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MDANLAAVADTALLVAAIRAHETTRDDRLFADPFAARLAGDRGHELLAGALAATGESATAQIVVRTRFWD DALLEAAQQISQVVILAAGMDARAYRLAWPDGTVVYELDQPHVLSAKDGVLAGERPACRRVAVGVDLAQD WPAALRRAGLDPSAPAVWLIEGLLQYLDEAAVTALLDRVDALSARASVLLYDVVGKALLESDFMAPVLES MARSGAPWRFGTDDPGGLCERLGWSATVTDVAEPGNRYQRWYAPAVPMDVAGVPRGYFVQATKQAAGD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0219 | - | - | 100% (279) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_4557 | - | 3e-40 | 37.83% (304) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_4441 | - | 1e-37 | 46.86% (207) | methyltransferase, putative, family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3793c | - | 6e-40 | 45.61% (228) | hypothetical protein Mb3793c |
| M. gilvum PYR-GCK | Mflv_5024 | - | 7e-40 | 44.69% (226) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv3767c | - | 6e-40 | 45.61% (228) | hypothetical protein Rv3767c |
| M. leprae Br4923 | MLBr_02640 | - | 9e-35 | 45.00% (200) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_4607c | - | 3e-39 | 38.91% (293) | hypothetical protein MAB_4607c |
| M. marinum M | MMAR_0955 | - | 5e-40 | 38.82% (304) | hypothetical protein MMAR_0955 |
| M. smegmatis MC2 155 | MSMEG_0607 | - | 1e-105 | 69.29% (267) | methyltransferase, putative, family protein |
| M. thermoresistible (build 8) | TH_4502 | - | 8e-37 | 45.67% (208) | PUTATIVE methyltransferase |
| M. ulcerans Agy99 | MUL_0706 | - | 6e-39 | 37.95% (303) | hypothetical protein MUL_0706 |
| M. vanbaalenii PYR-1 | Mvan_1346 | - | 8e-35 | 39.71% (277) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02640|M.leprae_Br4923 ---MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTN
TH_4502|M.thermoresistible__bu MSSLRTDDDTWDIATSVGSTAVMVAASRAAETEREDALIRDPYAKVLVAG
MAB_4607c|M.abscessus_ATCC_199 ---MRVDGDTWDITSSVGATALGVAAARATETLRADALIRDPFAQILVDA
Mflv_5024|M.gilvum_PYR-GCK --MARTDGDTWDLASSVGATATSVAASRAFASRGPDALIDDPYARLLVEA
Mvan_1346|M.vanbaalenii_PYR-1 --MARTDNDTWDLASSVGATATMVAAARAVATRAPRPVIDDPFAAPLVQA
Mb3793c|M.bovis_AF2122/97 --MPRTDNDSWAITESVGATALGVAAARAAETESDNPLINDPFARIFVDA
Rv3767c|M.tuberculosis_H37Rv --MPRTDNDSWAITESVGATALGVAAARAAETESDNPLINDPFARIFVDA
MMAR_0955|M.marinum_M --MARTEDDSWEITESVGATALGVASARAAETRSQHPLISDPFAQVFLDA
MUL_0706|M.ulcerans_Agy99 --MARTEDDSWEITESVGATALGVASARAAETRSQHPLISDPFAQVFLDA
MAV_0219|M.avium_104 ----MMDAN----LAAVADTALLVAAIRAHETTRDDRLFADPFAARLAGD
MSMEG_0607|M.smegmatis_MC2_155 ----MGDTPNPDAGRAVADTGLLVAAIRAAESRREDRLFEDPFAEKLAGE
. :*. *. **: ** : :: **:* :
MLBr_02640|M.leprae_Br4923 TGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNN
