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LSDLTDGIMTITLNRPDAANAVRPDDRDTLIALLEAADADEKVRVVVLRANGKHFCSGADVTALADRRGR GEKRVLEPTRRIMNGAQKLVASVLDCNKPVIAAVHGAATGLGAHIVYASDLVIATENAYFAESFVKRGLV VDGGGCYLLPRRIGMQKAKEMAFFGERLSAAEALALGLVNRVVGADEFDAAVADFAGRLAQAPTSAIAFT KRLLNDSPDTDRSGAFVAEAMAQEIQSYAHDSKEGVQAFVEKRPTEFTGW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1939 | - | - | 100% (261) | enoyl-CoA hydratase/isomerase |
| M. avium 104 | MAV_2641 | - | e-134 | 91.19% (261) | enoyl CoA hydratase |
| M. avium 104 | MAV_1884 | - | 7e-41 | 37.55% (253) | enoyl-CoA isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1174c | echA10 | 1e-32 | 33.59% (256) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2444 | - | 9e-37 | 38.08% (260) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv1142c | echA10 | 1e-32 | 33.59% (256) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 1e-24 | 32.94% (255) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_4570c | - | 2e-34 | 37.40% (254) | enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_4022 | echA10_1 | 2e-38 | 34.52% (252) | enoyl-CoA hydratase EchA10_1 |
| M. smegmatis MC2 155 | MSMEG_5185 | - | 2e-42 | 37.25% (255) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3522 | - | 5e-54 | 45.31% (256) | PUTATIVE putative enoyl-CoA hydratase/isomerase |
| M. ulcerans Agy99 | MUL_3887 | echA10_1 | 3e-38 | 34.52% (252) | enoyl-CoA hydratase EchA10_1 |
| M. vanbaalenii PYR-1 | Mvan_4579 | - | 3e-39 | 36.08% (255) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1174c|M.bovis_AF2122/97 --------MSNYRIDTRTIVPGLAVTLADGVLSVTIDRPESLNSLTKPVL
Rv1142c|M.tuberculosis_H37Rv --------MSNYRIDTRTIVPGLAVTLADGVLSVTIDRPESLNSLTKPVL
MSMEG_5185|M.smegmatis_MC2_155 -MTSTDAS-AETVTRDYPSIDDVSVSLTDGVLAVTLNRPDSLNSLNRDML
Mvan_4579|M.vanbaalenii_PYR-1 -MKGTFMTTTDPTTDAYEGIADLAVGLDDGVLTVTLNRPNSLNSLTAPML
MAB_4570c|M.abscessus_ATCC_199 -------------MSLDESVGAPDVAVDGGIMRVTFTRPDRMNALNGPAT
MAV_1939|M.avium_104 -------------MLSDLT--------DGIMT-ITLNRPDAANAVRPDDR
TH_3522|M.thermoresistible__bu -------------MADEQPGIGVVTDGDGVRR-ITIDRVDVGNSLSPLAR
Mflv_2444|M.gilvum_PYR-GCK -------------MADTEVLLS--SDRDGVRT-LTLNRPHRRNALDARLW
MMAR_4022|M.marinum_M ---------MSLEADSAGPEGSVTSRRDGTLLRITLDRPSRRNSLTQNMI
MUL_3887|M.ulcerans_Agy99 ---------MSLEADSAGPEGSVTSRRDGTLLRITLDRPSRRNSLTRNMI
MLBr_01241|M.leprae_Br4923 MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLM
:*: * *::
Mb1174c|M.bovis_AF2122/97 AGMADAIEGAATDPRVKVVRLGG--AGRGFSSGGAIS--VDDVWASGPP-
Rv1142c|M.tuberculosis_H37Rv AGMADAIEGAATDPRVKVVRLGG--AGRGFSSGGAIS--VDDVWASGPP-
MSMEG_5185|M.smegmatis_MC2_155 DAVADAMEVAATDPAVRVVRLGG--AGRGFSSGAGIS--EEDQNAKGHD-
Mvan_4579|M.vanbaalenii_PYR-1 QAFAATLERAAGDPRVRVVRIGG--AGRGFCSGAGIS--EEDHANPGAAG
MAB_4570c|M.abscessus_ATCC_199 SGLIEALESIPGRDDVRVVVISGGAPGSAFSAGADVT--ELAAGSADLTP
MAV_1939|M.avium_104 DTLIALLEAADADEKVRVVVLRA-NG-KHFCSGADVTALADRRGRGEKRV
TH_3522|M.thermoresistible__bu DALTEAIRDADRDPAVRAVLLTA-AGSRHFCTGAGIS--ADSR-PGQRRP
Mflv_2444|M.gilvum_PYR-GCK VELADALRALKREQDVRALVLTG-AG-GAFCSGADIG-------TGEQIH
MMAR_4022|M.marinum_M EMLLDTLGGAATDDSLRAILIRG-AG-ADFCAGADWV--AASTGTQRPRT
MUL_3887|M.ulcerans_Agy99 EMLLDTLGGAATDDSLRAILIRG-AA-ADFCAGADWV--AASTGTQRHRT
MLBr_01241|M.leprae_Br4923 KSLKQVLKRITYDHSVRVVVLTG--AGRGFCSGADQKFTAPVPQVEGLTQ
. : ::.: : . *.:*.
