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VQDPPNRSFDPSLLREAVIRRIYRRTSAEGTIRVPAVPAMIDEYLQLCGNVCATLSVWYAPEQFAQLRSA LEVELAKAFKASPRSDVLISYHAPFGTGVNFHVQADWRTIEADYEQWVAVRPPPLFGTEPDARVLTLAAE ADDPATYRVLDVGAGTGRNALALARRGHPVDAVEMTAKFAEAMRADAERESLGVNVIQSDVFTAMENTRD RYQLMVLSEVVPDFRTAHELRGMFELAAECLAPGGRLVFNTFLARDGYVPDAAAVQFSQQCNSMVFTRDE VMGAAGGLPLALVADDSAYEYEKTHSPAESWPPTGWFEGWAGGLDVFDVERDDSPIELRWIVFAKTRAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2748 | - | - | 100% (349) | hypothetical protein MAV_2748 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2446 | - | 1e-113 | 57.91% (335) | hypothetical protein Mb2446 |
| M. gilvum PYR-GCK | Mflv_5088 | - | 1e-105 | 51.73% (346) | methyltransferase type 12 |
| M. tuberculosis H37Rv | Rv2423 | - | 1e-113 | 57.91% (335) | hypothetical protein Rv2423 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3750 | - | 1e-116 | 60.06% (333) | hypothetical protein MMAR_3750 |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_3824 | - | 2e-06 | 28.57% (175) | PUTATIVE thiopurine S-methyltransferase (tpmt) superfamily |
| M. ulcerans Agy99 | MUL_3309 | - | 5e-05 | 29.52% (105) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1267 | - | 1e-100 | 51.16% (346) | methyltransferase type 12 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2446|M.bovis_AF2122/97 MDNLPIESAESTRLAKAAMTRRFYTRSVVKGEITLPAVPSMIDEYVTMCA
Rv2423|M.tuberculosis_H37Rv MDNLPIESAESTRLAKAAMTRRFYTRSVVKGEITLPAVPSMIDEYVTMCA
MMAR_3750|M.marinum_M ---MPLSSVDSQQSLKNSMTRRFYSRSEVTGKITLPAVPAMIDEYVKMCD
Mflv_5088|M.gilvum_PYR-GCK ------MSID-TAYMRDALTRRLLRRGVSGGTITLPAVPAMVDEYVSMCN
Mvan_1267|M.vanbaalenii_PYR-1 ----MLMSID-TAYMREAMARRLLRRGVSSGKITLPAVPGLVDEYVSVCN
MAV_2748|M.avium_104 MQDPPNRSFD-PSLLREAVIRRIYRRTSAEGTIRVPAVPAMIDEYLQLCG
TH_3824|M.thermoresistible__bu -------------MEWDDMYRRGVPPPWSIG-APQPELAALLDAGPAQCP
MUL_3309|M.ulcerans_Agy99 --------MTAPDPTDPTRFEEMYRDQRVAHGLPAATPWDIGGPQPVVEQ
.. . : .
Mb2446|M.bovis_AF2122/97 GLFAGVGRKFSDEELAHLRAVLQGQLAEAYAASQRSTIVISYNAPMGPTL
Rv2423|M.tuberculosis_H37Rv GLFAGVGRKFSDEELAHLRAVLQGQLAEAYAASQRSTIVISYNAPMGPTL
MMAR_3750|M.marinum_M GMFADVGRKFSEEELAHLRSVLEGQLAQAYSASPRSSIIISFNAPVGPTL
Mflv_5088|M.gilvum_PYR-GCK KIFAALGRRFNADELSHLRSLLAKELANAFDGSNRSNIVISYDAPIGNVL
Mvan_1267|M.vanbaalenii_PYR-1 KIFGALGRKFSGDELDHLRSLLAKELANAYAGSNRSNIVITYDAPVGTVL
MAV_2748|M.avium_104 NVCATLSVWYAPEQFAQLRSALEVELAKAFKASPRSDVLISYHAPFGTGV
TH_3824|M.thermoresistible__bu --------------------------------------------------
MUL_3309|M.ulcerans_Agy99 --------------------------------------------------
Mb2446|M.bovis_AF2122/97 HYQVRAQWRTVAQEYENWIATREPPLFGTEPDARVWALANEAADPTTHRV
Rv2423|M.tuberculosis_H37Rv HYQVRAQWRTVAQEYENWIATREPPLFGTEPDARVWALANEAADPTTHRV
MMAR_3750|M.marinum_M NYEVNARWWTVEAAYENWIDTRKPPLFGTEPDARVWALANEAADPSTHRV
Mflv_5088|M.gilvum_PYR-GCK NYHIQPQWTSLADTYDNWVATRKPPLFGTHPDARVTTLAAEIADPTTARV
Mvan_1267|M.vanbaalenii_PYR-1 NYFIQPQVSTLEESYDSWVASRKPPLFGINPDARVTALSTEITSPETARV
MAV_2748|M.avium_104 NFHVQADWRTIEADYEQWVAVRPPPLFGTEPDARVLTLAAEADDPATYRV