TH_4502|M.thermoresistible__bu AGTG-VWELILDDDFTAKIEAADPETAAIFDHMGNYQAVRTHFFDTYFAR
MAB_4607c|M.abscessus_ATCC_199 TGKATGWERLVAG----DIDWPDPEAGRIYDRMVDYQATRTHFFDEYFLA
Mflv_5024|M.gilvum_PYR-GCK VGLPHFVKVARGEID------FDGDPLFGAQQAINQIVVRTRIFDDFLTD
Mvan_1346|M.vanbaalenii_PYR-1 VGVDFFTRLATGELTTEELDTNDAESPVGMSRFADAMAARTRFFDDFFAE
Mb3793c|M.bovis_AF2122/97 AGDG-IWSMYTNRTLLAGATDLDPDLRAPIQQMIDFMAARTAFFDEYFLA
Rv3767c|M.tuberculosis_H37Rv AGDG-IWSMYTNRTLLAGATDLDPDLRAPIQQMIDFMAARTAFFDEYFLA
MMAR_0955|M.marinum_M VGDG-VWNWHSAPQLPAELLEIEPDLPLQMEAMVSYMASRTAFFDEFFLD
MUL_0706|M.ulcerans_Agy99 VGDG-VWNWHSAPQLPAELLEIEPDLPLQMEAMVSYMASRTAFFDEFFLD
MAV_0219|M.avium_104 RGHE----------------LLAGALAATGESATAQIVVRTRFWDDALLE
MSMEG_0607|M.smegmatis_MC2_155 TGRR----------------MLEEALATTGDKSTLQIVVRTKFWDEALLR
* . . ** ::* :
MLBr_02640|M.leprae_Br4923 AVID---GIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTL
TH_4502|M.thermoresistible__bu AAEA---GIRQVVILASGLDSRAYRLPWPDGTVVYEIDQPKVLEYKSATL
MAB_4607c|M.abscessus_ATCC_199 AAAA---GIRQVVILASGLDSRAYRLDWPAGTTVYEIDQPQVLKFKDSAL
Mflv_5024|M.gilvum_PYR-GCK AGQR-EPQIRQAVILASGLDTRAYRLDWPAGTVVYEIDQPEVIDFKTAVL
Mvan_1346|M.vanbaalenii_PYR-1 AMRAGPPPIRQGVILASGLDARAYRLSWPQDMVLFEIDQPEVLTFKAATL
Mb3793c|M.bovis_AF2122/97 TADA---GVRQVVILASGLDSRAWRLPWPDGTVVYELDQPKVLEFKSATL
Rv3767c|M.tuberculosis_H37Rv TADA---GVRQVVILASGLDSRAWRLPWPDGTVVYELDQPKVLEFKSATL
MMAR_0955|M.marinum_M ATRA---GIGQAVILAAGLDSRAWRLPWPAGTTVFELDQPRVLEFKAATL
MUL_0706|M.ulcerans_Agy99 ATRA---GIGQAVILAAGLDSRAWRLPWPAGTTVFELDQPRVLEFKAATL
MAV_0219|M.avium_104 AAQQ----ISQVVILAAGMDARAYRLAWPDGTVVYELDQPHVLSAKDGVL
MSMEG_0607|M.smegmatis_MC2_155 ATTH----VDQVVLLAAGMDARAFRLAWPAGTVVYELDQPEVIAAKSGLL
: : * *:**:*:*:**:** ** . .::*:***.*: * *
MLBr_02640|M.leprae_Br4923 AEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPA
TH_4502|M.thermoresistible__bu AAHGVQPAADRREVAVDLRHDWPKALRAKGFDPQQRTAWLAEGLLMYLPA
MAB_4607c|M.abscessus_ATCC_199 AAH--QPTAQRRGVAIDLREDWPAALRAAGFDSAQPTAWLAEGLLPYLPA
Mflv_5024|M.gilvum_PYR-GCK TDAGVAPAADRRTVGIDLREDWPTALRDAGFDPDRPTAWIAEGLLPYLPP
Mvan_1346|M.vanbaalenii_PYR-1 ADLGVRPSTKLATVAVDLRNDWPAALAEAGFDASAPTAWIAEGLLGYLPP
Mb3793c|M.bovis_AF2122/97 RQHGAQPASQLVNVPIDLRQDWPKALQKAGFDPSKPCAWLAEGLVRYLPA
Rv3767c|M.tuberculosis_H37Rv RQHGAQPASQLVNVPIDLRQDWPKALQKAGFDPSKPCAWLAEGLVRYLPA
MMAR_0955|M.marinum_M AEHGAEPACGRVAVAVDLRQDWPTALRQAGFDPSVPSVWSAEGLMPYLPA
MUL_0706|M.ulcerans_Agy99 AEHGAEPACGRVAVAVDLRQDWPTALRQAGFDPSVSSVWSAEGLMPYLPA
MAV_0219|M.avium_104 AGE--RPACRRVAVGVDLAQDWPAALRRAGLDPSAPAVWLIEGLLQYLDE
