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NTQAAVLSDIADGVLTITLNRPEAANAVRPDDRDALIALLAAADADEKVRVVVLRANGKHFCSGADVGSL AERRARGEKRVLEPTRRIMNGAQKLVASVLDCNKPVIAAVHGAATGLGAHVVYASDLVIATENAYFAESF VKRGLVVDGGGCYLLPRRIGMQKAKEMAFFGEKLSATEAFTLGLVNRVVSAADFDATVADFAGRLAGAPT SAIAFTKRLLNDSPDTDRSGAFVAEAMAQEIQSYSHDSTEGVQAFVEKRPTEFTGW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2641 | - | - | 100% (267) | enoyl CoA hydratase |
| M. avium 104 | MAV_1939 | - | e-134 | 91.19% (261) | enoyl-CoA hydratase/isomerase |
| M. avium 104 | MAV_1884 | - | 9e-39 | 36.36% (253) | enoyl-CoA isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1174c | echA10 | 1e-33 | 34.38% (256) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2444 | - | 2e-37 | 38.08% (260) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv1142c | echA10 | 1e-33 | 34.38% (256) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 2e-24 | 33.33% (267) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_4570c | - | 6e-32 | 36.22% (254) | enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_4022 | echA10_1 | 1e-36 | 33.73% (252) | enoyl-CoA hydratase EchA10_1 |
| M. smegmatis MC2 155 | MSMEG_5185 | - | 8e-40 | 35.69% (255) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3522 | - | 5e-52 | 44.53% (256) | PUTATIVE putative enoyl-CoA hydratase/isomerase |
| M. ulcerans Agy99 | MUL_3887 | echA10_1 | 6e-37 | 34.13% (252) | enoyl-CoA hydratase EchA10_1 |
| M. vanbaalenii PYR-1 | Mvan_4207 | - | 8e-40 | 40.77% (260) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1174c|M.bovis_AF2122/97 --MSNYRIDTRTIVPG------LAVTLADG--VLSVTIDRPESLNSLTKP
Rv1142c|M.tuberculosis_H37Rv --MSNYRIDTRTIVPG------LAVTLADG--VLSVTIDRPESLNSLTKP
MSMEG_5185|M.smegmatis_MC2_155 --MTSTDASAETVTRDYPSIDDVSVSLTDG--VLAVTLNRPDSLNSLNRD
MAB_4570c|M.abscessus_ATCC_199 --MS---LDESVGAPD--------VAVDGG--IMRVTFTRPDRMNALNGP
MAV_2641|M.avium_104 ------MNTQAAVLSD----------IADG--VLTITLNRPEAANAVRPD
TH_3522|M.thermoresistible__bu ------MADEQPGIGV----------VTDGDGVRRITIDRVDVGNSLSPL
Mflv_2444|M.gilvum_PYR-GCK ------MADTEVLLSS----------DRDG--VRTLTLNRPHRRNALDAR
Mvan_4207|M.vanbaalenii_PYR-1 ------MVDDQVLLST----------DRDG--VRTLTLNRPERRNALDAR
MMAR_4022|M.marinum_M MSLEADSAGPEGSVTS----------RRDG-TLLRITLDRPSRRNSLTQN
MUL_3887|M.ulcerans_Agy99 MSLEADSAGPEGSVTS----------RRDG-TLLRITLDRPSRRNSLTRN
MLBr_01241|M.leprae_Br4923 --MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALD
: :*: * *::
Mb1174c|M.bovis_AF2122/97 VLAGMADAIEGAATDPRVKVVRLGG--AGRGFSSGGAISVDDVWAS--GP
Rv1142c|M.tuberculosis_H37Rv VLAGMADAIEGAATDPRVKVVRLGG--AGRGFSSGGAISVDDVWAS--GP
MSMEG_5185|M.smegmatis_MC2_155 MLDAVADAMEVAATDPAVRVVRLGG--AGRGFSSGAGISEEDQNAK--GH
MAB_4570c|M.abscessus_ATCC_199 ATSGLIEALESIPGRDDVRVVVISGGAPGSAFSAGADVTELAAGSA--DL
MAV_2641|M.avium_104 DRDALIALLAAADADEKVRVVVLRANG--KHFCSGADVGSLAERRARGEK
TH_3522|M.thermoresistible__bu ARDALTEAIRDADRDPAVRAVLLTAAGS-RHFCTGAGIS--ADSRP-GQR
Mflv_2444|M.gilvum_PYR-GCK LWVELADALRALKREQDVRALVLTGAG--GAFCSGADIGTGEQIHP----
Mvan_4207|M.vanbaalenii_PYR-1 LWVELADALRDLKRDHDVRALVLTGAG--GAFCSGADIGTGEQIHP----
MMAR_4022|M.marinum_M MIEMLLDTLGGAATDDSLRAILIRGAG--ADFCAGADWVAASTGTQ--RP
MUL_3887|M.ulcerans_Agy99 MIEMLLDTLGGAATDDSLRAILIRGAA--ADFCAGADWVAASTGTQ--RH
MLBr_01241|M.leprae_Br4923 LMKSLKQVLKRITYDHSVRVVVLTGAG--RGFCSGADQKFTAPVPQVEGL
: : ::.: : . *.:*.