Mb1174c|M.bovis_AF2122/97 ----TDTVAEANRTVRAIVALPQPVVAVVQGPTVGCGVSLALACDLVLAS
Rv1142c|M.tuberculosis_H37Rv ----TDTVAEANRTVRAIVALPQPVVAVVQGPTVGCGVSLALACDLVLAS
MSMEG_5185|M.smegmatis_MC2_155 ---AAAVLDAANRAVAAIVALPKPVVAVVHGPAAGVGVSLALACDIVLAS
Mvan_4579|M.vanbaalenii_PYR-1 P--PTDVLDGANRCIRAIANLPQPSVAVVQGAAAGVGVSLALACDVVIAS
MAB_4570c|M.abscessus_ATCC_199 LQAAELTMDNAERLVRAVLNCPVPTIAEVTGVAAGIGASVGLACDLIYAA
MAV_1939|M.avium_104 LEPTRRIMNGAQKLVASVLDCNKPVIAAVHGAATGLGAHIVYASDLVIAT
TH_3522|M.thermoresistible__bu GDVARLLQQGWQRLVASILDCAKPVVAAVNGTAAGAGAGLVLAADLVVMS
Mflv_2444|M.gilvum_PYR-GCK P---RYKLDRLTDVALALHELAIPTIAKVTGIAVGAGWNLALGCDLVVAT
MMAR_4022|M.marinum_M GDLLRRIPHAAHRVIELLHTIHLPVVCGVQGWAAGLGANLALAADFTVAS
MUL_3887|M.ulcerans_Agy99 GDLLRRIPHAAHRVIELLHTIHLPVVCGVQGWAAGLGANLALAADFTVAT
MLBr_01241|M.leprae_Br4923 PVRALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRVAS
: * :. : * : * * : ..*. :
Mb1174c|M.bovis_AF2122/97 DNAFFMLAHTNVGLMP-DGGASALVQAAIGRIRAMHMALLPDRVPAAEAL
Rv1142c|M.tuberculosis_H37Rv DNAFFMLAHTNVGLMP-DGGASALVQAAIGRIRAMHMALLPDRVPAAEAL
MSMEG_5185|M.smegmatis_MC2_155 DQAFFLLAFTKIGLMP-DGGASALVAAAIGRIRAMRLALLADRLTATDAY
Mvan_4579|M.vanbaalenii_PYR-1 EKAFFMLAFTKIGLMP-DGGASALIAAAVGRIRAMRMALLAERISAREAY
MAB_4570c|M.abscessus_ATCC_199 DTAFFLLAFANIGLMP-DGGSSALVSASIGRVKANAMALLAQPLSATDAF
MAV_1939|M.avium_104 ENAYFAESFVKRGLVV-DGGGCYLLPRRIGMQKAKEMAFFGERLSAAEAL
TH_3522|M.thermoresistible__bu ERAMLVEPFVARGILP-DSGAVYLLTRIVGLRRATELLMLGEPVDAARCE
Mflv_2444|M.gilvum_PYR-GCK PESRFCQIFSKRGLSV-DLGGSWLLPKTVGLQQAKRLVLLADMIDADEAH
MMAR_4022|M.marinum_M SDATFWEPFVVRGFSP-DSGSTWLLPRLVGLARARRMLLLGEQVTAPEAA
MUL_3887|M.ulcerans_Agy99 SDATFWEPFVVRGFSP-DSGSTWLLPRLVGLARARRMLLLGEQVTAPEAA
MLBr_01241|M.leprae_Br4923 TRAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSGRDVGAEEAE
: : *: : * *: :* :* : : : * .