MSMEG_0607|M.smegmatis_MC2_155 ADA--SPRCRWTALGVDLTRDWTTALRSTTFDPARPAVWLAEGLLQYLDE
* : :** .**. ** :*. .* ***: **
MLBr_02640|M.leprae_Br4923 TAQDGLFTEIGGLSAVGSRIAVETSP--LHGDEWREQMQLRFRRV-SDAL
TH_4502|M.thermoresistible__bu DAQDRLFENITALSAPGSRLAVETAA--EEPVDRREQMRARMERI-ASQF
MAB_4607c|M.abscessus_ATCC_199 DAQDNLFRDIGVLSAAGSRVAVEGYEG-KLVLDESEEEAVRREQV-RAAF
Mflv_5024|M.gilvum_PYR-GCK DAQDRLLDSITALSAPGSRLATEHMD--AKALTG-----DWAKAM-TERA
Mvan_1346|M.vanbaalenii_PYR-1 DAQDRLLDTIGELSAPGSRLAVESVP--THHEADQEELREKMKES-SDRW
Mb3793c|M.bovis_AF2122/97 RAQDLLFERIDALSRPGSWLASNVPGAGFLDPERMRRQRADMRRMRAAAA
Rv3767c|M.tuberculosis_H37Rv RAQDLLFERIDALSRPGSWLASNVPGAGFLDPERMRRQRADMRRMRAAAA
MMAR_0955|M.marinum_M VAQDLLFERVQGLTVRASRIAVEALGPKFLDPQVRANRSARMERIRAVMA
MUL_0706|M.ulcerans_Agy99 VAQDLLFERVQGLTVRASRIAVEALGPKFLDPQVRANRSARIERIRAVMA
MAV_0219|M.avium_104 AAVTALLDRVDALSARASVLLYDVVGKALLESDFMAPVLESMARS-GAPW
MSMEG_0607|M.smegmatis_MC2_155 TAVHTLFDRVDAMSAPGSVLLYDVVGKTLLDAAMLAAVRESMARS-GAPW
* *: : :: .* : :
MLBr_02640|M.leprae_Br4923 G--FEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRW-
TH_4502|M.thermoresistible__bu G--LEKALDVAQLMYDDPDRADVPEWLTGHGWRTEWVSAPDEMRRLDRFV
MAB_4607c|M.abscessus_ATCC_199 KTAIDVDVTIENLIYEDENRADPAEWLDAHGWSVTKTDAHDEMARLGRP-
Mflv_5024|M.gilvum_PYR-GCK R-RHGSDIDLTKLFYNGE-RRSATEHLGAVGWQTSVQTSNDAYIANGFG-
Mvan_1346|M.vanbaalenii_PYR-1 R-SHGFDVDFSELVFLGE-RADVTDYLRDRGWTVDATPTNQLLTRYGLA-
Mb3793c|M.bovis_AF2122/97 KLVET-EISDVDDLWYAEQRTAVAEWLRERGWDVSTATLPELLARYGRS-
Rv3767c|M.tuberculosis_H37Rv KLVET-EISDVDDLWYAEQRTAVAEWLRERGWDVSTATLPELLARYGRS-
MMAR_0955|M.marinum_M HVEPQREIPRTDELWYFEEREDVGDWFRRHDWDVTVTPSGELMAGYGRA-
MUL_0706|M.ulcerans_Agy99 HVEPQREIPRTDELWYFEEREDVGDWFRRHDWDVTVTPSGELMAGYGRA-
MAV_0219|M.avium_104 R-------------FGTDDPGGLCERLG---WSATVTDVAEPGNRYQRWY
MSMEG_0607|M.smegmatis_MC2_155 R-------------FGTDAPGELSTRLG---WSANVTDIAEPGNAYGRWF
: : * . :
MLBr_02640|M.leprae_Br4923 ------GDGVPMAD-DKDAFAEFVTAHRL----
TH_4502|M.thermoresistible__bu AAAMPPGDDADAADLDDTAFSKFVTAERPS---
MAB_4607c|M.abscessus_ATCC_199 ----------VAEDVERGTFRGQLIQGELR---
Mflv_5024|M.gilvum_PYR-GCK --------PIRDDLLAMIGDSGYLTAWRP----
Mvan_1346|M.vanbaalenii_PYR-1 --------PLDSD--EGFAEVVYVSATR-----
Mb3793c|M.bovis_AF2122/97 ---------IPHSGEDSIPPNLFVSAQRATS--
Rv3767c|M.tuberculosis_H37Rv ---------IPHSGEDSIPPNLFVSAQRATS--
MMAR_0955|M.marinum_M ---------AAAQVEDRVPTNLFVAAQRK----
MUL_0706|M.ulcerans_Agy99 ---------AAAQVEDRVPTNLFVAAQRN----
MAV_0219|M.avium_104 AP-------AVPMDVAGVPRGYFVQATKQAAGD
MSMEG_0607|M.smegmatis_MC2_155 TP-------AVPLDVPGVPRGYFVEATKPG---
: .