Mb1174c|M.bovis_AF2122/97 P----TDTVAEAN-RTVRAIVALPQPVVAVVQGPTVGCGVSLALACDLVL
Rv1142c|M.tuberculosis_H37Rv P----TDTVAEAN-RTVRAIVALPQPVVAVVQGPTVGCGVSLALACDLVL
MSMEG_5185|M.smegmatis_MC2_155 D----AAAVLDAANRAVAAIVALPKPVVAVVHGPAAGVGVSLALACDIVL
MAB_4570c|M.abscessus_ATCC_199 TPLQAAELTMDNAERLVRAVLNCPVPTIAEVTGVAAGIGASVGLACDLIY
MAV_2641|M.avium_104 RVLEPTRRIMNGAQKLVASVLDCNKPVIAAVHGAATGLGAHVVYASDLVI
TH_3522|M.thermoresistible__bu RPGDVARLLQQGWQRLVASILDCAKPVVAAVNGTAAGAGAGLVLAADLVV
Mflv_2444|M.gilvum_PYR-GCK ------RYKLDRLTDVALALHELAIPTIAKVTGIAVGAGWNLALGCDLVV
Mvan_4207|M.vanbaalenii_PYR-1 ------RYKLDRLTDVALALHELAVPTIAKVTGIAVGAGWNLALGCDLVV
MMAR_4022|M.marinum_M RTGDLLRRIPHAAHRVIELLHTIHLPVVCGVQGWAAGLGANLALAADFTV
MUL_3887|M.ulcerans_Agy99 RTGDLLRRIPHAAHRVIELLHTIHLPVVCGVQGWAAGLGANLALAADFTV
MLBr_01241|M.leprae_Br4923 TQPVRALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRV
. : *.:. : * : * * : ..*.
Mb1174c|M.bovis_AF2122/97 ASDNAFFMLAHTNVGLMP-DGGASALVQAAIGRIRAMHMALLPDRVPAAE
Rv1142c|M.tuberculosis_H37Rv ASDNAFFMLAHTNVGLMP-DGGASALVQAAIGRIRAMHMALLPDRVPAAE
MSMEG_5185|M.smegmatis_MC2_155 ASDQAFFLLAFTKIGLMP-DGGASALVAAAIGRIRAMRLALLADRLTATD
MAB_4570c|M.abscessus_ATCC_199 AADTAFFLLAFANIGLMP-DGGSSALVSASIGRVKANAMALLAQPLSATD
MAV_2641|M.avium_104 ATENAYFAESFVKRGLVV-DGGGCYLLPRRIGMQKAKEMAFFGEKLSATE
TH_3522|M.thermoresistible__bu MSERAMLVEPFVARGILP-DSGAVYLLTRIVGLRRATELLMLGEPVDAAR
Mflv_2444|M.gilvum_PYR-GCK ATPESRFCQIFSKRGLSV-DLGGSWLLPKTVGLQQAKRLVLLADMIDADE
Mvan_4207|M.vanbaalenii_PYR-1 ATPESRFCQIFSKRGLSV-DLGGSWLLPRIVGLQQAKRLVLLAEMIGADE
MMAR_4022|M.marinum_M ASSDATFWEPFVVRGFSP-DSGSTWLLPRLVGLARARRMLLLGEQVTAPE
MUL_3887|M.ulcerans_Agy99 ATSDATFWEPFVVRGFSP-DSGSTWLLPRLVGLARARRMLLLGEQVTAPE
MLBr_01241|M.leprae_Br4923 ASTRAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSGRDVGAEE
: : : *: : * *: :* :* : : : *
Mb1174c|M.bovis_AF2122/97 ALSWGLVSAVYPAADFDAEVDKLISRLLAGPALAIAKTKNAINA-ATLTE
Rv1142c|M.tuberculosis_H37Rv ALSWGLVSAVYPAADFDAEVDKLISRLLAGPALAIAKTKNAINA-ATLTE
