
MLBr_00204|M.leprae_Br4923 --------------------------------------------------
Rv1868|M.tuberculosis_H37Rv ALANDGNLASIRALSAPAAAAVDAVIARIGHR--------GLGEAELANL
Mb1899|M.bovis_AF2122/97 ALANDGNLASIRALSAPAAAAVDAVIARIGHR--------GLGEAELANL
MMAR_2747|M.marinum_M ALARDGNVDSIRALSASAAAALDATVARLAHR--------GCGEAELANP
MUL_3007|M.ulcerans_Agy99 ALARDGNVDSIRALSASAAAALDATVARLAHR--------GCGEAELANP
MAV_2850|M.avium_104 ALAADGNLASIRALAPKTAAAVDAAVARIGHR--------GPGDAELASQ
Mflv_0493|M.gilvum_PYR-GCK AHLLKRGYRHLGEVLHEAGRLPDADLVFFFDRRELPLVVSGDDVTELVHR
Mvan_1818|M.vanbaalenii_PYR-1 AHALKRGYRHLGEVLARSGRLPDADLVFFFDRSELPRVVGDDDISELVQS
MLBr_00204|M.leprae_Br4923 --------------------------------------------------
Rv1868|M.tuberculosis_H37Rv TFADDPALLLKTAAEIAARPAGPAHPATLIQRLAAG-----TRSARELAH
Mb1899|M.bovis_AF2122/97 TFADDPALLLKTAAEIAARPAGPAHPATLIQRLAAG-----TRSARELAH
MMAR_2747|M.marinum_M SFGDDPALLLTAAAKAAAAPATPAAAPTLSQRLAAS-----ARGSRELAH
MUL_3007|M.ulcerans_Agy99 SFGDDPALLLTAAAKAAAAPATPAAAPTLSQRLAAS-----ARGSRELAH
MAV_2850|M.avium_104 TFADDPAMLLSAAAAAAAAPAEPAAPATLAERLAAN-----ARGSKELAH
Mflv_0493|M.gilvum_PYR-GCK ARQRREALPFQAALEFGDVSVGRPTPIVR--AAVSGDGVVAGRPAGHGSV
Mvan_1818|M.vanbaalenii_PYR-1 AVKRREALAYQDSLEFEDVSVGRPRPVVAPPVITSTADQVVGRPASRGTV
MLBr_00204|M.leprae_Br4923 --------------------------------------------------
Rv1868|M.tuberculosis_H37Rv DTTIRFTHELRMTLRELGSRRVAADVIDVVDDVFYLTCDELITTPADARL
Mb1899|M.bovis_AF2122/97 DTTIRFTHELRMTLRELGSRRVAADVIDVVDDVFYLTCDELITTPADARL
MMAR_2747|M.marinum_M DTTIRFTHDLRMTLRELASRRVTADLMDTIDDVYYLTADELVTMPADARL
MUL_3007|M.ulcerans_Agy99 DTTIRFTHDLRMTLRELASRRVTADLMDTIDDVYYLTADELVTMPADARL
MAV_2850|M.avium_104 DATMRFTHELRMTLRALGSLRVEADLIDAVDDVYYLTCNELVTMPGDARL
Mflv_0493|M.gilvum_PYR-GCK EGVVRVARSVVEARDLQPGEILVAPVTDVGWTPYFAVIAALVTDIGSSVS
Mvan_1818|M.vanbaalenii_PYR-1 EGTVRVAKTIQDARDVQRGEILVAPVTDVGWTPYFTVIAALITDIGSSVS
MLBr_00204|M.leprae_Br4923 --------------------------------------------------
Rv1868|M.tuberculosis_H37Rv R---IKRRRAERERLQAQRPPDVIDHAWVPVE-------------
Mb1899|M.bovis_AF2122/97 R---IKRRRAERERLQAQRPPDVIDHAWVPVE-------------
MMAR_2747|M.marinum_M R---IKRRRTERERLQAQHPPEVIDGNWNPAL-------------
MUL_3007|M.ulcerans_Agy99 R---IKRRRTERERLQAQHPPEVIDGNWNPAL-------------
MAV_2850|M.avium_104 R---IKRRRTERERLQVQCPPEVIDGRWTPPQHCAEGSPAQRPAG
Mflv_0493|M.gilvum_PYR-GCK HGAVVAREYGLPCVVNTLVGTQVLRTGDRVRVDGDRGLVTVLDSP
Mvan_1818|M.vanbaalenii_PYR-1 HGAVVAREYGLPCVVNTLVGTQVLRTGDRVRVDGDRGVVTRLG--
MLBr_00204|M.leprae_Br4923 ---------------------------------------------