Mb1174c|M.bovis_AF2122/97 SWGLVSAVYPAADFDAEVDKLISRLLAGPALAIAKTKNAINA-ATLTELA
Rv1142c|M.tuberculosis_H37Rv SWGLVSAVYPAADFDAEVDKLISRLLAGPALAIAKTKNAINA-ATLTELA
MSMEG_5185|M.smegmatis_MC2_155 DWGLISAVYPADEFDAAVDKVLAKLRNGPAVALRKTKQAINE-ATLTELD
Mvan_4579|M.vanbaalenii_PYR-1 DWGLVSSVHPAEEFDAEVDKVIATLVAGPAVALRKTKDAINA-ATLTELE
MAB_4570c|M.abscessus_ATCC_199 AAGLVNEALPGDQLRERVDKTARRLAHGSRRAMQLTKEAMNA-VSLKLFD
MAV_1939|M.avium_104 ALGLVNRVVGADEFDAAVADFAGRLAQAPTSAIAFTKRLLND-SPDTDRS
TH_3522|M.thermoresistible__bu QLGLVNRVVAPDAVYPSALELARRLAAGPTVMLSLTKRLLAV-SSESSRD
Mflv_2444|M.gilvum_PYR-GCK GLGLVTWVKPAGEIDGFIDELADRLAAGPPFALAQSKALLND-GATATLR
MMAR_4022|M.marinum_M DWGLIHQVVDATALDSAVDELLTRLARGPTVAIGLAKQALNH-GQHATLT
MUL_3887|M.ulcerans_Agy99 DWGLIHQVVDATDLDSAVDELLTRLARGPTVAIGLAKQALNH-GQHATLT
MLBr_01241|M.leprae_Br4923 QIGLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRALWGGLDAASLD
**: . . : . :* :
Mb1174c|M.bovis_AF2122/97 PTLLRELDGQA-LLLRTDDFAEGATAFQQRRTPMFTGR-----------
Rv1142c|M.tuberculosis_H37Rv PTLLRELDGQA-LLLRTDDFAEGATAFQQRRTPMFTGR-----------
MSMEG_5185|M.smegmatis_MC2_155 DAIAREREGQL-ELLVANDFREGAQAFQQNRRPEFTDQ-----------
Mvan_4579|M.vanbaalenii_PYR-1 AALERETAGQL-VLLKSADFREGTHAFQQRRVAKFTDS-----------
MAB_4570c|M.abscessus_ATCC_199 EAIARERDGQI-ELLISPDAHEGFAAFLEGRRPNFS-------------
MAV_1939|M.avium_104 GAFVAEAMAQE-IQSYAHDSKEGVQAFVEKRPTEFTGW-----------
TH_3522|M.thermoresistible__bu RAFTEEAWAQE-IVSTTRDLQEGLCAFAERREPRFNGY-----------
Mflv_2444|M.gilvum_PYR-GCK EALANEARAQP-GNFATADSAEAYAAFAAKRDPEFSGAWALYEQPEEQR
MMAR_4022|M.marinum_M ESMTHELFSLE-LTCRTSDFKEGLTAFRQHRTPKFEGR-----------
MUL_3887|M.ulcerans_Agy99 ESMTHELFNLE-LTCRTSDFKEGLTAFRQHRTPKFEGR-----------
MLBr_01241|M.leprae_Br4923 KHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARGCATSPG---
: * : : *. . * . :