MSMEG_5185|M.smegmatis_MC2_155 AYDWGLISAVYPADEFDAAVDKVLAKLRNGPAVALRKTKQAINE-ATLTE
MAB_4570c|M.abscessus_ATCC_199 AFAAGLVNEALPGDQLRERVDKTARRLAHGSRRAMQLTKEAMNA-VSLKL
MAV_2641|M.avium_104 AFTLGLVNRVVSAADFDATVADFAGRLAGAPTSAIAFTKRLLND-SPDTD
TH_3522|M.thermoresistible__bu CEQLGLVNRVVAPDAVYPSALELARRLAAGPTVMLSLTKRLLAV-SSESS
Mflv_2444|M.gilvum_PYR-GCK AHGLGLVTWVKPAGEIDGFIDELADRLAAGPPFALAQSKALLND-GATAT
Mvan_4207|M.vanbaalenii_PYR-1 ARDLGLVTWVKPSGEIDAFVDDLADRLAGGPPFALAQSKALLND-GANAT
MMAR_4022|M.marinum_M AADWGLIHQVVDATALDSAVDELLTRLARGPTVAIGLAKQALNH-GQHAT
MUL_3887|M.ulcerans_Agy99 AADWGLIHQVVDATDLDSAVDELLTRLARGPTVAIGLAKQALNH-GQHAT
MLBr_01241|M.leprae_Br4923 AEQIGLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRALWGGLDAAS
. **: . . :: . :* :
Mb1174c|M.bovis_AF2122/97 LAPTLLRELDGQA-LLLRTDDFAEGATAFQQRRTPMFTGR----------
Rv1142c|M.tuberculosis_H37Rv LAPTLLRELDGQA-LLLRTDDFAEGATAFQQRRTPMFTGR----------
MSMEG_5185|M.smegmatis_MC2_155 LDDAIAREREGQL-ELLVANDFREGAQAFQQNRRPEFTDQ----------
MAB_4570c|M.abscessus_ATCC_199 FDEAIARERDGQI-ELLISPDAHEGFAAFLEGRRPNFS------------
MAV_2641|M.avium_104 RSGAFVAEAMAQE-IQSYSHDSTEGVQAFVEKRPTEFTGW----------
TH_3522|M.thermoresistible__bu RDRAFTEEAWAQE-IVSTTRDLQEGLCAFAERREPRFNGY----------
Mflv_2444|M.gilvum_PYR-GCK LREALANEARAQP-GNFATADSAEAYAAFAAKRDPEFSGAWALYEQPEEQ
Mvan_4207|M.vanbaalenii_PYR-1 LREALANEARAQP-GNFATADSVEAYAAFAAKREPEFTGAWVQYEKPTQK
MMAR_4022|M.marinum_M LTESMTHELFSLE-LTCRTSDFKEGLTAFRQHRTPKFEGR----------
MUL_3887|M.ulcerans_Agy99 LTESMTHELFNLE-LTCRTSDFKEGLTAFRQHRTPKFEGR----------
MLBr_01241|M.leprae_Br4923 LDKHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARGCATSPG--
: * : : *. . * . :
Mb1174c|M.bovis_AF2122/97 ---
Rv1142c|M.tuberculosis_H37Rv ---
MSMEG_5185|M.smegmatis_MC2_155 ---
MAB_4570c|M.abscessus_ATCC_199 ---
MAV_2641|M.avium_104 ---
TH_3522|M.thermoresistible__bu ---
Mflv_2444|M.gilvum_PYR-GCK R--
Mvan_4207|M.vanbaalenii_PYR-1 DEE
MMAR_4022|M.marinum_M ---
MUL_3887|M.ulcerans_Agy99 ---
MLBr_01241|M.leprae_Br4923 ---