TH_3824|M.thermoresistible__bu -----------------------------------------VQGTVRGEV
MUL_3309|M.ulcerans_Agy99 ---------------------------------------LVALGAVKGEV
.. .*
Mb2446|M.bovis_AF2122/97 LEIGAGTGRNALALARRGHPVDVVEMTPKFADIIRSDAERDSLDVRVIMR
Rv2423|M.tuberculosis_H37Rv LEIGAGTGRNALALARRGHPVDVVEMTPKFADIIRSDAERDSLDVRVIMR
MMAR_3750|M.marinum_M LEIGAGTGRNALALARRGHPVDVVELTPKFAEMIRADAEKEGLDVRVIVR
Mflv_5088|M.gilvum_PYR-GCK LDIGAGTGRNALALAKKGHPVDAVELTPKFADILREEAYKHLLGVRVIDR
Mvan_1267|M.vanbaalenii_PYR-1 LDIGAGTGRNALALARRGHPVDAVELTPKFAEILRTEAFKHLLNIRVIDR
MAV_2748|M.avium_104 LDVGAGTGRNALALARRGHPVDAVEMTAKFAEAMRADAERESLGVNVIQS
TH_3824|M.thermoresistible__bu LDAGCGEAALSLELAARGHTVVGLDCSAAAVAAATATAAERGLTTATFAQ
MUL_3309|M.ulcerans_Agy99 LDPGTGPGHHAIYYASKGYSATGIDGSATAIERARDNAAKAGVSVN-FQV
*: * * . :: * :*:.. :: :. * . : :
Mb2446|M.bovis_AF2122/97 DVFSTMDDLRQDYQLMVLSEVVPDFRTTQQLR-NLFELAAQCLAPGARLV
Rv2423|M.tuberculosis_H37Rv DVFSTMDDLRQDYQLMVLSEVVPDFRTTQQLR-NLFELAAQCLAPGARLV
MMAR_3750|M.marinum_M DVFTTIADLRRDYQLIVLSEVVSDFRTTQQLR-ELFELAAQCLAPGARLV
Mflv_5088|M.gilvum_PYR-GCK DIFETLDDLQKDYSLIILSEVTPDFRSPEQIR-AVFELAAQCLAPGGRLV
Mvan_1267|M.vanbaalenii_PYR-1 DVFETMDDLQKDYQLIVLSEVVSDFRNVAQLR-AIFELAAGCLAPGGRLV
MAV_2748|M.avium_104 DVFTAMENTRDRYQLMVLSEVVPDFRTAHELR-GMFELAAECLAPGGRLV
TH_3824|M.thermoresistible__bu ADLTEFGGYDGRFSTIIDSGLLHALP-VDRRQ-AYLRAIHRAAAPNARLF
MUL_3309|M.ulcerans_Agy99 ADATRLEGLDNRFDTVVDCAFYHTFGTAPELQRSYVQALWRATKPGARLY
: . :. :: . . : . : .. . *..**
Mb2446|M.bovis_AF2122/97 FNAFLANGDYAPD-------QAAREFGQQMYTGMCTRAEMSAAAAGLPLE
Rv2423|M.tuberculosis_H37Rv FNAFLANGDYAPD-------QAAREFGQQMYTGMCTRAEMSAAAAGLPLE
MMAR_3750|M.marinum_M FNAFLACGGYTPD-------QAAREFGQQAYTTIFTRHELSVAAAGLPVE
Mflv_5088|M.gilvum_PYR-GCK FNVFMPRPGFMSDDAVNELADSARQLAQQVYSAIFFGDEIDTAGAGLPLR
Mvan_1267|M.vanbaalenii_PYR-1 FNTFMPRPGYLSDDAVRELADAARELGQQVYTTIFTGEEIDIASAGLSLR
MAV_2748|M.avium_104 FNTFLARDGYVPD-------AAAVQFSQQCNSMVFTRDEVMGAAGGLPLA
TH_3824|M.thermoresistible__bu ILTFAERP-----------------FGDGHGPDGFTAEELRDTVG-----
MUL_3309|M.ulcerans_Agy99 MYEFGAHQVNGLT--------AIRSLPEENFREMLPLGGWEITYLG---P
: * : : :
Mb2446|M.bovis_AF2122/97 LVADDSVYDYEKTHLPPGAWPPTSWYADWIRGL-DVFTTNVESCPIEMRW
Rv2423|M.tuberculosis_H37Rv LVADDSVYDYEKTHLPPGAWPPTSWYADWIRGL-DVFTTNVESCPIEMRW
MMAR_3750|M.marinum_M LIADDSVYDYEKAHLPADAWPPTSWYADWVSGL-DVFPVAREMSPIELRW
Mflv_5088|M.gilvum_PYR-GCK LMSNDSVYEFEKENLPPGAWPHTGWYAEWVSGQ-DIFDVPREQSPVEMRW
Mvan_1267|M.vanbaalenii_PYR-1 LMTNDSVYEYEKENLPAGHWPPTGWYAEWVSGQ-DIFDVPREQSPVDMRW
MAV_2748|M.avium_104 LVADDSAYEYEKTHSPAESWPPTGWFEGWAGGL-DVFDVERDDSPIELRW
TH_3824|M.thermoresistible__bu -------VLWTVDEIRPAKLYVNDFTGDLLDGPPTAYERAADGKLMFPGF
MUL_3309|M.ulcerans_Agy99 TTYRTTVSMETLETMAARNPEVADQVGPLVERFKTIQPWLTDGIAHVPFW
. . : :
Mb2446|M.bovis_AF2122/97 LVFQRRR--
Rv2423|M.tuberculosis_H37Rv LVFQRRR--
MMAR_3750|M.marinum_M LVFRKTH--
Mflv_5088|M.gilvum_PYR-GCK LVYQKTG--
Mvan_1267|M.vanbaalenii_PYR-1 LVYQKTG--
MAV_2748|M.avium_104 IVFAKTRAG
TH_3824|M.thermoresistible__bu LVSAHKD--
MUL_3309|M.ulcerans_Agy99 EVHATRPD-
*